ES2048263T3 - Composicion liofilizada de mdm y metodo para su fabricacion. - Google Patents
Composicion liofilizada de mdm y metodo para su fabricacion.Info
- Publication number
- ES2048263T3 ES2048263T3 ES89119819T ES89119819T ES2048263T3 ES 2048263 T3 ES2048263 T3 ES 2048263T3 ES 89119819 T ES89119819 T ES 89119819T ES 89119819 T ES89119819 T ES 89119819T ES 2048263 T3 ES2048263 T3 ES 2048263T3
- Authority
- ES
- Spain
- Prior art keywords
- solution
- acid
- lyophilized
- mdm
- bencilpenylloic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 10
- 239000002253 acid Substances 0.000 abstract 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000013016 damping Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9446—Antibacterials
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
UNA COMPOSICION (MDM) MEZCLA DETERMINANTE MENOR LIOFILIZADA, ESTABLE DE ALMACENAJE QUE PUEDEN SER RECONSTITUIDAS CON AGUA PARA PRODUCIR UNA SOLUCION QUE ES USADA PARA DETECTAR ALERGIAS O HIPERSENSIBILIDADES A PENICILINAS, COMPRENDEN: ACIDO BENCILPENILOICO; BENCILPENICILIN; ACIDO BENCILPENICILOICO EN DONDE AL MENOS SOBRE EL 94.5 % DEL ACIDO BENCILPENICILOICO ES EL ESTEROISOMERO (5R,6R)-BENCIL-D-ACIDO PENICILOICO; UNA SAL DE METAL ALCALI; UNA SUSTANCIA AMORTIGUADORA DE PH; Y UNA CANTIDAD BAJA CRITICAMENTE DE AGUA. EN EL METODO DEL INVENTO, ES PREPARADA UNA SOLUCION ACUOSA DE ACIDO BENCILPENILOICO, UNA SAL DE METAL ALCALI, Y UNA SUSTANCIA AMORTIGUADORA DE PH. EL ACIDO BENCILPENILOICO EN ESTA SOLUCION ES NEUTRALIZADA CON HIDROXIDO DE SODIO ACUOSO. MIENTRAS MANTENIENDO ESTA SOLUCION A UNA TEMPERATURA DESDE SOBRE 0 C A SOBRE 5 C, LOS SIGUIENTES PASOS SON REPRESENTADOS : PRIMERO, LOS ACIDOS BENCILPENICILIN Y EL BENCILPENICILOICO SON DISUELTOS DENTRO DE LA SOLUCION. EL ACIDO BENCILPENICILOICO EN LA SOLUCION ES NEUTRALIZADO CON HIDROXIDO DE SODIO ACUOSO. SIGUIENTE, EL PH DE LA SOLUCION ES AJUSTADO A UN PH FISIOLOGICO. ESTA SOLUCION ES ENTONCES FILTRADA ESTERIL. DESPUES DE REPRESENTAR ESOS PASOS EN EL QUE LA SOLUCION ES MANTENIDA A UNA TEMPERATURA DESDE SOBRE 0 C A SOBRE 5 C, LA SOLUCION ES CONGELADA EN CONTENEDORES DESHIDRATADOS. DESPUES DE CONGELAR, LA SOLUCION CONGELADA ES LIOFILIZADA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26574988A | 1988-11-01 | 1988-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2048263T3 true ES2048263T3 (es) | 1994-03-16 |
Family
ID=23011751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89119819T Expired - Lifetime ES2048263T3 (es) | 1988-11-01 | 1989-10-25 | Composicion liofilizada de mdm y metodo para su fabricacion. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0367090B1 (es) |
| AT (1) | ATE100210T1 (es) |
| DE (1) | DE68912270T2 (es) |
| DK (1) | DK542089A (es) |
| ES (1) | ES2048263T3 (es) |
| IE (1) | IE60788B1 (es) |
| PT (1) | PT92163B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT1588U1 (de) * | 1994-04-27 | 1997-08-25 | Mahl Christian Dr | Verfahren zur herstellung von testsubstanzen für verfahren mit erfassung elektromagnetischer schwingungen |
| EP3087991A1 (en) * | 2003-11-08 | 2016-11-02 | Prothera Biologics | Composition of inter-alpha inhibitor proteins from human plasma for therapeutic use |
| TR201808152T4 (tr) | 2008-05-28 | 2018-07-23 | Prothera Biologics Inc | Kandan inter-alfa inhibitör proteinlerinin hazırlanması ve bunların bileşimi. |
| WO2014039987A2 (en) | 2012-09-09 | 2014-03-13 | Prothera Biologics, Inc. | Treatment of disease using inter-alpha inhibitor proteins |
| HK1217633A1 (zh) * | 2013-01-15 | 2017-01-20 | Teva Pharmaceutical Industries Ltd. | 冻乾方法 |
| AR094481A1 (es) | 2013-01-15 | 2015-08-05 | Teva Pharma | Formulaciones de albu-bche (albúmina-butirilcolinesterasa), preparación y sus usos |
| CN106187934A (zh) * | 2016-07-08 | 2016-12-07 | 上海上药新亚药业有限公司 | 一种羧苄西林钠杂质g的合成方法 |
| US20190269765A1 (en) | 2016-09-13 | 2019-09-05 | Prothera Biologics, Inc. | Methods for treating pulmonary disease using inter-alpha inhibitor proteins |
| AU2018258466B2 (en) | 2017-04-25 | 2025-05-22 | Prothera Biologics, Inc. | Methods for quantifying inter-alpha inhibitor proteins |
| US20180326095A1 (en) * | 2017-05-11 | 2018-11-15 | AllerQuest LLC | Kits and methods to detect penicillin allergy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316882A (en) * | 1978-04-20 | 1982-02-23 | Levine Bernard B | Compositions for testing to predict and/or diagnose allergy to penicillins |
| US4183910A (en) * | 1978-04-20 | 1980-01-15 | Levine Bernard B | Method for testing to predict and/or diagnose allergy to penicillins, and compounds and compositions for use in such tests |
| JPS63174927A (ja) * | 1987-01-14 | 1988-07-19 | Tanabe Seiyaku Co Ltd | 抗菌性凍結乾燥製剤 |
-
1989
- 1989-10-25 DE DE89119819T patent/DE68912270T2/de not_active Expired - Lifetime
- 1989-10-25 EP EP89119819A patent/EP0367090B1/en not_active Expired - Lifetime
- 1989-10-25 AT AT89119819T patent/ATE100210T1/de not_active IP Right Cessation
- 1989-10-25 ES ES89119819T patent/ES2048263T3/es not_active Expired - Lifetime
- 1989-10-30 IE IE339789A patent/IE60788B1/en not_active IP Right Cessation
- 1989-10-31 PT PT92163A patent/PT92163B/pt not_active IP Right Cessation
- 1989-10-31 DK DK542089A patent/DK542089A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK542089A (da) | 1990-05-02 |
| IE60788B1 (en) | 1994-08-10 |
| DE68912270D1 (de) | 1994-02-24 |
| PT92163B (pt) | 1995-07-18 |
| EP0367090B1 (en) | 1994-01-12 |
| PT92163A (pt) | 1990-05-31 |
| DK542089D0 (da) | 1989-10-31 |
| DE68912270T2 (de) | 1994-04-28 |
| IE893397L (en) | 1990-05-01 |
| EP0367090A1 (en) | 1990-05-09 |
| ATE100210T1 (de) | 1994-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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