ES2051707T3 - Implantes para la liberacion de macromoleculas bioactivas. - Google Patents
Implantes para la liberacion de macromoleculas bioactivas.Info
- Publication number
- ES2051707T3 ES2051707T3 ES87106859T ES87106859T ES2051707T3 ES 2051707 T3 ES2051707 T3 ES 2051707T3 ES 87106859 T ES87106859 T ES 87106859T ES 87106859 T ES87106859 T ES 87106859T ES 2051707 T3 ES2051707 T3 ES 2051707T3
- Authority
- ES
- Spain
- Prior art keywords
- implants
- release
- bioactive macromolecules
- bioactive
- macromolecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
LA INVENCION TRATA DE PREPARACIONES PARA IMPLANTACION CAPACES DE MOSTRAR ACCION PROLONGADA CUANDO SE INSERTAN, QUE ESTAN CONSTITUIDAS POR POLVO DE SUSTANCIAS LIPOIDES NATURALES MEZCLADAS CON MACROMOLECULAS BIOACTIVAS, QUE DESPUES SE COMPRIMEN EN FORMA DE DISCO O VARILLA QUE PUEDE TROCEARSE Y UTILIZARSE EN TROCITOS PEQUEÑOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000509526A CA1257199A (en) | 1986-05-20 | 1986-05-20 | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2051707T3 true ES2051707T3 (es) | 1994-07-01 |
Family
ID=4133165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87106859T Expired - Lifetime ES2051707T3 (es) | 1986-05-20 | 1987-05-12 | Implantes para la liberacion de macromoleculas bioactivas. |
Country Status (10)
Country | Link |
---|---|
US (2) | US5110595A (es) |
EP (1) | EP0246540B1 (es) |
JP (1) | JPS6322012A (es) |
AT (1) | ATE79024T1 (es) |
AU (1) | AU603793B2 (es) |
CA (1) | CA1257199A (es) |
DE (1) | DE3780862T2 (es) |
DK (1) | DK251287A (es) |
ES (1) | ES2051707T3 (es) |
GR (1) | GR3005395T3 (es) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863736A (en) * | 1987-03-16 | 1989-09-05 | Monsanto Company | Somatotropin prolonged release |
US5688519A (en) * | 1987-04-06 | 1997-11-18 | Leonard; Robert J. | Flash-flow fused medicinal implants |
EP0353045B1 (en) * | 1988-07-26 | 1995-11-15 | Rutgers, The State University of New Jersey | Devices and methods for growth promotion in poultry roasters |
WO1990010437A1 (en) * | 1989-03-09 | 1990-09-20 | Endocon, Inc. | Partially fused peptide pellet |
DE3919982A1 (de) * | 1989-06-19 | 1990-12-20 | Liedtke Pharmed Gmbh | Orale lipidarzneiform |
AU6430190A (en) * | 1989-10-10 | 1991-05-16 | Pitman-Moore, Inc. | Sustained release composition for macromolecular proteins |
NZ237084A (en) * | 1990-02-12 | 1993-10-26 | Lucky Ltd | Composition for the prolonged release of somatotropin comprising the somatotropin, a tocopherol component, and an assistant delaying agent |
WO1992014449A1 (en) * | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
US5801141A (en) * | 1991-06-24 | 1998-09-01 | American Cyanamid Company | Implant compositions containing a biologically active protein, peptide or polypeptide |
SG47955A1 (en) * | 1991-06-24 | 1998-04-17 | American Cyanamid Co | Implant compositions containing a biologically active protein peptide or polypeptide |
YU87892A (sh) * | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
US5374616A (en) * | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
KR100260632B1 (ko) * | 1992-12-28 | 2000-07-01 | 성재갑 | 이식형 소마토트로핀 조성물 |
JPH07112940A (ja) * | 1993-08-26 | 1995-05-02 | Takeda Chem Ind Ltd | 徐放性非経口投与製剤およびその製造方法 |
GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
US5449679A (en) * | 1994-07-29 | 1995-09-12 | Leonard; Robert J. | Process and products for reducing biological fluid levels of a lipid soluble waste |
USRE40546E1 (en) * | 1996-05-01 | 2008-10-21 | Scarista, Ltd. | 1,3-Propane diol esters and ethers and methods for their use in drug delivery |
DK0823897T3 (da) * | 1995-05-01 | 2004-12-06 | Scarista Ltd | Nicotinsyreestere og farmaceutiske præparater indeholdende disse |
MY118354A (en) * | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
AUPN366795A0 (en) * | 1995-06-20 | 1995-07-13 | Peptide Technology Limited | Formulation for preventing reproductive function |
US5827904A (en) * | 1996-09-27 | 1998-10-27 | Hahn; David | Medical implant composition |
GB9705102D0 (en) * | 1997-03-12 | 1997-04-30 | Scotia Holdings Inc | Presentation of fatty acids |
US5874098A (en) * | 1997-05-28 | 1999-02-23 | Ivy Laboratories, Inc. | Pellet implant system |
GB9723068D0 (en) * | 1997-10-31 | 1998-01-07 | Patel Atulkumar S | A skin-moisturing preparation |
KR19990071255A (ko) | 1998-02-28 | 1999-09-15 | 성재갑 | 소마토트로핀과 비타민의 합제 조성물 |
US6263880B1 (en) | 1998-06-22 | 2001-07-24 | Neovasys, Inc. | Method of enhancing blood flow in tissue |
US20010033839A1 (en) * | 1999-10-04 | 2001-10-25 | Emilio Barbera-Guillem | Vaccine and immunotherapy for solid nonlymphoid tumor and related immune dysregulation |
US6488649B1 (en) | 1998-11-24 | 2002-12-03 | Edward M. Lichten | Implant device |
RU2271196C2 (ru) * | 1999-06-04 | 2006-03-10 | Элзэ Копэрейшн | Имплантируемая композиция (варианты) и способ ее приготовления |
JP2001058955A (ja) * | 1999-06-17 | 2001-03-06 | Inst Of Physical & Chemical Res | 生理活性ペプチド徐放性製剤 |
CN1278438C (zh) | 2000-09-25 | 2006-10-04 | 三星Sdi株式会社 | 用于可充电锂电池的正电极活性材料及其制备方法 |
GB0121709D0 (en) * | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
EP2050460A1 (en) * | 2001-09-24 | 2009-04-22 | Imperial Innovations Limited | PYY and agonists thereof for modification of feeding behaviour |
JP4733922B2 (ja) | 2002-01-10 | 2011-07-27 | インペリアル・イノベ−ションズ・リミテッド | 摂食行動の修正 |
US8058233B2 (en) * | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
GB0300571D0 (en) * | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
KR100486028B1 (ko) * | 2004-04-20 | 2005-05-03 | 주식회사 펩트론 | 단백질 함유 서방성 리피드 임플란트 및 이의 제조방법 |
CA2910494C (en) | 2004-07-19 | 2018-10-23 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
AU2005325213B2 (en) * | 2004-08-04 | 2010-10-07 | Evonik Corporation | Methods for manufacturing delivery devices and devices thereof |
WO2006134340A2 (en) | 2005-06-13 | 2006-12-21 | Imperial Innovations Limited | Oxyntomodulin analogues and their effects on feeding behaviour |
GB0511986D0 (en) * | 2005-06-13 | 2005-07-20 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
CA3163418A1 (en) | 2006-10-06 | 2008-05-22 | Jeffrey S. Isenberg | Prevention of tissue ischemia, related methods and compositions |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
RU2506273C2 (ru) | 2007-07-09 | 2014-02-10 | Импиэриэл Инноувейшнс Лимитид | Аналог панкреатического полипептида человека (варианты), фармацевтическая композиция на его основе, способ лечения ожирения или диабета, способ снижения аппетита, уменьшения поглощения пищи или снижения потребления калорий и способ косметического снижения массы посредством указанного аналога |
MX2010003979A (es) | 2007-10-16 | 2010-06-02 | Biocon Ltd | Composicion farmaceutica oralmente administrable y proceso para su preparacion. |
ES2718612T3 (es) | 2007-12-20 | 2019-07-03 | Evonik Corp | Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual |
JP2010229284A (ja) | 2009-03-27 | 2010-10-14 | Fujifilm Corp | 光硬化性組成物 |
GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
GB201001333D0 (en) | 2010-01-27 | 2010-03-17 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
GB201101459D0 (en) | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
US9944687B2 (en) | 2011-07-04 | 2018-04-17 | Imperial Innovations Limited | Compounds and their effects on feeding behaviour |
WO2013039916A1 (en) | 2011-09-12 | 2013-03-21 | The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services | Compositions for and methods of treatment and enhanced detection of non-pituitary tumors |
US9879012B2 (en) | 2012-03-29 | 2018-01-30 | Regents Of The University Of Colorado, A Body Corporate | Click nucleic acids |
WO2014160183A1 (en) | 2013-03-13 | 2014-10-02 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Methods for modulating chemotherapeutic cytotoxicity |
IL242979B2 (en) | 2013-07-02 | 2023-03-01 | Cortice Biosciences Inc | A method for treating degenerative nerve diseases |
CA2923835C (en) | 2013-09-11 | 2022-11-29 | The Administrators Of The Tulane Educational Fund | Novel anthranilic amides and the use thereof |
WO2015057583A1 (en) | 2013-10-14 | 2015-04-23 | The United States Of America, As Represented By The Secretary | Treatment of chronic kidney disease with sahps |
DE102013018193A1 (de) | 2013-10-30 | 2015-05-13 | Martin-Luther-Universität Halle-Wittenberg, Körperschaft des öffentlichen Rechts | Injizierbare Depotformulierungen zur kontrollierten Wirkstofffreisetzung |
DE102014005782A1 (de) | 2014-04-23 | 2015-10-29 | Martin-Luther-Universität Halle-Wittenberg | lnjizierbare und implantierbare Trägersysteme auf Basis von modifizierten Poly(dikarbonsäure-multiol estern) zur kontrollierten Wirkstofffreisetzung |
WO2015177572A1 (en) | 2014-05-23 | 2015-11-26 | Imperial Innovations Limited | Peptide yy (pyy) analogues |
WO2016164412A1 (en) | 2015-04-07 | 2016-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hypoxia-inducible factor 1 (hif-1) inhibitors |
GB201720188D0 (en) | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Analogues of PYY |
GB201908424D0 (en) | 2019-06-12 | 2019-07-24 | Imp College Innovations Ltd | Novel compounds |
GB201908426D0 (en) | 2019-06-12 | 2019-07-24 | Imp College Innovations Ltd | Appetite suppressing compounds |
KR20230125802A (ko) | 2020-12-11 | 2023-08-29 | 아이피2아이피오 이노베이션스 리미티드 | 신규 화합물 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2895875A (en) * | 1950-10-20 | 1959-07-21 | Erich M H Radde | Subcutaneous hormone pellets |
US3312594A (en) * | 1963-06-21 | 1967-04-04 | Squibb & Sons Inc | Longlasting troche |
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US4450150A (en) * | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
CA1076480A (en) * | 1975-04-28 | 1980-04-29 | John S. Kent | Inert core implant pellet |
GB1523965A (en) * | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
US4180560A (en) * | 1976-10-26 | 1979-12-25 | Syntex Corporation | Inert core implant pellet |
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
GB2051574B (en) * | 1979-05-10 | 1984-01-18 | Kyoto Pharma Ind | Adjuvant for promoting absorption of pharmacologically active substances through the rectum |
US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
JPS56122317A (en) * | 1980-02-29 | 1981-09-25 | Koken:Kk | Drug transporting material and its preparation |
JPS56138111A (en) * | 1980-03-28 | 1981-10-28 | Teijin Ltd | Suppository containing unsaturated fatty acid or salt thereof |
US4393041A (en) * | 1980-04-25 | 1983-07-12 | International Minerals & Chemical Corp. | Fibrin binder/carrier for active biochemical agents |
US4322323A (en) * | 1980-12-01 | 1982-03-30 | Alza Corporation | Erodible device comprising surfactant for modifying the rate of erosion of the device |
US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
SU1011126A1 (ru) * | 1981-07-14 | 1983-04-15 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Средство дл лечени сахарного диабета |
NL193099C (nl) * | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
DD212185A1 (de) * | 1982-12-21 | 1984-08-08 | Adw Ddr | Verfahren zur herstellung von phospholipid-wirkstoff-kombinationen |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
US4882167A (en) * | 1983-05-31 | 1989-11-21 | Jang Choong Gook | Dry direct compression compositions for controlled release dosage forms |
CA1196864A (en) * | 1983-06-10 | 1985-11-19 | Mattheus F.A. Goosen | Controlled release of injectable and implantable insulin compositions |
WO1985000372A1 (fr) * | 1983-07-01 | 1985-01-31 | Battelle Memorial Institute | Polypeptide biodegradable et son utilisation pour le relargage progressif de medicaments |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
DE3474511D1 (en) * | 1983-11-01 | 1988-11-17 | Terumo Corp | Pharmaceutical composition containing urokinase |
US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
DE3413608A1 (de) * | 1984-04-11 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Implantierbare zubereitungen von regulatorischen peptiden mit gesteuerter freisetzung und verfahren zu ihrer herstellung |
US4568536A (en) * | 1985-02-08 | 1986-02-04 | Ethicon, Inc. | Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition |
US4638045A (en) * | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
US4670249A (en) * | 1985-04-12 | 1987-06-02 | International Minerals & Chemical Corp. | Growth-promoting compositions |
DE3523454A1 (de) * | 1985-07-01 | 1987-01-08 | Eberhard Prof Dr Nuernberg | Formkoerper |
IL79681A (en) * | 1985-08-12 | 1991-06-10 | Int Minerals & Chem Corp | Transition metal complexes of growth hormones and their prolonged release compositions |
US4692441A (en) * | 1985-08-16 | 1987-09-08 | Merck & Co., Inc. | Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities |
US4775659A (en) * | 1985-08-19 | 1988-10-04 | Eli Lilly And Company | Injectable semi-solid formulations |
US4837381A (en) * | 1986-08-11 | 1989-06-06 | American Cyanamid Company | Compositions for parenteral administration and their use |
-
1986
- 1986-05-20 CA CA000509526A patent/CA1257199A/en not_active Expired
-
1987
- 1987-04-06 AU AU71089/87A patent/AU603793B2/en not_active Ceased
- 1987-05-12 EP EP87106859A patent/EP0246540B1/en not_active Expired - Lifetime
- 1987-05-12 DE DE8787106859T patent/DE3780862T2/de not_active Revoked
- 1987-05-12 AT AT87106859T patent/ATE79024T1/de not_active IP Right Cessation
- 1987-05-12 ES ES87106859T patent/ES2051707T3/es not_active Expired - Lifetime
- 1987-05-18 DK DK251287A patent/DK251287A/da not_active Application Discontinuation
- 1987-05-20 JP JP62123628A patent/JPS6322012A/ja active Pending
- 1987-06-19 US US07/063,968 patent/US5110595A/en not_active Expired - Lifetime
-
1991
- 1991-11-22 US US07/796,023 patent/US5939380A/en not_active Expired - Lifetime
-
1992
- 1992-08-10 GR GR920400983T patent/GR3005395T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3780862T2 (de) | 1993-01-14 |
US5110595A (en) | 1992-05-05 |
ATE79024T1 (de) | 1992-08-15 |
AU7108987A (en) | 1988-09-15 |
AU603793B2 (en) | 1990-11-29 |
EP0246540A3 (en) | 1988-06-08 |
JPS6322012A (ja) | 1988-01-29 |
DK251287D0 (da) | 1987-05-18 |
US5939380A (en) | 1999-08-17 |
DE3780862D1 (de) | 1992-09-10 |
CA1257199A (en) | 1989-07-11 |
GR3005395T3 (es) | 1993-05-24 |
EP0246540A2 (en) | 1987-11-25 |
DK251287A (da) | 1987-11-21 |
EP0246540B1 (en) | 1992-08-05 |
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