ES2022024A6 - Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos) - Google Patents

Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos)

Info

Publication number
ES2022024A6
ES2022024A6 ES9001271A ES9001271A ES2022024A6 ES 2022024 A6 ES2022024 A6 ES 2022024A6 ES 9001271 A ES9001271 A ES 9001271A ES 9001271 A ES9001271 A ES 9001271A ES 2022024 A6 ES2022024 A6 ES 2022024A6
Authority
ES
Spain
Prior art keywords
derivatives
uracile
substituted
related compounds
tumour activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9001271A
Other languages
English (en)
Inventor
Ubeda Antonio Espinosa
Guadix Antonio Entrena
Quesada Encarnacion Camacho
Seglar Jose Francisc Dominguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Granada
Original Assignee
Universidad de Granada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Granada filed Critical Universidad de Granada
Priority to ES9001271A priority Critical patent/ES2022024A6/es
Priority to PCT/ES1991/000028 priority patent/WO1991017147A1/es
Publication of ES2022024A6 publication Critical patent/ES2022024A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SINTESIS DE NUEVOS DERIVADOS DE URACILO CON ACTIVIDAD ANTIUMORAL Y COMPUESTOS REFERIBLES (N-1-DERIVADOS DE URACILOS-5-SUSTITUIDOS). LA PRESENTE INVENCION SE REFIERE A LA SINTESIS DE NUEVOS COMPUESTOS QUIMICOS CON INTERESANTES PROPIEDADES ANTITUMORALES Y BAJA TOXICIDAD AGUDA, SEGUN LA REACCION QUE APARECE EN EL GRAFICO. EN EL CASO DE LOS COMPUESTOS EN LOS QUE X=SO, SE PARTE DE UNO EN EL QUE X=S, OBTENIDO SEGUN DICHO ESQUEMA, EL CUAL SE SOMETE A OXIDACION CON PERYODATO SODICO.
ES9001271A 1990-05-07 1990-05-07 Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos) Expired - Fee Related ES2022024A6 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9001271A ES2022024A6 (es) 1990-05-07 1990-05-07 Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos)
PCT/ES1991/000028 WO1991017147A1 (es) 1990-05-07 1991-05-06 Nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5-sustituidos)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9001271A ES2022024A6 (es) 1990-05-07 1990-05-07 Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos)

Publications (1)

Publication Number Publication Date
ES2022024A6 true ES2022024A6 (es) 1991-11-16

Family

ID=8267185

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9001271A Expired - Fee Related ES2022024A6 (es) 1990-05-07 1990-05-07 Sintesis de nuevos derivados de uracilo con actividad antitumoral y compuestos referibles (n-1-derivados de uracilos-5- sustituidos)

Country Status (2)

Country Link
ES (1) ES2022024A6 (es)
WO (1) WO1991017147A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049144B1 (en) * 1980-10-01 1984-08-29 Beecham Group Plc 5-fluoro uracil derivatives

Also Published As

Publication number Publication date
WO1991017147A1 (es) 1991-11-14

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20141120