ES2064074T3 - Procedimiento y aparato para separar y volver a poner en suspension particulas superparamagneticas. - Google Patents
Procedimiento y aparato para separar y volver a poner en suspension particulas superparamagneticas.Info
- Publication number
- ES2064074T3 ES2064074T3 ES91900016T ES91900016T ES2064074T3 ES 2064074 T3 ES2064074 T3 ES 2064074T3 ES 91900016 T ES91900016 T ES 91900016T ES 91900016 T ES91900016 T ES 91900016T ES 2064074 T3 ES2064074 T3 ES 2064074T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- container
- particles
- suspension
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 239000000725 suspension Substances 0.000 title abstract 2
- 239000012530 fluid Substances 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Compounds Of Iron (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
LAS PARTICULAS SUPERPARAMAGNETICAS SE SEPARAN DE UNA SUSPENSION DE LAS MISMAS EN UN PRIMER FLUIDO Y SE VUELVEN A SUSPENDER EN EL MISMO FLUIDO O EN OTRO DISTINTO QUE SE ENCUENTRA EN UN CONTENEDOR, A BASE DE SOMETERLAS A UN PRIMER CAMPO ELECTROMAGNETICO PARA LLEVAR LAS PARTICULAS A UNA SUPERFICIE O ZONA DEL CONTENEDOR Y DESPUES VOLVER A SUSPENDER LAS PARTICULAS EN EL FLUIDO QUE SE ENCUENTRA EN EL CONTENEDOR MEDIANTE UNA SEGUNDA APLICACION DE UN CAMPO MAGNETICO. SE PRESENTA UN APARATO QUE CONTIENE EL CONTENEDOR (1), MEDIOS (2, 3) PARA PRODUCIR DICHAS PRIMERA Y SEGUNDA APLICACIONES DE CAMPOS ELECTROMAGNETICOS, RECEPTACULOS REACTIVOS (7) Y UNA FRASCO DE LAVADO (8). SE PUEDE INCLUIR TAMBIEN UN DISPOSITIVOS CONTADOR DE PARTICULAS Y TAL APARATO SE PUEDE UTILIZAR PARA CONTAR CELULAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898927744A GB8927744D0 (en) | 1989-12-07 | 1989-12-07 | Process and apparatus |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064074T3 true ES2064074T3 (es) | 1995-01-16 |
Family
ID=10667610
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91900016T Expired - Lifetime ES2064074T3 (es) | 1989-12-07 | 1990-12-06 | Procedimiento y aparato para separar y volver a poner en suspension particulas superparamagneticas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5681478A (es) |
EP (1) | EP0504192B1 (es) |
JP (1) | JPH05502294A (es) |
AT (1) | ATE114047T1 (es) |
AU (1) | AU642186B2 (es) |
CA (1) | CA2072135A1 (es) |
DE (1) | DE69014130T2 (es) |
DK (1) | DK0504192T3 (es) |
ES (1) | ES2064074T3 (es) |
GB (1) | GB8927744D0 (es) |
WO (1) | WO1991009308A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8927742D0 (en) * | 1989-12-07 | 1990-02-07 | Diatec A S | Process and apparatus |
US5622831A (en) * | 1990-09-26 | 1997-04-22 | Immunivest Corporation | Methods and devices for manipulation of magnetically collected material |
ATE195081T1 (de) * | 1992-09-24 | 2000-08-15 | Amersham Pharm Biotech Uk Ltd | Verfahren und vorrichtung zur magnetischen abscheidung |
EP0589636B1 (en) * | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Magnetic separation method and apparatus therefor |
US5686271A (en) * | 1994-06-09 | 1997-11-11 | Gamera Bioscience Corporation | Apparatus for performing magnetic cycle reaction |
JP3962789B2 (ja) * | 1995-02-21 | 2007-08-22 | ダブリュー. シディキー,イクバール | 磁性粒子を利用した混合/分離装置及びその方法 |
US6500343B2 (en) | 1995-02-21 | 2002-12-31 | Iqbal W. Siddiqi | Method for mixing and separation employing magnetic particles |
US6884357B2 (en) | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
US20030127396A1 (en) * | 1995-02-21 | 2003-07-10 | Siddiqi Iqbal Waheed | Apparatus and method for processing magnetic particles |
US5790246A (en) * | 1996-04-18 | 1998-08-04 | Montores Pty. Ltd. | Apparatus and network for determining a parameter of a particle in a fluid employing detector and processor |
US6143578A (en) * | 1996-05-10 | 2000-11-07 | Bayer Corporation | Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology |
EP1947442A3 (en) | 1997-05-05 | 2008-07-30 | ChemoMetec A/S | A method and a system for determination of biological particles in a liquid sample |
DE19823719B4 (de) * | 1998-05-27 | 2011-12-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zum Aufkonzentrieren von Substanzen |
CN1399718A (zh) | 1999-04-09 | 2003-02-26 | 宇宙硬件最佳技术股份有限公司 | 用于纯化细胞、化学物质和蛋白质结构的多级电磁分离器 |
US6672458B2 (en) * | 2000-05-19 | 2004-01-06 | Becton, Dickinson And Company | System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample |
US20030095897A1 (en) * | 2001-08-31 | 2003-05-22 | Grate Jay W. | Flow-controlled magnetic particle manipulation |
EP1487969A4 (en) * | 2001-12-07 | 2008-07-09 | Dyax Corp | METHOD AND DEVICE FOR WASHING MAGNETICALLY RESPONSIVE PARTICLES |
US7514270B2 (en) * | 2002-04-12 | 2009-04-07 | Instrumentation Laboratory Company | Immunoassay probe |
KR20050008720A (ko) | 2002-05-17 | 2005-01-21 | 벡톤 디킨슨 앤드 컴퍼니 | 표적 핵산 서열의 분리, 증폭 및 검출을 위한 자동화 시스템 |
US7601491B2 (en) * | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
JP3711988B2 (ja) * | 2003-05-12 | 2005-11-02 | 株式会社日立製作所 | 微粒子アレー分析システム、微粒子アレーキットおよび化学分析方法 |
WO2005005044A1 (en) * | 2003-07-10 | 2005-01-20 | Universite Libre De Bruxelles | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed |
US7947450B2 (en) * | 2003-07-10 | 2011-05-24 | Universite Libre De Bruxelles | Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed |
US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
EP2038900B1 (en) * | 2006-06-21 | 2016-04-20 | Spinomix S.A. | A method for manipulating magnetic particles in a liquid medium |
US8585279B2 (en) | 2006-06-21 | 2013-11-19 | Spinomix S.A. | Device and method for manipulating and mixing magnetic particles in a liquid medium |
US8999732B2 (en) | 2006-06-21 | 2015-04-07 | Spinomix, S.A. | Method for manipulating magnetic particles in a liquid medium |
US8870446B2 (en) | 2006-06-21 | 2014-10-28 | Spinomix S.A. | Device and method for manipulating and mixing magnetic particles in a liquid medium |
US8283185B2 (en) * | 2006-10-30 | 2012-10-09 | Stc.Unm | Magnetically susceptible particles and apparatuses for mixing the same |
CN101563164B (zh) * | 2006-12-20 | 2012-06-13 | 皇家飞利浦电子股份有限公司 | 用于分离磁性粒子的方法和设备、磁性粒子以及磁性粒子的用途 |
WO2010068812A1 (en) * | 2008-12-10 | 2010-06-17 | Abqmr, Inc. | Nuclear magnetic resonance apparatus, methods and associated technology |
EP2368639A1 (de) * | 2010-03-23 | 2011-09-28 | Siemens Aktiengesellschaft | Vorrichtung und Verfahren zur Magnetseparation eines Fluids |
US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
US9428547B2 (en) | 2010-04-21 | 2016-08-30 | Dna Electronics, Inc. | Compositions for isolating a target analyte from a heterogeneous sample |
US20120135494A1 (en) * | 2010-11-30 | 2012-05-31 | General Electric Company | Systems and methods for magnetic separation of biological materials |
GB2497317A (en) * | 2011-12-06 | 2013-06-12 | Univ Dublin | System and method for the detection of analytes using rod-shaped nanoparticles |
DE102012210077A1 (de) * | 2012-06-15 | 2013-12-19 | Siemens Aktiengesellschaft | Verfahren und Anordnung zur Markierung von Zellen in einer Zellsuspension |
US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
CN104764681B (zh) * | 2015-04-16 | 2017-11-24 | 郑州大学 | 尘的再悬浮装置及其使用方法 |
US10953092B2 (en) * | 2015-09-22 | 2021-03-23 | California Institute Of Technology | Method and apparatus for particle actuation in a space |
CN108290166B (zh) * | 2015-11-30 | 2021-07-20 | Dh科技发展私人贸易有限公司 | 用于处理流体的电磁组合件 |
SG11201901233SA (en) * | 2016-10-31 | 2019-03-28 | Amgen Inc | Purification systems and methods |
EP3567098B1 (en) * | 2017-01-04 | 2023-01-04 | Nanjing GenScript Biotech Co., Ltd. | Automatic purification system and biological sample purification method |
US20200360879A1 (en) | 2017-11-21 | 2020-11-19 | Dh Technologies Development Pte. Ltd. | 3-D Mixing and Particle Delivery Via Movable Electromagnets Assemblies |
WO2020019001A1 (en) * | 2018-07-20 | 2020-01-23 | Cornell University | Magnetic separation of biological entities from fluid sample |
WO2024112874A1 (en) * | 2022-11-22 | 2024-05-30 | Lo Biosciences, Inc. | Magnetic capture device |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2973096A (en) * | 1958-04-18 | 1961-02-28 | Robert A Cummings Jr | Magnetic separation apparatus and treating methods involving magnetic separation |
US3219318A (en) * | 1961-08-22 | 1965-11-23 | Hershler Abe | Fluid treating method and apparatus |
US3703958A (en) * | 1969-08-11 | 1972-11-28 | Massachusetts Inst Technology | Eddy current apparatus and method of application to a conductive material |
JPS5549626B2 (es) * | 1972-07-21 | 1980-12-12 | ||
US3985649A (en) * | 1974-11-25 | 1976-10-12 | Eddelman Roy T | Ferromagnetic separation process and material |
US4075462A (en) * | 1975-01-08 | 1978-02-21 | William Guy Rowe | Particle analyzer apparatus employing light-sensitive electronic detector array |
US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
JPS5785002A (en) * | 1980-11-17 | 1982-05-27 | Matsushita Electric Ind Co Ltd | Plastic lens |
JPS5845445A (ja) * | 1981-09-11 | 1983-03-16 | Asahi Tekkosho:Kk | 太陽熱集熱器 |
JPS58107501A (ja) * | 1981-12-21 | 1983-06-27 | Matsushita Electric Ind Co Ltd | プラスチツクレンズ |
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
JPS58193687A (ja) * | 1982-05-10 | 1983-11-11 | Res Dev Corp Of Japan | 微小物の撹拌分離方法 |
JPS5986615A (ja) * | 1982-11-11 | 1984-05-18 | Showa Denko Kk | 重合性組成物 |
GB2134819A (en) * | 1983-01-28 | 1984-08-22 | Univ Southampton | Magnetic collection of particles from a fluid |
JPS59193915A (ja) * | 1983-04-20 | 1984-11-02 | Tokuyama Soda Co Ltd | 高屈折率透明樹脂の製造方法 |
US4698302A (en) * | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
JPS6225162A (ja) * | 1985-07-26 | 1987-02-03 | Du Pont Mitsui Polychem Co Ltd | アルカリ分散性ホツトメルト組成物 |
EP0363441B1 (en) * | 1987-03-02 | 1992-09-09 | Ionode Pty. Ltd. | Mixing apparatus and method |
EP0318913B1 (en) * | 1987-11-30 | 1994-03-30 | Nippon Steel Corporation | Method of washing off magnetically separated particles |
US4895650A (en) * | 1988-02-25 | 1990-01-23 | Gen-Probe Incorporated | Magnetic separation rack for diagnostic assays |
US5147529A (en) * | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
GB8927742D0 (en) * | 1989-12-07 | 1990-02-07 | Diatec A S | Process and apparatus |
-
1989
- 1989-12-07 GB GB898927744A patent/GB8927744D0/en active Pending
-
1990
- 1990-12-06 CA CA002072135A patent/CA2072135A1/en not_active Abandoned
- 1990-12-06 DK DK91900016.6T patent/DK0504192T3/da active
- 1990-12-06 US US07/852,182 patent/US5681478A/en not_active Expired - Fee Related
- 1990-12-06 AU AU68793/91A patent/AU642186B2/en not_active Ceased
- 1990-12-06 EP EP91900016A patent/EP0504192B1/en not_active Expired - Lifetime
- 1990-12-06 DE DE69014130T patent/DE69014130T2/de not_active Expired - Fee Related
- 1990-12-06 WO PCT/EP1990/002122 patent/WO1991009308A1/en active IP Right Grant
- 1990-12-06 JP JP3500649A patent/JPH05502294A/ja not_active Withdrawn
- 1990-12-06 ES ES91900016T patent/ES2064074T3/es not_active Expired - Lifetime
- 1990-12-06 AT AT91900016T patent/ATE114047T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU642186B2 (en) | 1993-10-14 |
DE69014130D1 (de) | 1994-12-15 |
ATE114047T1 (de) | 1994-11-15 |
WO1991009308A1 (en) | 1991-06-27 |
DE69014130T2 (de) | 1995-03-23 |
AU6879391A (en) | 1991-07-18 |
JPH05502294A (ja) | 1993-04-22 |
CA2072135A1 (en) | 1991-06-08 |
DK0504192T3 (da) | 1995-01-02 |
EP0504192A1 (en) | 1992-09-23 |
GB8927744D0 (en) | 1990-02-07 |
EP0504192B1 (en) | 1994-11-09 |
US5681478A (en) | 1997-10-28 |
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