US2196322A - Pharmaceutical - Google Patents
Pharmaceutical Download PDFInfo
- Publication number
- US2196322A US2196322A US178132A US17813237A US2196322A US 2196322 A US2196322 A US 2196322A US 178132 A US178132 A US 178132A US 17813237 A US17813237 A US 17813237A US 2196322 A US2196322 A US 2196322A
- Authority
- US
- United States
- Prior art keywords
- inhalant
- oil
- ephedrine
- essentially
- ethyl oleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
Description
Patented Apr. 9, 1940 UNITED STATES PATENT OFFICE PHARMACEUTICAL No Drawing.
Application December 4, 1937,
Serial No. 178,132
,9 Claims. (Cl. 16758) This invention relates to inhalan s, i. e., preparations for nasal administration, as by dropping or spraying.
Heretofore, oil-soluble inhalant medicinal agents (e. g., ephedrine) have been incorporated in mineral-oil vehicles for the production of inhalants. Numerous cases of lipoid pneumonia have resulted from the use of such preparations, apparently because of the non-absorption of oil vehicle finding its way' into the alveoli of the lung.
It is the object of this invention to provide non-injurious inhalants; more particularly, to provide preparations of oil-soluble inhalant ll medicinal agents embodying a vehicle absorbable by the lungs.
It has been found that certain oily aliphatic esters are absorbable by the body and constitute effective vehicles for oil-soluble inhalant medlcg0 inal agents. In the event these absorbable oily aliphatic esters enter the lung, they do not remain there, either because of their tendency to pass into water solution or because of their susceptibility to enzyme hydrolysis. Moreover, the 535 slight water-solubility of some of these esters enhances the effectiveness of the .medicinal agents, since aqueous fluids are present in the nasal passages.
The following esters, inter alia, have been found to be absorbable eifective vehicles:
Aliphatic polyhydroxy compounds completely 5 esterified with higher fatty acids, such as ,glyceryl' trioleate, remain unabsorbed in the lung. The
absorbable vehicles specifically disclosed belong to the group: consisting of lower-alkyl esters of 'higher fatty acids and aliphatic polyhydroxy compounds partially esterified with higher fatty acids;
These absorbable vehicles are eflective for all inhalants embodying oil-soluble medicinal agents.
The following examples are illustrative of the application of this invention to plain and compound ephedrine inhalants and to non-ephedrine inhalants.
Example 1 A plain ephedrine inhalant is made by incorporating 1.5 g. ephedrine in 148.5 g. ethyl oleate.
Example 2 A compound ephedrine inhalant is made by incorporating the following in 144.0 g. ethyl l0 I Example 3- A non-ephedrine inhalant is made by incorporating the following in 144.0- g. ethyl oleate:
Grams Phenol 1.1
Menthol 1.1 25
Example 4 An inhalant is made by incorporating p-phenethyl amine, p-phenyl-isopropylamine, m (or p) hYdIOXY-a- (methylaminomethyl) -benzyl alcohol,
or the like in ethyl oleate.
Example 5 p-phenethyl amine or amed cinal derivative thereof is incorporated in the compound inhalant preparation of Example 2 in place of ephedrine.
In the compound inhalants, a variety of substances can be used instead of the phenol, camphor, menthol, oil of thyme, and oil of lilac. Menthol and camphor are employed torelieve congestion, and oil of thyme and oil of lilac to improve the odor of the product; and these may be replaced by other similarly efiective agents. The phenol is used because of its anesthetic and antiseptic properties; and may be, replaced by anesthetics such as 'benzyl alcohol, saligenin, chlorobutanol, or the alkyl esters of para-amino- 50 benzoic acid, and/or by antiseptics such as hydroxy-quinoline, chlor-hydroxy-quinoline, or
ethyl butyl resorcinol.
When the inhalant is unsatisfactory because of excessive viscosity of the vehicle, adjustment can u be made by replacing part of the viscous vehicle with ethyl oleate. Conversely, if the ethyl oleate preparations are too thin, this vehicle may be partly replaced with one having a higher viscosity. i
The invention may be variously otherwise embodied within the scope of the appended claims.
We claim:
1. An inhalant essentially comprising an oilsoluble inhalant medicinal agent and a lungabsorbable vehicle of the group consisting of lower-alkyl esters of higher fatty acids and allphatic polyhydroxy compounds incompletely esterifled with higher fatty acids.
2. An inhalant essentially comprising an oil soluble inhalant medicinal agent and a lungabsorbable oily aliphatic mono-ester of a higher fatty acid. v
3. An inhalant essentially comprising an oil- 20 soluble inhalant medicinal agent and a lung'- absorbable oily aliphatic mono-ester of a higher unsaturated fatty acid.
4. An inhalant essentially comprising an oilsoluble inhalant medicinal agent and ethyl oleate.
5. An, inhalant essentially comprising an oilsoluble inhalant medicinal agent and an ethyl ester of the mixture of fatty acids derivable I from an oil of the group consisting of olive oil,
coconut oil, and linseed oil.
6. An inhalant essentially comprising an oilsoluble inhalant medicinal agent and glyceryl mono-oleate. i
7. An inhalant essentially comprising ephedrine and ethyl oleate.
8. An inhalant essentially comprising phenol, menthol, camphor, and ethyl oleate.
9.- A medicinal inhalant preparation essentially comprising p-phenethylamine and ethyl oleate.
FERDINAND W. NITARDY. WALTER G. CHRISTIANSEN.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US178132A US2196322A (en) | 1937-12-04 | 1937-12-04 | Pharmaceutical |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US178132A US2196322A (en) | 1937-12-04 | 1937-12-04 | Pharmaceutical |
Publications (1)
Publication Number | Publication Date |
---|---|
US2196322A true US2196322A (en) | 1940-04-09 |
Family
ID=22651333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US178132A Expired - Lifetime US2196322A (en) | 1937-12-04 | 1937-12-04 | Pharmaceutical |
Country Status (1)
Country | Link |
---|---|
US (1) | US2196322A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0160501A2 (en) * | 1984-04-25 | 1985-11-06 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
WO1992005781A1 (en) * | 1990-09-28 | 1992-04-16 | The Procter & Gamble Company | Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form |
US5143934A (en) * | 1990-11-21 | 1992-09-01 | A/S Dumex (Dumex Ltd.) | Method and composition for controlled delivery of biologically active agents |
-
1937
- 1937-12-04 US US178132A patent/US2196322A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0160501A2 (en) * | 1984-04-25 | 1985-11-06 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
EP0160501A3 (en) * | 1984-04-25 | 1986-12-30 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
WO1992005781A1 (en) * | 1990-09-28 | 1992-04-16 | The Procter & Gamble Company | Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form |
US5175152A (en) * | 1990-09-28 | 1992-12-29 | Singh Nikhilesh N | Composition containing ephedrine base and alkyl salicylate for the delivery of ephedrine base in vapor form |
US5143934A (en) * | 1990-11-21 | 1992-09-01 | A/S Dumex (Dumex Ltd.) | Method and composition for controlled delivery of biologically active agents |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69231994T3 (en) | Chlorofluorocarbon-free aerosol formulations | |
US5096916A (en) | Treatment of chronic obstructive pulmonary disease (copd) by inhalation of an imidazoline | |
AU724070B2 (en) | Use of mupirocin for the manufacture of a medicament for the treatment of bacterial infections associated with colonisation of the nasopharynx by pathogenic organisms | |
US4668513A (en) | Method for combating snoring | |
DE69828817T2 (en) | PHARMACEUTICAL AEROSOL COMPOSITIONS | |
PT1277467E (en) | Non-chlorofluorocarbon aerosol formulations | |
US6156792A (en) | Calcium mupirocin non-aqueous nasal spray for otitis media or for recurrent acute bacterial sinusitis | |
JP2017052804A (en) | Ophthalmological aqueous composition | |
EP0243308A2 (en) | Stabilization of the preservative Thiomersal in ophthalmic pharmaceutical compositions | |
JPS6036414A (en) | Medicine for oral, nasal and pharyngal mucosa | |
US3232833A (en) | Heparin containing compositions | |
DE202014105553U1 (en) | Cineole-containing composition for nasal administration | |
US2196322A (en) | Pharmaceutical | |
WO1983003544A1 (en) | Perfluorohydrocarbons as vehicles for administering drugs | |
JP2017057145A (en) | External composition | |
DE2611183C2 (en) | Stabilized formulation of PGE-type prostaglandin-like drugs | |
IE51097B1 (en) | Stable benzoyl peroxide compositions | |
DE3317530A1 (en) | Antisnoring composition | |
ITMI20090829A1 (en) | OPHTHALMIC COMPOSITIONS FOR THE REITITIZATION, CYCLING, AND DISINFECTION OF THE EYE FABRICS | |
CN103766339A (en) | Composition containing trans-cinnamaldehyde | |
EP0680760A1 (en) | Topical antipruritic composition containing a phosphonic acid diester compound | |
US3374144A (en) | Ophthalmic composition | |
Dunn et al. | A Mixture of High Molecular Alkyl-dimethyl-benzyl-ammonium Chlorides as an Antiseptic. | |
US2546895A (en) | Aerial disinfectants and method of using the same | |
US5250286A (en) | Treatment of chronic obstructive pulmonary disease (COPD) by inhalation of an imidazoline |