ES2062010T3 - Proceso para la cloracion de azucares. - Google Patents
Proceso para la cloracion de azucares.Info
- Publication number
- ES2062010T3 ES2062010T3 ES89307933T ES89307933T ES2062010T3 ES 2062010 T3 ES2062010 T3 ES 2062010T3 ES 89307933 T ES89307933 T ES 89307933T ES 89307933 T ES89307933 T ES 89307933T ES 2062010 T3 ES2062010 T3 ES 2062010T3
- Authority
- ES
- Spain
- Prior art keywords
- sugar
- reaction
- protected
- persulphite
- thionyl chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Abstract
LOS AZUCARES Y DERIVADOS DE AZUCARES PARCIALMENTE PROTEGIDOS SE CLORAN POR REACCION DE GRUPOS HIDROXILO SIN PROTEGER CON CLORURO DE TIONILO PARA FORMAR UN PERSULFITO, SEGUIDA DE DESCOMPOSICION DEL GRUPO SULFITO PARA FORMAR CLOROSULFITOS, DESPLAZAMIENTO DE LOS GRUPOS CLOROSULFITO E INSERCION DE LOS ATOMOS DE CLORO EN UNA O MAS POSICIONES, CARACTERIZADA PORQUE LA FORMACION Y DESPLAZAMIENTO DE LOS GRUPOS CLOROSULFITO Y LA INSERCION DE LOS ATOMOS DE CLORO SE EFECTUA POR REACCION CON CLORURO DE TIONILO EN UN DISOLVENTE INERTE EN PRESENCIA DE UNA SAL CUATERNARIA DE FORMLA GENERAL (I), EN DONDE R1, R2 Y R3, QUE PUEDEN SER EL MISMO O DIFERENTES, SON UN GRUPO ALQUILO INFERIOR, Y R4 ES UN GRUPO HIDROCARBONADO CON 7 ATOMOS DE CARBONO POR LO MENOS, Y CUANDO EL AZUCAR O DERIVADO DE AZUCAR PARCIALMENTE PROTEGIDO TIENE MAS QUE 3 GRUPOS HIDROXI NO PROTEGIDOS, EL PROCESO CONSTA DE LAS SIGUIENTES ETAPAS: (A) REACCION DEL AZUCAR O DERIVADO DE AZUCAR PARCIALMENTE PROTEGIDO CON CLORURO DE TIONILO EN PRESENCIADE PIRIDINA PARA FORMAR UN PERSULFITO; (B) SEPARACION DEL PERSULFITO PARA ELIMINAR PIRIDINA LIBRE; Y (C) REACCION DEL POLISULFITO SEPARADO CON CLORURO DE TIONILO EN UN DISOLVENTE O MEDIO DE SUSPENSION INERTE, EN PRESENCIA DE UNA SAL CUATERNARIA DE FORMULA GENERAL (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888818430A GB8818430D0 (en) | 1988-08-03 | 1988-08-03 | Process |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2062010T3 true ES2062010T3 (es) | 1994-12-16 |
Family
ID=10641538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89307933T Expired - Lifetime ES2062010T3 (es) | 1988-08-03 | 1989-08-03 | Proceso para la cloracion de azucares. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4977254A (es) |
EP (1) | EP0354050B1 (es) |
JP (1) | JP3055910B2 (es) |
KR (1) | KR0137951B1 (es) |
AT (1) | ATE99317T1 (es) |
CA (1) | CA1316532C (es) |
DE (1) | DE68911788T2 (es) |
DK (1) | DK170805B1 (es) |
ES (1) | ES2062010T3 (es) |
GB (2) | GB8818430D0 (es) |
IE (1) | IE61917B1 (es) |
PT (1) | PT91357B (es) |
RU (1) | RU1836375C (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0373118A3 (de) * | 1988-12-07 | 1991-10-16 | Ciba-Geigy Ag | Verfahren zur Herstellung von geschützten Mono- und Oligozuckerhalogeniden |
US5136031A (en) * | 1990-07-09 | 1992-08-04 | Tate & Lyle Public Limited Company | Chlorination of sugars |
DE4227752A1 (de) * | 1992-08-21 | 1994-02-24 | Basf Ag | Verfahren zur Herstellung von Alkylglykosiden |
US6555677B2 (en) * | 2000-10-31 | 2003-04-29 | Merck & Co., Inc. | Phase transfer catalyzed glycosidation of an indolocarbazole |
AU2691802A (en) | 2000-11-17 | 2002-05-27 | Mcneil Ppc Inc | Improved sucralose composition and process for its preparation |
US6943248B2 (en) * | 2003-04-30 | 2005-09-13 | Tate & Lyle Public Limited Company | Crystalline form of sucralose, and method for producing it |
US20050214425A1 (en) * | 2004-03-23 | 2005-09-29 | Roma Vazirani | Sugar substitute prepared with nutritive and high-intensity sweeteners |
GB2417555A (en) * | 2004-07-28 | 2006-03-01 | John Charles Fry | Sucralose analysis |
US20060247180A1 (en) * | 2005-04-29 | 2006-11-02 | Bergey James L | Purgative composition and uses thereof |
CN101253187A (zh) * | 2005-08-30 | 2008-08-27 | 法马德医疗保险私人有限公司 | 含有蔗糖酯的反应物中吡啶及其类似物的除去方法 |
US7741477B2 (en) * | 2006-01-10 | 2010-06-22 | Alembic Limited | Process for purification of sucralose |
CN1814609B (zh) * | 2006-03-06 | 2010-11-10 | 盐城捷康三氯蔗糖制造有限公司 | 一种提高三氯蔗糖合成收率的方法 |
WO2008004246A1 (en) * | 2006-07-06 | 2008-01-10 | Alembic Limited | An improved process for the preparation of sucralose of high purity |
US20080103295A1 (en) * | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
US8258291B2 (en) * | 2006-10-25 | 2012-09-04 | Mamtek International Limited | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC) |
CN101626997B (zh) * | 2006-12-05 | 2013-01-09 | 塔特和莱利技术有限公司 | 三苯甲基氯的回收 |
CN100591684C (zh) * | 2006-12-27 | 2010-02-24 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖结晶方法 |
KR20080073879A (ko) * | 2007-02-07 | 2008-08-12 | 주식회사 일신케미칼 | 수크랄로오스의 제조방법 |
CN101260126B (zh) * | 2007-03-06 | 2010-12-22 | 盐城捷康三氯蔗糖制造有限公司 | 三氯蔗糖的结晶方法 |
US20080300392A1 (en) * | 2007-06-04 | 2008-12-04 | Polymed Therapeutics, Inc. | Novel chlorination process for preparing sucralose |
US20080300401A1 (en) * | 2007-06-04 | 2008-12-04 | Polymed Therapeutics, Inc. | Novel chlorination process for preparing sucralose |
US7932380B2 (en) * | 2008-03-06 | 2011-04-26 | Wanhe International (Group) Co. Ltd. | Process for the preparation of sucralose |
US20100022765A1 (en) * | 2008-07-23 | 2010-01-28 | David Losan Ho | Methods for extracting and purifying sucralose intermediate |
CN102241708B (zh) * | 2011-05-10 | 2013-10-30 | 山东大学 | 一种半乳糖苷化合物及其制备方法 |
CN105153247B (zh) * | 2015-08-28 | 2017-11-21 | 山东康宝生化科技有限公司 | 一种解决固体光气法合成三氯蔗糖酯时蔗糖酯结块的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2036007A (en) * | 1978-10-18 | 1980-06-25 | Tate & Lyle Ltd | A Method for the Preparation of 2-chloro-2-deoxy Saccharides |
DE3062467D1 (en) * | 1979-12-20 | 1983-04-28 | Tate & Lyle Plc | Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose |
EP0043649B1 (en) * | 1980-07-08 | 1984-09-12 | TATE & LYLE PUBLIC LIMITED COMPANY | Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs) |
DE3102516A1 (de) * | 1981-01-27 | 1982-08-12 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von optisch aktiven 2-chlorpropionsaeureestern |
DE3261037D1 (en) * | 1981-08-21 | 1984-11-29 | Tate & Lyle Plc | 4' halo-substituted sucrose derivatives |
US4605784A (en) * | 1984-12-19 | 1986-08-12 | Eastman Kodak Company | Process for the preparation of ether-containing chlorides |
GB8500862D0 (en) * | 1985-01-14 | 1985-02-20 | Tate & Lyle Plc | Composition |
GB8525871D0 (en) * | 1985-10-21 | 1985-11-27 | Tate & Lyle Plc | Chemical compound |
GB8525954D0 (en) * | 1985-10-21 | 1985-11-27 | Mcneilab Inc | Chlorination of carbohydrates &c alcohols |
-
1988
- 1988-08-03 GB GB888818430A patent/GB8818430D0/en active Pending
-
1989
- 1989-07-31 GB GB8917468A patent/GB2221462B/en not_active Expired - Lifetime
- 1989-08-02 CA CA000607337A patent/CA1316532C/en not_active Expired - Lifetime
- 1989-08-02 IE IE249889A patent/IE61917B1/en not_active IP Right Cessation
- 1989-08-02 RU SU894614838A patent/RU1836375C/ru active
- 1989-08-02 US US07/388,657 patent/US4977254A/en not_active Expired - Lifetime
- 1989-08-02 DK DK379389A patent/DK170805B1/da not_active IP Right Cessation
- 1989-08-03 DE DE89307933T patent/DE68911788T2/de not_active Expired - Lifetime
- 1989-08-03 AT AT89307933T patent/ATE99317T1/de not_active IP Right Cessation
- 1989-08-03 ES ES89307933T patent/ES2062010T3/es not_active Expired - Lifetime
- 1989-08-03 KR KR1019890011119A patent/KR0137951B1/ko not_active IP Right Cessation
- 1989-08-03 EP EP89307933A patent/EP0354050B1/en not_active Expired - Lifetime
- 1989-08-03 PT PT91357A patent/PT91357B/pt active IP Right Grant
- 1989-08-03 JP JP1202247A patent/JP3055910B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK170805B1 (da) | 1996-01-22 |
RU1836375C (ru) | 1993-08-23 |
US4977254A (en) | 1990-12-11 |
DE68911788D1 (de) | 1994-02-10 |
PT91357B (pt) | 1995-05-04 |
EP0354050A3 (en) | 1991-09-04 |
GB8818430D0 (en) | 1988-09-07 |
IE61917B1 (en) | 1994-11-30 |
KR0137951B1 (ko) | 1998-04-30 |
CA1316532C (en) | 1993-04-20 |
GB2221462A (en) | 1990-02-07 |
GB8917468D0 (en) | 1989-09-13 |
DK379389A (da) | 1990-02-04 |
EP0354050B1 (en) | 1993-12-29 |
EP0354050A2 (en) | 1990-02-07 |
KR900003190A (ko) | 1990-03-26 |
ATE99317T1 (de) | 1994-01-15 |
JPH02160796A (ja) | 1990-06-20 |
DE68911788T2 (de) | 1994-04-14 |
DK379389D0 (da) | 1989-08-02 |
GB2221462B (en) | 1992-04-22 |
JP3055910B2 (ja) | 2000-06-26 |
PT91357A (pt) | 1990-03-08 |
IE892498L (en) | 1990-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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