ES2037499T3 - Procedimiento para el aislamiento del factor de la coagulacion sanguinea ix. - Google Patents
Procedimiento para el aislamiento del factor de la coagulacion sanguinea ix.Info
- Publication number
- ES2037499T3 ES2037499T3 ES199090107974T ES90107974T ES2037499T3 ES 2037499 T3 ES2037499 T3 ES 2037499T3 ES 199090107974 T ES199090107974 T ES 199090107974T ES 90107974 T ES90107974 T ES 90107974T ES 2037499 T3 ES2037499 T3 ES 2037499T3
- Authority
- ES
- Spain
- Prior art keywords
- adsorption
- procedure
- blood coagulation
- isolation
- elution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 108010076282 Factor IX Proteins 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 238000001179 sorption measurement Methods 0.000 abstract 3
- 238000010828 elution Methods 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- -1 SULPHATE CARBON HYDRATES Chemical class 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 229940019700 blood coagulation factors Drugs 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
EL INVENTO SE REFIERE A UN PROCEDIMIENTO PARA AISLAR FACTORES (IX) DE COAGULACION SANGUINEA, QUE CONSISTE EN ADSORCION DE PLASMA O DE UNA SOLUCION O FRACCION DE PLASMA QUE CONTIENE EL FACTOR (IX) POR UN ADSORBENTE QUE LLEVA EL GRUPO (ALFA)-HIDROXILO-AMINO, ELUCION DE LA ADSORVION CON UNA AMINA ORGANICA PRIMARIA Y DE BAJO PESO MOLECULAR; ADSORCION DEL ELNATO EN UNA MATRIZ QUE LLEVA HIDRATOS DE CARBONO SULFATADOS, ELUCION DE LA ADSORCION CON UN GRADIENTE DE SAL, CONCENTRACION DE LA ELUCION Y ENFRIAMIENTO A BAJO CERO DE LA CONCENTRACION Y SE CARACTERIZA PROQUE ANTES O DESPUES DE LA PRIMERA ADSORCION SE EFECTUA LA INACTIVACION DE LOS VIRUS PRESENTES A TRAVES DE MEDIDAS CONOCIDAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3914869A DE3914869C1 (es) | 1989-05-05 | 1989-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2037499T3 true ES2037499T3 (es) | 1993-06-16 |
Family
ID=6380171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES199090107974T Expired - Lifetime ES2037499T3 (es) | 1989-05-05 | 1990-04-26 | Procedimiento para el aislamiento del factor de la coagulacion sanguinea ix. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5061789A (es) |
EP (1) | EP0396022B1 (es) |
JP (1) | JP2593951B2 (es) |
AT (1) | ATE76751T1 (es) |
DE (2) | DE3914869C1 (es) |
DK (1) | DK0396022T3 (es) |
ES (1) | ES2037499T3 (es) |
GR (1) | GR3005036T3 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT395597B (de) * | 1991-01-25 | 1993-01-25 | Immuno Ag | Reagens zur bestimmung von faktor viii-aktivitaet |
AT402261B (de) * | 1991-01-25 | 1997-03-25 | Immuno Ag | Komplex enthaltend den gerinnungsfaktor ix |
AU671586B2 (en) | 1991-03-01 | 1996-09-05 | Aventis Behring Llc | Preparation of factor IX |
IT1262899B (it) * | 1992-03-27 | 1996-07-22 | Sclavo Spa | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
DE4342132C1 (de) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
DE19504852C2 (de) * | 1995-02-15 | 2003-01-23 | Octapharma Ag Lachen | Verfahren zur Reinigung Vitamin K-abhängiger Gerinnungsfaktoren durch Affinitäts-Chromatographie |
US5714583A (en) | 1995-06-07 | 1998-02-03 | Genetics Institute, Inc. | Factor IX purification methods |
DE10045434B4 (de) * | 2000-09-14 | 2005-07-14 | Fresenius Hemocare Gmbh | Adsorbens mit unterschiedlich modifizierten Oberflächenbereichen, Verfahren zu dessen Herstellung und Verwendung davon |
AU2011343813B2 (en) | 2010-12-15 | 2015-05-21 | Takeda Pharmaceutical Company Limited | Eluate collection using conductivity gradient |
US9663553B2 (en) | 2014-01-29 | 2017-05-30 | Hemarus Therapeutics Limited | Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma |
JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥方法 |
JP7495426B2 (ja) | 2019-03-14 | 2024-06-04 | テルモ ビーシーティー バイオテクノロジーズ,エルエルシー | 凍結乾燥容器用充填治具、システム及び使用方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3920625A (en) * | 1973-06-19 | 1975-11-18 | Kabi Ab | Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates |
DE3172210D1 (en) * | 1980-05-27 | 1985-10-17 | Miles Lab | Blood coagulation promoting product and process of preparing same |
DE3033932C2 (de) * | 1980-09-10 | 1984-05-24 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten |
DE3101752A1 (de) * | 1981-01-21 | 1982-08-26 | Behringwerke Ag, 3550 Marburg | "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen" |
US4447416A (en) * | 1982-04-28 | 1984-05-08 | American National Red Cross | Plasma protein concentrates of reduced thrombogenicity and their use in clinical replacement therapy |
US4721572A (en) * | 1985-07-12 | 1988-01-26 | Miles Laboratories, Inc. | Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices |
US4725673A (en) * | 1986-08-29 | 1988-02-16 | Alpha Therapeutic Corporation | Plasma fraction purification using silica resin bound to a ligand |
EP0317376B2 (fr) * | 1987-10-23 | 1996-04-03 | Centre Regional De Transfusion Sanguine De Lille | Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques |
DE3826792C1 (es) * | 1988-08-06 | 1989-07-06 | Biotest Pharma Gmbh, 6072 Dreieich, De |
-
1989
- 1989-05-05 DE DE3914869A patent/DE3914869C1/de not_active Expired - Fee Related
-
1990
- 1990-04-26 AT AT90107974T patent/ATE76751T1/de not_active IP Right Cessation
- 1990-04-26 DE DE9090107974T patent/DE59000141D1/de not_active Expired - Lifetime
- 1990-04-26 EP EP90107974A patent/EP0396022B1/de not_active Expired - Lifetime
- 1990-04-26 ES ES199090107974T patent/ES2037499T3/es not_active Expired - Lifetime
- 1990-04-26 DK DK90107974.9T patent/DK0396022T3/da active
- 1990-05-01 US US07/517,081 patent/US5061789A/en not_active Expired - Fee Related
- 1990-05-02 JP JP2115330A patent/JP2593951B2/ja not_active Expired - Lifetime
-
1992
- 1992-06-26 GR GR920400491T patent/GR3005036T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0396022T3 (da) | 1992-07-20 |
JP2593951B2 (ja) | 1997-03-26 |
JPH02306994A (ja) | 1990-12-20 |
EP0396022B1 (de) | 1992-06-03 |
EP0396022A1 (de) | 1990-11-07 |
DE3914869C1 (es) | 1990-08-09 |
DE59000141D1 (de) | 1992-07-09 |
GR3005036T3 (es) | 1993-05-24 |
US5061789A (en) | 1991-10-29 |
ATE76751T1 (de) | 1992-06-15 |
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