ES2062061T3 - Compuestos radiohalogenados para el marcaje especifico de sitio. - Google Patents
Compuestos radiohalogenados para el marcaje especifico de sitio.Info
- Publication number
- ES2062061T3 ES2062061T3 ES89401557T ES89401557T ES2062061T3 ES 2062061 T3 ES2062061 T3 ES 2062061T3 ES 89401557 T ES89401557 T ES 89401557T ES 89401557 T ES89401557 T ES 89401557T ES 2062061 T3 ES2062061 T3 ES 2062061T3
- Authority
- ES
- Spain
- Prior art keywords
- radiohalogenated
- compounds
- specific site
- site marking
- radiohalogenated compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000012634 fragment Substances 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Abstract
LA INVENCION SE REFIERE A COMPUESTO RADIOHALOGENADOS QUE SON UTILES COMO COMPUESTOS INTERMEDIOS PARA PREPARAR CONJUGADOS DE ANTICUERPOS RADIOHALOGENADOS EN LOS QUE EL COMPUESTO RADIOHALOGENADO ESTA UNIDO ESPECIFICAMENTE POR UN PUNTO A UNA PORCION O UN FRAGMENTO DE ANTICUERPO. TAMBIEN INCLUYE LA INVENCION METODOS PARA LA PREPARACION DE LOS COMPUESTOS Y LOS CONJUGADOS DEL ANTICUERPO ASI COMO METODOS PARA SU EMPLEO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/203,793 US4966999A (en) | 1988-06-07 | 1988-06-07 | Radiohalogenated compounds for site specific labeling |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062061T3 true ES2062061T3 (es) | 1994-12-16 |
Family
ID=22755342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89401557T Expired - Lifetime ES2062061T3 (es) | 1988-06-07 | 1989-06-06 | Compuestos radiohalogenados para el marcaje especifico de sitio. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4966999A (es) |
EP (1) | EP0348261B1 (es) |
JP (1) | JPH02504643A (es) |
AT (1) | ATE98630T1 (es) |
AU (1) | AU3772889A (es) |
CA (1) | CA1318615C (es) |
DE (1) | DE68911397T2 (es) |
ES (1) | ES2062061T3 (es) |
WO (1) | WO1989011876A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5463080A (en) * | 1992-08-27 | 1995-10-31 | Bracco International B.V. | 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents |
US5424402A (en) * | 1993-10-18 | 1995-06-13 | Board Of Trustees Of The University Of Kentucky | Non-destructive method for radiolabelling biomolecules by halogenation |
US6011021A (en) * | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
US5856106A (en) * | 1995-11-01 | 1999-01-05 | Biotransplant, Inc. | Determination of antibody production against administered therapeutic glycoproteins, especially monoclonal antibodies |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
US6384022B1 (en) | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
RU2218179C2 (ru) | 1996-06-17 | 2003-12-10 | Гилфорд Фармасьютикалз Инк. | СПОСОБЫ ЛЕЧЕНИЯ РАКА С ПРИМЕНЕНИЕМ ИНГИБИТОРОВ NAALADазы |
KR20000036227A (ko) | 1996-09-27 | 2000-06-26 | 토마스 씨. 서 | 날라다아제조성물, 글루탐산염 이상 치료법 및 동물내의 뉴우런활성법 |
US5962521A (en) * | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
US5981209A (en) * | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
US6028216A (en) * | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
US6129757A (en) * | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
CN1314882A (zh) | 1998-07-06 | 2001-09-26 | 吉尔福德药物有限公司 | 用作药物化合物的naalad酶抑制剂和组合物 |
US6265609B1 (en) | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
US6395718B1 (en) | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
US20060198819A1 (en) * | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
BRPI0720282B8 (pt) * | 2006-12-15 | 2021-05-25 | Baxalta GmbH | construção proteica, composição farmacêutica, e, kit |
CA2706017A1 (en) * | 2007-03-30 | 2008-10-09 | Jorge R. Barrio | In vivo imaging of sulfotransferases |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
ES2597954T3 (es) * | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
EP2459226B1 (en) | 2009-07-27 | 2016-06-29 | Lipoxen Technologies Limited | Glycopolysialylation of proteins other than blood coagulation proteins |
ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
ES2909486T3 (es) * | 2015-06-19 | 2022-05-06 | Centurion Biopharma Corp | Sistemas de administración para liberación controlada de fármaco |
CA3083983A1 (en) | 2017-11-30 | 2019-06-06 | Centurion Biopharma Corporation | Albumin-binding prodrugs of auristatin e derivatives |
KR20200117988A (ko) | 2017-11-30 | 2020-10-14 | 센추리온 바이오파마 코포레이션 | 메이탄시노이드계 약물 전달 시스템 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2808416A (en) * | 1954-08-23 | 1957-10-01 | Eastman Kodak Co | Hydrazides of benzoic acid and derivatives thereof as antioxidants for fats and oils |
US3809721A (en) * | 1970-12-23 | 1974-05-07 | Merck & Co Inc | Substituted 2-aminomethyl-4,6-disubstituted phenols |
DE2260933C3 (de) * | 1972-12-08 | 1981-08-20 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Verfahren zur Herstellung von durch radioaktives Halogen markierten organischen Verbindungen |
US3979506A (en) * | 1974-10-11 | 1976-09-07 | Pierce Chemical Company | Radioactive compounds for labeling proteins |
US4474746A (en) * | 1980-08-08 | 1984-10-02 | State University Of New York | Diagnostic radiopharmaceuticals for localization in target tissues exhibiting a regional pH shift relative to surrounding tissues |
US4450149A (en) * | 1981-06-15 | 1984-05-22 | Research Corporation | Radiohalogenation method |
US4430319A (en) * | 1982-05-21 | 1984-02-07 | State University Of New York | Radioactive iodine labeled phenolic amines |
DK226986A (da) * | 1985-05-17 | 1986-11-18 | Neorx Corp | Radiohalogenerede smaa molekyler til proteinmaerkning |
US4764598A (en) * | 1985-08-22 | 1988-08-16 | The United States Of America As Represented By The Department Of Energy | Precursors to radiopharmaceutical agents for tissue imaging |
-
1988
- 1988-06-07 US US07/203,793 patent/US4966999A/en not_active Expired - Lifetime
-
1989
- 1989-06-05 CA CA000601795A patent/CA1318615C/en not_active Expired - Lifetime
- 1989-06-06 ES ES89401557T patent/ES2062061T3/es not_active Expired - Lifetime
- 1989-06-06 EP EP89401557A patent/EP0348261B1/en not_active Expired - Lifetime
- 1989-06-06 AU AU37728/89A patent/AU3772889A/en not_active Abandoned
- 1989-06-06 DE DE68911397T patent/DE68911397T2/de not_active Expired - Fee Related
- 1989-06-06 JP JP1506891A patent/JPH02504643A/ja active Pending
- 1989-06-06 WO PCT/US1989/002467 patent/WO1989011876A1/en unknown
- 1989-06-06 AT AT89401557T patent/ATE98630T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH02504643A (ja) | 1990-12-27 |
EP0348261A1 (en) | 1989-12-27 |
DE68911397D1 (de) | 1994-01-27 |
ATE98630T1 (de) | 1994-01-15 |
CA1318615C (en) | 1993-06-01 |
EP0348261B1 (en) | 1993-12-15 |
US4966999A (en) | 1990-10-30 |
DE68911397T2 (de) | 1994-05-26 |
AU3772889A (en) | 1990-01-05 |
WO1989011876A1 (en) | 1989-12-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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