ES2059686T3 - Uso de amidas heterociclicas para inhibir metastasis tumorales. - Google Patents

Uso de amidas heterociclicas para inhibir metastasis tumorales.

Info

Publication number
ES2059686T3
ES2059686T3 ES89122192T ES89122192T ES2059686T3 ES 2059686 T3 ES2059686 T3 ES 2059686T3 ES 89122192 T ES89122192 T ES 89122192T ES 89122192 T ES89122192 T ES 89122192T ES 2059686 T3 ES2059686 T3 ES 2059686T3
Authority
ES
Spain
Prior art keywords
heterociclic
amides
tumor metastasis
inhibit tumor
fenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89122192T
Other languages
English (en)
Inventor
George Charles Fuller
George Reilly Martin
Richard August Mueller
Reuven Reich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2059686T3 publication Critical patent/ES2059686T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO PARA INHIBIR LA METASTASIS DE TUMORES EN UN ANIMAL POR MEDIO DE LA ADMINISTRACION DE UNA CANTIDAD EFICAZ DE UNA AMIDA HETEROCICLICA REPRESENTADA POR LA FORMULA EN DONDE R1 Y R2 SON LOS MISMOS O DIFERENTES MIEMBROS DEL GRUPO COMPUESTO POR HALO, FENIL, FENIL SUSTITUIDO Y UN GRUPO EN DONDE Q, R Y T SON INDEPENDIENTEMENTE UN ENTERO DE 1 A 8 SIEMPRE QUE Q + R + T SEA IGUAL A, O MENOR QUE 10; Y ES TIO O SULFINIL; ALK ES UNA CADENA RECTA O DIVIDIDA DE ALQUILENO BAJO Y R3 ES UNA AMINA HETEROCICLICA REPRESENTADA POR LA FOMULA EN DONDE R4 ES SELECCIONADO DEL GRUPO COMPUESTO POR HIDROGENO, ALQUIL BAJO, FENIL, FENIL SUSTITUIDO, BENCIL O BENCIL SUSTITUIDO; P VA DE 0 A 2; O UNA SAL FARMACEUTICAMENTE ACEPTABLE.
ES89122192T 1988-12-02 1989-12-01 Uso de amidas heterociclicas para inhibir metastasis tumorales. Expired - Lifetime ES2059686T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/279,584 US5010080A (en) 1988-12-02 1988-12-02 Use of heterocyclic amides to inhibit tumor metastasis

Publications (1)

Publication Number Publication Date
ES2059686T3 true ES2059686T3 (es) 1994-11-16

Family

ID=23069592

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89122192T Expired - Lifetime ES2059686T3 (es) 1988-12-02 1989-12-01 Uso de amidas heterociclicas para inhibir metastasis tumorales.

Country Status (7)

Country Link
US (1) US5010080A (es)
EP (1) EP0372410B1 (es)
JP (1) JP2774845B2 (es)
AT (1) ATE96026T1 (es)
CA (1) CA2004442A1 (es)
DE (1) DE68910090T2 (es)
ES (1) ES2059686T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE119151T1 (de) * 1990-09-07 1995-03-15 Searle & Co Phenolische thioetheramide als 5-lipoxygenase- inhibitoren.
US6071949A (en) * 1995-03-14 2000-06-06 The United States Of America As Represented By The Department Of Health And Human Services Use of lipoxygenase inhibitors as anti-cancer therapeutic and intervention agents
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
AU2002344951A1 (en) * 2001-07-02 2003-01-21 Boehringer Ingelheim International Gmbh Substituted piperazine and diazepanes as histamine h3 receptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.

Also Published As

Publication number Publication date
DE68910090T2 (de) 1994-03-10
CA2004442A1 (en) 1990-06-02
EP0372410A2 (en) 1990-06-13
EP0372410A3 (en) 1991-05-22
JP2774845B2 (ja) 1998-07-09
US5010080A (en) 1991-04-23
ATE96026T1 (de) 1993-11-15
JPH02243679A (ja) 1990-09-27
EP0372410B1 (en) 1993-10-20
DE68910090D1 (de) 1993-11-25

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