ES2051690T3 - Un complejo y su procedimiento de preparacion. - Google Patents

Un complejo y su procedimiento de preparacion.

Info

Publication number
ES2051690T3
ES2051690T3 ES86307849T ES86307849T ES2051690T3 ES 2051690 T3 ES2051690 T3 ES 2051690T3 ES 86307849 T ES86307849 T ES 86307849T ES 86307849 T ES86307849 T ES 86307849T ES 2051690 T3 ES2051690 T3 ES 2051690T3
Authority
ES
Spain
Prior art keywords
complex
preparation procedure
molecula
immunogen
pharmacy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86307849T
Other languages
English (en)
Inventor
Gregory John Russell-Jones
Aizpurua Henry James De
Peter Allan Howe
Geoffery Lewis Burge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotech Australia Pty Ltd
Inhibin Pty Ltd
Original Assignee
Biotech Australia Pty Ltd
Biotechnology Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3771313&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2051690(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotech Australia Pty Ltd, Biotechnology Australia Pty Ltd filed Critical Biotech Australia Pty Ltd
Application granted granted Critical
Publication of ES2051690T3 publication Critical patent/ES2051690T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Vending Machines For Individual Products (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPLEJO DE UN FARMACO, HORMONA, PEPTIDO BIOACTIVO, O INMUNOGENO CON EL SOPORTE DE LA MOLECULA DE VITAMINA B12 Y UN METODO PARA SUMINISTRAR DICHO COMPLEJO AL INTESTINO DE UN VERTEBRADO HUESPED CON EL FIN DE SUMINISTRAR EL COMPLEJO A LA CIRCULACION DEL HUESPED Y ELICITAR POR TANTO UNA RESPUESTA FARMACOLOGICA AL FARMACO, HORMONA O MOLECULA BIOACTIVA O ELICITAR UNA RESPUESTA INMUNOLOGICA SISTEMICA AL INMUNOGENO. LA INVENCION TAMBIEN PROPORCIONA UN METODO PARA LA PRODUCCION DEL COMPLEJO. ADEMAS LA INVENCION PROPORCIONA MEDICAMENTOS QUE CONTIENEN EL COMPLEJO.
ES86307849T 1985-10-10 1986-10-10 Un complejo y su procedimiento de preparacion. Expired - Lifetime ES2051690T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPH283885 1985-10-10

Publications (1)

Publication Number Publication Date
ES2051690T3 true ES2051690T3 (es) 1994-07-01

Family

ID=3771313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86307849T Expired - Lifetime ES2051690T3 (es) 1985-10-10 1986-10-10 Un complejo y su procedimiento de preparacion.

Country Status (16)

Country Link
US (2) US5428023A (es)
EP (1) EP0220030B1 (es)
JP (1) JPH08779B2 (es)
KR (1) KR940003057B1 (es)
CN (1) CN1045391C (es)
AT (1) ATE64534T1 (es)
CA (1) CA1330791C (es)
DK (1) DK167099B1 (es)
ES (1) ES2051690T3 (es)
GR (1) GR3002160T3 (es)
HK (1) HK69094A (es)
IL (1) IL80264A (es)
IN (1) IN165029B (es)
NZ (1) NZ217821A (es)
WO (1) WO1987002251A1 (es)
ZA (1) ZA867703B (es)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643889A (en) * 1984-07-11 1997-07-01 Temple University-Of The Commonwealth System Of Pennsylvania Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
US4842868A (en) * 1986-09-26 1989-06-27 Helwing Robert F Covalently bonded active agents with carbonium ion base groups
US5807832A (en) * 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12
US4997815A (en) * 1988-11-01 1991-03-05 Children's Hospital Medical Center Of Northern California Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5108921A (en) * 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
WO1990012095A1 (en) * 1989-04-03 1990-10-18 Purdue Research Foundation Method for enhancing transmembrane transport of exogenous molecules
FR2649321A1 (fr) * 1989-07-07 1991-01-11 Inst Nat Sante Rech Med Compositions a base de derives nucleotidiques, leurs procedes de preparation, et leurs utilisations notamment en tant que compositions pharmaceutiques
GR900100249A (el) * 1990-03-28 1992-06-30 Purdue Research Foundation Μεθοδος δια την ηυξημενην δια των μεμβρανων μεταφοραν εξωγενων μοριων.
ATE156705T1 (de) * 1991-04-02 1997-08-15 Biotech Australia Pty Ltd Systeme zur oralen freisetzung von mikropartikeln
WO1994028015A1 (en) * 1993-05-20 1994-12-08 Biotech Australia Pty. Limited Lhrh antagonists
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5840880A (en) * 1994-04-08 1998-11-24 Receptagen Corporation Receptor modulating agents
US5739287A (en) * 1994-04-08 1998-04-14 University Of Washington Biotinylated cobalamins
US5869465A (en) * 1994-04-08 1999-02-09 Receptagen Corporation Methods of receptor modulation and uses therefor
ATE225799T1 (de) * 1994-04-08 2002-10-15 Receptagen Corp Rezeptor modulierendes mitteln und entsprechendes verfahren
US5574018A (en) * 1994-07-29 1996-11-12 Amgen Inc. Conjugates of vitamin B12 and proteins
WO1996006632A1 (en) * 1994-09-01 1996-03-07 Allied Medical Research Associates Compositions and methods for delivery of polypeptides
WO1997014711A1 (en) * 1995-10-19 1997-04-24 Receptagen Corporation Vitamin b12 receptor modulating agents and methods related thereto
US5739313A (en) * 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
JP2001501596A (ja) 1996-08-27 2001-02-06 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション バイオコンジュゲートおよび生物学的活性剤の送達
US6054133A (en) * 1997-07-10 2000-04-25 The Regents Of The University Of California Anti-microbial targeting for intracellular pathogens
AU4328399A (en) * 1998-06-15 2000-01-05 Alza Corporation Nucleic acid-cobalamin complexes and their use in gene therapy
FR2787029A1 (fr) * 1998-12-09 2000-06-16 Biovector Therapeutics Utilisation dans une composition pharmaceutique pour l'administration par voie nasale de vitamine b12 pour la delivrance d'agents actifs au systeme nerveux central
US20010008627A1 (en) 1999-01-22 2001-07-19 Soll David R. Hiv-encoded chemoattractant
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
DE19930729A1 (de) * 1999-07-05 2001-01-11 Achim Goepferich Blockcopolymere zur Herstellung biomimetischer Oberflächen
CA2387757A1 (en) * 1999-10-15 2001-04-26 Henricus P. C. Hogenkamp Cobalamin conjugates useful as imaging agents and as antitumor agents
EP1239887A1 (en) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
NZ521898A (en) 2000-03-31 2004-11-26 Purdue Research Foundation Use of a ligand-immunogen conjugate such as folate-FITC for enhancing an endogenous immune response
EP1754712A3 (en) * 2000-10-25 2009-01-14 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
WO2002055530A2 (en) * 2000-10-25 2002-07-18 Mayo Foundation Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
WO2002067995A1 (en) * 2001-02-26 2002-09-06 Council Of Scientific And Industrial Research Carrier systems comprising vitamin b12 - biodegradable micro particulate conju gates for peroral delivery of drugs, peptides/proteins and vaccines
KR20040015234A (ko) 2001-05-02 2004-02-18 펄듀 리서치 파운데이션 대식세포 매개된 질환의 치료와 진단
US6752986B2 (en) 2001-05-24 2004-06-22 The Cleveland Clinic Foundation Composition and methods for affecting metallocorrinoid uptake
US20030018009A1 (en) * 2001-06-20 2003-01-23 Collins Douglas A. Adenosyl-cobalamin fortified compositions
US20060074034A1 (en) * 2001-09-17 2006-04-06 Collins Douglas A Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
WO2003028634A2 (en) * 2001-09-28 2003-04-10 Purdue Research Foundation Method of treatment using ligand-immunogen conjugates
EP1435973A4 (en) * 2001-09-28 2007-05-02 Mayo Foundation SIMULTANEOUS ADMINISTRATION OF A TRANSPORT PROTEIN WITH CONJUGATED COBALAMINE FOR THE DISTRIBUTION OF MEDICINAL PRODUCTS
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
US8043603B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043602B2 (en) 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
FR2839407B1 (fr) * 2002-05-02 2004-12-17 Canon Kk Procede et dispositif d'ajustement de la taille maximale des sequences d'information transmises dans un reseau de telecommunications
CN101648028B (zh) 2002-05-06 2012-11-21 恩多塞特公司 维生素-定向的显象剂
KR100440725B1 (ko) * 2002-06-20 2004-07-15 주식회사 그린진 바이오텍 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법
KR20040080778A (ko) 2003-03-13 2004-09-20 삼성전자주식회사 4색 구동 액정 표시 장치 및 이에 사용하는 표시판
US7232805B2 (en) * 2003-09-10 2007-06-19 Inflabloc Pharmaceuticals, Inc. Cobalamin conjugates for anti-tumor therapy
EP1773354A4 (en) * 2004-08-02 2010-05-05 Bebaas Inc COMPOSITIONS OF VITAMIN B12
BRPI0610419A2 (pt) * 2005-05-17 2012-10-23 Cargill Inc lecitina granular, lisolecitina, processo para produzir lecitina granular, composição granular, processo para produzir uma composição de lecitina granular, produto, e, processos para produzir lisolecitina granular e para produzir uma composição de lisolecitina granular
US20070009434A1 (en) 2005-07-05 2007-01-11 Low Philip S Imaging and therapeutic method using monocytes
EP1933851A4 (en) * 2005-09-07 2008-09-24 Bebaas Inc COMPOSITIONS OF VITAMIN B12
US20070178141A1 (en) * 2005-09-07 2007-08-02 Bebaas, Inc. Vitamin B12 compositions
US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
WO2007038346A2 (en) 2005-09-23 2007-04-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US20130084329A1 (en) 2005-12-09 2013-04-04 Hanall Biopharma Co., Ltd. Compositions for external application, containing adenosylcobalamin for improvement of skin diseases
KR100658436B1 (ko) * 2005-12-09 2006-12-27 한국화학연구원 아데노실코발라민 함유 피부질환 치료용 외용제 조성물
WO2007092299A2 (en) 2006-02-03 2007-08-16 Purdue Research Foundation Targeted conjugates and radiation
US8685752B2 (en) 2006-11-03 2014-04-01 Purdue Research Foundation Ex vivo flow cytometry method and device
US8586595B2 (en) 2007-02-07 2013-11-19 Purdue Research Foundation Positron emission tomography imaging method
US8883723B2 (en) * 2007-03-05 2014-11-11 Syracuse University Conjugate of insulin and vitamin B12 for oral delivery
US20110092416A1 (en) * 2007-03-05 2011-04-21 Robert Patrick Doyle Vitamine B12 - Peptide Conjugates for Oral Delivery
US7851342B2 (en) * 2007-03-30 2010-12-14 Intel Corporation In-situ formation of conductive filling material in through-silicon via
WO2008148001A2 (en) 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
CA2695366C (en) * 2007-08-03 2016-10-04 Shaklee Corporation Nutritional supplement system
US20100330161A1 (en) * 2009-06-29 2010-12-30 Syracuse University Technology Transfer And Industrial Development Office Oral delivery of tetanus toxoid
WO2011130716A2 (en) 2010-04-16 2011-10-20 Access Pharmaceuticals, Inc. A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers
US8614184B2 (en) 2010-09-22 2013-12-24 Ronald P. Santasiero HCG formulations for achieving weight loss
KR20140026396A (ko) 2011-03-08 2014-03-05 어섹스 팔마큐티칼스 인코포레이티드 생물학적 막을 가로질러 활성물질의 전달을 위한 표적화된 나노담체 시스템
US9120858B2 (en) 2011-07-22 2015-09-01 The Research Foundation Of State University Of New York Antibodies to the B12-transcobalamin receptor
AU2013263349B2 (en) 2012-05-17 2016-09-08 Extend Biosciences, Inc Carriers for improved drug delivery
WO2015126841A1 (en) 2014-02-18 2015-08-27 Plasmatech Biopharmaceuticals, Inc. Nutritional and therapeutic mucoadhesive formulations
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
CA2964463C (en) 2014-10-22 2024-02-13 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US10420850B2 (en) 2015-08-14 2019-09-24 Endocyte, Inc. Method of imaging with a chelating agent

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2372066A (en) * 1940-12-23 1945-03-20 Parke Davis & Co Biological product and process of obtaining same
US3042588A (en) * 1957-04-04 1962-07-03 Distillers Co Yeast Ltd Process for producing cobalaminpeptide complexes
GB963373A (en) * 1961-12-11 1964-07-08 Glaxo Group Ltd Improvements in or relating to substituted cobamides
GB1152461A (en) * 1965-06-16 1969-05-21 Ivan Rolovich New Derivatives of Cobalamins
FR5372M (es) * 1966-02-10 1967-10-16
LU64101A1 (es) * 1970-10-28 1973-05-03
IT1044233B (it) * 1973-04-04 1980-03-20 Zambelletti L S P A Derivati della vitamina bi2 ad azione vitaminica di lunga durata
JPS5247012B2 (es) * 1974-11-16 1977-11-29
US3981863A (en) * 1975-02-25 1976-09-21 Micromedic Diagonistics, Inc. Cyanocobalamin derivatives
US4133951A (en) * 1975-05-08 1979-01-09 The Radiochemical Centre Limited Vitamin B-12 cobalt-57 and process
DE2546474A1 (de) * 1975-10-17 1977-04-21 Murray M D Israel Injizierbares pharmazeutisches thyroxinpraeparat und verfahren zu dessen herstellung
FR2373285A1 (fr) * 1976-11-25 1978-07-07 Roussel Uclaf Nouveaux derives du coenzyme b 12, procede de preparation et application a titre de medicaments de ces nouveaux produits
DE2718700A1 (de) * 1977-04-27 1978-11-02 Hans A Dipl Chem Dr Thoma Verfahren zur gesamtbestimmung von hormonen und pharmaka
US4209614A (en) * 1978-05-30 1980-06-24 E. R. Squibb & Sons, Inc. Vitamin B12 derivative suitable for radiolabeling
US4377570A (en) * 1979-01-29 1983-03-22 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
US4360358A (en) * 1980-03-07 1982-11-23 Yash Sharma Immunoassay with solid phase having coating containing blood platelet substitute
CA1165238A (en) * 1980-03-12 1984-04-10 Demetrios P. Papahadjopoulos Activated liposomes and method
DE3176524D1 (en) * 1981-06-22 1987-12-17 Battelle Memorial Institute A method for determining bioactive substances
DE3262956D1 (en) * 1981-06-22 1985-05-15 Technicon Instr Labelled vitamin b12 derivatives, their preparation and use
US4454125A (en) * 1982-04-22 1984-06-12 Demopoulos Harry B Dry powder formulations having improved flow and compressibility characteristics, and method for the preparation thereof
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4746508A (en) * 1983-06-06 1988-05-24 Beth Israel Hospital Assn. Drug administration
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
US4751285A (en) * 1986-10-09 1988-06-14 Toohey John I Derivative of cobalamin containing persulfide sulfur and glutathione
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
IL84167A (en) * 1986-10-24 1991-04-15 Southern Res Inst Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation

Also Published As

Publication number Publication date
DK292587D0 (da) 1987-06-09
WO1987002251A1 (en) 1987-04-23
ZA867703B (en) 1987-06-24
IL80264A (en) 1991-11-21
ATE64534T1 (de) 1991-07-15
DK167099B1 (da) 1993-08-30
EP0220030A2 (en) 1987-04-29
IN165029B (es) 1989-08-05
HK69094A (en) 1994-07-22
KR870700361A (ko) 1987-12-28
JPS63501015A (ja) 1988-04-14
DK292587A (da) 1987-06-09
JPH08779B2 (ja) 1996-01-10
CN1045391C (zh) 1999-10-06
KR940003057B1 (ko) 1994-04-13
EP0220030A3 (en) 1987-09-30
US5589463A (en) 1996-12-31
CN86107590A (zh) 1987-05-20
CA1330791C (en) 1994-07-19
IL80264A0 (en) 1987-01-30
NZ217821A (en) 1989-07-27
EP0220030B1 (en) 1991-06-19
US5428023A (en) 1995-06-27
GR3002160T3 (en) 1992-12-30

Similar Documents

Publication Publication Date Title
ES2051690T3 (es) Un complejo y su procedimiento de preparacion.
MX9206306A (es) Peptidos, procedimiento para su produccion y composicion farmaceutica que los contiene.
ATE189400T1 (de) Knochenwachstumsfördernde zusammensetzung
ES2019570B3 (es) Dispositivo para el tratamiento termico del cuello de los preformados.
ATE94390T1 (de) Orale darreichungsformen mit verzoegerter abgabe.
ES2023976B3 (es) Procedimiento para el enriquecimiento de helio.
ES2143132T3 (es) Monohidratos de derivado de acido aminobenceno-sulfonico y su metodo de preparacion.
AR025052A1 (es) Derivados de 2-dialquilaminoalquilbifenilo sustituidos, procedimiento para su preparacion, medicamentos que contienen estos compuestos y el uso de estoscompuestos para la preparacion de medicamentos.
ES8307494A1 (es) "un procedimiento para preparar una composicion farmaceutica que proporciona un efecto anti-inflamatorio y analgesico junto con un dano gastrico minimizado".
ES2019595B3 (es) Empleo de glicofurol para licuacion de preparaciones medicas, para el llenado en capsulas de gelatina blanda
EP0078215A3 (en) Solid galenic form for oral administration and process for its preparation
AR030662A1 (es) Beta-tio-alfa-aminoacidos, procedimiento para su fabricacion, medicamentos que contienen estos compuestos y el uso de los tioaminoacidos para la preparacion de medicamentos
AR011457A1 (es) Sales de bismuto de antibioticos del grupo de la moenomicina, procedimiento para su preparacion, su utilizacion y medicamentos que contienen tales sales
AR003434A1 (es) Compuesto de tiludronato, composiciones farmaceuticas que los contienen y proceso para producir dicho compuesto y procedimiento para producir lascomposiciones farmaceuticas.
NO863082D0 (no) Preparat for intramuskulaer injeksjon av legemidler, vitaminer eller vaksiner.
ES2045157T3 (es) Composiciones cosmeticas de aplicacion topica y su procedimiento de preparacion.
ES2061718T3 (es) Utilizacion de antigestagenos para la preparacion de medicamentos.
AR247723A1 (es) Nuevo procedimiento para preparar acido 4-amino-5-hexenoico y nuevo compuesto intermedio producido por este procedimento
ES2036523T3 (es) 4-aminoarildihidropiridinlactonas, procedimiento para su obtencion y su empleo en medicamentos.
SV1992000012A (es) Proceso para fabricar derivados de aminoacidos. ref. ran 4070/81
ES548888A0 (es) Tunel para el tratamiento termico de frascos de vidrio
ES240074Y (es) Tarjeta para el control de horarios en la administracion de medicamentos.
IT8636067V0 (it) Cono e simili per gelato da passeggio,con decorazione a bandiera e struttura anti-sgocciolamento
ES205570Y (es) Metodo para encapsular hermeticamente el cuello de bote- llas.
SV1987000046A (es) Metodo para fabricar derivados de piramida, ref. ran 4430/20.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 220030

Country of ref document: ES