ES2058626T3 - Benzazepinas con actividad antidopaminergica. - Google Patents

Benzazepinas con actividad antidopaminergica.

Info

Publication number
ES2058626T3
ES2058626T3 ES90102747T ES90102747T ES2058626T3 ES 2058626 T3 ES2058626 T3 ES 2058626T3 ES 90102747 T ES90102747 T ES 90102747T ES 90102747 T ES90102747 T ES 90102747T ES 2058626 T3 ES2058626 T3 ES 2058626T3
Authority
ES
Spain
Prior art keywords
benzazepines
antidopaminergic activity
antidopaminergic
activity
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102747T
Other languages
English (en)
Inventor
Louis Brammer Hansen
Kristian Tage Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2058626T3 publication Critical patent/ES2058626T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

NUEVAS 2,3,4,5-TETRAHIDRO-1H-3BENZOACEPINAS, LAS CUALES TIENEN EN LA POSICION 7 UN GRUPO METOXILOMETILOOXILO, EN EL HIDROGENO DE POSICION 8, TIENEN UN HALOGENO O UN GRUPO NITROGENO Y EN LA POSICION 5 TIENEN UN SISTEMA DE ANILLO ORTO ENLAZADO, OPCIONALMENTE FENILO SUSTITUIDO, CON EFECTOS INTERESANTES SOBRE EL SISTEMA NERVIOSO CENTRAL.
ES90102747T 1989-02-14 1990-02-12 Benzazepinas con actividad antidopaminergica. Expired - Lifetime ES2058626T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK067489A DK67489D0 (da) 1989-02-14 1989-02-14 Nye benzazepinderivater

Publications (1)

Publication Number Publication Date
ES2058626T3 true ES2058626T3 (es) 1994-11-01

Family

ID=8096246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102747T Expired - Lifetime ES2058626T3 (es) 1989-02-14 1990-02-12 Benzazepinas con actividad antidopaminergica.

Country Status (15)

Country Link
US (1) US5079243A (es)
EP (1) EP0383247B1 (es)
JP (1) JPH03197463A (es)
AT (1) ATE109473T1 (es)
AU (1) AU624678B2 (es)
DE (1) DE69011150T2 (es)
DK (2) DK67489D0 (es)
ES (1) ES2058626T3 (es)
FI (1) FI94956C (es)
IE (1) IE64967B1 (es)
IL (1) IL93287A0 (es)
NO (1) NO174746C (es)
NZ (1) NZ232491A (es)
PT (1) PT93133B (es)
ZA (1) ZA901079B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK23392D0 (da) * 1992-02-24 1992-02-24 Novo Nordisk As Heterocykliske forbindelser, deres anvendelse og fremstilling
US5470850A (en) * 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
JP5258561B2 (ja) * 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4187314A (en) * 1977-02-02 1980-02-05 Smithkline Corporation Substituted furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and pharmaceutical use
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
ZA792042B (en) * 1978-05-08 1980-05-28 Scherico Ltd Substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4349472A (en) * 1979-04-27 1982-09-14 Schering Corporation (S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CA1234110A (en) * 1983-08-12 1988-03-15 Joel G. Berger Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
DK107688D0 (da) * 1988-03-01 1988-03-01 Novo Industri As Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner
DK325188D0 (da) * 1988-06-15 1988-06-15 Novo Industri As Hidtil ukendte benzazepinderivater

Also Published As

Publication number Publication date
ZA901079B (en) 1990-11-28
IL93287A0 (en) 1990-11-29
AU624678B2 (en) 1992-06-18
EP0383247B1 (en) 1994-08-03
PT93133B (pt) 1996-02-29
DE69011150T2 (de) 1994-12-08
FI900729A0 (fi) 1990-02-14
IE900400L (en) 1990-08-14
IE64967B1 (en) 1995-09-20
JPH03197463A (ja) 1991-08-28
FI94956B (fi) 1995-08-15
US5079243A (en) 1992-01-07
EP0383247A1 (en) 1990-08-22
NO174746B (no) 1994-03-21
FI94956C (fi) 1995-11-27
PT93133A (pt) 1990-08-31
DK0383247T3 (da) 1994-10-03
NO174746C (no) 1994-06-29
NZ232491A (en) 1992-05-26
DE69011150D1 (de) 1994-09-08
NO900700L (no) 1990-08-15
ATE109473T1 (de) 1994-08-15
DK67489D0 (da) 1989-02-14
AU4935290A (en) 1990-08-23
NO900700D0 (no) 1990-02-13

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