WO2003010144A3 - A process for synthesis of fluoroquinolonic derivatives - Google Patents

A process for synthesis of fluoroquinolonic derivatives Download PDF

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Publication number
WO2003010144A3
WO2003010144A3 PCT/YU2002/000014 YU0200014W WO03010144A3 WO 2003010144 A3 WO2003010144 A3 WO 2003010144A3 YU 0200014 W YU0200014 W YU 0200014W WO 03010144 A3 WO03010144 A3 WO 03010144A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
group
procedure
fluoroquinolonic
pharmacopoeic
Prior art date
Application number
PCT/YU2002/000014
Other languages
French (fr)
Other versions
WO2003010144A2 (en
Inventor
Slobodan Stankovic
Slobodan Mitov
Caslav Stanojevic
Original Assignee
Farmaceutsko Hemijska Ind Zdra
Slobodan Stankovic
Slobodan Mitov
Caslav Stanojevic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutsko Hemijska Ind Zdra, Slobodan Stankovic, Slobodan Mitov, Caslav Stanojevic filed Critical Farmaceutsko Hemijska Ind Zdra
Publication of WO2003010144A2 publication Critical patent/WO2003010144A2/en
Publication of WO2003010144A3 publication Critical patent/WO2003010144A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A simple and for use convenient procedure for obtaining of antibiotics from the group of fluoroquinolonic derivatives, of general formula (I), is developed where R and R2 denote hydrogen atom, or alkyl group with C1-C4, and R1 denotes alkyl group with C1-C4 or cycloakyl group (such as cyclopropyl group, for example), and/or salts and hydrates thereof, by reaction of piperazin or piperazin derivatives with the compound of general formula VI in an inert solvent of pharmacopoeic purity, at risen temperature. The lower reaction temperature, work at atmospheric pressure, technical simplicity of the procedure of purification by conversion and isolation in the form of pharmaceutically acceptable salts, yield increase, reducing prices on the procedure for industrial use, as well as pharmacopoeic purity of the product, enabled their use as the antibiotics in human and veterinary medicine.
PCT/YU2002/000014 2001-07-25 2002-07-24 A process for synthesis of fluoroquinolonic derivatives WO2003010144A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YUP-534/01 2001-07-25
YUP053401 2001-07-25

Publications (2)

Publication Number Publication Date
WO2003010144A2 WO2003010144A2 (en) 2003-02-06
WO2003010144A3 true WO2003010144A3 (en) 2003-10-16

Family

ID=25550352

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/YU2002/000014 WO2003010144A2 (en) 2001-07-25 2002-07-24 A process for synthesis of fluoroquinolonic derivatives

Country Status (1)

Country Link
WO (1) WO2003010144A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1321121C (en) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 Post processing method for preparing levo-ofloxacin
FR2916446B1 (en) * 2007-05-24 2009-08-21 Biocodex Sa NOVEL PROCESS FOR SYNTHESIZING FLUOROQUINOLONES
CN104447537B (en) * 2014-11-17 2016-08-24 河南大学 A kind of 3,3 '-methylene containing ethyl quinolinium ring-bis-fluoro quinolone derivatives and its preparation method and application
CN113788828B (en) * 2021-10-26 2023-06-30 黄河水利职业技术学院 Preparation method and application of isofraxine analogue from norfloxacin to isofraxine analogue

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2006098A6 (en) * 1988-03-03 1989-04-01 Investchemi S A Ciprofloxacine hydrochloride mono:hydrate prepn.
ES2006099A6 (en) * 1988-03-03 1989-04-01 Investchemi S A Ciprofloxacine hydrochloride mono:hydrate prepn.
ES2010135A6 (en) * 1989-02-10 1989-10-16 Union Quimico Farma Norfloxacin bactericide prepn.
ES2012307A6 (en) * 1989-05-05 1990-03-01 Union Quimico Farma Improvements in the object of Patent 8801824 for procedure for obtaining ciprofloxacin
WO2001002365A1 (en) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Ciprofloxacin hydrates and method for their production

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2006098A6 (en) * 1988-03-03 1989-04-01 Investchemi S A Ciprofloxacine hydrochloride mono:hydrate prepn.
ES2006099A6 (en) * 1988-03-03 1989-04-01 Investchemi S A Ciprofloxacine hydrochloride mono:hydrate prepn.
ES2010135A6 (en) * 1989-02-10 1989-10-16 Union Quimico Farma Norfloxacin bactericide prepn.
ES2012307A6 (en) * 1989-05-05 1990-03-01 Union Quimico Farma Improvements in the object of Patent 8801824 for procedure for obtaining ciprofloxacin
WO2001002365A1 (en) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Ciprofloxacin hydrates and method for their production

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. BOUZARD ET AL: "Fluoronaphthridine and Quinolones as Antibacterial agents. 2. Synthesis and Structure-activity Relationships of New 1-tert-Butyl-7-substituted Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 5, 1990, pages 1344 - 1352, XP002220084, ISSN: 0022-2623 *
KOGA H ET AL: "STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBACTERIAL 6,7- AND 7,8-DISUBSTITUTED 1-ALKYL- 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 23, no. 12, 1 December 1980 (1980-12-01), pages 1358 - 1363, XP000654167, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2003010144A2 (en) 2003-02-06

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