ES2010135A6 - Norfloxacin bactericide prepn. - Google Patents

Norfloxacin bactericide prepn.

Info

Publication number
ES2010135A6
ES2010135A6 ES8900476A ES8900476A ES2010135A6 ES 2010135 A6 ES2010135 A6 ES 2010135A6 ES 8900476 A ES8900476 A ES 8900476A ES 8900476 A ES8900476 A ES 8900476A ES 2010135 A6 ES2010135 A6 ES 2010135A6
Authority
ES
Spain
Prior art keywords
prepn
norfloxacin
bactericide
reacting
norfloxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8900476A
Other languages
Spanish (es)
Inventor
Molina Isidro Lopez
Coto Antonio Domingo
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Quimico Farmaceutica SA
Original Assignee
Union Quimico Farmaceutica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica SA filed Critical Union Quimico Farmaceutica SA
Priority to ES8900476A priority Critical patent/ES2010135A6/en
Publication of ES2010135A6 publication Critical patent/ES2010135A6/en
Expired legal-status Critical Current

Links

Landscapes

  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Norfloxazine of formula (I) for use as an anti-bacterial agent against gram-negative micro-organisms, is made by (a) reacting 3-chloro 4-fluoro aniline with diethyl ethoxy-methylene malonate; (b) ethylation with an alkylating agent; (c) cyclising by heating to give the quinoline carboxylic acid; and (presumably) (d) reacting with piperazine.
ES8900476A 1989-02-10 1989-02-10 Norfloxacin bactericide prepn. Expired ES2010135A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8900476A ES2010135A6 (en) 1989-02-10 1989-02-10 Norfloxacin bactericide prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8900476A ES2010135A6 (en) 1989-02-10 1989-02-10 Norfloxacin bactericide prepn.

Publications (1)

Publication Number Publication Date
ES2010135A6 true ES2010135A6 (en) 1989-10-16

Family

ID=8260338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8900476A Expired ES2010135A6 (en) 1989-02-10 1989-02-10 Norfloxacin bactericide prepn.

Country Status (1)

Country Link
ES (1) ES2010135A6 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049630A1 (en) * 1992-02-28 1994-04-16 Elmuquimica Farm Sl Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc
ES2049631A1 (en) * 1992-02-28 1994-04-16 Elmuquimica Farm Sl Substd. piperazinyl quinolone carboxylic acid deriv. prepn. - involves conversion of 3-chloro-4-fluoro:aniline to acetanilide, redn. conversion to formanilide, ring closure with ethoxy-malonyl chloride, etc.
ES2049652A1 (en) * 1992-09-16 1994-04-16 Genesis Para La Investigacion Prepn of quinoline carboxylic acid derivs used to produce ofloxacin antibiotic - comprises reacting tri:fluoro:aniline with a di:alkyl alkoxymethylene malonate and then with propyl acetate deriv, followed by hydrolysis and ring closure
EP0684942A4 (en) * 1993-02-16 1995-12-27
WO2003010144A3 (en) * 2001-07-25 2003-10-16 Farmaceutsko Hemijska Ind Zdra A process for synthesis of fluoroquinolonic derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049630A1 (en) * 1992-02-28 1994-04-16 Elmuquimica Farm Sl Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc
ES2049631A1 (en) * 1992-02-28 1994-04-16 Elmuquimica Farm Sl Substd. piperazinyl quinolone carboxylic acid deriv. prepn. - involves conversion of 3-chloro-4-fluoro:aniline to acetanilide, redn. conversion to formanilide, ring closure with ethoxy-malonyl chloride, etc.
ES2049652A1 (en) * 1992-09-16 1994-04-16 Genesis Para La Investigacion Prepn of quinoline carboxylic acid derivs used to produce ofloxacin antibiotic - comprises reacting tri:fluoro:aniline with a di:alkyl alkoxymethylene malonate and then with propyl acetate deriv, followed by hydrolysis and ring closure
EP0684942A4 (en) * 1993-02-16 1995-12-27
WO2003010144A3 (en) * 2001-07-25 2003-10-16 Farmaceutsko Hemijska Ind Zdra A process for synthesis of fluoroquinolonic derivatives

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040916