ES2058365T3 - 1,3,4,5-tetrahidrobenz(c,d)indoles. - Google Patents

1,3,4,5-tetrahidrobenz(c,d)indoles.

Info

Publication number
ES2058365T3
ES2058365T3 ES89103871T ES89103871T ES2058365T3 ES 2058365 T3 ES2058365 T3 ES 2058365T3 ES 89103871 T ES89103871 T ES 89103871T ES 89103871 T ES89103871 T ES 89103871T ES 2058365 T3 ES2058365 T3 ES 2058365T3
Authority
ES
Spain
Prior art keywords
indoles
tetrahidrobenz
tetrahydrobenz
medicaments
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89103871T
Other languages
English (en)
Inventor
Bodo Dr Junge
Bernd Dr Richter
Thomas Dr Glaser
Jorg Dr Traber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2058365T3 publication Critical patent/ES2058365T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE PUEDEN OBTENER 1,3,4,5 - TETRAHIDROBENZIL (C,D) INDOLES, SIEMPRE QUE SE AMINEN REDUCTIVAMENTE A MODO DE EJEMPLO LOS CORRESPONDIENTES CETONAS CON AMINAS. LOS NUEVOS COMPUESTOS SE PUEDEN UTILIZAR COMO ACTIVADORES EN MEDICAMENTOS.
ES89103871T 1988-03-18 1989-03-06 1,3,4,5-tetrahidrobenz(c,d)indoles. Expired - Lifetime ES2058365T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3809155A DE3809155A1 (de) 1988-03-18 1988-03-18 1,3,4,5-tetrahydrobenz-(c,d)-indole

Publications (1)

Publication Number Publication Date
ES2058365T3 true ES2058365T3 (es) 1994-11-01

Family

ID=6350115

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89103871T Expired - Lifetime ES2058365T3 (es) 1988-03-18 1989-03-06 1,3,4,5-tetrahidrobenz(c,d)indoles.

Country Status (18)

Country Link
US (1) US5021438A (es)
EP (1) EP0332968B1 (es)
JP (1) JPH02204479A (es)
KR (1) KR890014474A (es)
CN (1) CN1036566A (es)
AT (1) ATE90093T1 (es)
AU (1) AU614343B2 (es)
DD (1) DD283606A5 (es)
DE (2) DE3809155A1 (es)
DK (1) DK131789A (es)
ES (1) ES2058365T3 (es)
FI (1) FI891252A (es)
HU (1) HU204034B (es)
IL (1) IL89623A (es)
NO (1) NO890892L (es)
NZ (1) NZ228341A (es)
PT (1) PT90012B (es)
ZA (1) ZA892049B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5273975A (en) * 1989-06-09 1993-12-28 The Upjohn Company Heterocyclic amines having central nervous system activity
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
TW219933B (es) * 1990-02-26 1994-02-01 Lilly Co Eli
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
ATE129710T1 (de) * 1990-08-13 1995-11-15 Hoechst Roussel Pharma Carbamoyl-1-(pyridinylalkyl)-1h-indole, -indoline und verwandte verbindungen.
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
US5244911A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz(cd)indoles and pharmaceutical use thereof
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5641794A (en) * 1991-03-28 1997-06-24 Eli Lilly Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
CZ285762B6 (cs) * 1993-06-10 1999-11-17 Eli Lilly And Company Farmaceutický prostředek vhodný pro prevenci dávení a zvracení a pro ošetřování sexuální dysfunkce savců a jeho použití
TW430660B (en) * 1996-05-30 2001-04-21 Mochida Pharm Co Ltd Novel benzindole derivatives for neuron cell protection, processes for production, and the pharmaceutical compounds containing them
US6723730B2 (en) * 2000-07-20 2004-04-20 Neurogen Corporation Capsaicin receptor ligands
KR20210134928A (ko) 2019-02-27 2021-11-11 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뇌 장애를 치료하기 위한 n-치환된 인돌 및 다른 헤테로사이클
JP2022521789A (ja) 2019-02-27 2022-04-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳障害を治療するためのアゼピノ－インドール及び他の複素環化合物
US20230295106A1 (en) * 2019-10-14 2023-09-21 The Regents Of The University Of California Ergoline-like compounds for promoting neural plasticity
CN115584206A (zh) * 2022-10-13 2023-01-10 吕辉 一种水性无机纳米陶瓷阻燃涂料及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE542760A (es) * 1954-11-12
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles
FR2471373A1 (fr) * 1979-12-10 1981-06-19 Roussel Uclaf Nouveaux derives de la benzindolamine, leurs sels, procede de preparation, application a titre de medicaments et composition les renfermant
DE3346513A1 (de) 1983-12-22 1985-07-11 Süddeutsche Kühlerfabrik Julius Fr. Behr GmbH & Co. KG, 7000 Stuttgart Vorrichtung zum erwaermen von wasser
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
DE3719924A1 (de) * 1986-12-22 1988-06-30 Bayer Ag 8-substituierte 2-aminotetraline
DE3718892A1 (de) * 1987-06-05 1988-12-22 Bayer Ag Polyhydrobenz(c,d)indol-sulfonamide

Also Published As

Publication number Publication date
IL89623A (en) 1993-01-14
DK131789A (da) 1989-09-19
NZ228341A (en) 1990-12-21
PT90012B (pt) 1994-06-30
EP0332968B1 (de) 1993-06-02
HUT50767A (en) 1990-03-28
DD283606A5 (de) 1990-10-17
DE58904539D1 (de) 1993-07-08
KR890014474A (ko) 1989-10-23
US5021438A (en) 1991-06-04
NO890892L (no) 1989-09-19
ZA892049B (en) 1989-11-29
EP0332968A1 (de) 1989-09-20
PT90012A (pt) 1989-11-10
AU3152689A (en) 1989-09-28
AU614343B2 (en) 1991-08-29
IL89623A0 (en) 1989-09-10
NO890892D0 (no) 1989-03-02
DE3809155A1 (de) 1989-09-28
FI891252A (fi) 1989-09-19
FI891252A0 (fi) 1989-03-16
HU204034B (en) 1991-11-28
ATE90093T1 (de) 1993-06-15
JPH02204479A (ja) 1990-08-14
DK131789D0 (da) 1989-03-17
CN1036566A (zh) 1989-10-25

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