ES2052861T3 - Composicion de disolucion acuosa de elcatonina. - Google Patents

Composicion de disolucion acuosa de elcatonina.

Info

Publication number
ES2052861T3
ES2052861T3 ES89120254T ES89120254T ES2052861T3 ES 2052861 T3 ES2052861 T3 ES 2052861T3 ES 89120254 T ES89120254 T ES 89120254T ES 89120254 T ES89120254 T ES 89120254T ES 2052861 T3 ES2052861 T3 ES 2052861T3
Authority
ES
Spain
Prior art keywords
elcatonin
aqueous solution
active ingredient
histidine
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89120254T
Other languages
English (en)
Inventor
Hitoshi Yamada
Ken Endo
Kikuo Kotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Application granted granted Critical
Publication of ES2052861T3 publication Critical patent/ES2052861T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL PRESENTE INVENTO PROPORCIONA UNA COMPOSICION PARA UNA SOLUCION ACUOSA CONTENIENDO ELCATONINA COMO INGREDIENTE ACTIVO USADO PARA LA HIPORCALCEMINA O ENFERMEDAD DE PAGET DE LOS HUESOS O PARA SUAVIZAR EL DOLOR EN LA OSTEOPOROSIS, ETC Y EL CUAL ES ALTAMENTE ESTABLE FRENTE A LAS SACUDIDAS, LA LUZ Y EL CALOR. ESTA COMPOSICION CONTIENE UNA CANTIDAD EFECTIVA DE ELCATONINA COMO INGREDIENTE ACTIVO Y UN COMPUESTO MONOCARBON Y/O LA SAL SOLUBLE EN AGUAS DEL MISMO EN LA CONCENTRACION MOLECULAR DE 0.05-20 MMOL Y TIENE UN PTL DE 5.0-6.5 Y UNA FUERZA IONICA DE N= 0.01-0.5. LOS EJEMPLOS PREFERIDOS DEL COMPUESTO MONOCARBOXI Y SUS SALES SON ACIDO ACETICO, ACIDO LACTICO, L-HISTIDINA, ACETATO DE SODIO, ACETATO DE POTASIO, LACTATO DE SODIO, LACTATO DE POTASIO Y CLOROHIDRATO DE L-HISTIDINA.
ES89120254T 1988-12-23 1989-11-02 Composicion de disolucion acuosa de elcatonina. Expired - Lifetime ES2052861T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63324999A JPH02174726A (ja) 1988-12-23 1988-12-23 エルカトニン水溶液組成物の安定化法

Publications (1)

Publication Number Publication Date
ES2052861T3 true ES2052861T3 (es) 1994-07-16

Family

ID=18172004

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89120254T Expired - Lifetime ES2052861T3 (es) 1988-12-23 1989-11-02 Composicion de disolucion acuosa de elcatonina.

Country Status (10)

Country Link
US (1) US4977139A (es)
EP (1) EP0375885B1 (es)
JP (1) JPH02174726A (es)
KR (1) KR950003493B1 (es)
AT (1) ATE83380T1 (es)
AU (1) AU629142B2 (es)
CA (1) CA2001671C (es)
DE (1) DE68903937T2 (es)
ES (1) ES2052861T3 (es)
GR (1) GR3007338T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3179538B2 (ja) * 1990-12-11 2001-06-25 ノバルティス アクチエンゲゼルシャフト 安定なヒトカルシトニンの水性溶液
US5571788A (en) * 1991-12-09 1996-11-05 Ciba-Geigy Corporation Stable calcitonin pharmaceutical compositions
US5721207A (en) * 1995-04-18 1998-02-24 Innapharma, Inc. Method for treatment of pain
EP1391209A4 (en) * 2001-05-30 2009-12-16 Chugai Pharmaceutical Co Ltd PROTEIN PREPARATION
JP2002037737A (ja) * 2001-08-02 2002-02-06 Nippon Kayaku Co Ltd ブレオマイシン類の安定な水溶液

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51128993A (en) * 1975-05-01 1976-11-10 Tanpakushitsu Kenkyu Shiyoureikai Process for preparing new polypeptides
JPS61267528A (ja) * 1984-11-26 1986-11-27 Yamanouchi Pharmaceut Co Ltd 吸収促進剤を含有するカルシトニン経鼻剤

Also Published As

Publication number Publication date
CA2001671C (en) 1995-10-17
KR950003493B1 (ko) 1995-04-13
JPH02174726A (ja) 1990-07-06
ATE83380T1 (de) 1993-01-15
GR3007338T3 (es) 1993-07-30
AU629142B2 (en) 1992-09-24
EP0375885B1 (en) 1992-12-16
DE68903937D1 (de) 1993-01-28
EP0375885A1 (en) 1990-07-04
JPH0524137B2 (es) 1993-04-06
US4977139A (en) 1990-12-11
KR900009089A (ko) 1990-07-02
DE68903937T2 (de) 1993-04-22
CA2001671A1 (en) 1990-06-23
AU4397589A (en) 1990-06-28

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