ES2063268T3 - Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia. - Google Patents
Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia.Info
- Publication number
- ES2063268T3 ES2063268T3 ES90306020T ES90306020T ES2063268T3 ES 2063268 T3 ES2063268 T3 ES 2063268T3 ES 90306020 T ES90306020 T ES 90306020T ES 90306020 T ES90306020 T ES 90306020T ES 2063268 T3 ES2063268 T3 ES 2063268T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- carbon atoms
- optionally substituted
- dementia
- depressions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Lubricants (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
Abstract
LA INVENCION CONCIERNE A COMPUESTOS QUE TIENEN LA FORMULA: O A UNA SAL DE ELLOS, EN DONDE E REPRESENTA HIDROGENO, ALQUILO INFERIOR O UN GRUPO AR1-A1-; AR Y AR1 SON LOS MISMOS O DIFERENTES GRUPOS ARILO (INCLUYENDO LOS HETEROARILOS), LOS CUALES ESTAN OPCIONALMENTE SUSTITUIDOS, P.EJ. POR UNO O MAS SUSTITUYENTES COMUNMENTE USADOS EN QUIMICA FARMACEUTICA; A Y A1 SON LOS MISMOS O DIFERENTES GRUPOS ALQUILENO, QUE TIENEN UNO O DOS ATOMOS DE CARBONO, ENLAZANDO AR Y AR1 A N Y SIENDO OPCIONALMENTE SUSTITUIDO POR ALQUILO INFERIOR Y/O ARILO OPCIONALMENTE SUSTITUIDO, B ES UN GRUPO ALQUILENO DE 3 O 4 ATOMOS DE CARBONO, EL CUAL PUEDE ESTAR SUSTITUIDO POR ALQUILO INFERIOR; D1 REPRESENTA HALOGENO, CH3, CR1R2NH2, SO3H O SO2NR6R7 DONDE R1 Y R2 SON INDEPENDIENTEMENTE HIDROGENO O ALQUILO INFERIOR Y R6 Y R7 SON CADA UNO HIDROGENO, ALQUILO INFERIOR O ARALQUILO DE 7 A 12 ATOMOS DE CARBONO O R6 Y R7 JUNTO CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS REPRESENTAN UN ANILLO DE 5 O 6 MIEMBROS; TALES COMPUESTOS SE USAN, PARA TRATAR DEPRESIONES O INSUFICIENCIA CEREBRAL O DEMENCIAS EN ANIMALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898912784A GB8912784D0 (en) | 1989-06-02 | 1989-06-02 | Amines |
GB898927087A GB8927087D0 (en) | 1989-11-30 | 1989-11-30 | Amines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2063268T3 true ES2063268T3 (es) | 1995-01-01 |
Family
ID=26295435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90306020T Expired - Lifetime ES2063268T3 (es) | 1989-06-02 | 1990-06-01 | Aminas aromaticas y heteroaromaticas para el tratamiento de depresiones, trastornos de insuficiencia cerebral o demencia. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5086073A (es) |
EP (1) | EP0407032B1 (es) |
JP (1) | JPH0347155A (es) |
KR (1) | KR910000133A (es) |
AT (1) | ATE113833T1 (es) |
AU (1) | AU641394B2 (es) |
CA (1) | CA2017966A1 (es) |
DE (1) | DE69013994T2 (es) |
ES (1) | ES2063268T3 (es) |
GB (1) | GB2233558B (es) |
HU (1) | HUT58270A (es) |
PT (1) | PT94218A (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5430044A (en) * | 1987-02-06 | 1995-07-04 | Fisons Corporation | Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties |
GB9125615D0 (en) * | 1991-12-02 | 1992-01-29 | Wyeth John & Brother Ltd | Amines |
GB9320051D0 (en) * | 1993-09-29 | 1993-11-17 | Lilly Industries Ltd | Pharmaceutical compounds |
WO2000006149A1 (en) * | 1998-07-31 | 2000-02-10 | Eli Lilly And Company | Sulfonamide derivatives |
GB0417802D0 (en) * | 2004-08-10 | 2004-09-15 | Novartis Ag | Organic compounds |
US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
EP1848430B1 (en) | 2004-12-31 | 2017-08-02 | Dr. Reddy's Laboratories Ltd. | Novel benzylamine derivatives as cetp inhibitors |
WO2013024358A2 (en) | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
WO2013046045A1 (en) | 2011-09-27 | 2013-04-04 | Dr. Reddy's Laboratories, Ltd. | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB841634A (en) * | 1957-04-17 | 1960-07-20 | Ici Ltd | Triphenylmethane derivatives and their use in molluscicidal compositions |
GB942309A (en) * | 1959-02-06 | 1963-11-20 | Wellcome Found | Tertiary n-bromobenzyl-n-butylamines and their preparation |
DE1116227B (de) * | 1959-07-09 | 1961-11-02 | Thomae Gmbh Dr K | Verfahren zur Herstellung von tertiaeren Aminen |
CH419131A (fr) * | 1961-01-31 | 1966-08-31 | Olin Mathieson | Procédé de préparation de dihydrodibenzothiazépines |
DE1227447B (de) * | 1962-03-30 | 1966-10-27 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Phenylisopropylaminen |
GB1031425A (en) * | 1962-03-30 | 1966-06-02 | Chinoin Gyogyszer Es Vegyeszet | New aralkylamines and their preparation |
CA943127A (en) * | 1970-01-19 | 1974-03-05 | Crompton And Knowles Corporation | Dye intermediates, dyestuffs prepared therefrom and process for making dyes and intermediates |
JPS4740907Y1 (es) * | 1970-09-19 | 1972-12-11 | ||
US3956078A (en) * | 1972-12-14 | 1976-05-11 | M & T Chemicals Inc. | Electrodeposition of copper |
CS163580B1 (es) * | 1973-04-10 | 1975-09-15 | ||
IE40727B1 (en) * | 1974-03-09 | 1979-08-01 | Hoechst Ag | Aralkylamines |
GB1532957A (en) * | 1974-11-04 | 1978-11-22 | Glaxo Lab Ltd | Bis(aminomethyl)naphthalene derivatives |
DE2940509C2 (de) * | 1978-10-06 | 1995-01-26 | Nippon Paint Co Ltd | Polymerisierbare Aminosäureverbindungen und ihre Verwendung |
EP0177078A1 (en) * | 1984-09-12 | 1986-04-09 | Duphar International Research B.V | Spasmolytically active tertiary amine derivatives and method of preparing the same |
US4647591A (en) * | 1985-10-07 | 1987-03-03 | Eli Lilly And Company | Method for improving memory |
EG18188A (en) * | 1986-05-01 | 1992-09-30 | Pfizer Ltd | Process for preparation anti-arhythmia agents |
US4649161A (en) * | 1986-06-16 | 1987-03-10 | Massachusetts Institute Of Technology | Method for treating depression with d-fenfluramine |
HU207280B (en) * | 1986-09-25 | 1993-03-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new phenyl-alkyl-amines and pharmaceutical compositions containing them |
NL8700842A (es) * | 1987-04-10 | 1988-11-01 | Duphar Int Res | |
JP2581707B2 (ja) * | 1987-10-02 | 1997-02-12 | 科研製薬株式会社 | 抗真菌剤組成物 |
GB8813185D0 (en) * | 1988-06-03 | 1988-07-06 | Wyeth John & Brother Ltd | New method & amines used therein |
-
1990
- 1990-05-30 HU HU903266A patent/HUT58270A/hu unknown
- 1990-05-30 AU AU56080/90A patent/AU641394B2/en not_active Ceased
- 1990-05-30 US US07/530,758 patent/US5086073A/en not_active Expired - Fee Related
- 1990-05-31 KR KR1019900007947A patent/KR910000133A/ko not_active Application Discontinuation
- 1990-05-31 CA CA002017966A patent/CA2017966A1/en not_active Abandoned
- 1990-05-31 PT PT94218A patent/PT94218A/pt not_active Application Discontinuation
- 1990-05-31 JP JP2143236A patent/JPH0347155A/ja active Pending
- 1990-06-01 AT AT90306020T patent/ATE113833T1/de not_active IP Right Cessation
- 1990-06-01 DE DE69013994T patent/DE69013994T2/de not_active Expired - Fee Related
- 1990-06-01 EP EP90306020A patent/EP0407032B1/en not_active Expired - Lifetime
- 1990-06-01 ES ES90306020T patent/ES2063268T3/es not_active Expired - Lifetime
- 1990-06-01 GB GB9012223A patent/GB2233558B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GB9012223D0 (en) | 1990-07-18 |
HUT58270A (en) | 1992-02-28 |
AU641394B2 (en) | 1993-09-23 |
US5086073A (en) | 1992-02-04 |
EP0407032A3 (en) | 1992-01-02 |
HU903266D0 (en) | 1990-10-28 |
EP0407032B1 (en) | 1994-11-09 |
JPH0347155A (ja) | 1991-02-28 |
DE69013994D1 (de) | 1994-12-15 |
GB2233558A (en) | 1991-01-16 |
KR910000133A (ko) | 1991-01-29 |
DE69013994T2 (de) | 1995-04-13 |
AU5608090A (en) | 1990-12-06 |
CA2017966A1 (en) | 1990-12-02 |
PT94218A (pt) | 1991-02-08 |
ATE113833T1 (de) | 1994-11-15 |
EP0407032A2 (en) | 1991-01-09 |
GB2233558B (en) | 1993-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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