ES2061733T3 - Nuevos derivados peptidicos inhibidores de la agregacion de plaquetas. - Google Patents

Nuevos derivados peptidicos inhibidores de la agregacion de plaquetas.

Info

Publication number
ES2061733T3
ES2061733T3 ES88870179T ES88870179T ES2061733T3 ES 2061733 T3 ES2061733 T3 ES 2061733T3 ES 88870179 T ES88870179 T ES 88870179T ES 88870179 T ES88870179 T ES 88870179T ES 2061733 T3 ES2061733 T3 ES 2061733T3
Authority
ES
Spain
Prior art keywords
platelet aggregation
inhibitors
peptidic derivatives
derivatives inhibitors
new peptidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88870179T
Other languages
English (en)
Inventor
Steven Paul Adams
Larry Philip Feigen
Masateru Miyano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of ES2061733T3 publication Critical patent/ES2061733T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN NUEVOS DERIVADOS DE TETRAPEPTIDOS QUE TIENEN UNA ACTIVIDAD UTIL COMO INHIBIDORES DE LA AGREGACION DE PLAQUETAS. ESTOS DERIVADOS TIENEN LA SECUENCIA X - GLY - ASP - Y EN LA QUE X PUEDE SER ARGININA E Y SER O - METILTIROSINA.
ES88870179T 1987-12-03 1988-12-02 Nuevos derivados peptidicos inhibidores de la agregacion de plaquetas. Expired - Lifetime ES2061733T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/128,379 US4857508A (en) 1987-12-03 1987-12-03 Novel platelet-aggregation inhibitor peptide derivatives

Publications (1)

Publication Number Publication Date
ES2061733T3 true ES2061733T3 (es) 1994-12-16

Family

ID=22435083

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88870179T Expired - Lifetime ES2061733T3 (es) 1987-12-03 1988-12-02 Nuevos derivados peptidicos inhibidores de la agregacion de plaquetas.

Country Status (7)

Country Link
US (1) US4857508A (es)
EP (1) EP0319506B1 (es)
JP (1) JPH01190699A (es)
AT (1) ATE102629T1 (es)
CA (1) CA1315479C (es)
DE (1) DE3888310T2 (es)
ES (1) ES2061733T3 (es)

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CA1311583C (en) * 1986-12-15 1992-12-15 Gerard Armand Marguerie De Rotrou Peptide derivatives and their application, in particular in therapy
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
ATE140926T1 (de) * 1987-12-10 1996-08-15 Jolla Cancer Res Found Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5053393A (en) * 1988-07-20 1991-10-01 Monsanto Company Novel platelet-aggregation inhibitor
AU628910B2 (en) * 1988-12-20 1992-09-24 La Jolla Cancer Research Foundation Polypeptide-polymer conjugates active in wound healing
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5344783A (en) * 1989-06-16 1994-09-06 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5770564A (en) * 1989-06-16 1998-06-23 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5061693A (en) * 1989-07-28 1991-10-29 Merck & Co., Inc. Fibrinogen receptor antagonists
US5328840A (en) * 1989-08-15 1994-07-12 The Research Foundation Of The State University Of New York Method for preparing targeted carrier erythrocytes
US5120859A (en) * 1989-09-22 1992-06-09 Genentech, Inc. Chimeric amino acid analogues
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
WO1991004746A1 (en) * 1989-09-29 1991-04-18 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5338723A (en) * 1989-10-13 1994-08-16 Merck & Co., Inc. Fibrinogen receptor antagonists
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
JPH05509294A (ja) * 1990-04-06 1993-12-22 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 血栓症治療のための方法および組成物
WO1992007872A1 (en) * 1990-10-29 1992-05-14 California Institute Of Biological Research Tenascin related peptides
JPH06502643A (ja) * 1990-11-01 1994-03-24 スミスクライン・ビーチャム・コーポレイション フィブリノーゲン拮抗剤としてのγ−ターンペプチド模倣化合物
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
KR930703024A (ko) * 1991-02-08 1993-11-29 리챠드 티. 딘 영상용 테크네튬-99m표지폴리펩티드
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
JP3258659B2 (ja) * 1991-03-06 2002-02-18 ジー．デイー．サール アンド カンパニー 血小板凝集阻害剤として有用なフェニルアミジン誘導体類
EP0578728B1 (en) * 1991-04-05 1998-07-01 Genentech, Inc. PLATELET AGGREGATION INHIBITORS HAVING HIGH SPECIFICITY FOR GP IIbIIIa
EP0584066A4 (en) * 1991-04-11 1994-10-12 Rhone Poulenc Rorer Int Anti-thrombotic peptide and pseudopeptide derivatives.
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
US5220050A (en) * 1991-05-17 1993-06-15 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
WO1993000108A1 (en) * 1991-06-28 1993-01-07 Corvas International, Inc. Novel inhibitors of platelet aggregation
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
US5625093A (en) * 1991-10-15 1997-04-29 G. D. Searle & Co. Substituted β-amino acid derivatives useful as platelet aggregation inhibitors
US5254573A (en) * 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
ATE179074T1 (de) * 1991-11-07 1999-05-15 Univ Southern California Zusammensetzungen und verfahren zur verhinderung der adhäsionbildung
WO1993012103A1 (en) * 1991-12-13 1993-06-24 G.D. Searle & Co. Phenyl amidines lactones useful as platelet aggregation inhibitors
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5264457A (en) * 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
LT3284B (en) 1992-04-23 1995-06-26 Merck & Co Inc Fibrinogen receptor antagonists
AU4540693A (en) * 1992-06-25 1994-01-24 G.D. Searle & Co. Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors
CA2101599A1 (en) * 1992-08-31 1994-03-01 Wilhelm Bannwarth Tri- and tetracyclic compounds
AU5594294A (en) * 1992-11-18 1994-06-08 Du Pont Merck Pharmaceutical Company, The Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
US5409939A (en) * 1993-02-12 1995-04-25 G. D. Searle & Co. Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
US5614106A (en) * 1993-03-12 1997-03-25 Baxter International Inc. Method and apparatus for collection of platelets
US5614539A (en) * 1993-03-15 1997-03-25 G. D. Searle & Co. Urea compounds which are useful as platelet aggregation inhibitors
US5612355A (en) * 1993-06-23 1997-03-18 G. D. Searle & Co. Phenyl amidine lactones useful as platelet aggregation inhibitors
BR9407839A (pt) * 1993-10-15 1997-05-13 Rhone Poulenc Rorer Pharma Composto composição farmacêutica e processo para a prevenção ou tratamento de trombose em um mamífero em necessidade desta terapia
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
US5639765A (en) * 1995-01-17 1997-06-17 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting bone loss
US5602155A (en) * 1995-01-17 1997-02-11 G. D. Searle & Co. Platelet aggregation inhibitors
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
US5681820A (en) * 1995-05-16 1997-10-28 G. D. Searle & Co. Guanidinoalkyl glycine β-amino acids useful for inhibiting tumor metastasis
CA2263647C (en) 1996-08-21 2011-02-15 Zofia J. Chrzan Stable non-hygroscopic crystalline form of n-[n-n-(4-(piperidin-4-yl)butanoyl)-n-ethylglycyl] compounds
ES2230624T5 (es) * 1996-11-27 2010-10-25 Aventis Pharmaceuticals Inc. Composicion farmaceutica que comprende un compuesto que tiene actividad anti-xa y un compuesto antagonista de la agregacion plaquetaria.
US5932693A (en) * 1996-12-10 1999-08-03 Washington University Antithrombotic peptides
KR100620935B1 (ko) 1998-03-19 2006-09-13 브리스톨-마이어스스퀴브컴파니 용해도가 높은 약물에 대한 2상 서방성 전달 시스템과 방법
JP6042330B2 (ja) 2010-07-09 2016-12-14 ビーエイチヴィ ファーマ、インコーポレイテッド レモグリフロジンを含めた半減期が短い医薬品のための組合せ即時／遅延放出送達システム

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Also Published As

Publication number Publication date
DE3888310D1 (de) 1994-04-14
DE3888310T2 (de) 1994-08-11
CA1315479C (en) 1993-03-30
EP0319506B1 (en) 1994-03-09
ATE102629T1 (de) 1994-03-15
JPH01190699A (ja) 1989-07-31
EP0319506A2 (en) 1989-06-07
EP0319506A3 (en) 1990-08-16
US4857508A (en) 1989-08-15

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