ES2059259A1 - Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral. - Google Patents
Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral.Info
- Publication number
- ES2059259A1 ES2059259A1 ES09201894A ES9201894A ES2059259A1 ES 2059259 A1 ES2059259 A1 ES 2059259A1 ES 09201894 A ES09201894 A ES 09201894A ES 9201894 A ES9201894 A ES 9201894A ES 2059259 A1 ES2059259 A1 ES 2059259A1
- Authority
- ES
- Spain
- Prior art keywords
- areno
- indols
- intermediates
- synthesis
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE NUEVOS ARENOL[E]INDOLES UTILES COMO INTERMEDIOS EN LA SINTESIS DE PRODUCTOS CON ACTIVIDAD ANTITUMORAL. COMPRENDE: (A) HACER REACCIONAR (VI) CON UNA BASE FUERTE Y DESPUES CON UN ALDEHIDO AR-CHO PARA DAR (VII); (B) OXIDAR (VII) PARA DAR LA CETONA (VIII); (C) HACER REACCIONAR (VIII) CON UNA BASE FUERTE Y DESPUES CON UN CLORURO DE ACILO CLCOR, PARA DAR (IX); (D) SOMETER A CICLACION FOTOQUIMICA (IX) PARA DAR (I). EN ESTAS FORMULAS AR REPRESENTA FENILO O FENILO SUSTITUIDO; AR'' REPRESENTA UN RADICAL (I) (II) O (III); R REPRESENTA UN GRUPO ACILO, AR'''' REPRESENTA 4-METOXICARBONIL-N-METOXIMETIL-2-PIRRILO, 4-METOXIFENILO O 3,4,5-TRIMETOXIFENILO. LOS COMPUESTOS (I) SON UTILES COMO INTERMEDIOS EN LA SINTESIS DE HEXAHIDROARENO[E]CIDOPROPA[C]INDOL-4-ONAS CON ACTIVIDAD AN TITUMORAL.
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201894A ES2059259B1 (es) | 1992-09-22 | 1992-09-22 | Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral. |
AT93920859T ATE176471T1 (de) | 1992-09-22 | 1993-09-22 | Verfahren zu herstellung von areno(e>indole |
JP50781894A JP3338854B2 (ja) | 1992-09-22 | 1993-09-22 | 新しいアレノ〔e〕インドールの製造方法 |
DK93920859T DK0623619T3 (da) | 1992-09-22 | 1993-09-22 | Fremgangsmåde til fremstilling af areno[e]indoler |
CA002124072A CA2124072A1 (en) | 1992-09-22 | 1993-09-22 | New areno[e] indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity |
EP93920859A EP0623619B1 (en) | 1992-09-22 | 1993-09-22 | PREPARATION METHOD OF ARENO[e]INDOLS |
PCT/ES1993/000078 WO1994006796A1 (es) | 1992-09-22 | 1993-09-22 | NUEVOS ARENO[e]INDOLES, PROCEDIMIENTO PARA SU PREPARACION Y SU APLICACION COMO INTERMEDIOS EN LA SINTESIS DE PRODUCTOS CON ACTIVIDAD ANTITUMORAL |
DE69323418T DE69323418T2 (de) | 1992-09-22 | 1993-09-22 | VERFAHREN ZU HERSTELLUNG VON ARENO[e]INDOLE |
ES93920859T ES2130283T3 (es) | 1992-09-22 | 1993-09-22 | Procedimiento de preparacion de areno(e)indoles. |
AU48205/93A AU4820593A (en) | 1992-09-22 | 1993-09-22 | New areno{e}indols, preparation method and application as intermediates in the synthesis of products with antitumoralt activity |
TW083100017A TW239128B (es) | 1992-09-22 | 1994-01-04 | |
US08/252,658 US5571927A (en) | 1992-09-22 | 1994-05-19 | Areno [E]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity |
US08/674,863 US5631384A (en) | 1992-09-22 | 1996-07-03 | Areno [e]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09201894A ES2059259B1 (es) | 1992-09-22 | 1992-09-22 | Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2059259A1 true ES2059259A1 (es) | 1994-11-01 |
ES2059259B1 ES2059259B1 (es) | 1995-10-01 |
Family
ID=8278210
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09201894A Expired - Lifetime ES2059259B1 (es) | 1992-09-22 | 1992-09-22 | Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral. |
ES93920859T Expired - Lifetime ES2130283T3 (es) | 1992-09-22 | 1993-09-22 | Procedimiento de preparacion de areno(e)indoles. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93920859T Expired - Lifetime ES2130283T3 (es) | 1992-09-22 | 1993-09-22 | Procedimiento de preparacion de areno(e)indoles. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5571927A (es) |
EP (1) | EP0623619B1 (es) |
JP (1) | JP3338854B2 (es) |
AT (1) | ATE176471T1 (es) |
AU (1) | AU4820593A (es) |
CA (1) | CA2124072A1 (es) |
DE (1) | DE69323418T2 (es) |
DK (1) | DK0623619T3 (es) |
ES (2) | ES2059259B1 (es) |
TW (1) | TW239128B (es) |
WO (1) | WO1994006796A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4415463C2 (de) * | 1994-05-03 | 1996-09-26 | Lutz F Prof Dr Tietze | Acetale und Glykoside von 6-Hydroxy-2,3-dihydro-1H-indolen und 5-Hydroxy-1,2-dihydro-3H-pyrrolo(3,2-e)indolen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
CN101211088B (zh) * | 2006-12-28 | 2011-08-10 | 中国科学院西安光学精密机械研究所 | 单晶体可调谐宽带非共线飞秒光参量放大方法及装置 |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
-
1992
- 1992-09-22 ES ES09201894A patent/ES2059259B1/es not_active Expired - Lifetime
-
1993
- 1993-09-22 EP EP93920859A patent/EP0623619B1/en not_active Expired - Lifetime
- 1993-09-22 DE DE69323418T patent/DE69323418T2/de not_active Expired - Fee Related
- 1993-09-22 AU AU48205/93A patent/AU4820593A/en not_active Abandoned
- 1993-09-22 JP JP50781894A patent/JP3338854B2/ja not_active Expired - Fee Related
- 1993-09-22 DK DK93920859T patent/DK0623619T3/da active
- 1993-09-22 AT AT93920859T patent/ATE176471T1/de not_active IP Right Cessation
- 1993-09-22 WO PCT/ES1993/000078 patent/WO1994006796A1/es active IP Right Grant
- 1993-09-22 CA CA002124072A patent/CA2124072A1/en not_active Abandoned
- 1993-09-22 ES ES93920859T patent/ES2130283T3/es not_active Expired - Lifetime
-
1994
- 1994-01-04 TW TW083100017A patent/TW239128B/zh active
- 1994-05-19 US US08/252,658 patent/US5571927A/en not_active Expired - Fee Related
-
1996
- 1996-07-03 US US08/674,863 patent/US5631384A/en not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
JOURNAL AMERICAN CHEMICAL SOCIETY, Vol. 109, n 9, 1.987, pßgs. 2711-2717; MAGNUS et al., "Studies on the synthesis of the antitumor agent CC-1065. Synthesis of PDE I and PDE II, inhibitors of cyclic - Adenosine - 3', 5' - monophosphate phosphodiesterase using the 3, 3' - Bipyrrole strategy". * |
Also Published As
Publication number | Publication date |
---|---|
EP0623619A1 (en) | 1994-11-09 |
US5571927A (en) | 1996-11-05 |
JPH07501344A (ja) | 1995-02-09 |
DK0623619T3 (da) | 1999-09-20 |
DE69323418T2 (de) | 1999-09-09 |
ES2130283T3 (es) | 1999-07-01 |
CA2124072A1 (en) | 1994-03-31 |
TW239128B (es) | 1995-01-21 |
ATE176471T1 (de) | 1999-02-15 |
ES2059259B1 (es) | 1995-10-01 |
EP0623619B1 (en) | 1999-02-03 |
WO1994006796A1 (es) | 1994-03-31 |
AU4820593A (en) | 1994-04-12 |
US5631384A (en) | 1997-05-20 |
JP3338854B2 (ja) | 2002-10-28 |
DE69323418D1 (de) | 1999-03-18 |
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