ES2049630A1 - Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc - Google Patents

Prepn of piperazinyl quinoline carboxylic acid deriv from 3-chloro-4-fluoro aniline - by conversion to the acetanilide, redn with di:borane, conversion to the formanilide, ring closure with ethoxy malonyl chloride, etc

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Publication number
ES2049630A1
ES2049630A1 ES9200446A ES9200446A ES2049630A1 ES 2049630 A1 ES2049630 A1 ES 2049630A1 ES 9200446 A ES9200446 A ES 9200446A ES 9200446 A ES9200446 A ES 9200446A ES 2049630 A1 ES2049630 A1 ES 2049630A1
Authority
ES
Spain
Prior art keywords
conversion
chloro
carboxylic acid
redn
formanilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9200446A
Other languages
Spanish (es)
Other versions
ES2049630B1 (en
Inventor
Gomez Alvarez-Builla
Lopez Vaquero
Navio Garcia
Arinero Calatayud
Gonzalez Ramos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BYK LEO LABORATORIO FARMACEUTICO, S.L.
Original Assignee
ELMUQUIMICA FARM SL
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Application filed by ELMUQUIMICA FARM SL filed Critical ELMUQUIMICA FARM SL
Priority to ES9200446A priority Critical patent/ES2049630B1/en
Publication of ES2049630A1 publication Critical patent/ES2049630A1/en
Application granted granted Critical
Publication of ES2049630B1 publication Critical patent/ES2049630B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1-Ethyl 6-fluoro-1,4-dihydro- 4-oxo-7-(1-piperazinyl) quinoline 3-carboxylic acid is prepd. by (1) reaction of acetic anhydride with 3-chloro 4-fluoroaniline to give the acetanilide; (2) redn. with diborane to N-ethyl 3-chloro 4-fluoroaniline; (3) reaction with formic acid to give N-ethyl-3-chloro-4-fluoro-formanilide; (4) reaction with POCl3 and ethoxymalonyl chloride and basifying to give 1-ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxo quinoline 3-carboxylic acid; and (5) reaction with piperazine to obtain the required prod.
ES9200446A 1992-02-28 1992-02-28 NEW PROCEDURE FOR OBTAINING THE ACID 1-ETIL-6-FLUORO-1,4-DIHIDRO-4-OXO-7- (1-PIPERACINIL) -3-QUINOLIN CARBOXILICO. Expired - Fee Related ES2049630B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9200446A ES2049630B1 (en) 1992-02-28 1992-02-28 NEW PROCEDURE FOR OBTAINING THE ACID 1-ETIL-6-FLUORO-1,4-DIHIDRO-4-OXO-7- (1-PIPERACINIL) -3-QUINOLIN CARBOXILICO.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9200446A ES2049630B1 (en) 1992-02-28 1992-02-28 NEW PROCEDURE FOR OBTAINING THE ACID 1-ETIL-6-FLUORO-1,4-DIHIDRO-4-OXO-7- (1-PIPERACINIL) -3-QUINOLIN CARBOXILICO.

Publications (2)

Publication Number Publication Date
ES2049630A1 true ES2049630A1 (en) 1994-04-16
ES2049630B1 ES2049630B1 (en) 1994-12-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES9200446A Expired - Fee Related ES2049630B1 (en) 1992-02-28 1992-02-28 NEW PROCEDURE FOR OBTAINING THE ACID 1-ETIL-6-FLUORO-1,4-DIHIDRO-4-OXO-7- (1-PIPERACINIL) -3-QUINOLIN CARBOXILICO.

Country Status (1)

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ES (1) ES2049630B1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292317A (en) * 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
ES8600747A1 (en) * 1985-01-31 1985-11-01 Andreu Sa Dr Piperazinyl quinoline carboxylic acid derivs.
EP0220523A2 (en) * 1985-10-01 1987-05-06 Kanebo, Ltd. Novel quinolinecarboxylic acid compounds, processes for preparing them, pharmaceutical composition and use
ES2010135A6 (en) * 1989-02-10 1989-10-16 Union Quimico Farma Norfloxacin bactericide prepn.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292317A (en) * 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
ES8600747A1 (en) * 1985-01-31 1985-11-01 Andreu Sa Dr Piperazinyl quinoline carboxylic acid derivs.
EP0220523A2 (en) * 1985-10-01 1987-05-06 Kanebo, Ltd. Novel quinolinecarboxylic acid compounds, processes for preparing them, pharmaceutical composition and use
ES2010135A6 (en) * 1989-02-10 1989-10-16 Union Quimico Farma Norfloxacin bactericide prepn.

Also Published As

Publication number Publication date
ES2049630B1 (en) 1994-12-16

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Legal Events

Date Code Title Description
PC2A Transfer of patent

Owner name: BYK LEO LABORATORIO FARMACEUTICO, S.L.

PC2A Transfer of patent
FD1A Patent lapsed

Effective date: 20040916