ES2055670A1 - Metodo de producir 5-nucleotidos. - Google Patents

Metodo de producir 5-nucleotidos.

Info

Publication number
ES2055670A1
ES2055670A1 ES09301524A ES9301524A ES2055670A1 ES 2055670 A1 ES2055670 A1 ES 2055670A1 ES 09301524 A ES09301524 A ES 09301524A ES 9301524 A ES9301524 A ES 9301524A ES 2055670 A1 ES2055670 A1 ES 2055670A1
Authority
ES
Spain
Prior art keywords
nucleotide
nucleoside
producing
suspension
phosphorylatipon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301524A
Other languages
English (en)
Other versions
ES2055670B1 (es
Inventor
Akira Haze
Hiroyuki Hatano
Tomomi Ikemoto
Yoshifumi Kitamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES2055670A1 publication Critical patent/ES2055670A1/es
Application granted granted Critical
Publication of ES2055670B1 publication Critical patent/ES2055670B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

METODO PARA PRODUCIR 5''-NUCLEOTIDOS, QUE COMPRENDE MANTENER UNA SUSPENSION DE UNO O VARIOS NUCLEOSIDO(S) EN UN DISOLVENTE ORGANICO A UNA TEMPERATURA NO MENOR QUE APROXIMADAMENTE 20GC, Y LUEGO SOMETER LA SUSPENSION RESULTANTE A UNA FOSFORILACION DEL O DE LOS NUCLEOSIDO(S). LOS 5''-NUCLEOTIDOS SE PUEDEN PRODUCIR A PARTIR DE UN NUCLEOSIDO CON ALTA PUREZA Y ALTO RENDIMIENTO EN UN PERIODO DE TIEMPO DE REACCION ACORTADO, Y SE CONSIGUE CON FACILIDAD LA ELIMINACION DE IMPUREZAS EN EL PROCEDIMIENTO DE PURIFICACION DE NUCLEOTIDOS.
ES09301524A 1992-07-08 1993-07-07 Metodo de producir 5-nucleotidos. Expired - Lifetime ES2055670B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18114592 1992-07-08

Publications (2)

Publication Number Publication Date
ES2055670A1 true ES2055670A1 (es) 1994-08-16
ES2055670B1 ES2055670B1 (es) 1995-02-16

Family

ID=16095679

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09301524A Expired - Lifetime ES2055670B1 (es) 1992-07-08 1993-07-07 Metodo de producir 5-nucleotidos.

Country Status (7)

Country Link
US (1) US5623069A (es)
KR (1) KR100270246B1 (es)
CN (1) CN1033272C (es)
CA (1) CA2100027C (es)
ES (1) ES2055670B1 (es)
IT (1) IT1264061B (es)
TW (1) TW279165B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101665525B (zh) * 2009-09-10 2013-05-01 广东肇庆星湖生物科技股份有限公司 一种核苷酸的合成方法
CN101891772B (zh) * 2010-07-16 2012-11-28 广东肇庆星湖生物科技股份有限公司 一种5’-核苷酸二钠的制备方法
CN101914125A (zh) * 2010-08-12 2010-12-15 广东肇庆星湖生物科技股份有限公司 一种5’-鸟苷磷酸化反应液的萃取工艺
CN104151383A (zh) * 2014-07-15 2014-11-19 南通香地生物有限公司 尿苷酸二钠盐的生产方法
CN114315934A (zh) * 2021-12-22 2022-04-12 成都市海通药业有限公司 一种胞磷胆碱重要中间体胞苷酸的合成和精制方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167599A (ja) * 1983-03-11 1984-09-21 Takeda Chem Ind Ltd イノシンおよびグアノシンの化学的リン酸化法
EP0453597A1 (en) * 1988-10-25 1991-10-30 Ajinomoto Co., Inc. Process for producing a mixture of inosinic acid and guanosinic acid by direct phosphorylation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1645896C3 (de) * 1965-03-17 1975-01-02 Ajinomoto Co., Inc., Tokio Verfahren zur Herstellung von 5'-Ribonucleotiden nd S'-Desoxyribonucleotiden
DE1620568A1 (de) * 1965-10-04 1970-08-27 Takeda Chemical Industries Ltd Verfahren zur Herstellung von Nucleotiden
US3433783A (en) * 1967-07-03 1969-03-18 Takeda Chemical Industries Ltd Method for the production of ribonucleoside-5'-phosphate
JPS5980694A (ja) * 1982-10-30 1984-05-10 Seikagaku Kogyo Co Ltd リン酸化合物の製造方法
JPS59163397A (ja) * 1983-03-09 1984-09-14 Seikagaku Kogyo Co Ltd リン酸化合物の製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59167599A (ja) * 1983-03-11 1984-09-21 Takeda Chem Ind Ltd イノシンおよびグアノシンの化学的リン酸化法
EP0453597A1 (en) * 1988-10-25 1991-10-30 Ajinomoto Co., Inc. Process for producing a mixture of inosinic acid and guanosinic acid by direct phosphorylation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS WPIL, 84-272851, 1994, Derwent Publications Ltd., London, GB, & JP-A-59167599 (TAKEDA CHEMICALS IND KK), 21.9.84 * Resumen * *

Also Published As

Publication number Publication date
KR940005659A (ko) 1994-03-22
ITTO930501A1 (it) 1995-01-07
ES2055670B1 (es) 1995-02-16
CN1033272C (zh) 1996-11-13
CN1086219A (zh) 1994-05-04
KR100270246B1 (ko) 2000-10-16
CA2100027A1 (en) 1994-01-09
US5623069A (en) 1997-04-22
IT1264061B (it) 1996-09-09
CA2100027C (en) 2003-10-07
ITTO930501A0 (it) 1993-07-07
TW279165B (es) 1996-06-21

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