ES2053076T3 - Preparacion de hidroxifuranon. - Google Patents
Preparacion de hidroxifuranon.Info
- Publication number
- ES2053076T3 ES2053076T3 ES90201150T ES90201150T ES2053076T3 ES 2053076 T3 ES2053076 T3 ES 2053076T3 ES 90201150 T ES90201150 T ES 90201150T ES 90201150 T ES90201150 T ES 90201150T ES 2053076 T3 ES2053076 T3 ES 2053076T3
- Authority
- ES
- Spain
- Prior art keywords
- distillation
- amino acid
- hydroxifuranon
- preparation
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- INAXVXBDKKUCGI-UHFFFAOYSA-N 4-hydroxy-2,5-dimethylfuran-3-one Chemical compound CC1OC(C)=C(O)C1=O INAXVXBDKKUCGI-UHFFFAOYSA-N 0.000 abstract 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 238000004821 distillation Methods 0.000 abstract 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N 2,3,4,5-tetrahydroxyhexanal Chemical compound CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960002591 hydroxyproline Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000002972 pentoses Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/205—Heterocyclic compounds
- A23L27/2052—Heterocyclic compounds having oxygen or sulfur as the only hetero atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
- A23L27/21—Synthetic spices, flavouring agents or condiments containing amino acids
- A23L27/215—Synthetic spices, flavouring agents or condiments containing amino acids heated in the presence of reducing sugars, e.g. Maillard's non-enzymatic browning
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Seasonings (AREA)
- Furan Compounds (AREA)
Abstract
EL INVENTO PROPORCIONA UN PROCESO PARA PREPARAR 5-METIL- NATURAL Y 2,5-DIMETIL-4-HIDROXI-2,3-DIHIDROFURAN-3-UNO, MEDIANTE EL CALENTAMIENTO Y LA REACCION DE UNA PENTOSA O 6-DEOXIHEXOSA EN PRESENCIA DE UN ACIDO AMINO Y SEPARANDO DIRECTAMENTE LA HIDROXIFURANONA DE LA MEZCLA DE LA REACCION, MEDINATE LA DESTILACION A BAJA PRESION. LA DESTILACION ES LLEVADA A CABO, PREFERIBLEMENTE, EN PRESENCIA DE UN SOLVENTE ORGANICO DE ALTO PUNTO DE EBULLICION, PARTICULARMENTE EL GLICOL PROPILENO O GLICEROL. EL ACIDO AMINO ES, PREFERIBLEMENTE, LISINA, PROLINA O HIDROXIPROLINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP89201269 | 1989-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2053076T3 true ES2053076T3 (es) | 1994-07-16 |
Family
ID=8202394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90201150T Expired - Lifetime ES2053076T3 (es) | 1989-05-18 | 1990-05-04 | Preparacion de hidroxifuranon. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5149840A (es) |
| EP (1) | EP0398417B1 (es) |
| JP (1) | JPH0730065B2 (es) |
| DE (1) | DE69000329T2 (es) |
| ES (1) | ES2053076T3 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602259A (en) * | 1993-12-17 | 1997-02-11 | Pacific Corporation | Method for producing 4-hydroxy-5-methyl-3[2H]-furanone and uses of same |
| AU738718B2 (en) | 1997-02-14 | 2001-09-27 | Mitsuwa Tiger Co., Ltd. | Ball catching tool |
| FR2772376B1 (fr) * | 1997-12-17 | 2000-03-10 | Aromes Et Parfums Franc | Nouveaux derives du furane, leurs procedes de synthese et leur utilisation comme exhausteur d'aromes |
| JP3403980B2 (ja) | 1999-05-13 | 2003-05-06 | 美津濃株式会社 | 野球用グラブ |
| WO2001092247A2 (en) * | 2000-05-31 | 2001-12-06 | Maxygen, Inc. | Preparation of 4-hydroxy-3[2h]-furanones |
| DE60139692D1 (de) * | 2001-10-01 | 2009-10-08 | Nestle Sa | Peptide als Geschmacksstoffe |
| CN107235941A (zh) * | 2016-03-28 | 2017-10-10 | 苏州禾研生物技术有限公司 | 一种呋喃酮的合成方法 |
| CN107235942A (zh) * | 2016-03-28 | 2017-10-10 | 苏州凯祥生物科技有限公司 | 一种呋喃酮的制备方法 |
| CN112047911B (zh) * | 2020-09-18 | 2023-01-13 | 厦门欧米克生物科技有限公司 | 一种呋喃酮的催化合成方法 |
| CN119798193A (zh) * | 2025-01-02 | 2025-04-11 | 万华化学集团股份有限公司 | 一种通过动态管式反应器连续制备呋喃酮的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2936308A (en) * | 1955-06-02 | 1960-05-10 | John E Hodge | Novel reductones and methods of making them |
| CH486850A (de) * | 1964-12-31 | 1970-03-15 | Firmenich & Cie | Verwendung von Dihydrofuranderivaten als Geschmackstoffe |
| US4013800A (en) * | 1967-03-15 | 1977-03-22 | Ajinomoto Co., Inc. | 4-hydroxy-5-methyl-2,3-dihydrofuran-3-one and methods of making and using the same |
| GB1199101A (en) * | 1967-03-15 | 1970-07-15 | Ajinomoto Kk | Substance and Reaction Products Suitable for Improving the Flavour and Aroma of Food and Medicines |
| NL6712748A (es) * | 1967-09-18 | 1969-03-20 | ||
| US3558664A (en) * | 1969-02-12 | 1971-01-26 | Eastman Kodak Co | Dihydro-5-hydroxy-4,4-dialkyl-3 (2h)-furanones |
| BE760075A (fr) * | 1970-01-13 | 1971-06-09 | Int Flavors & Fragrances Inc | Methodes et compositions pour aromatiser les denrees alimentaires |
| US4208338A (en) * | 1977-08-11 | 1980-06-17 | Givaudan Corporation | Cyano dihydro furanones |
| US4181666A (en) * | 1977-08-11 | 1980-01-01 | Givaudan Corporation | Process for making furanones |
| EP0090150B1 (fr) * | 1982-03-26 | 1986-11-20 | Firmenich Sa | Procédé pour la préparation de 4-hydroxy-2,5-diméthyl-2,3-dihydrofuran-3-one |
| JPS63307869A (ja) * | 1987-01-20 | 1988-12-15 | San Ei Chem Ind Ltd | ヒドロキシフラノン類の製法 |
| DE10011690C2 (de) * | 2000-03-10 | 2002-02-07 | Siemens Ag | Verfahren zur Zylindergleichstellung |
| WO2001094254A1 (fr) * | 2000-06-05 | 2001-12-13 | Fujikin Incorporated | Reacteur de production d'humidite |
-
1990
- 1990-05-04 DE DE9090201150T patent/DE69000329T2/de not_active Expired - Lifetime
- 1990-05-04 EP EP90201150A patent/EP0398417B1/en not_active Expired - Lifetime
- 1990-05-04 ES ES90201150T patent/ES2053076T3/es not_active Expired - Lifetime
- 1990-05-18 US US07/527,282 patent/US5149840A/en not_active Expired - Lifetime
- 1990-05-18 JP JP2130132A patent/JPH0730065B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5149840A (en) | 1992-09-22 |
| JPH035471A (ja) | 1991-01-11 |
| DE69000329D1 (de) | 1992-10-29 |
| EP0398417B1 (en) | 1992-09-23 |
| JPH0730065B2 (ja) | 1995-04-05 |
| EP0398417A1 (en) | 1990-11-22 |
| DE69000329T2 (de) | 1993-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2059768T3 (es) | Procedimiento para la separacion de hf via destilacion azeotropica. | |
| DK262683A (da) | Dynorphinamidanaloger | |
| ES2053076T3 (es) | Preparacion de hidroxifuranon. | |
| ES548667A0 (es) | Un procedimiento para la preparacion de polipeptidos. | |
| AR004668A1 (es) | Un acido nucleico aislado purificado, un vector de expresion recombinante que lo comprende, una celula que comprende dicho vector, un metodo para laproduccion de un polipeptido de h.pylori, una composicion de vacuna, el uso de dicha composicion para preparar medicamentos, un polipeptido purificado de h. | |
| ATE83374T1 (de) | Neue galenische form von fenofibrat. | |
| ES2102009T5 (es) | Tratamiento para el asma. | |
| ES2052507T3 (es) | Peptido, proceso para su sintesis, compuesto farmaceutico que lo contiene y utilizacion del mismo. | |
| CO4650046A1 (es) | Metodo para la sintesis de analogos de la hormona paratiroidea y del peptido relacionado con la hormona paratiroidea | |
| DE69024230D1 (de) | An fette gebundene aminosäuren, peptide oder deren derivate | |
| MX22095A (es) | Proceso mejorado para compuestos anticonvulsivos de amino acidos ciclicos y productos resultantes. | |
| ES8501364A1 (es) | Un metodo para la preparacion de nuevos polipeptidos. | |
| ES507889A0 (es) | Procedimiento para la separacion de aceite y-o fosfatidiletanolamina a partir de productos de fosfatidilcolina que los contienen, solubles en alcochol . | |
| MX172711B (es) | Procedimiento para la fabricacion de cloro-1-difluor-1,1 etano | |
| ES549185A0 (es) | Procedimiento para sintetizar peptidos a partir de aminoaci-dos | |
| ES2185628T3 (es) | Procedimiento para preparar proteinas modificadas. | |
| ES2140682T3 (es) | Procedimiento para separar pentafluoroetano de una mezcla que comprende hidrocarburos halogenados y cloropentafluoroetano. | |
| BR8108064A (pt) | Processo para a separacao de fosfolipidios acilados dos produtos de fosfatidilcolina contendo os mesmos | |
| MX170141B (es) | Procedimiento para preparar 1,1- dicloro-1-fluoretano | |
| ES2072244T1 (es) | Compuestos y productos de reaccion de amadori, procedimiento para su fabricacion y uso de los mismos. | |
| ES2053466T3 (es) | Procedimiento para preparar compuestos intermedios de 7-oxabicicloheptano-amino-alcohol utiles para la preparacion de antagonistas de los receptores de tromboxano a2 y nuevos compuestos intermedios producidos con el. | |
| Ueki et al. | Facile removal of a peptide chain from a solid phase resin support by hydrolysis using tetrabutylammonium fluoride trihydrate in N, N-dimethylformamide | |
| ES2062402T3 (es) | Procedimiento para la preparacion de 1,1-diclorotetrafluoroetano. | |
| PT83837B (pt) | Processo para a preparacao de peptideos por utilizacao de percloratos | |
| ES495482A0 (es) | Procedimiento para la recuperacion de acidos carboxilicos a partir de mezclas que contienen esteres de glicoles deriva- dos de estos acidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 398417 Country of ref document: ES |