ES2038263T3 - Procedimiento para la fabricacion de derivados de trans-1, 1,2-trifenil-but-1-eno. - Google Patents
Procedimiento para la fabricacion de derivados de trans-1, 1,2-trifenil-but-1-eno.Info
- Publication number
- ES2038263T3 ES2038263T3 ES198888115306T ES88115306T ES2038263T3 ES 2038263 T3 ES2038263 T3 ES 2038263T3 ES 198888115306 T ES198888115306 T ES 198888115306T ES 88115306 T ES88115306 T ES 88115306T ES 2038263 T3 ES2038263 T3 ES 2038263T3
- Authority
- ES
- Spain
- Prior art keywords
- trans
- derivatives
- eno
- triphenyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873736682 DE3736682A1 (de) | 1987-10-29 | 1987-10-29 | Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2038263T3 true ES2038263T3 (es) | 1993-07-16 |
Family
ID=6339363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198888115306T Expired - Lifetime ES2038263T3 (es) | 1987-10-29 | 1988-09-19 | Procedimiento para la fabricacion de derivados de trans-1, 1,2-trifenil-but-1-eno. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4960937A (enExample) |
| EP (1) | EP0313799B1 (enExample) |
| AT (1) | ATE85605T1 (enExample) |
| DE (2) | DE3736682A1 (enExample) |
| DK (1) | DK170300B1 (enExample) |
| ES (1) | ES2038263T3 (enExample) |
| FI (1) | FI94625C (enExample) |
| GR (1) | GR3007027T3 (enExample) |
| HU (1) | HU202824B (enExample) |
| NO (1) | NO169120C (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0677507B1 (en) * | 1993-10-25 | 1998-04-08 | Taiho Pharmaceutical Company Limited | Process for producing acid-addition salt of z-isomer of triphenylethylene compound |
| WO1995018786A1 (en) * | 1994-01-03 | 1995-07-13 | Klinge Pharma Gmbh | Method for the production of e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene |
| US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
| EP0883587A1 (en) | 1996-01-20 | 1998-12-16 | Bradford University | Tamoxifen and analogues thereof |
| GB9715479D0 (en) * | 1997-07-23 | 1997-10-01 | Univ Bradford | Tamoxifen and analogues thereof |
| RU2214236C2 (ru) | 1997-08-15 | 2003-10-20 | Дьюк Юниверсити | Способ профилактики или лечения эстрогензависимых заболеваний и расстройств |
| CN114133334B (zh) * | 2021-11-09 | 2024-07-19 | 北京京丰制药(山东)有限公司 | 枸橼酸他莫昔芬的工业化制备工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637389A (enExample) * | 1962-09-13 | |||
| GB1013907A (en) * | 1962-09-13 | 1965-12-22 | Ici Ltd | Alkene derivatives |
| DE3046719C2 (de) * | 1980-12-11 | 1983-02-17 | Klinge Pharma GmbH, 8000 München | 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel |
| DE3462398D1 (en) * | 1983-05-24 | 1987-04-02 | Bristol Myers Co | Process for the conversion of the e isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen hcl |
| GB2160202B (en) * | 1984-06-12 | 1987-12-02 | Nat Res Dev | Preparation of tamoxifen |
| CN1013859B (zh) * | 1986-11-21 | 1991-09-11 | 中国人民解放军防化研究院第四所 | 枸橼酸三苯氧胺合成方法的改进 |
-
1987
- 1987-10-29 DE DE19873736682 patent/DE3736682A1/de not_active Withdrawn
-
1988
- 1988-09-19 DE DE8888115306T patent/DE3878394D1/de not_active Expired - Fee Related
- 1988-09-19 ES ES198888115306T patent/ES2038263T3/es not_active Expired - Lifetime
- 1988-09-19 AT AT88115306T patent/ATE85605T1/de not_active IP Right Cessation
- 1988-09-19 EP EP88115306A patent/EP0313799B1/de not_active Expired - Lifetime
- 1988-09-28 FI FI884461A patent/FI94625C/fi not_active IP Right Cessation
- 1988-10-27 US US07/263,209 patent/US4960937A/en not_active Expired - Fee Related
- 1988-10-27 NO NO884800A patent/NO169120C/no not_active IP Right Cessation
- 1988-10-28 HU HU885630A patent/HU202824B/hu not_active IP Right Cessation
- 1988-10-28 DK DK604288A patent/DK170300B1/da not_active IP Right Cessation
-
1993
- 1993-02-11 GR GR920402546T patent/GR3007027T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO884800L (no) | 1989-05-02 |
| DE3736682A1 (de) | 1989-05-11 |
| EP0313799A2 (de) | 1989-05-03 |
| GR3007027T3 (enExample) | 1993-07-30 |
| NO169120C (no) | 1992-05-13 |
| FI884461A0 (fi) | 1988-09-28 |
| ATE85605T1 (de) | 1993-02-15 |
| FI94625B (fi) | 1995-06-30 |
| HU202824B (en) | 1991-04-29 |
| HUT51592A (en) | 1990-05-28 |
| NO884800D0 (no) | 1988-10-27 |
| US4960937A (en) | 1990-10-02 |
| DK604288D0 (da) | 1988-10-28 |
| NO169120B (no) | 1992-02-03 |
| DK170300B1 (da) | 1995-07-31 |
| FI884461A7 (fi) | 1989-04-30 |
| EP0313799A3 (en) | 1990-05-30 |
| DK604288A (da) | 1989-04-30 |
| FI94625C (fi) | 1995-10-10 |
| DE3878394D1 (de) | 1993-03-25 |
| EP0313799B1 (de) | 1993-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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