ES2066020T3 - Concentrado de factor von willebrand pasteurizado y purificado y procedimiento para su preparacion. - Google Patents
Concentrado de factor von willebrand pasteurizado y purificado y procedimiento para su preparacion.Info
- Publication number
- ES2066020T3 ES2066020T3 ES90102716T ES90102716T ES2066020T3 ES 2066020 T3 ES2066020 T3 ES 2066020T3 ES 90102716 T ES90102716 T ES 90102716T ES 90102716 T ES90102716 T ES 90102716T ES 2066020 T3 ES2066020 T3 ES 2066020T3
- Authority
- ES
- Spain
- Prior art keywords
- von willebrand
- concentrate
- preparation
- willebrand factor
- pasteurized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
EL INVENTO DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION PARA LA PRODUCCION DE UNOS CONCENTRADOS DE FACTRES LIBRES DE AÑUBLO QUE CONSISTE EN PASTERIZAR UNA SOLUCION DE UNOS COMPLEJOS DE ESTOS FACTORES CON FACTOR VIII; C Y TRATAR EL PRODUCTO PASTEURIZADO EN UN INTERCAMBIADOR DE ANIONES, PARA OBTENER UN CONCENTRADO CON FACTORES LIBRES DE AÑUBLO Y UN PRODUCTO RESIDUAL SEPARADO DEL CONCENTRADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3904354A DE3904354A1 (de) | 1989-02-14 | 1989-02-14 | Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2066020T3 true ES2066020T3 (es) | 1995-03-01 |
Family
ID=6374025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90102716T Expired - Lifetime ES2066020T3 (es) | 1989-02-14 | 1990-02-12 | Concentrado de factor von willebrand pasteurizado y purificado y procedimiento para su preparacion. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6239261B1 (es) |
EP (1) | EP0383234B1 (es) |
JP (1) | JP2930243B2 (es) |
KR (1) | KR0149999B1 (es) |
AT (1) | ATE114669T1 (es) |
AU (1) | AU638969B2 (es) |
CA (1) | CA2009946C (es) |
DE (2) | DE3904354A1 (es) |
DK (1) | DK0383234T3 (es) |
ES (1) | ES2066020T3 (es) |
IE (1) | IE900511L (es) |
PT (1) | PT93128B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
FR2644064B1 (fr) * | 1989-02-17 | 1994-05-27 | Aquitaine Dev Transf Sanguine | Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant |
DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
DE4435392B4 (de) * | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
AT406867B (de) | 1997-02-27 | 2000-10-25 | Immuno Ag | Verfahren zur gewinnung von hochreinem vwf oder faktor viii/vwf-komplex |
US6605222B1 (en) * | 1998-05-20 | 2003-08-12 | Baxter Aktiengesellschaft | Method for producing a factor VIII/von Willebrand factor complex |
PL198123B1 (pl) | 1999-02-22 | 2008-05-30 | Baxter Int | Kompozycja czynnika VIII bez dodatku albuminy i jej zastosowanie |
DE10022092A1 (de) * | 2000-05-08 | 2001-11-15 | Aventis Behring Gmbh | Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung |
US7365173B2 (en) * | 2002-02-04 | 2008-04-29 | American National Red Cross | Method for the production of pure virally inactivated butyrylcholinesterase |
DE10246125A1 (de) * | 2002-10-01 | 2004-04-15 | Aventis Behring Gmbh | Konzentrat eines Faktor VIII:C-haltigen von-Willebrand-Faktors und das dazu gehörige Verfahren |
DE102004009400A1 (de) * | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
CA2554018A1 (en) * | 2004-03-04 | 2005-09-29 | Wyeth | Lyophilization method to improve excipient crystallization |
FR2874216B1 (fr) | 2004-08-16 | 2006-11-03 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre de facteur von willebrand (fvw) par voie chromatographique et concentre de fvw susceptible d'etre ainsi obtenu |
KR20070101227A (ko) | 2004-09-07 | 2007-10-16 | 아케믹스 코포레이션 | 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도 |
CA2578046A1 (en) * | 2004-09-07 | 2006-03-16 | Archemix Corp. | Aptamer medicinal chemistry |
US7566701B2 (en) * | 2004-09-07 | 2009-07-28 | Archemix Corp. | Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics |
US20090203766A1 (en) * | 2007-06-01 | 2009-08-13 | Archemix Corp. | vWF aptamer formulations and methods for use |
CA2742328C (en) | 2008-11-07 | 2019-02-26 | Baxter International Inc. | Factor viii formulations |
JP6583766B2 (ja) * | 2015-02-02 | 2019-10-02 | 学校法人北里研究所 | タンパク質分離方法、タンパク質分析方法、及びタンパク質分離キット |
KR101841587B1 (ko) | 2016-01-12 | 2018-05-14 | 주식회사 녹십자홀딩스 | 피브리노겐의 정제방법 |
CN105622746A (zh) * | 2016-02-04 | 2016-06-01 | 江西博雅生物制药股份有限公司 | 一种从冷沉淀提取凝血因子ⅷ的废料中提取人血管性血友病因子的制备工艺 |
CN105541997A (zh) * | 2016-02-04 | 2016-05-04 | 江西博雅生物制药股份有限公司 | 一种高纯度和高活性血管性血友病因子的制备工艺 |
CN105622747A (zh) * | 2016-02-04 | 2016-06-01 | 江西博雅生物制药股份有限公司 | 一种vWF活性保护液 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4027013A (en) * | 1976-01-22 | 1977-05-31 | William L. Wilson | Clottable fibrinogen free factor VIII and albumin product and process |
DE2902158A1 (de) * | 1979-01-20 | 1980-07-31 | Biotest Serum Institut Gmbh | Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen |
US4210580A (en) | 1979-06-19 | 1980-07-01 | David Amrani | Process for separation and isolation of AHF and fibronectin from blood plasma |
US4278594A (en) | 1979-06-19 | 1981-07-14 | David Amrani | Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma |
GB2079292A (en) | 1980-07-05 | 1982-01-20 | Speywood Lab Ltd | Blood Clotting Factor Production |
US4361509A (en) | 1981-12-14 | 1982-11-30 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
DE3237512A1 (de) * | 1982-10-09 | 1984-04-12 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat |
GB8403473D0 (en) | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
US4543210A (en) * | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
US4743680A (en) * | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
DE3707213A1 (de) * | 1987-03-06 | 1988-09-15 | Behringwerke Ag | Verfahren zur herstellung von faktor viii:c-mangelplasma und ein so erhaltenes mangelplasma |
US4774323A (en) * | 1987-06-29 | 1988-09-27 | Rorer Pharmaceutical Corporation | Purification of von Willebrand Factor solutions using gel permeation chromatography |
FR2632309B1 (fr) * | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
FR2651437A1 (fr) * | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
-
1989
- 1989-02-14 DE DE3904354A patent/DE3904354A1/de not_active Withdrawn
-
1990
- 1990-02-12 DK DK90102716.9T patent/DK0383234T3/da active
- 1990-02-12 ES ES90102716T patent/ES2066020T3/es not_active Expired - Lifetime
- 1990-02-12 AT AT90102716T patent/ATE114669T1/de not_active IP Right Cessation
- 1990-02-12 DE DE59007785T patent/DE59007785D1/de not_active Expired - Fee Related
- 1990-02-12 KR KR1019900001674A patent/KR0149999B1/ko not_active IP Right Cessation
- 1990-02-12 EP EP90102716A patent/EP0383234B1/de not_active Expired - Lifetime
- 1990-02-13 PT PT93128A patent/PT93128B/pt not_active IP Right Cessation
- 1990-02-13 JP JP2029777A patent/JP2930243B2/ja not_active Expired - Fee Related
- 1990-02-13 CA CA002009946A patent/CA2009946C/en not_active Expired - Fee Related
- 1990-02-13 IE IE900511A patent/IE900511L/xx not_active IP Right Cessation
- 1990-02-13 AU AU49339/90A patent/AU638969B2/en not_active Ceased
-
1994
- 1994-06-02 US US08/253,232 patent/US6239261B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR900012615A (ko) | 1990-09-01 |
EP0383234B1 (de) | 1994-11-30 |
EP0383234A2 (de) | 1990-08-22 |
PT93128A (pt) | 1990-08-31 |
DE3904354A1 (de) | 1990-08-16 |
AU4933990A (en) | 1990-08-30 |
DK0383234T3 (da) | 1995-05-01 |
JPH02264799A (ja) | 1990-10-29 |
EP0383234A3 (de) | 1991-08-07 |
AU638969B2 (en) | 1993-07-15 |
CA2009946C (en) | 2000-04-11 |
CA2009946A1 (en) | 1990-08-14 |
KR0149999B1 (ko) | 1998-08-17 |
JP2930243B2 (ja) | 1999-08-03 |
US6239261B1 (en) | 2001-05-29 |
DE59007785D1 (de) | 1995-01-12 |
IE900511L (en) | 1990-08-14 |
PT93128B (pt) | 1995-12-29 |
ATE114669T1 (de) | 1994-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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