ATE225799T1 - Rezeptor modulierendes mitteln und entsprechendes verfahren - Google Patents

Rezeptor modulierendes mitteln und entsprechendes verfahren

Info

Publication number
ATE225799T1
ATE225799T1 AT95916284T AT95916284T ATE225799T1 AT E225799 T1 ATE225799 T1 AT E225799T1 AT 95916284 T AT95916284 T AT 95916284T AT 95916284 T AT95916284 T AT 95916284T AT E225799 T1 ATE225799 T1 AT E225799T1
Authority
AT
Austria
Prior art keywords
receptor modulating
corresponding method
modulating agent
receptor
vitamin
Prior art date
Application number
AT95916284T
Other languages
English (en)
Inventor
A Charles Morgan
D Scott Wilbur
Pradip M Pathare
Original Assignee
Receptagen Corp
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/406,191 external-priority patent/US5840880A/en
Priority claimed from US08/406,192 external-priority patent/US5739287A/en
Priority claimed from US08/406,194 external-priority patent/US5869465A/en
Application filed by Receptagen Corp, Univ Washington filed Critical Receptagen Corp
Application granted granted Critical
Publication of ATE225799T1 publication Critical patent/ATE225799T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
AT95916284T 1994-04-08 1995-04-07 Rezeptor modulierendes mitteln und entsprechendes verfahren ATE225799T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22483194A 1994-04-08 1994-04-08
US08/406,191 US5840880A (en) 1994-04-08 1995-03-16 Receptor modulating agents
US08/406,192 US5739287A (en) 1994-04-08 1995-03-16 Biotinylated cobalamins
US08/406,194 US5869465A (en) 1994-04-08 1995-03-16 Methods of receptor modulation and uses therefor
PCT/US1995/004404 WO1995027723A1 (en) 1994-04-08 1995-04-07 Receptor modulating agents and methods relating thereto

Publications (1)

Publication Number Publication Date
ATE225799T1 true ATE225799T1 (de) 2002-10-15

Family

ID=27499380

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95916284T ATE225799T1 (de) 1994-04-08 1995-04-07 Rezeptor modulierendes mitteln und entsprechendes verfahren

Country Status (9)

Country Link
US (2) US5840712A (de)
EP (1) EP0754189B1 (de)
JP (1) JPH10502334A (de)
KR (1) KR100361075B1 (de)
AT (1) ATE225799T1 (de)
AU (1) AU2283595A (de)
CA (1) CA2187346C (de)
DE (1) DE69528523T2 (de)
WO (1) WO1995027723A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1015475A1 (de) * 1995-10-19 2000-07-05 Receptagen Corporation Wirkstoffe zur modulation von vitaminen b12? -rezeptoren
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
US20010023288A1 (en) * 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
WO2000002050A1 (en) * 1998-07-07 2000-01-13 Department Of Radiation Oncology, University Of Washington Trifunctional reagent for conjugation to a biomolecule
EP1007533B1 (de) 1996-08-27 2005-06-22 University Of Utah Research Foundation Biokonjugate und verabreichung von bioaktiven substanzen
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
AU2003204343B2 (en) * 1998-06-12 2007-03-15 Access Pharmaceuticals Australia Pty Limited Vitamin B12 derivatives and methods for their preparation
AU5436499A (en) * 1998-08-20 2000-03-14 Axis Biochemicals Asa Assay method for cardiovascular disease
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
AUPQ071299A0 (en) * 1999-06-02 1999-06-24 Access Pharmaceuticals Australia Pty Limited Vitamin directed dual targeting therapy
KR20020059618A (ko) * 1999-10-15 2002-07-13 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 이미지화제 및 항종양제로서 유용한 코발라민 콘쥬게이트
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
MXPA02003772A (es) 1999-10-15 2005-04-28 Mayo Foundation Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes terapeuticos.
US6797521B2 (en) 1999-10-26 2004-09-28 University Of Utah Research Foundation Fluorescent cobalamins and uses thereof
ATE459635T1 (de) * 1999-10-26 2010-03-15 Univ Utah Res Found Fluoreszierende cobalamine und deren verwendung
CA2404082A1 (en) 2000-03-27 2001-10-04 Zyomyx, Inc. Site-specific, covalent bioconjugation of proteins
WO2002002093A2 (en) 2000-06-30 2002-01-10 Eli Lilly And Company Combination containing an antifolate and methylmalonic acid lowering agent
WO2002042427A2 (en) * 2000-10-25 2002-05-30 Surromed, Inc. Mass tags for quantitative analysis
WO2002055530A2 (en) * 2000-10-25 2002-07-18 Mayo Foundation Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
ES2622399T3 (es) * 2001-03-16 2017-07-06 University Of Utah Research Foundation Cobalaminas fluorescentes y usos de las mismas
PL373511A1 (en) * 2001-05-15 2005-09-05 Faulk Pharmaceuticals, Inc. Substantially homogeneous bio-affecting material having a pre-determined ratio of bioaffecting component to cell targeting component, the method for making such a material and the method of its use
US6752986B2 (en) * 2001-05-24 2004-06-22 The Cleveland Clinic Foundation Composition and methods for affecting metallocorrinoid uptake
EP1435973A4 (de) * 2001-09-28 2007-05-02 Mayo Foundation Gleichzeitige verabreichung eines transportproteins mit konjugiertem cobalamin zur abgabe von mitteln
US20040047917A1 (en) * 2002-09-06 2004-03-11 Stephen Wilson Drug delivery and targeting with vitamin B12 conjugates
EP1596815A4 (de) * 2003-02-20 2007-07-04 Cleveland Clinic Foundation Zusammensetzung und verfahren zur hemmung des überlebens von zellen
US7232805B2 (en) * 2003-09-10 2007-06-19 Inflabloc Pharmaceuticals, Inc. Cobalamin conjugates for anti-tumor therapy
WO2005061527A1 (en) * 2003-12-22 2005-07-07 Solidago Ag Cobalamine derivatives useful for diagnosis and treatment of abnormal cellular proliferation
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
BRPI0610419A2 (pt) * 2005-05-17 2012-10-23 Cargill Inc lecitina granular, lisolecitina, processo para produzir lecitina granular, composição granular, processo para produzir uma composição de lecitina granular, produto, e, processos para produzir lisolecitina granular e para produzir uma composição de lisolecitina granular
US9044461B2 (en) 2006-04-07 2015-06-02 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
CA2648718A1 (en) * 2006-04-07 2007-10-18 The Research Foundation Of State University Of New York Transcobalamin receptor polypeptides, nucleic acids, and modulators thereof, and related methods of use in modulating cell growth and treating cancer and cobalamin deficiency
EP2118150B1 (de) * 2007-02-14 2015-09-23 Biocompatibles UK Limited Derivatisierung biologischer moleküle
WO2008115805A2 (en) * 2007-03-19 2008-09-25 Inflabloc Pharmaceuticals, Inc. Cobalamin taxane bioconjugates
WO2011130716A2 (en) 2010-04-16 2011-10-20 Access Pharmaceuticals, Inc. A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers
KR20140026396A (ko) 2011-03-08 2014-03-05 어섹스 팔마큐티칼스 인코포레이티드 생물학적 막을 가로질러 활성물질의 전달을 위한 표적화된 나노담체 시스템
US9120858B2 (en) 2011-07-22 2015-09-01 The Research Foundation Of State University Of New York Antibodies to the B12-transcobalamin receptor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4167556A (en) * 1977-06-02 1979-09-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Determination of transcobalamins
CA1180273A (en) * 1981-06-22 1985-01-02 Technicon Instruments Corporation Assay of vitamin b in12 xx
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5241070A (en) * 1988-09-26 1993-08-31 Ciba Corning Diagnostics Corp. Nucleophilic polysubstituted aryl acridinium esters and uses thereof
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
DE3900648A1 (de) * 1989-01-11 1990-07-12 Boehringer Mannheim Gmbh Neue cobalamin-saeurehydrazide und davon abgeleitete cobalamin-konjugate
WO1990010014A1 (en) * 1989-02-28 1990-09-07 Teijin Limited New vitamin b12 derivative, production thereof, and application thereof
US5310656A (en) * 1989-06-26 1994-05-10 Tritech Partners Vitamin B12 assay
US5294536A (en) * 1992-04-23 1994-03-15 Pb Diagnostic Systems, Inc. Conjugates
WO1993023557A1 (en) * 1992-05-08 1993-11-25 Receptagen Corporation Anti-receptor agents to the vitamin b12/transcobalamin ii receptor
DE4239815A1 (de) * 1992-11-26 1994-06-01 Boehringer Mannheim Gmbh Verbesserte B¶1¶¶2¶-Konjugate
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
US5739287A (en) * 1994-04-08 1998-04-14 University Of Washington Biotinylated cobalamins
US5574018A (en) * 1994-07-29 1996-11-12 Amgen Inc. Conjugates of vitamin B12 and proteins

Also Published As

Publication number Publication date
US5840712A (en) 1998-11-24
DE69528523D1 (de) 2002-11-14
CA2187346A1 (en) 1995-10-19
KR970702290A (ko) 1997-05-13
WO1995027723A1 (en) 1995-10-19
CA2187346C (en) 2010-06-29
EP0754189B1 (de) 2002-10-09
US6083926A (en) 2000-07-04
AU2283595A (en) 1995-10-30
KR100361075B1 (ko) 2003-04-10
JPH10502334A (ja) 1998-03-03
EP0754189A1 (de) 1997-01-22
DE69528523T2 (de) 2003-06-12

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties