ES2010135A6 - Norfloxacin bactericide prepn. - Google Patents
Norfloxacin bactericide prepn.Info
- Publication number
- ES2010135A6 ES2010135A6 ES8900476A ES8900476A ES2010135A6 ES 2010135 A6 ES2010135 A6 ES 2010135A6 ES 8900476 A ES8900476 A ES 8900476A ES 8900476 A ES8900476 A ES 8900476A ES 2010135 A6 ES2010135 A6 ES 2010135A6
- Authority
- ES
- Spain
- Prior art keywords
- prepn
- norfloxacin
- bactericide
- reacting
- norfloxazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Norfloxazine of formula (I) for use as an anti-bacterial agent against gram-negative micro-organisms, is made by (a) reacting 3-chloro 4-fluoro aniline with diethyl ethoxy-methylene malonate; (b) ethylation with an alkylating agent; (c) cyclising by heating to give the quinoline carboxylic acid; and (presumably) (d) reacting with piperazine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8900476A ES2010135A6 (en) | 1989-02-10 | 1989-02-10 | Norfloxacin bactericide prepn. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8900476A ES2010135A6 (en) | 1989-02-10 | 1989-02-10 | Norfloxacin bactericide prepn. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2010135A6 true ES2010135A6 (en) | 1989-10-16 |
Family
ID=8260338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8900476A Expired ES2010135A6 (en) | 1989-02-10 | 1989-02-10 | Norfloxacin bactericide prepn. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2010135A6 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049630A1 (en) * | 1992-02-28 | 1994-04-16 | Elmuquimica Farm Sl | Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc |
ES2049631A1 (en) * | 1992-02-28 | 1994-04-16 | Elmuquimica Farm Sl | Substd. piperazinyl quinolone carboxylic acid deriv. prepn. - involves conversion of 3-chloro-4-fluoro:aniline to acetanilide, redn. conversion to formanilide, ring closure with ethoxy-malonyl chloride, etc. |
ES2049652A1 (en) * | 1992-09-16 | 1994-04-16 | Genesis Para La Investigacion | Prepn of quinoline carboxylic acid derivs used to produce ofloxacin antibiotic - comprises reacting tri:fluoro:aniline with a di:alkyl alkoxymethylene malonate and then with propyl acetate deriv, followed by hydrolysis and ring closure |
EP0684942A4 (en) * | 1993-02-16 | 1995-12-27 | ||
WO2003010144A3 (en) * | 2001-07-25 | 2003-10-16 | Farmaceutsko Hemijska Ind Zdra | A process for synthesis of fluoroquinolonic derivatives |
-
1989
- 1989-02-10 ES ES8900476A patent/ES2010135A6/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049630A1 (en) * | 1992-02-28 | 1994-04-16 | Elmuquimica Farm Sl | Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc |
ES2049631A1 (en) * | 1992-02-28 | 1994-04-16 | Elmuquimica Farm Sl | Substd. piperazinyl quinolone carboxylic acid deriv. prepn. - involves conversion of 3-chloro-4-fluoro:aniline to acetanilide, redn. conversion to formanilide, ring closure with ethoxy-malonyl chloride, etc. |
ES2049652A1 (en) * | 1992-09-16 | 1994-04-16 | Genesis Para La Investigacion | Prepn of quinoline carboxylic acid derivs used to produce ofloxacin antibiotic - comprises reacting tri:fluoro:aniline with a di:alkyl alkoxymethylene malonate and then with propyl acetate deriv, followed by hydrolysis and ring closure |
EP0684942A4 (en) * | 1993-02-16 | 1995-12-27 | ||
WO2003010144A3 (en) * | 2001-07-25 | 2003-10-16 | Farmaceutsko Hemijska Ind Zdra | A process for synthesis of fluoroquinolonic derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040916 |