DK0422937T3 - Fibrinogenreceptorantagonister - Google Patents

Fibrinogenreceptorantagonister

Info

Publication number
DK0422937T3
DK0422937T3 DK90311148.2T DK90311148T DK0422937T3 DK 0422937 T3 DK0422937 T3 DK 0422937T3 DK 90311148 T DK90311148 T DK 90311148T DK 0422937 T3 DK0422937 T3 DK 0422937T3
Authority
DK
Denmark
Prior art keywords
fibrinogen
chem
phenyl
sequence
formula
Prior art date
Application number
DK90311148.2T
Other languages
English (en)
Inventor
Daniel F Veber
Ruth F Nutt
Stephen F Brady
Mark E Duggan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0422937T3 publication Critical patent/DK0422937T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
DK90311148.2T 1989-10-13 1990-10-11 Fibrinogenreceptorantagonister DK0422937T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42104989A 1989-10-13 1989-10-13

Publications (1)

Publication Number Publication Date
DK0422937T3 true DK0422937T3 (da) 1994-03-28

Family

ID=23668978

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90311148.2T DK0422937T3 (da) 1989-10-13 1990-10-11 Fibrinogenreceptorantagonister

Country Status (17)

Country Link
US (1) US5374622A (da)
EP (1) EP0422937B1 (da)
JP (1) JP2559289B2 (da)
KR (1) KR910007958A (da)
AT (1) ATE102219T1 (da)
AU (1) AU644380B2 (da)
CA (1) CA2027314A1 (da)
DE (1) DE69007004T2 (da)
DK (1) DK0422937T3 (da)
ES (1) ES2062400T3 (da)
FI (1) FI905023A0 (da)
IE (1) IE66253B1 (da)
IL (1) IL95918A0 (da)
NO (1) NO904430L (da)
NZ (1) NZ235564A (da)
PT (1) PT95581A (da)
ZA (1) ZA908159B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686566A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
CA2101942C (en) * 1991-02-08 2001-01-30 Richard T. Dean Technetium-99m labeled polypeptides for imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
IL103252A (en) 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
US5663166A (en) * 1991-10-18 1997-09-02 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
WO1993008818A1 (en) * 1991-11-07 1993-05-13 The University Of Southern California Compositions and methods for preventing adhesion formation
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
AU696206B2 (en) * 1992-10-02 1998-09-03 Cis Bio International Multimeric polyvalent antithrombotic agents
CA2148945A1 (en) * 1992-11-18 1994-05-26 Gregory James Wells Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein iib/iiia
JPH08509708A (ja) * 1993-03-29 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 血小板糖蛋白▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の調製のための新規な方法および中間体化合物
JP2954355B2 (ja) * 1993-04-08 1999-09-27 ダイアテク，インコーポレイテッド 血栓イメージング用の放射性同位体標識化合物
US5646000A (en) * 1994-09-29 1997-07-08 Merck & Co., Inc. Compounds and methods for identifying activated platelets
US5858972A (en) * 1996-01-11 1999-01-12 La Jolla Cancer Research Foundation Antithrombotic agents and methods of use
US6623981B2 (en) * 1998-01-27 2003-09-23 Bristol-Myers Squibb Company Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
CN1203846C (zh) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 高溶解性药物的双相控释递送系统和方法
KR20010087125A (ko) 1998-04-16 2001-09-15 데이비드 비. 맥윌리암스 인테그린 수용체에 대한 인테그린의 결합을 억제하는 화합물
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
CA2804926C (en) 2010-07-09 2019-01-08 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5921656A (ja) * 1982-07-28 1984-02-03 Takeda Chem Ind Ltd ポリペプチド誘導体
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
CA1311583C (en) * 1986-12-15 1992-12-15 Gerard Armand Marguerie De Rotrou Peptide derivatives and their application, in particular in therapy
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
EP0394326B1 (en) * 1987-12-10 1996-07-31 La Jolla Cancer Research Foundation Methods for the production of conformationally stabilized cell adhesion peptides
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides
NZ235563A (en) * 1989-10-13 1993-04-28 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical composition
AU6470590A (en) * 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides

Also Published As

Publication number Publication date
IE66253B1 (en) 1995-12-27
CA2027314A1 (en) 1991-04-14
AU6456890A (en) 1991-04-18
NZ235564A (en) 1993-10-26
US5374622A (en) 1994-12-20
NO904430L (no) 1991-04-15
EP0422937B1 (en) 1994-03-02
JP2559289B2 (ja) 1996-12-04
AU644380B2 (en) 1993-12-09
ZA908159B (en) 1991-07-31
EP0422937A1 (en) 1991-04-17
PT95581A (pt) 1991-09-13
JPH03206097A (ja) 1991-09-09
FI905023A0 (fi) 1990-10-12
NO904430D0 (no) 1990-10-12
KR910007958A (ko) 1991-05-30
DE69007004T2 (de) 1994-10-06
IL95918A0 (en) 1991-07-18
IE903629A1 (en) 1991-04-24
ES2062400T3 (es) 1994-12-16
ATE102219T1 (de) 1994-03-15
DE69007004D1 (de) 1994-04-07

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