ES2130283T3 - Procedimiento de preparacion de areno(e)indoles. - Google Patents

Procedimiento de preparacion de areno(e)indoles.

Info

Publication number
ES2130283T3
ES2130283T3 ES93920859T ES93920859T ES2130283T3 ES 2130283 T3 ES2130283 T3 ES 2130283T3 ES 93920859 T ES93920859 T ES 93920859T ES 93920859 T ES93920859 T ES 93920859T ES 2130283 T3 ES2130283 T3 ES 2130283T3
Authority
ES
Spain
Prior art keywords
sand
phenyl
acyle
viii
vii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93920859T
Other languages
English (en)
Inventor
Koen Alexander
Garcia Jose Delamano
Benedikt Sas
Suarez Gabriel Tojo
Gravalos Dolores Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of ES2130283T3 publication Critical patent/ES2130283T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LOS ARENO[E]INDOLES TIENEN LA FORMULA (I). EL METODO COMPRENDE: (A) HACER REACCIONAR (VI) CON UN ALDEHIDO AR'''' RA OBTENER (VII); (B): OXIDAR (VII) PARA OBTENER LA CETONA (VIII); (C) HACER REACCIONAR (VIII) CON UNA BASE FUERTE Y POSTERIORMENTE CON UN CLORURO ACILO CICOR PARA PRODUCIR (IX); (D) SOMETER A CICLIZACION FOTOQUIMICA A (IX) PARA PRODUCIR (I). EN LA MENCIONADA FORMULA AR ES FENILO O FENILO SUSTITUIDO; AR'' ES UN RADICAL (I) O (II); R ES UN GRUPO ACILO, AR'''' ES UN GRUPO FENILO, PIROLILO, FURANILO O CIANOFENILO SUSTITUIDO HASTA TRES VECES POR UNO DE LOS RADICALES R, R1, R2 O R3. LOS COMPONENTES (I) SON UTILES COMO INTERMEDIARIOS EN LA SINTESIS DE HEXAHIDROARENO(E)CICLOPROPA(C)INDOL
ES93920859T 1992-09-22 1993-09-22 Procedimiento de preparacion de areno(e)indoles. Expired - Lifetime ES2130283T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201894A ES2059259B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral.

Publications (1)

Publication Number Publication Date
ES2130283T3 true ES2130283T3 (es) 1999-07-01

Family

ID=8278210

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09201894A Expired - Lifetime ES2059259B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral.
ES93920859T Expired - Lifetime ES2130283T3 (es) 1992-09-22 1993-09-22 Procedimiento de preparacion de areno(e)indoles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09201894A Expired - Lifetime ES2059259B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral.

Country Status (11)

Country Link
US (2) US5571927A (es)
EP (1) EP0623619B1 (es)
JP (1) JP3338854B2 (es)
AT (1) ATE176471T1 (es)
AU (1) AU4820593A (es)
CA (1) CA2124072A1 (es)
DE (1) DE69323418T2 (es)
DK (1) DK0623619T3 (es)
ES (2) ES2059259B1 (es)
TW (1) TW239128B (es)
WO (1) WO1994006796A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4415463C2 (de) * 1994-05-03 1996-09-26 Lutz F Prof Dr Tietze Acetale und Glykoside von 6-Hydroxy-2,3-dihydro-1H-indolen und 5-Hydroxy-1,2-dihydro-3H-pyrrolo(3,2-e)indolen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
CN101211088B (zh) * 2006-12-28 2011-08-10 中国科学院西安光学精密机械研究所 单晶体可调谐宽带非共线飞秒光参量放大方法及装置
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Also Published As

Publication number Publication date
TW239128B (es) 1995-01-21
DK0623619T3 (da) 1999-09-20
JPH07501344A (ja) 1995-02-09
CA2124072A1 (en) 1994-03-31
WO1994006796A1 (es) 1994-03-31
EP0623619B1 (en) 1999-02-03
ATE176471T1 (de) 1999-02-15
EP0623619A1 (en) 1994-11-09
DE69323418T2 (de) 1999-09-09
DE69323418D1 (de) 1999-03-18
US5631384A (en) 1997-05-20
JP3338854B2 (ja) 2002-10-28
AU4820593A (en) 1994-04-12
ES2059259A1 (es) 1994-11-01
US5571927A (en) 1996-11-05
ES2059259B1 (es) 1995-10-01

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