ES2011245B3 - Proceso de preparacion de 5-(2,5-dimetilfenoxi)-2,2-acido dimetilpentanoico - Google Patents
Proceso de preparacion de 5-(2,5-dimetilfenoxi)-2,2-acido dimetilpentanoicoInfo
- Publication number
- ES2011245B3 ES2011245B3 ES86117076T ES86117076T ES2011245B3 ES 2011245 B3 ES2011245 B3 ES 2011245B3 ES 86117076 T ES86117076 T ES 86117076T ES 86117076 T ES86117076 T ES 86117076T ES 2011245 B3 ES2011245 B3 ES 2011245B3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- dimetilpentanoico
- dimetilfenoxi
- preparation process
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- NKTOLZVEWDHZMU-UHFFFAOYSA-N 2,5-xylenol Chemical compound CC1=CC=C(C)C(O)=C1 NKTOLZVEWDHZMU-UHFFFAOYSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- HEMJJKBWTPKOJG-UHFFFAOYSA-N Gemfibrozil Chemical compound CC1=CC=C(C)C(OCCCC(C)(C)C(O)=O)=C1 HEMJJKBWTPKOJG-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- -1 alkali metal salt Chemical class 0.000 abstract 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 abstract 2
- VEFLKXRACNJHOV-UHFFFAOYSA-N 1,3-dibromopropane Chemical compound BrCCCBr VEFLKXRACNJHOV-UHFFFAOYSA-N 0.000 abstract 1
- MFESCIUQSIBMSM-UHFFFAOYSA-N I-BCP Chemical compound ClCCCBr MFESCIUQSIBMSM-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 229960003627 gemfibrozil Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003880 polar aprotic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/806,312 US4665226A (en) | 1985-12-09 | 1985-12-09 | Process for preparing 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2011245B3 true ES2011245B3 (es) | 1990-01-01 |
Family
ID=25193782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES86117076T Expired - Lifetime ES2011245B3 (es) | 1985-12-09 | 1986-12-08 | Proceso de preparacion de 5-(2,5-dimetilfenoxi)-2,2-acido dimetilpentanoico |
Country Status (22)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5235097A (en) * | 1990-05-11 | 1993-08-10 | Egis Gyogyszergyar | Process for the preparation of 2,2-dimethyl-5-(2,5-dimethyl-phenoxy)-pentanoic acid, intermediates for preparing this compound and process for preparing the intermediates |
| HU205891B (en) * | 1990-05-11 | 1992-07-28 | Gyogyszerkutato Intezet | Process for producing 2,2-dimethyl-5-/2,5-dimethyl-phenoxy/-pentanoic acid |
| US5041640A (en) * | 1990-09-20 | 1991-08-20 | Warner-Lambert Company | Process for mono-, di-, trisubstituted acetic acids |
| BE1007058A3 (fr) * | 1992-06-16 | 1995-03-07 | Omnichem Sa | Un procede nouveau pour la preparation de l'acide 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoique. |
| IT1265087B1 (it) * | 1993-05-20 | 1996-10-30 | Recordati Chem Pharm | Processo per la preparazione di gemfibrozil |
| US5530145A (en) * | 1994-06-14 | 1996-06-25 | Syn-Tech Chem & Pharm Co., Ltd. | Anticholesteremic compounds |
| US5412112A (en) * | 1994-06-14 | 1995-05-02 | Industrial Technology Research Institute | Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids |
| AU2003257210A1 (en) * | 2002-08-08 | 2004-02-25 | Smithkline Beecham Corporation | Methods for the isolation and purification of ansamitocins |
| CN101440032B (zh) * | 2008-11-13 | 2012-05-23 | 浙江大学 | 一种吉非罗齐的多晶型及其制备方法 |
| WO2020212955A1 (en) * | 2019-04-18 | 2020-10-22 | Hikal Limited | Process for the preparation of a key intermediate of gemfibrozil |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674836A (en) * | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
| US3707566A (en) * | 1970-03-30 | 1972-12-26 | Parke Davis & Co | Aryloxypentane compounds |
| US3759986A (en) * | 1970-03-30 | 1973-09-18 | Parke Davis & Co | Esters of 2,2-dimethyl-5-(aryloxy)-1-pentanols |
| GB1422679A (en) * | 1972-11-16 | 1976-01-28 | Funai Pharmaceutical Ind Ltd | Substituted phenoxy-a-methylpropionic acid derivatives and a process for producing the same |
| GB2025942A (en) * | 1978-05-31 | 1980-01-30 | Sori Soc Rech Ind | Phenoxyalkylcarboxylic acids |
| ES533668A0 (es) * | 1983-06-24 | 1985-10-01 | Yamanouchi Pharma Co Ltd | Un compuesto fenoxi |
-
1985
- 1985-12-09 US US06/806,312 patent/US4665226A/en not_active Expired - Lifetime
-
1986
- 1986-11-18 IN IN1005/DEL/86A patent/IN166169B/en unknown
- 1986-11-19 IE IE306086A patent/IE59499B1/en not_active IP Right Cessation
- 1986-11-24 ZA ZA868893A patent/ZA868893B/xx unknown
- 1986-11-24 AU AU65606/86A patent/AU590358B2/en not_active Ceased
- 1986-11-25 CA CA000523753A patent/CA1267155A/en not_active Expired - Fee Related
- 1986-12-01 FI FI864900A patent/FI85974C/fi not_active IP Right Cessation
- 1986-12-03 KR KR860010302A patent/KR870005954A/ko active Granted
- 1986-12-05 IL IL80885A patent/IL80885A/xx unknown
- 1986-12-05 PH PH34561A patent/PH24273A/en unknown
- 1986-12-08 JP JP61290642A patent/JP2506094B2/ja not_active Expired - Fee Related
- 1986-12-08 DK DK198605882A patent/DK174496B1/da not_active IP Right Cessation
- 1986-12-08 EP EP86117076A patent/EP0226161B1/en not_active Expired
- 1986-12-08 DE DE8686117076T patent/DE3666805D1/de not_active Expired
- 1986-12-08 NO NO864933A patent/NO164293C/no unknown
- 1986-12-08 HU HU865104A patent/HU195635B/hu not_active IP Right Cessation
- 1986-12-08 ES ES86117076T patent/ES2011245B3/es not_active Expired - Lifetime
- 1986-12-08 AT AT86117076T patent/ATE47832T1/de not_active IP Right Cessation
- 1986-12-09 CN CN86108472A patent/CN1012896B/zh not_active Expired
- 1986-12-09 PT PT83888A patent/PT83888B/pt not_active IP Right Cessation
-
1987
- 1987-12-03 KR KR1019860010302Q patent/KR950003120B1/ko not_active Expired - Fee Related
-
1989
- 1989-11-15 GR GR89400242T patent/GR3000216T3/el unknown
-
1993
- 1993-10-21 HK HK1121/93A patent/HK112193A/en not_active IP Right Cessation
Also Published As
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