ES2065670T3 - Metodo y composicion para el aporte controlado de agentes biologicamente activos. - Google Patents

Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Info

Publication number
ES2065670T3
ES2065670T3 ES91901710T ES91901710T ES2065670T3 ES 2065670 T3 ES2065670 T3 ES 2065670T3 ES 91901710 T ES91901710 T ES 91901710T ES 91901710 T ES91901710 T ES 91901710T ES 2065670 T3 ES2065670 T3 ES 2065670T3
Authority
ES
Spain
Prior art keywords
crystalline phase
biologically active
active agents
liquid crystalline
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901710T
Other languages
English (en)
Inventor
Pia Lading
Yvonne Lundsholm
Tomas Norling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xellia Pharmaceuticals ApS
Original Assignee
Dumex AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dumex AS filed Critical Dumex AS
Application granted granted Critical
Publication of ES2065670T3 publication Critical patent/ES2065670T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA DISTRIBUCION CONTROLADA DE AGENTES BIOLOGICAMENTE ACTIVOS COMO PRODUCTOS FARMACEUTICOS A SITIOS DEL CUERPO SE EJECUTA POR LA COMBINACION DE UN MONOGLICERIDO Y UN ACEITE VEGETAL. AL CONTACTO CON UN LIQUIDO ACUOSO, LA COMPOSICION FORMA UNA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL INVERTIDA QUE LIBERA EL AGENTE ACTIVO DE MANERA CONTROLADA. EL METODO DE DISTRIBUCION ES PARTICULARMENTE UTIL PARA EL TRATAMIENTO DE ENFERMEDAD PERIODONTAL MEDIANTE LA INSERCION DE LA COMPOSICION DE PRECURSOR DE FASE CRISTALINA LIQUIDA DIRECTAMENTE EN LA CAVIDAD PERIODONTAL, EN DONDE AGUA DEL FLUIDO GENGIVAL INDUCE LA FORMACION ESPONTANEA IN SITU DE LA MATRIZ DE FASE CRISTALINA LIQUIDA HEXAGONAL.
ES91901710T 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos. Expired - Lifetime ES2065670T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/DK1990/000299 WO1992009272A1 (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents
CA002095354A CA2095354C (en) 1990-11-21 1990-11-21 Method and composition for controlled delivery of biologically active agents

Publications (1)

Publication Number Publication Date
ES2065670T3 true ES2065670T3 (es) 1995-02-16

Family

ID=25676134

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91901710T Expired - Lifetime ES2065670T3 (es) 1990-11-21 1990-11-21 Metodo y composicion para el aporte controlado de agentes biologicamente activos.

Country Status (15)

Country Link
US (1) US5143934A (es)
EP (1) EP0558475B1 (es)
JP (1) JPH03135925A (es)
KR (1) KR0180750B1 (es)
AT (1) ATE115402T1 (es)
AU (1) AU647768B2 (es)
CA (1) CA2095354C (es)
DE (1) DE69015212T2 (es)
DK (1) DK0558475T3 (es)
ES (1) ES2065670T3 (es)
FI (1) FI109452B (es)
GR (1) GR3015329T3 (es)
HU (1) HU220216B (es)
NO (1) NO305931B1 (es)
WO (1) WO1992009272A1 (es)

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SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5262164A (en) * 1989-11-17 1993-11-16 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5620700A (en) * 1990-10-30 1997-04-15 Alza Corporation Injectable drug delivery system and method
US5531925A (en) * 1991-10-04 1996-07-02 Gs Biochem Ab Particles, method of preparing said particles and uses thereof
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
WO1995017901A1 (en) * 1993-12-29 1995-07-06 Matrix Pharmaceutical, Inc. Methods and compositions for the treatment of a host with a cellular proliferative disease
ATE333867T1 (de) * 1994-03-18 2006-08-15 Shire Lab Inc Emulgierte arzneistoffabgabesysteme
AU2593695A (en) * 1994-05-20 1995-12-18 Novavax, Inc. Antibacterial oil-in-water emulsions
SE518578C2 (sv) * 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5824638A (en) * 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US5744062A (en) * 1996-08-29 1998-04-28 R.I.T.A. Corporation Balanced emulsifier blends for oil-in-water emulsions
EP1033127A4 (en) 1997-03-18 2006-07-26 Sunstar Inc COMPOSITIONS FOR THE FORMATION OF SOLID-PARTICULAR PARTICLES
ES2202901T3 (es) 1997-09-09 2004-04-01 Lyotropic Therapeutics, Inc. Particulas recubiertas, procedimiento para su fabricacion y uso.
US6638621B2 (en) * 2000-08-16 2003-10-28 Lyotropic Therapeutics, Inc. Coated particles, methods of making and using
US6017516A (en) * 1997-10-31 2000-01-25 Lekar Pharma Limited Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate
GB9827034D0 (en) * 1998-12-10 1999-02-03 Univ Manchester Delivery formulation
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
JP2003171301A (ja) * 2001-11-09 2003-06-20 Mahidol Univ 歯周炎治療における補助剤としてのカルメグゲル
AU2003258075A1 (en) * 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
MXPA05002033A (es) 2002-08-26 2005-10-19 Sla Pharma Ag Una composicion farmaceutica.
CA2502734A1 (en) * 2002-08-29 2004-03-11 Toray Industries, Inc. Medicinal composition for periodontal pocket administration containing bisphosphonic acid derivative or its salt as the active ingredient
DK1415646T3 (da) * 2002-11-01 2009-12-21 Univ Mahidol Gel omfattende et antimikrobielt ekstrakt som tilsætningsmiddel i behandlingen af periodontitis
DE10332680A1 (de) * 2003-07-18 2005-02-17 Biomet Deutschland Gmbh Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen
WO2005027807A1 (en) 2003-09-19 2005-03-31 Drugtech Corporation Pharmaceutical delivery system
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
WO2006043705A1 (ja) * 2004-10-19 2006-04-27 National Institute Of Advanced Industrial Scienceand Technology Ｉｉ型キュービック液晶組成物
US20060127437A1 (en) * 2004-12-13 2006-06-15 Misty Anderson Kennedy Semisolid system and combination semisolid, multiparticulate system for sealing tissues and/or controlling biological fluids
AR048742A1 (es) * 2004-12-22 2006-05-24 Gador Sa Sistema de aplicacion de medicamentos intra-oral
US7125954B2 (en) * 2005-01-27 2006-10-24 General Electric Company Method for producing polyether polymers
MX2007011464A (es) * 2005-03-18 2007-10-12 Lg Household & Health Care Ltd Blanqueador dental.
AU2006244260A1 (en) * 2005-05-09 2006-11-16 Drugtech Corporation Modified-release pharmaceutical compositions
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
AU2006332518A1 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Composition and method of use thereof
US20070154516A1 (en) * 2006-01-05 2007-07-05 Drugtech Corporation Drug delivery system
US20100105750A1 (en) * 2008-10-23 2010-04-29 Nycomed Us Inc. Stable metronidazole gel formulations
EP2498754B1 (en) * 2009-06-25 2018-06-06 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Reverse hexagonal mesophases (h ii) and uses thereof
WO2011001425A1 (en) 2009-07-01 2011-01-06 Dexcel Pharma Technologies Ltd. Local therapeutic release device
US8865198B2 (en) 2010-10-25 2014-10-21 Dexcel Pharma Technologies Ltd. Method for treating a periodontal disease
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US8895536B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating chronic inflammation and inflammatory diseases
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
RU2508101C1 (ru) * 2012-10-16 2014-02-27 Открытое акционерное общество "Биосинтез" Мягкая лекарственная форма комбинированного действия для локального лечения заболеваний пародонта
SG11201505245XA (en) * 2013-01-14 2015-08-28 Infirst Healthcare Ltd Compositions and methods for treating severe pain
CA2897878A1 (en) * 2013-01-14 2014-07-17 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
SG11201505243PA (en) * 2013-02-04 2015-08-28 Infirst Healthcare Ltd Compositions and methods for treating chronic inflammation and inflammatory diseases
WO2014175814A1 (en) * 2013-04-26 2014-10-30 Bioglan Ab Composition for use in reducing scab formation and promoting healing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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US2196322A (en) * 1937-12-04 1940-04-09 Squibb & Sons Inc Pharmaceutical
DK116528A (es) * 1966-09-30
US4568535A (en) * 1982-08-06 1986-02-04 Loesche Walter J Composition for periodontal administration
US4698359A (en) * 1982-08-24 1987-10-06 Cilag, Ag Medicated suppository
SE8206744D0 (sv) * 1982-11-26 1982-11-26 Fluidcarbon International Ab Preparat for kontrollerad avgivning av substanser
US4780320A (en) * 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
EP1169958A1 (en) * 2000-06-28 2002-01-09 Tege Patents Aktiengesellschaft Vending machine cooking unit

Also Published As

Publication number Publication date
HUT75453A (en) 1997-05-28
EP0558475B1 (en) 1994-12-14
NO931832D0 (no) 1993-05-19
HU9301346D0 (en) 1993-09-28
HU220216B (hu) 2001-11-28
WO1992009272A1 (en) 1992-06-11
FI932278A0 (fi) 1993-05-19
GR3015329T3 (en) 1995-06-30
KR0180750B1 (ko) 1999-03-20
ATE115402T1 (de) 1994-12-15
DE69015212T2 (de) 1995-05-04
US5143934A (en) 1992-09-01
AU7049991A (en) 1992-06-25
JPH03135925A (ja) 1991-06-10
FI109452B (fi) 2002-08-15
NO305931B1 (no) 1999-08-23
AU647768B2 (en) 1994-03-31
FI932278A (fi) 1993-05-19
DK0558475T3 (da) 1995-04-24
DE69015212D1 (de) 1995-01-26
NO931832L (no) 1993-07-19
CA2095354C (en) 2001-10-09
EP0558475A1 (en) 1993-09-08
CA2095354A1 (en) 1992-05-22

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