ES2055001T3 - Formulaciones de proteinas hidrofobas estabilizadas. - Google Patents
Formulaciones de proteinas hidrofobas estabilizadas.Info
- Publication number
- ES2055001T3 ES2055001T3 ES89123384T ES89123384T ES2055001T3 ES 2055001 T3 ES2055001 T3 ES 2055001T3 ES 89123384 T ES89123384 T ES 89123384T ES 89123384 T ES89123384 T ES 89123384T ES 2055001 T3 ES2055001 T3 ES 2055001T3
- Authority
- ES
- Spain
- Prior art keywords
- formulations
- hydrophobic proteins
- stabilized hydrophobic
- stabilized
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
DICHA FORMULACION FARMACEUTICAMENTE ACEPTABLE CONTIENE UNA CANTIDAD FARMACEUTICAMENTE ACEPTABLE DE UNA PROTEINA. LOS MEDIOS Y METODOS PARA PREPARAR DICHAS FORMULACIONES SON DISPUESTAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/285,159 US5104651A (en) | 1988-12-16 | 1988-12-16 | Stabilized hydrophobic protein formulations of g-csf |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055001T3 true ES2055001T3 (es) | 1994-08-16 |
Family
ID=23093007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89123384T Expired - Lifetime ES2055001T3 (es) | 1988-12-16 | 1989-12-18 | Formulaciones de proteinas hidrofobas estabilizadas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5104651A (es) |
EP (1) | EP0373679B1 (es) |
JP (1) | JP2888969B2 (es) |
AT (1) | ATE107513T1 (es) |
AU (1) | AU621695B2 (es) |
CA (1) | CA2005143C (es) |
DE (1) | DE68916385T2 (es) |
ES (1) | ES2055001T3 (es) |
HK (1) | HK1006812A1 (es) |
WO (1) | WO1990006762A1 (es) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9107846D0 (en) * | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
US5847086A (en) * | 1991-06-20 | 1998-12-08 | Centeon L.L.C. | Therapeutic fragments of von Willebrand factor |
WO1993000107A1 (en) * | 1991-06-20 | 1993-01-07 | Rhone-Poulenc Rorer International (Holdings) Inc. | Therapeutic fragments of von willebrand factor |
IT1254359B (it) * | 1992-05-11 | 1995-09-14 | Serono Cesare Ist Ricerca | Composizioni farmaceutiche contenenti il-6 |
EP0582932A1 (de) * | 1992-08-11 | 1994-02-16 | F. Hoffmann-La Roche Ag | Therapeutisches System zur parenteralen Verabreichung von hämatopoetischen Wachstumsfaktoren |
DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
DE4242919A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF |
CA2092271C (en) * | 1993-03-09 | 2009-10-13 | Eddie Reed | Use of g-csf for treating taxol side-effects |
US5777193A (en) * | 1994-03-04 | 1998-07-07 | Ludwig Institute For Cancer Research | Animals with targeted gene disruption |
USRE38424E1 (en) | 1994-11-21 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Method for treating taxol side-effects with G-CSF |
WO1996024369A1 (en) * | 1995-02-06 | 1996-08-15 | Genetics Institute, Inc. | Formulations for il-12 |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6979442B1 (en) * | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
EP1129720B1 (en) | 2000-02-29 | 2004-06-23 | Pfizer Products Inc. | Stabilized granulocyte colony stimulating factor |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
HU228583B1 (en) * | 2000-11-07 | 2013-04-29 | Novartis Vaccines & Diagnostic | Stabilized interferon compositions |
US20020141970A1 (en) * | 2001-03-05 | 2002-10-03 | Pettit Dean K. | Stable aqueous solutions of granulocyte macrophage colony-stimulating factor |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
EP1425304B9 (en) * | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf conjugates |
US7157277B2 (en) * | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7214660B2 (en) * | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7173003B2 (en) * | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
MXPA04012496A (es) * | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
AU2003261723A1 (en) | 2002-08-27 | 2004-03-19 | Takeda Chemical Industries, Ltd. | Cxcr4 antagonist and use thereof |
US7273921B2 (en) * | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
BRPI0408358A (pt) * | 2003-03-14 | 2006-03-21 | Neose Technologies Inc | polìmeros hidrossolúveis ramificados e seus conjugados |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
BRPI0410164A (pt) * | 2003-05-09 | 2006-05-16 | Neose Technologies Inc | composições e métodos para preparação de mutantes de glicosilação de hormÈnio do crescimento humano |
WO2005012484A2 (en) * | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
DE10348550A1 (de) * | 2003-10-20 | 2005-06-16 | Hexal Biotech Forschungsgmbh | Stabile wässrige G-CSF-haltige Zusammensetzungen |
US8338373B2 (en) * | 2003-10-24 | 2012-12-25 | Nora Therapeutics, Inc. | Method for reducing the risk of spontaneous abortion in a human female subject |
EP2196210A1 (en) * | 2003-10-24 | 2010-06-16 | Nora, LLC | A method for reducing the likelihood of preeclampsia in a subject in need thereof |
US20090226397A1 (en) * | 2003-10-24 | 2009-09-10 | Nora Therapeutics, Inc. | Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination |
US7220407B2 (en) * | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
EP1694347B1 (en) * | 2003-11-24 | 2013-11-20 | BioGeneriX AG | Glycopegylated erythropoietin |
US8633157B2 (en) * | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
EP1694351A2 (en) * | 2003-12-03 | 2006-08-30 | Neose Technologies, Inc. | Glycopegylated follicle stimulating hormone |
US20070254836A1 (en) * | 2003-12-03 | 2007-11-01 | Defrees Shawn | Glycopegylated Granulocyte Colony Stimulating Factor |
US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
CN101072789B (zh) * | 2004-01-08 | 2013-05-15 | 生物种属学股份公司 | 肽的o-连接的糖基化 |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
US20090292110A1 (en) * | 2004-07-23 | 2009-11-26 | Defrees Shawn | Enzymatic modification of glycopeptides |
WO2006031811A2 (en) * | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
JP5948627B2 (ja) | 2004-10-29 | 2016-07-20 | レイショファーム ゲーエムベーハー | 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化 |
US20060153799A1 (en) * | 2004-11-05 | 2006-07-13 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
EP1858543B1 (en) * | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20110003744A1 (en) * | 2005-05-25 | 2011-01-06 | Novo Nordisk A/S | Glycopegylated Erythropoietin Formulations |
EP2975135A1 (en) * | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
CN101193658B (zh) | 2005-06-01 | 2011-08-31 | 马克西根控股公司 | 聚乙二醇化g-csf多肽及其产生方法 |
DE102005033250A1 (de) | 2005-07-15 | 2007-01-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Reinigung von G-CSF |
KR100735784B1 (ko) * | 2005-07-20 | 2007-07-06 | 재단법인 목암생명공학연구소 | 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물 |
JP2009515508A (ja) * | 2005-08-19 | 2009-04-16 | ネオス テクノロジーズ インコーポレイテッド | グリコpeg化因子viiおよび因子viia |
US20070105755A1 (en) * | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
DE102006009437A1 (de) | 2006-03-01 | 2007-09-13 | Bioceuticals Arzneimittel Ag | G-CSF-Flüssigformulierung |
RU2322452C2 (ru) * | 2006-03-27 | 2008-04-20 | Михаил Николаевич Смирнов | Иммуномодулирующая композиция |
US9187532B2 (en) * | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
JP2010505874A (ja) | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー/エス | ポリペプチドコンジュゲートの精製方法 |
CN101600448B (zh) * | 2006-10-04 | 2015-11-25 | 诺和诺德公司 | 甘油连接的peg化的糖和糖肽 |
US8455450B2 (en) | 2006-12-21 | 2013-06-04 | Biokine Therapeutics Ltd. | Methods for obtaining a therapeutically effective amount of hematopoietic precursor cells and long term engraftment thereof |
KR20150064246A (ko) * | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | 글리코페길화 g―csf를 이용하는 치료 방법 |
WO2008151258A2 (en) * | 2007-06-04 | 2008-12-11 | Neose Technologies, Inc. | O-linked glycosylation using n-acetylglucosaminyl transferases |
CA2690611C (en) * | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
US7968811B2 (en) * | 2007-06-29 | 2011-06-28 | Harley-Davidson Motor Company Group, Inc. | Integrated ignition and key switch |
EP2185689A2 (en) | 2007-08-09 | 2010-05-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
DE102007040932A1 (de) | 2007-08-27 | 2009-03-05 | Biogenerix Ag | Flüssigformulierung von G-CSF |
BRPI0815280A2 (pt) | 2007-08-27 | 2018-11-27 | Biogenerix Ag | medicamento que compreende uma formulação líquida aquosa de g-csf, receptáculo para a administração de medicamentos líquidos, seringa ou ampola, kit para a administração parenteral de g-csf |
US8207112B2 (en) * | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
WO2009046015A2 (en) * | 2007-09-30 | 2009-04-09 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
US20100286067A1 (en) * | 2008-01-08 | 2010-11-11 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
WO2009108806A1 (en) | 2008-02-27 | 2009-09-03 | Novo Nordisk A/S | Conjugated factor viii molecules |
US9155780B2 (en) | 2009-02-11 | 2015-10-13 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
ES2462517T3 (es) | 2009-06-14 | 2014-05-23 | Biokine Therapeutics Ltd. | Terapia con péptidos para aumentar los niveles de plaquetas |
EP2399572A1 (en) | 2010-06-22 | 2011-12-28 | Sandoz AG | Long-term storage of non-glycosylated recombinant human G-CSF |
EP2841084B1 (en) | 2012-04-24 | 2018-05-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist peptide for use in the treatment of large cell lung cancer |
HUE049282T2 (hu) | 2012-09-07 | 2020-09-28 | Coherus Biosciences Inc | Adalimumab stabil vizes formulációi |
WO2016167291A1 (ja) | 2015-04-13 | 2016-10-20 | 国立研究開発法人産業技術総合研究所 | 環状化サイトカイン及びその製法 |
AU2016291817A1 (en) | 2015-07-16 | 2018-02-22 | Biolinerx Ltd. | Compositions and methods for treating cancer |
US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
CA3014530A1 (en) | 2016-02-23 | 2017-08-31 | Biolinerx Ltd. | Methods of treating acute myeloid leukemia |
US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
WO2018138267A1 (en) | 2017-01-27 | 2018-08-02 | Cinfa Biotech S.L. | Method for determining the efficacy of a g-csf containing composition |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4623717A (en) * | 1980-03-05 | 1986-11-18 | Miles Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
EP0080879B1 (en) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
AU1234383A (en) * | 1982-03-17 | 1983-09-22 | Inter-Yeda Ltd. | Interferon stabilised with polyvinyl-pyrrolidone |
US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
GR871067B (en) * | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
-
1988
- 1988-12-16 US US07/285,159 patent/US5104651A/en not_active Expired - Lifetime
-
1989
- 1989-12-01 JP JP2501371A patent/JP2888969B2/ja not_active Expired - Lifetime
- 1989-12-01 WO PCT/US1989/005455 patent/WO1990006762A1/en unknown
- 1989-12-01 AU AU46689/89A patent/AU621695B2/en not_active Expired
- 1989-12-11 CA CA002005143A patent/CA2005143C/en not_active Expired - Lifetime
- 1989-12-18 AT AT89123384T patent/ATE107513T1/de not_active IP Right Cessation
- 1989-12-18 ES ES89123384T patent/ES2055001T3/es not_active Expired - Lifetime
- 1989-12-18 DE DE68916385T patent/DE68916385T2/de not_active Expired - Lifetime
- 1989-12-18 EP EP89123384A patent/EP0373679B1/en not_active Expired - Lifetime
-
1998
- 1998-06-23 HK HK98106061A patent/HK1006812A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU621695B2 (en) | 1992-03-19 |
US5104651A (en) | 1992-04-14 |
ATE107513T1 (de) | 1994-07-15 |
CA2005143C (en) | 1995-07-11 |
JPH03502808A (ja) | 1991-06-27 |
EP0373679B1 (en) | 1994-06-22 |
DE68916385T2 (de) | 1994-10-13 |
EP0373679A3 (en) | 1991-04-17 |
AU4668989A (en) | 1990-07-10 |
JP2888969B2 (ja) | 1999-05-10 |
CA2005143A1 (en) | 1990-06-16 |
EP0373679A2 (en) | 1990-06-20 |
HK1006812A1 (en) | 1999-03-19 |
WO1990006762A1 (en) | 1990-06-28 |
DE68916385D1 (de) | 1994-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2055001T3 (es) | Formulaciones de proteinas hidrofobas estabilizadas. | |
NO180362C (no) | Fremgangsmåte for fremstilling av cyklosporinholdige preparater | |
AU6973987A (en) | C(29)-carbonyloxymilbemycin derivatives for controlling parasitic pests of animals and plants | |
NO885213D0 (no) | Stabiliserte legemidler, fremgangsmte til deres fremstilling samt stabile legemiddeltilberedninger. | |
HU900708D0 (en) | Process for preparation of substituted 1,3-oxathiolanes and pharmaceutical preparations containing them | |
NO882075D0 (no) | 9-alfa-hydroksysteroider, deres fremstilling, en fremgangsmaate for fremstilling av de tilsvarende 9(11)-dehydro-derivater samt farmasoeytiske preparater inneholdend | |
BR9006934A (pt) | Formulacoes aquosas estabilizadas de pequenos peptidios | |
FI91160B (fi) | Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi | |
NO172986C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte 9h-puriner | |
NO172575C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive benzocykloalkanderivater | |
FI864552A (fi) | Human-lysozym. | |
NO171679C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-fenyl-3-(1-piperazinyl)-1h-indazoler | |
FI884240A (fi) | Menetelmä paikalliseen käyttöön tarkoitetun farmaseuttisen valmisteen valmistamiseksi | |
AU2732988A (en) | Vectors and compounds for expression of zymogen forms of human protein c | |
NO872233D0 (no) | Fremgangsmaate for fremstilling av farmasoeytiske preparater | |
NO891926L (no) | Fremgangsmaate for fremstilling av stabile protein- eller peptidpreparater. | |
DK116687D0 (da) | Farmaceutisk praeparat indeholdende aenovantroneae | |
HU907361D0 (en) | Process for the production of /n-(gamma-glutamyl)-glycyl/-alanine derivatives and medical preparations containing them | |
AU2846689A (en) | Methods for preparing proteins of altered structure | |
GB8617594D0 (en) | Preparation of biologically active proteins | |
GB8630699D0 (en) | Preparation of biologically active proteins | |
AU2125088A (en) | Solubilization of proteins for pharmaceutical compositions | |
NO883663D0 (no) | Fremgangsmaate for fremstilling av farmasoeytiske preparater | |
CS417788A1 (en) | Method of immunoglobulins' stabilized preparations' virus contamination inactivation | |
IL81926A0 (en) | Pharmaceutical compositions for the oral administration of active proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 373679 Country of ref document: ES |