ES2048263T3 - Composicion liofilizada de mdm y metodo para su fabricacion. - Google Patents

Composicion liofilizada de mdm y metodo para su fabricacion.

Info

Publication number
ES2048263T3
ES2048263T3 ES89119819T ES89119819T ES2048263T3 ES 2048263 T3 ES2048263 T3 ES 2048263T3 ES 89119819 T ES89119819 T ES 89119819T ES 89119819 T ES89119819 T ES 89119819T ES 2048263 T3 ES2048263 T3 ES 2048263T3
Authority
ES
Spain
Prior art keywords
solution
acid
lyophilized
mdm
bencilpenylloic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89119819T
Other languages
English (en)
Inventor
Sudhakar S Dr Wagle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB Pharma GmbH
Original Assignee
Schwarz Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwarz Pharma AG filed Critical Schwarz Pharma AG
Application granted granted Critical
Publication of ES2048263T3 publication Critical patent/ES2048263T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9446—Antibacterials

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

UNA COMPOSICION (MDM) MEZCLA DETERMINANTE MENOR LIOFILIZADA, ESTABLE DE ALMACENAJE QUE PUEDEN SER RECONSTITUIDAS CON AGUA PARA PRODUCIR UNA SOLUCION QUE ES USADA PARA DETECTAR ALERGIAS O HIPERSENSIBILIDADES A PENICILINAS, COMPRENDEN: ACIDO BENCILPENILOICO; BENCILPENICILIN; ACIDO BENCILPENICILOICO EN DONDE AL MENOS SOBRE EL 94.5 % DEL ACIDO BENCILPENICILOICO ES EL ESTEROISOMERO (5R,6R)-BENCIL-D-ACIDO PENICILOICO; UNA SAL DE METAL ALCALI; UNA SUSTANCIA AMORTIGUADORA DE PH; Y UNA CANTIDAD BAJA CRITICAMENTE DE AGUA. EN EL METODO DEL INVENTO, ES PREPARADA UNA SOLUCION ACUOSA DE ACIDO BENCILPENILOICO, UNA SAL DE METAL ALCALI, Y UNA SUSTANCIA AMORTIGUADORA DE PH. EL ACIDO BENCILPENILOICO EN ESTA SOLUCION ES NEUTRALIZADA CON HIDROXIDO DE SODIO ACUOSO. MIENTRAS MANTENIENDO ESTA SOLUCION A UNA TEMPERATURA DESDE SOBRE 0 C A SOBRE 5 C, LOS SIGUIENTES PASOS SON REPRESENTADOS : PRIMERO, LOS ACIDOS BENCILPENICILIN Y EL BENCILPENICILOICO SON DISUELTOS DENTRO DE LA SOLUCION. EL ACIDO BENCILPENICILOICO EN LA SOLUCION ES NEUTRALIZADO CON HIDROXIDO DE SODIO ACUOSO. SIGUIENTE, EL PH DE LA SOLUCION ES AJUSTADO A UN PH FISIOLOGICO. ESTA SOLUCION ES ENTONCES FILTRADA ESTERIL. DESPUES DE REPRESENTAR ESOS PASOS EN EL QUE LA SOLUCION ES MANTENIDA A UNA TEMPERATURA DESDE SOBRE 0 C A SOBRE 5 C, LA SOLUCION ES CONGELADA EN CONTENEDORES DESHIDRATADOS. DESPUES DE CONGELAR, LA SOLUCION CONGELADA ES LIOFILIZADA.
ES89119819T 1988-11-01 1989-10-25 Composicion liofilizada de mdm y metodo para su fabricacion. Expired - Lifetime ES2048263T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26574988A 1988-11-01 1988-11-01

Publications (1)

Publication Number Publication Date
ES2048263T3 true ES2048263T3 (es) 1994-03-16

Family

ID=23011751

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89119819T Expired - Lifetime ES2048263T3 (es) 1988-11-01 1989-10-25 Composicion liofilizada de mdm y metodo para su fabricacion.

Country Status (7)

Country Link
EP (1) EP0367090B1 (es)
AT (1) ATE100210T1 (es)
DE (1) DE68912270T2 (es)
DK (1) DK542089A (es)
ES (1) ES2048263T3 (es)
IE (1) IE60788B1 (es)
PT (1) PT92163B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT1588U1 (de) * 1994-04-27 1997-08-25 Mahl Christian Dr Verfahren zur herstellung von testsubstanzen für verfahren mit erfassung elektromagnetischer schwingungen
US7932365B2 (en) * 2003-11-08 2011-04-26 Pro Thera Biologics, Llc Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
PT2291654T (pt) 2008-05-28 2018-06-15 Prothera Biologics Inc Preparação e composição de proteínas inibidoras de interalfa do sangue
US9572872B2 (en) 2012-09-09 2017-02-21 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
US9409662B2 (en) 2013-01-15 2016-08-09 Teva Pharmaceutical Industries, Ltd. Formulations of albu-BChE, preparation and uses thereof
EP2945593A4 (en) * 2013-01-15 2016-08-31 Teva Pharma METHOD OF LYOPHILIZATION
CN106187934A (zh) * 2016-07-08 2016-12-07 上海上药新亚药业有限公司 一种羧苄西林钠杂质g的合成方法
CA3036553A1 (en) 2016-09-13 2018-03-22 Prothera Biologics, Inc. Methods for treating pulmonary disease using inter-alpha inhibitor proteins
KR102587810B1 (ko) 2017-04-25 2023-10-11 프로테라 바이오로직스, 인크. 인터-알파 억제제 단백질을 정량화하는 방법
US20180326095A1 (en) * 2017-05-11 2018-11-15 AllerQuest LLC Kits and methods to detect penicillin allergy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316882A (en) * 1978-04-20 1982-02-23 Levine Bernard B Compositions for testing to predict and/or diagnose allergy to penicillins
US4183910A (en) * 1978-04-20 1980-01-15 Levine Bernard B Method for testing to predict and/or diagnose allergy to penicillins, and compounds and compositions for use in such tests
JPS63174927A (ja) * 1987-01-14 1988-07-19 Tanabe Seiyaku Co Ltd 抗菌性凍結乾燥製剤

Also Published As

Publication number Publication date
IE893397L (en) 1990-05-01
DE68912270T2 (de) 1994-04-28
DE68912270D1 (de) 1994-02-24
DK542089D0 (da) 1989-10-31
EP0367090A1 (en) 1990-05-09
IE60788B1 (en) 1994-08-10
PT92163A (pt) 1990-05-31
DK542089A (da) 1990-05-02
EP0367090B1 (en) 1994-01-12
PT92163B (pt) 1995-07-18
ATE100210T1 (de) 1994-01-15

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