ES2057553T3 - Sitios hidrofobicos de fijacion para peptidos de adherencia. - Google Patents

Sitios hidrofobicos de fijacion para peptidos de adherencia.

Info

Publication number
ES2057553T3
ES2057553T3 ES90905829T ES90905829T ES2057553T3 ES 2057553 T3 ES2057553 T3 ES 2057553T3 ES 90905829 T ES90905829 T ES 90905829T ES 90905829 T ES90905829 T ES 90905829T ES 2057553 T3 ES2057553 T3 ES 2057553T3
Authority
ES
Spain
Prior art keywords
peptides
hydrophobic
biologically active
domain
adhesion peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905829T
Other languages
English (en)
Inventor
Michael D Pierschbacher
Cyril J Honsik
Lisa B Dreisbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Application granted granted Critical
Publication of ES2057553T3 publication Critical patent/ES2057553T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SUMINISTRA UN METODO PARA LA ADHERENCIA DE PEPTIDOS QUE CONTENGAN PEPTIDOS DE ADHESION RGD A UNA SUPERFICIE SOLIDA, A TRAVES DE UN DOMINIO HIDROFOBICO DE LOS PEPTIDOS ASI ADHERIDOS. EL DOMINIO HIDROFOBICO PUEDE CONTENER BIEN UN AMINO ACIDO HIDROFOBICO, COMO LA LEUCINA, VALINA, ISOLEUCINA O FENILALANINA, O BIEN ACIDOS GRASOS COMO, POR EJEMPLO, ACIDO MITICO, ACIDO PALMITICO, ACIDO ARACHIDICO U OTROS ACIDOS GRASOS. ADEMAS, ESPACIADORES TALES COMO AMINO ACIDOS, LOCALIZADOS ENTRE EL DOMINIO HIDROFOBICO Y EL DOMINIO BIOLOGICAMENTE ACTIVO PUEDEN MEJORAR LA DETECCION DEL LUGAR BIOLOGICAMENTE ACTIVO. PEPTIDOS ESPECIFICOS INCLUYEN GRGDSPASSKG SUB 4 SRL SUB 6 RNH SUB 2; GRGDSPASSKS SUB 3 RL SUB 6 RNH SUB 2; Y GRGDSPASSKSSKRL SUB 6 RNH SUB 2. ACOPLADOS A UNA SUPERFICIE SOLIDA, DICHOS PEPTIDOS SE PUEDEN UTILIZAR PARA DETECTAR LA PRESENCIA DE UN LIGANDO COMPLEMENTARIO AL LUGAR BIOLOGICAMENTE ACTIVO.
ES90905829T 1989-03-20 1990-03-20 Sitios hidrofobicos de fijacion para peptidos de adherencia. Expired - Lifetime ES2057553T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/326,168 US5120829A (en) 1989-03-20 1989-03-20 Hydrophobic attachment site for adhesion peptides

Publications (1)

Publication Number Publication Date
ES2057553T3 true ES2057553T3 (es) 1994-10-16

Family

ID=23271081

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905829T Expired - Lifetime ES2057553T3 (es) 1989-03-20 1990-03-20 Sitios hidrofobicos de fijacion para peptidos de adherencia.

Country Status (9)

Country Link
US (4) US5120829A (es)
EP (1) EP0464140B1 (es)
JP (1) JP2723669B2 (es)
AT (1) ATE109161T1 (es)
CA (1) CA2046631A1 (es)
DE (1) DE69011102T2 (es)
DK (1) DK0464140T3 (es)
ES (1) ES2057553T3 (es)
WO (1) WO1990011297A1 (es)

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ATE361098T1 (de) * 1998-05-15 2007-05-15 Receptor Biologix Inc Vorbeugung und behandlung von hypergastrinemie
US6428579B1 (en) * 1998-07-01 2002-08-06 Brown University Research Foundation Implantable prosthetic devices coated with bioactive molecules
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EP1173469A2 (en) * 1999-04-16 2002-01-23 Children's Medical Center Corporation Adhesion modulatory peptides and methods for use
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
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DK1313440T3 (da) 2000-08-16 2008-11-03 Acologix Inc Dentalprodukter indeholdende knoglevækstforögende peptider
WO2002076499A2 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
US20030021786A1 (en) * 2001-07-09 2003-01-30 Gevas Philip C. Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus
US6810583B2 (en) * 2001-08-07 2004-11-02 International Business Machines Corporation Coupling of conductive vias to complex power-signal substructures
US6902932B2 (en) * 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US20110009960A1 (en) * 2001-11-16 2011-01-13 Allergan, Inc. Prosthetic fabric structure
GB0209896D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
GB0209893D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
WO2004088326A2 (en) * 2003-03-28 2004-10-14 Aphton Corporation Gastrin hormone immunoassays
EP1730193A2 (en) * 2004-03-29 2006-12-13 Receptor Biologix, Inc. Monoclonal antibodies to gastrin hormone
WO2006032980A1 (en) * 2004-09-22 2006-03-30 Receptor Biologix, Inc. Monoclonal antibolies to progastrin
US7638486B2 (en) 2005-07-18 2009-12-29 Acologix, Inc. Method for promoting hard tissue formation
GB2433506A (en) * 2005-12-20 2007-06-27 Sharp Kk A method of producing a multimeric capture agent
GB2433591A (en) * 2005-12-20 2007-06-27 Sharp Kk Method for functionalising a hydrophobic substrate
GB2433505A (en) * 2005-12-20 2007-06-27 Sharp Kk Capture agents for binding a ligand
CN101240030B (zh) * 2007-02-07 2010-08-11 首都医科大学 正十一烷基和rgd肽构建的缀合物、它们的合成及在医学中的应用
CN101240028B (zh) * 2007-02-07 2010-08-18 首都医科大学 正十五烷基和rgd肽构建的缀合物、它们的合成及在医学中的应用
CN101240027B (zh) * 2007-02-07 2011-04-20 首都医科大学 正壬烷基和rgd肽构建的缀合物、它们的合成及在医学中的应用
CN101240029B (zh) * 2007-02-07 2010-08-11 首都医科大学 正庚烷基和rgd肽构建的缀合物、其合成方法和应用
CN101240031B (zh) * 2007-02-07 2010-10-13 首都医科大学 正十七烷基和rgd肽构建的缀合物、其制备方法及应用
CA2734577A1 (en) 2007-08-16 2009-02-26 Carnegie Mellon University Inflammation-regulating compositions and methods
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US9204954B2 (en) * 2008-12-15 2015-12-08 Allergan, Inc. Knitted scaffold with diagonal yarn
US9308070B2 (en) * 2008-12-15 2016-04-12 Allergan, Inc. Pliable silk medical device
US9326840B2 (en) 2008-12-15 2016-05-03 Allergan, Inc. Prosthetic device and method of manufacturing the same
US9204953B2 (en) 2008-12-15 2015-12-08 Allergan, Inc. Biocompatible surgical scaffold with varying stretch
US20110052695A1 (en) * 2009-04-20 2011-03-03 Allergan, Inc. Drug delivery platforms comprising silk fibroin hydrogels and uses thereof
US20110189292A1 (en) * 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
WO2010123946A2 (en) * 2009-04-20 2010-10-28 Allergan, Inc. Silk fibroin hydrogels and uses thereof
US20110111031A1 (en) * 2009-04-20 2011-05-12 Guang-Liang Jiang Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof
AU2010292237A1 (en) * 2009-09-11 2012-04-05 Allergan, Inc. Prosthetic device and method of manufacturing the same
CA3066756A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
JPWO2019176860A1 (ja) * 2018-03-15 2021-01-14 東レ株式会社 細胞接着性材料

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Also Published As

Publication number Publication date
CA2046631A1 (en) 1990-09-21
US5587456A (en) 1996-12-24
DK0464140T3 (da) 1994-09-05
DE69011102D1 (de) 1994-09-01
US5760176A (en) 1998-06-02
JP2723669B2 (ja) 1998-03-09
DE69011102T2 (de) 1994-11-24
WO1990011297A1 (en) 1990-10-04
JPH04506511A (ja) 1992-11-12
EP0464140B1 (en) 1994-07-27
US5591822A (en) 1997-01-07
EP0464140A1 (en) 1992-01-08
ATE109161T1 (de) 1994-08-15
US5120829A (en) 1992-06-09

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