ES2038619T3 - Procedimiento para la preparacion de derivados de piridinetanolamina. - Google Patents

Procedimiento para la preparacion de derivados de piridinetanolamina.

Info

Publication number
ES2038619T3
ES2038619T3 ES198787108706T ES87108706T ES2038619T3 ES 2038619 T3 ES2038619 T3 ES 2038619T3 ES 198787108706 T ES198787108706 T ES 198787108706T ES 87108706 T ES87108706 T ES 87108706T ES 2038619 T3 ES2038619 T3 ES 2038619T3
Authority
ES
Spain
Prior art keywords
formula
piridinethanolamine
derivatives
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787108706T
Other languages
English (en)
Inventor
Leo Dr. Alig
Marcel Dr. Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2038619T3 publication Critical patent/ES2038619T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dental Preparations (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

LOS DERIVADOS DE PIRIDINETANOLAMINA DE FORMULA (I) EN LA QUE LOS SIMBOLOS N, X, Y, R1, R2 Y R3 TIENEN EL SIGNIFICADO QUE SE INDICA EN LA DESCRIPCION, ASI COMO SUS SALES FISIOLOGICAMENTE ACEPTABLES, TIENEN ACTIVIDAD CATABOLICA Y PUEDEN UTILIZARSE PARA EL TRATAMIENTO DE LA OBESIDAD Y DE LA DIABETES MELLITUS, O DE ESTADOS RELACIONADOS CON UNA ELEVADA DEGRADACION DE LAS PROTEINAS, O TAMBIEM COMO ADITIVOS PARA PIENSOS DE GANADO DE ENGORDE. SE PUEDEN OBTENER POR ALQUILACION DE LAS AMINAS PRIMARIAS O SECUNDARIAS CORRESPONDIENTES A LAS AMINAS SECUNDARIAS O TERCIARIAS DE FORMULA (I).
ES198787108706T 1986-06-27 1987-06-16 Procedimiento para la preparacion de derivados de piridinetanolamina. Expired - Lifetime ES2038619T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH260886 1986-06-27
CH118687 1987-03-27

Publications (1)

Publication Number Publication Date
ES2038619T3 true ES2038619T3 (es) 1993-08-01

Family

ID=25686931

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787108706T Expired - Lifetime ES2038619T3 (es) 1986-06-27 1987-06-16 Procedimiento para la preparacion de derivados de piridinetanolamina.

Country Status (18)

Country Link
US (2) US4800206A (es)
EP (1) EP0254856B1 (es)
AT (1) ATE66916T1 (es)
AU (1) AU594788B2 (es)
CA (1) CA1287061C (es)
DE (1) DE3772660D1 (es)
DK (1) DK166207C (es)
ES (1) ES2038619T3 (es)
FI (1) FI872589A (es)
GR (1) GR3003227T3 (es)
HU (1) HU198457B (es)
IL (1) IL82945A (es)
MC (1) MC1831A1 (es)
NO (1) NO170973C (es)
NZ (1) NZ220793A (es)
PH (1) PH25295A (es)
PT (1) PT85184B (es)
ZW (1) ZW10587A1 (es)

Families Citing this family (39)

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DE3627663A1 (de) * 1986-08-14 1988-03-03 Bayer Ag Heteroarylethylamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren
DE3729284A1 (de) * 1987-09-02 1989-03-23 Thomae Gmbh Dr K Neue heteroarylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FI892341A (fi) * 1988-06-10 1989-12-11 Hoffmann La Roche Propanolaminderivat.
DE3918834A1 (de) * 1989-01-26 1990-08-02 Bayer Ag Aryl- und heteroarylethanol-pyridylalkylamine, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer bei tieren und als mittel gegen adipositas
DE3905028A1 (de) * 1989-02-18 1990-08-23 Bayer Ag 2,4-dihalogen-6-pyridylethanolphenylisopropylamine, verfahren zu ihrer herstellung und ihre verwendung zur verschiebung des protein-fett-verhaeltnisses zugunsten von protein
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
CA2220399A1 (en) * 1995-05-10 1996-11-14 Pfizer Inc. .beta.-adrenergic agonists
GB2305665A (en) * 1995-09-26 1997-04-16 Merck & Co Inc Selective ß3 agonists for the treatment of diabetes aand obesity
US6677347B2 (en) * 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
AU2003248614B2 (en) * 2002-07-17 2007-08-30 Lek Pharmaceuticals D.D. Novel derivatives of pyridylethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, processes for their preparation, and pharmaceutical compositions containing them
EP1617845A4 (en) * 2003-04-28 2006-09-20 3M Innovative Properties Co COMPOSITIONS AND METHODS FOR INDUCING OPOID RECEPTORS
JP2007502288A (ja) * 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ含有化合物
EP1658076B1 (en) * 2003-08-27 2013-03-06 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
CA2537763A1 (en) * 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for cd5+ b cell lymphoma
CA2540541C (en) * 2003-10-03 2012-03-27 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US20090075980A1 (en) * 2003-10-03 2009-03-19 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and Analogs Thereof
US7544697B2 (en) * 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AU2004291122A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
AU2004291101A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
JP4891088B2 (ja) * 2003-11-25 2012-03-07 スリーエム イノベイティブ プロパティズ カンパニー 置換されたイミダゾ環系および方法
US8802853B2 (en) * 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
US8735421B2 (en) * 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
WO2005094531A2 (en) * 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) * 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) * 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8026366B2 (en) * 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) * 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US20070259881A1 (en) * 2004-06-18 2007-11-08 Dellaria Joseph F Jr Substituted Imidazo Ring Systems and Methods
US20090270443A1 (en) * 2004-09-02 2009-10-29 Doris Stoermer 1-amino imidazo-containing compounds and methods
JP2008523076A (ja) * 2004-12-08 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー 免疫調節性の組成物、合剤、および方法
WO2006083440A2 (en) 2004-12-30 2006-08-10 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
CA2592904C (en) * 2004-12-30 2015-04-07 3M Innovative Properties Company Chiral fused [1,2]imidazo[4,5-c] ring compounds
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
JP2008530113A (ja) 2005-02-11 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド オキシムおよびヒドロキシラミン置換イミダゾ［４，５−ｃ］環化合物および方法
CA2602590A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
US7906506B2 (en) * 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
EP3810777A4 (en) 2018-06-21 2022-03-30 Yumanity Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF NEUROLOGICAL DISORDERS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI791727A (fi) * 1978-06-05 1979-12-06 Ciba Geigy Ag Foerfarande foer framstaellning av n-alkylerade aminoalkoholer
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
US4338333A (en) * 1979-06-16 1982-07-06 Beecham Group Limited Ethanamine derivatives their preparation and use in pharmaceutical compositions
US4358455A (en) * 1980-12-23 1982-11-09 Merck & Co., Inc. Aralkylamindethanol heterocyclic compounds
EP0070133B1 (en) * 1981-07-11 1986-05-14 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
DE3368258D1 (en) * 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
EP0139921B1 (en) * 1983-08-17 1987-03-25 Beecham Group Plc 2-phenylethylamine derivatives
GB8415377D0 (en) * 1984-06-15 1984-07-18 Beecham Group Plc Compounds
GB8528633D0 (en) * 1985-11-21 1985-12-24 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0254856A2 (de) 1988-02-03
NO872701L (no) 1987-12-28
US4988714A (en) 1991-01-29
CA1287061C (en) 1991-07-30
FI872589A0 (fi) 1987-06-10
NO170973B (no) 1992-09-28
GR3003227T3 (en) 1993-02-17
AU594788B2 (en) 1990-03-15
HU198457B (en) 1989-10-30
HUT44508A (en) 1988-03-28
PH25295A (en) 1991-04-30
DK166207B (da) 1993-03-22
DK166207C (da) 1993-08-16
DE3772660D1 (de) 1991-10-10
EP0254856A3 (en) 1989-02-08
IL82945A0 (en) 1987-12-20
MC1831A1 (fr) 1988-06-03
AU7455787A (en) 1988-01-07
NO170973C (no) 1993-01-06
FI872589A (fi) 1987-12-28
PT85184A (en) 1987-07-01
DK329587D0 (da) 1987-06-26
DK329587A (da) 1987-12-28
IL82945A (en) 1991-06-10
NZ220793A (en) 1990-01-29
PT85184B (pt) 1990-03-30
NO872701D0 (no) 1987-06-26
US4800206A (en) 1989-01-24
ZW10587A1 (en) 1988-01-13
ATE66916T1 (de) 1991-09-15
EP0254856B1 (de) 1991-09-04

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