ES2060042T3 - Inhibidores de elastasa de beta-lactama. - Google Patents

Inhibidores de elastasa de beta-lactama.

Info

Publication number
ES2060042T3
ES2060042T3 ES90306030T ES90306030T ES2060042T3 ES 2060042 T3 ES2060042 T3 ES 2060042T3 ES 90306030 T ES90306030 T ES 90306030T ES 90306030 T ES90306030 T ES 90306030T ES 2060042 T3 ES2060042 T3 ES 2060042T3
Authority
ES
Spain
Prior art keywords
low
components
alkyl
beta
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90306030T
Other languages
English (en)
Inventor
Robert A Volkmann
V John Jasys
Michael S Kellog
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2060042T3 publication Critical patent/ES2060042T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPONENTES BETA-LACTO CON UNA POTENTE ACTIVIDAD INHIBIDORA DE ELASTASA. ESTOS COMPONENETES SE CARACTERIZAN POR TENER LAS FORMULAS GENERALES ESTRUCTURALES (I), (II), (III): ESTOS COMPONENETES SE CARACTERIZAN TAMBIEN EN QUE X E Y SON CADA UNO -S- O -CH2-, Y AL MENOS UNO DE ELLOS ES -S-, O ALTERNATIVAMENTE, X ES -SO- O -SO2- E Y ES -CH2-; R1 ES HIDROGENO, TRI(ALQUILOBAJO)-SILIL, -COOR'''' O -CONHR'''''', EN EL QUE R'''' Y R'''''' SON CADA UNO UN ALQUIL BAJO O UN FENILO (ALQUILOBAJO), Y PUEDEN SER IGUALES O DIFERENTES; R3 ES HIDOGENO, ALGUILO BAJO O UN OXI(ALQUILOBAJO); UNO DE LOS B Y D ES OXICARBORIL(ALQUILOBAJO), OXICARBONIL (ALQUILOBAJO), ALILOXICARBONIL O FENIL (ALQUILOBAJO) OXICARBONIL; Y EL OTRO DE LOS B Y D ES UN HIDROGENO O UN ALGUILO BAJO. DICHOS COMPONENETES SON UTILES COMO AGENTES ANTI INFLORIOS, PARTICULARMENTE EN EL TRATAMIENTO DE SINDROMES DE ESFUERZOS RESPIRATORIOS Y ARTRITIS REUMATOIDE.
ES90306030T 1989-06-01 1990-06-01 Inhibidores de elastasa de beta-lactama. Expired - Lifetime ES2060042T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/359,548 US5132300A (en) 1989-06-01 1989-06-01 Beta-lactam elastase inhibitors

Publications (1)

Publication Number Publication Date
ES2060042T3 true ES2060042T3 (es) 1994-11-16

Family

ID=23414295

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90306030T Expired - Lifetime ES2060042T3 (es) 1989-06-01 1990-06-01 Inhibidores de elastasa de beta-lactama.

Country Status (11)

Country Link
US (1) US5132300A (es)
EP (1) EP0401049B1 (es)
JP (1) JPH0780891B2 (es)
AT (1) ATE110388T1 (es)
CA (1) CA2017920C (es)
DE (1) DE69011747T2 (es)
DK (1) DK0401049T3 (es)
ES (1) ES2060042T3 (es)
FI (1) FI96314C (es)
IE (1) IE64767B1 (es)
PT (1) PT94243B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5474993A (en) * 1994-06-14 1995-12-12 Sterling Winthrop, Inc. Lactam inhibitors of cholesterol esterase
US7504228B2 (en) * 2001-06-05 2009-03-17 Qlt Inc. Integrin linked kinase modulation of monocyte activation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4493839A (en) * 1982-05-24 1985-01-15 Merck & Co., Inc. 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents
US4797396A (en) * 1984-07-02 1989-01-10 Merck & Co., Inc. β-Lactam derivatives as anti-inflammatory and antidegenerative agents
US4847247A (en) * 1984-07-30 1989-07-11 Merck & Co., Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.

Also Published As

Publication number Publication date
PT94243B (pt) 1997-01-31
FI96314C (fi) 1996-06-10
EP0401049B1 (en) 1994-08-24
ATE110388T1 (de) 1994-09-15
JPH0381279A (ja) 1991-04-05
FI902725A0 (fi) 1990-06-01
CA2017920C (en) 1999-07-06
DE69011747D1 (de) 1994-09-29
DK0401049T3 (da) 1994-09-19
IE901964L (en) 1990-12-01
DE69011747T2 (de) 1994-12-22
FI96314B (fi) 1996-02-29
EP0401049A3 (en) 1991-12-27
CA2017920A1 (en) 1990-12-01
IE64767B1 (en) 1995-09-06
JPH0780891B2 (ja) 1995-08-30
US5132300A (en) 1992-07-21
PT94243A (pt) 1991-02-08
EP0401049A2 (en) 1990-12-05

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