ES2042997T3 - Procedimiento de preparacion de agentes antialergicos y antiinflamatorios a base de dihidropiridinas. - Google Patents
Procedimiento de preparacion de agentes antialergicos y antiinflamatorios a base de dihidropiridinas.Info
- Publication number
- ES2042997T3 ES2042997T3 ES89301328T ES89301328T ES2042997T3 ES 2042997 T3 ES2042997 T3 ES 2042997T3 ES 89301328 T ES89301328 T ES 89301328T ES 89301328 T ES89301328 T ES 89301328T ES 2042997 T3 ES2042997 T3 ES 2042997T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- alcoxy
- ilo
- triazol
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000000043 antiallergic agent Substances 0.000 title 1
- -1 PYRROLIDINYL Chemical class 0.000 abstract 4
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical group C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA(I), EN LA QUE R ES FENILO QUE PUEDE ESTAR SUSTITUIDO POR NITRO, HALO, ALQUILO, ALCOXI, ARILALCOXI, FLUORO ALCOXI, ALQUILTIO, ALQUILSULFONILO (SIENDO TODOS LOS ALQUILO DE 1 A 4 C), OH, TRIFLUORMETILO O CIANO; R1 Y R2 SON H O ALQUILO DE 1 A 6 C O JUNTOS FORMAN UN GRUPO PIRROLIDINILO, PIPERIDINO, MORFOLINO, PIPERAZINILO O N - ALQUIL (O ALCANOIL) PIPERAZINILO, O R2 ES H O ALQUILO DE 1 A 4 C Y R1 ES CICLOALQUILO DE 3 A 7 C, ARILO, INDARILO O HETEROARILO O UN ALQUILO DIVERSAMENTE SUSTITUIDO; R3 ES OH, ALCOXI DE 1 A 6 C, ARIL - ALCOXI O NR4R5 (EN QUE R4 Y R5 TIENEN VARIOS SIGNIFICADOS QUE SE INDICAN); Y ES UN GRUPO ALQUILENO DE 2 A 8 C Y X ES 1,2,4 - TRIAZOL - 3 - ILO, 1,2,4 - TRIAZOL - 4 - ILO O TRIAZOL [2,3-A] - PIRIDIL - 2 - ILO OPCIONALMENTE SUSTITUIDO POR ALQUILO O FENILO. ESTOS COMPUESTOS SON ANTAGONISTAS DE PAF Y SON UTILES EN EL TRATAMIENTO DE CONDICIONES ALERGICAS, INFLAMATORIAS E HIPERSECRETORIAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888803963A GB8803963D0 (en) | 1988-02-19 | 1988-02-19 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2042997T3 true ES2042997T3 (es) | 1993-12-16 |
Family
ID=10632051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89301328T Expired - Lifetime ES2042997T3 (es) | 1988-02-19 | 1989-02-13 | Procedimiento de preparacion de agentes antialergicos y antiinflamatorios a base de dihidropiridinas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4859686A (es) |
| EP (1) | EP0329357B1 (es) |
| JP (1) | JPH01254665A (es) |
| AT (1) | ATE78252T1 (es) |
| DE (1) | DE68902064T2 (es) |
| DK (1) | DK71789A (es) |
| ES (1) | ES2042997T3 (es) |
| FI (1) | FI890775A7 (es) |
| GB (1) | GB8803963D0 (es) |
| GR (1) | GR3005472T3 (es) |
| IE (1) | IE890521L (es) |
| PT (1) | PT89747B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY104933A (en) * | 1987-09-30 | 1994-07-30 | Pfizer Ltd | Platelet activating factor antagonists |
| AU692619B2 (en) * | 1994-11-29 | 1998-06-11 | Gallagher Group Limited | Method of electronic control |
| EP2147679B1 (en) | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Compositions for blood-brain barrier transport |
| EP2392258B1 (en) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
| CN102458374A (zh) | 2009-05-06 | 2012-05-16 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
| GB8620880D0 (en) * | 1986-08-29 | 1986-10-08 | Pfizer Ltd | Therapeutic agents |
-
1988
- 1988-02-19 GB GB888803963A patent/GB8803963D0/en active Pending
-
1989
- 1989-01-06 US US07/294,322 patent/US4859686A/en not_active Expired - Fee Related
- 1989-02-13 AT AT89301328T patent/ATE78252T1/de not_active IP Right Cessation
- 1989-02-13 EP EP89301328A patent/EP0329357B1/en not_active Expired - Lifetime
- 1989-02-13 ES ES89301328T patent/ES2042997T3/es not_active Expired - Lifetime
- 1989-02-13 DE DE8989301328T patent/DE68902064T2/de not_active Expired - Lifetime
- 1989-02-16 DK DK071789A patent/DK71789A/da not_active Application Discontinuation
- 1989-02-17 PT PT89747A patent/PT89747B/pt not_active IP Right Cessation
- 1989-02-17 IE IE890521A patent/IE890521L/xx unknown
- 1989-02-17 FI FI890775A patent/FI890775A7/fi not_active Application Discontinuation
- 1989-02-20 JP JP1040148A patent/JPH01254665A/ja active Pending
-
1992
- 1992-08-20 GR GR920401809T patent/GR3005472T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68902064T2 (de) | 1992-12-03 |
| GR3005472T3 (es) | 1993-05-24 |
| JPH01254665A (ja) | 1989-10-11 |
| US4859686A (en) | 1989-08-22 |
| ATE78252T1 (de) | 1992-08-15 |
| FI890775A0 (fi) | 1989-02-17 |
| IE890521L (en) | 1989-08-19 |
| EP0329357B1 (en) | 1992-07-15 |
| DE68902064D1 (de) | 1992-08-20 |
| EP0329357A1 (en) | 1989-08-23 |
| DK71789A (da) | 1989-08-21 |
| GB8803963D0 (en) | 1988-03-23 |
| PT89747B (pt) | 1994-03-31 |
| FI890775A7 (fi) | 1989-08-20 |
| PT89747A (pt) | 1989-10-04 |
| DK71789D0 (da) | 1989-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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