ES2008753A6 - Procedimiento de preparacion de una composicion farmaceutica de liberacion controlada. - Google Patents
Procedimiento de preparacion de una composicion farmaceutica de liberacion controlada.Info
- Publication number
- ES2008753A6 ES2008753A6 ES8703025A ES8703025A ES2008753A6 ES 2008753 A6 ES2008753 A6 ES 2008753A6 ES 8703025 A ES8703025 A ES 8703025A ES 8703025 A ES8703025 A ES 8703025A ES 2008753 A6 ES2008753 A6 ES 2008753A6
- Authority
- ES
- Spain
- Prior art keywords
- release
- eudragit
- buflomedil hydrochloride
- manufacture
- medicinal preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZDPACSAHMZADFZ-UHFFFAOYSA-N 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride Chemical compound [Cl-].COC1=CC(OC)=CC(OC)=C1C(=O)CCC[NH+]1CCCC1 ZDPACSAHMZADFZ-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002113 buflomedil hydrochloride Drugs 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract 3
- 229940117841 methacrylic acid copolymer Drugs 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 229920003161 Eudragit® RS 30 D Polymers 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- 229920003148 Eudragit® E polymer Polymers 0.000 abstract 1
- 229920003159 Eudragit® RS 100 Polymers 0.000 abstract 1
- 229920003152 Eudragit® RS polymer Polymers 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 abstract 1
- 239000011247 coating layer Substances 0.000 abstract 1
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 abstract 1
- FSXVSUSRJXIJHB-UHFFFAOYSA-M ethyl prop-2-enoate;methyl 2-methylprop-2-enoate;trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CCOC(=O)C=C.COC(=O)C(C)=C.CC(=C)C(=O)OCC[N+](C)(C)C FSXVSUSRJXIJHB-UHFFFAOYSA-M 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
ESTE PROCEDIMIENTO DE PREPARACION DE UNA COMPOSICION FARMACEUTICA DE LIBERACION CONTROLADA EN BASE A HIDROCLORURO DE BUFLOMEDIL CON LA UTILIZACION DE COPOLIMEROS METRACRILICOS, CONSISTENTE EN LAS SIGUIENTES FASES: A) AMASAR HC1 DE BUFLOMEDIL CON LOS COPOLIMEROS METRACRILICOS, B) GRANULACION, C) REVESTIMIENTO POR COPOLIMEROS METRACRILICOS. ESTA COMPOSICION FARMACEUTICA SE UTILIZA EN CASOS DE INSUFICIENCIAS CIRCULATORIAS, ARTERIOPATIAS, DESORDENES VASOMOTORES DE LOS MIEMBROS E INSUFICIENCIAS VASCULARES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8622082A IT1213508B (it) | 1986-10-22 | 1986-10-22 | Preparato farmaceutico a base di buflomedil cloridrato, sotto formadi compresse a rilascio controllato e relativo procedimento di preparazione. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2008753A6 true ES2008753A6 (es) | 1989-08-01 |
Family
ID=11191221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8703025A Expired ES2008753A6 (es) | 1986-10-22 | 1987-10-22 | Procedimiento de preparacion de una composicion farmaceutica de liberacion controlada. |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS63183529A (es) |
| ES (1) | ES2008753A6 (es) |
| IT (1) | IT1213508B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2676364B1 (fr) * | 1991-05-17 | 1993-09-10 | Lafon Labor | Composition pharmaceutique a base de derives d'aminobutanone. |
| DE4317172A1 (de) * | 1993-05-22 | 1995-01-05 | Rhone Poulenc Rorer Gmbh | Geschmacksneutrale und schnellfreisetzende Buflomedil-Hydrochlorid-Arzneiform und Herstellungsverfahren desselben |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5244224A (en) * | 1975-10-01 | 1977-04-07 | Yamanouchi Pharmaceut Co Ltd | Printing on sugar-coated tablets |
| JPS5758631A (en) * | 1980-09-24 | 1982-04-08 | Toyo Jozo Co Ltd | Coating composition |
| JPS5883613A (ja) * | 1981-11-10 | 1983-05-19 | Toa Eiyou Kagaku Kogyo Kk | 硝酸イソソルビト−ル製剤 |
| JPS59110628A (ja) * | 1982-12-17 | 1984-06-26 | Sumitomo Chem Co Ltd | 胃溶性被覆薬剤の製造方法 |
| IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| JPS60101011A (ja) * | 1983-11-08 | 1985-06-05 | Toshiba Corp | 樹脂モ−ルド品の製造方法 |
| JPS61148115A (ja) * | 1984-12-21 | 1986-07-05 | Tooa Eiyoo Kk | 難溶性薬物の徐放性製剤及びその製造法 |
-
1986
- 1986-10-22 IT IT8622082A patent/IT1213508B/it active
-
1987
- 1987-10-22 ES ES8703025A patent/ES2008753A6/es not_active Expired
- 1987-10-22 JP JP26915487A patent/JPS63183529A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IT1213508B (it) | 1989-12-20 |
| JPS63183529A (ja) | 1988-07-28 |
| IT8622082A0 (it) | 1986-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-10-22 |
|
| FD1A | Patent lapsed |
Effective date: 20001023 |