ES2042994T3 - Derivados de pirimidina antiulcerantes. - Google Patents

Derivados de pirimidina antiulcerantes.

Info

Publication number
ES2042994T3
ES2042994T3 ES89301119T ES89301119T ES2042994T3 ES 2042994 T3 ES2042994 T3 ES 2042994T3 ES 89301119 T ES89301119 T ES 89301119T ES 89301119 T ES89301119 T ES 89301119T ES 2042994 T3 ES2042994 T3 ES 2042994T3
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
alkoxy
hydrogen
ulcant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301119T
Other languages
English (en)
Inventor
Conrad Santini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2042994T3 publication Critical patent/ES2042994T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

8 - (2 - PIRIMIDILSULFINIL) QUINOLEINAS DE LA FORMULA (I) O MAS SAL DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE DONDE Q ES H, FLUORO, CL, NITRO, AMINO, TRIFLUOROMETILO, ALCANO, ILAMINO O DE DOS A CUATRO C, ALCOXI DE 1 A 5 C, ALQUILO DE 1 A 5 C O DIALQUILAMINO, DICHO ALQUILO TIENE 1 A 4 C; X ES H, ALQUILO, ALCOXI DE 1 A 5 C O ALQUILO DE 1 A 5 C; Y ES H, FLUORO, CLORO, BROMO, ALCOXI DE 1 A 5 C O ALQUILO DE 1 A 5 C; Z ES H, ALQUILO DE 1 A 5 C, FENOXI, BENCILOXI, CICLOALQUILOXI DE 5 A 7 C, AMINO, ALQUILAMINO QUIE TIENE 1 A 4 C, DIALQUIL AMINO, DICHO ALQUILO TIENE 1 A 4 C, ANILINO, N - ALQUILANILINO, DICHO ALQUILO TIENE DE 1 A 4 C, BENCILANINO, N - ALQUILBENCILAMINO, DICHO ALQUILO TIENE DE 1 A 4 C, MORFOLINO, PIPERIDINO O PIRROLIDINO; Y N ES 1, SON INHIBIDORES DE SISTEMA H+/K+ ATPASA Y SON UTILES EN EL TRATAMIENTO DE ULCERAS.
ES89301119T 1988-02-16 1989-02-06 Derivados de pirimidina antiulcerantes. Expired - Lifetime ES2042994T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/156,371 US4808591A (en) 1988-02-16 1988-02-16 Antiulcer 8-(2-pyrimidylsulfinyl)quinolines

Publications (1)

Publication Number Publication Date
ES2042994T3 true ES2042994T3 (es) 1993-12-16

Family

ID=22559294

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301119T Expired - Lifetime ES2042994T3 (es) 1988-02-16 1989-02-06 Derivados de pirimidina antiulcerantes.

Country Status (20)

Country Link
US (1) US4808591A (es)
EP (1) EP0330329B1 (es)
JP (1) JPH0699424B2 (es)
KR (1) KR910002582B1 (es)
AT (1) ATE78477T1 (es)
AU (1) AU604398B2 (es)
CA (1) CA1317946C (es)
DE (1) DE68902152T2 (es)
DK (1) DK70389A (es)
ES (1) ES2042994T3 (es)
FI (1) FI90774C (es)
GR (1) GR3005745T3 (es)
HU (1) HU200455B (es)
IE (1) IE61945B1 (es)
IL (1) IL89257A (es)
MY (1) MY103822A (es)
NO (1) NO171850C (es)
NZ (1) NZ227996A (es)
PT (1) PT89712B (es)
ZA (1) ZA891133B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859679A (en) * 1988-07-19 1989-08-22 Pfizer Inc. Antiulcer (alkyldithio) quinoline derivatives
DE4037003A1 (de) * 1990-05-30 1991-12-05 Bayer Ag Substituierte azine
CA2060282C (en) * 1991-01-31 1997-11-25 Katsutoshi Ishikawa Pyrimidinyloxy(thio) quinoline derivative, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient
US5202329A (en) * 1991-01-31 1993-04-13 Mitsui Toatsu Chemicals Inc. Pyrimidinyloxy(thio)quinoline derivative, and agri-horticultural fungicide comprising the derivative as active ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO810064L (no) * 1980-01-10 1981-07-13 Nyegaard & Co As Fremgangsmaate for fremstilling av fysiologisk aktive pyrimidin-2-sulfider og s-oksyder derav
ES2038612T3 (es) * 1986-03-28 1993-08-01 Otsuka Pharmaceutical Co., Ltd. Compuestos de hidroquinolina, composiciones que los contienen y procedimientos para prepararlas.
WO1989005299A1 (en) * 1987-12-11 1989-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
JPH0615273A (ja) * 1992-07-01 1994-01-25 Funai Electric Co Ltd イオン水生成器の電源装置

Also Published As

Publication number Publication date
CA1317946C (en) 1993-05-18
DK70389A (da) 1989-10-17
DE68902152D1 (de) 1992-08-27
DK70389D0 (da) 1989-02-15
FI90774B (fi) 1993-12-15
IL89257A (en) 1993-01-31
IL89257A0 (en) 1989-09-10
AU604398B2 (en) 1990-12-13
PT89712A (pt) 1989-10-04
ZA891133B (en) 1990-09-26
FI890720A0 (fi) 1989-02-15
JPH01250377A (ja) 1989-10-05
HU200455B (en) 1990-06-28
HUT49347A (en) 1989-09-28
JPH0699424B2 (ja) 1994-12-07
AU2994689A (en) 1989-08-17
DE68902152T2 (de) 1992-12-17
PT89712B (pt) 1994-04-29
EP0330329B1 (en) 1992-07-22
GR3005745T3 (es) 1993-06-07
US4808591A (en) 1989-02-28
KR900012927A (ko) 1990-09-03
NO890632D0 (no) 1989-02-15
NZ227996A (en) 1990-08-28
KR910002582B1 (ko) 1991-04-27
ATE78477T1 (de) 1992-08-15
EP0330329A1 (en) 1989-08-30
IE61945B1 (en) 1994-11-30
NO890632L (no) 1989-08-17
FI890720A (fi) 1989-08-17
FI90774C (fi) 1994-03-25
NO171850C (no) 1993-05-12
MY103822A (en) 1993-09-30
IE890484L (en) 1989-08-16
NO171850B (no) 1993-02-01

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