ES2062591T3 - Cicloalcano (b) dihidroindoles e -indol sulfonamidas sustituidos por heterociclos. - Google Patents

Cicloalcano (b) dihidroindoles e -indol sulfonamidas sustituidos por heterociclos.

Info

Publication number
ES2062591T3
ES2062591T3 ES91104943T ES91104943T ES2062591T3 ES 2062591 T3 ES2062591 T3 ES 2062591T3 ES 91104943 T ES91104943 T ES 91104943T ES 91104943 T ES91104943 T ES 91104943T ES 2062591 T3 ES2062591 T3 ES 2062591T3
Authority
ES
Spain
Prior art keywords
dihydroindoles
substituted
cyclloalcan
heterocicles
sulphonamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91104943T
Other languages
English (en)
Inventor
Ulrich E Dr Muller
Ulrich Dr Rosentreter
Ulrich Dr Niewohner
Elisabeth Dr Perzborn
Erwin Dr Bischoff
Hans-Georg Dr Dellweg
Peter Dr Norman
Nigel J Dr Cuthbert
Hilary P Dr Francis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2062591T3 publication Critical patent/ES2062591T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS CICLOALCANO [B] DIHIDROINDOLES E-INDOLSULFONAMIDAS SUSTITUIDOS POR HETEROCICLOS PUEDEN SER PREPARADAS HACIENDO REACCIONAR LOS INDOLES CORRESPONDIENTES CON ACRILONITRILO Y LA HIDROLISIS POSTERIOR DE LOS COMPUESTOS DE CIANOETILO O MEDIANTE LA REACCION DE LAS HIDRAZINAS CORRESPONDIENTES CON CICLOALCANONAS. LOS CICLOALCANO [B] DIHIDROINDOLES E-INDOLSULFONAMIDAS SUSTITUIDOS POR HETEROCICLOS PUEDEN SER UTILIZADOS COMO COMPONENTES ACTIVOS EN MEDICAMENTOS, Y EN PARTICULAR EN EL TRATAMIENTO DE TROMBOEMBOLISMOS, ISQUEMIAS, ASMA Y ALERGIAS.
ES91104943T 1990-04-10 1991-03-28 Cicloalcano (b) dihidroindoles e -indol sulfonamidas sustituidos por heterociclos. Expired - Lifetime ES2062591T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909008108A GB9008108D0 (en) 1990-04-10 1990-04-10 Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles

Publications (1)

Publication Number Publication Date
ES2062591T3 true ES2062591T3 (es) 1994-12-16

Family

ID=10674203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91104943T Expired - Lifetime ES2062591T3 (es) 1990-04-10 1991-03-28 Cicloalcano (b) dihidroindoles e -indol sulfonamidas sustituidos por heterociclos.

Country Status (18)

Country Link
US (1) US5204374A (es)
EP (1) EP0451634B1 (es)
JP (1) JPH04234846A (es)
KR (1) KR910018374A (es)
AT (1) ATE102618T1 (es)
AU (1) AU632213B2 (es)
CA (1) CA2039873A1 (es)
DE (1) DE69101330T2 (es)
DK (1) DK0451634T3 (es)
ES (1) ES2062591T3 (es)
GB (1) GB9008108D0 (es)
HU (1) HU209645B (es)
IE (1) IE64843B1 (es)
IL (1) IL97795A (es)
NZ (1) NZ237709A (es)
PT (1) PT97280A (es)
TW (1) TW221995B (es)
ZA (1) ZA912609B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464746A (en) * 1991-12-17 1995-11-07 Abbott Laboratories Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
CA2166782A1 (en) * 1993-07-20 1995-02-02 James R. Fino Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
DE19506739A1 (de) * 1995-02-27 1996-08-29 Bayer Ag [3-Amino]-tetrahydrocarbazol-propansäureester
AU2003231513A1 (en) * 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Pgd2 receptor antagonist
AU2003231509A1 (en) * 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
CA2528321A1 (en) 2003-06-10 2004-12-23 Smithkline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
RU2005138126A (ru) 2003-06-12 2006-07-27 СмитКлайн Бичем Корпорейшн (US) Производные тетрагидрокарбазола и их фармацевтическое применение
MX2007015905A (es) * 2005-06-24 2008-03-06 Lilly Co Eli Derivados de tetrahidrocarbazol utiles como moduladores de receptor de androgeno (sarm).
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
US7662831B2 (en) 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
UA98777C2 (en) * 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
CN101434571B (zh) * 2007-11-13 2012-05-30 杭州容立医药科技有限公司 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法
PL2297100T3 (pl) * 2008-05-16 2013-03-29 Lilly Co Eli Tetrahydrocyklopenta[B]indolowe modulatory receptora androgenowego
WO2010008864A2 (en) * 2008-06-24 2010-01-21 Amira Pharmaceuticals, Inc. Cycloalkane[b]indole angtagonists of prostaglandin d2 receptors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946021A (en) * 1970-07-23 1976-03-23 Richardson-Merrell Inc. Bis-basic ketones of carbazole
US3975398A (en) * 1973-08-01 1976-08-17 Boehringer Mannheim G.M.B.H. 9-Substituted 3-aminocarbazole compounds
US4464379A (en) * 1981-06-01 1984-08-07 A. Nattermann & Cie Gmbh Indol acetic acid derivatives and anti-inflamatory and related uses thereof
DE3514696A1 (de) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3631824A1 (de) * 1986-02-21 1988-03-31 Bayer Ag Cycloalkano(1.2-b)indol-sulfonamide
US4940719A (en) * 1986-03-27 1990-07-10 Merck Frosst Canada, Inc. Tetrahydrocarbazole esters, pharmaceutical compositions and use
DE3613623A1 (de) * 1986-04-23 1987-10-29 Bayer Ag N-dihydroindolylethyl-sulfonamide

Also Published As

Publication number Publication date
DE69101330D1 (de) 1994-04-14
IE911186A1 (en) 1991-10-23
ZA912609B (en) 1992-01-29
CA2039873A1 (en) 1991-10-11
IE64843B1 (en) 1995-09-06
HU209645B (en) 1994-09-28
IL97795A0 (en) 1992-06-21
HU911140D0 (en) 1991-10-28
DK0451634T3 (da) 1994-05-02
DE69101330T2 (de) 1994-06-16
KR910018374A (ko) 1991-11-30
PT97280A (pt) 1992-01-31
HUT57205A (en) 1991-11-28
IL97795A (en) 1995-08-31
EP0451634A3 (en) 1992-01-02
EP0451634B1 (en) 1994-03-09
JPH04234846A (ja) 1992-08-24
AU632213B2 (en) 1992-12-17
US5204374A (en) 1993-04-20
NZ237709A (en) 1992-10-28
ATE102618T1 (de) 1994-03-15
AU7425291A (en) 1991-10-17
EP0451634A2 (en) 1991-10-16
GB9008108D0 (en) 1990-06-06
TW221995B (es) 1994-04-01

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