ES2000330A6 - Procedkimiento para la preparacion de derivados de n-metilados de la ergolina - Google Patents

Procedkimiento para la preparacion de derivados de n-metilados de la ergolina

Info

Publication number
ES2000330A6
ES2000330A6 ES8600251A ES8600251A ES2000330A6 ES 2000330 A6 ES2000330 A6 ES 2000330A6 ES 8600251 A ES8600251 A ES 8600251A ES 8600251 A ES8600251 A ES 8600251A ES 2000330 A6 ES2000330 A6 ES 2000330A6
Authority
ES
Spain
Prior art keywords
denotes
hydrogen atom
ergoline
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600251A
Other languages
English (en)
Inventor
Christian Gervais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES2000330A6 publication Critical patent/ES2000330A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS N-METILADOS DE LA ERGOLINA DE FORMULA GENERAL (I) POR METILACION DE UN DERIVADO DE LA ERGOLINA DE FORMULA GENERAL (II) POR MEDIO DE CARBONATO DE METILO EN PRESENCIA DE UN AGENTE ALCALINO OPERANDO EN UN DISOLVENTE APROTICO APOLAR EN PRESENCIA DE UN CATALIZADOR DE TRANSFERENCIA DE FASE. EN LAS FORMULAS GENERALES (I,II), R1 REPRESENTA CARBOXI, ALQUILOXICARBONILO O HIDROXIMETILO, R2 REPRESENTA HIDROGENO O METOXI, R3 REPRESENTA HIDROGENO O FORMA CON R2 UN ENLACE.
ES8600251A 1985-07-11 1986-07-11 Procedkimiento para la preparacion de derivados de n-metilados de la ergolina Expired ES2000330A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8510620A FR2584720B1 (fr) 1985-07-11 1985-07-11 Procede de preparation de derives n-methyles de l'ergoline

Publications (1)

Publication Number Publication Date
ES2000330A6 true ES2000330A6 (es) 1988-02-16

Family

ID=9321195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600251A Expired ES2000330A6 (es) 1985-07-11 1986-07-11 Procedkimiento para la preparacion de derivados de n-metilados de la ergolina

Country Status (11)

Country Link
US (1) US4754037A (es)
EP (1) EP0208622B1 (es)
JP (1) JPH0667936B2 (es)
KR (1) KR930010497B1 (es)
AT (1) ATE44742T1 (es)
CA (1) CA1261319A (es)
DE (1) DE3664471D1 (es)
ES (1) ES2000330A6 (es)
FR (1) FR2584720B1 (es)
GR (1) GR861782B (es)
PT (1) PT82934B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584719B1 (fr) * 1985-07-11 1987-10-02 Rhone Poulenc Sante Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol
US6063908A (en) * 1996-07-02 2000-05-16 Roche Diagnostics Corporation Reagents for lysergic acid diethylamide immunoassay
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
CN113480532B (zh) * 2021-07-06 2022-08-16 福安药业集团重庆博圣制药有限公司 一种尼麦角林合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
CA631701A (en) * 1961-11-28 Sandoz A.G. Compounds of the lysergic acid series alkylated at the indol nitrogen atom
US3228943A (en) * 1962-06-11 1966-01-11 Lumilysergol derivatives
AT251200B (de) * 1962-07-13 1966-12-27 Farmaceutici Italia Verfahren zur Herstellung neuer Derivate von Dihydro-D-lysergsäureamid und 1-Methyl-dihydro-D-lysergsäureamid
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
DE2618033A1 (de) * 1976-04-24 1977-11-10 Basf Ag Verfahren zur herstellung von aralkylarylaminen und alkylarylaminen
YU40004B (en) * 1977-07-21 1985-06-30 Lek Tovarna Farmacevtskih Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
IT1094965B (it) * 1978-04-05 1985-08-10 Corvi Mora E Procedimento di preparazione di derivati del lisergolo
IT1114212B (it) * 1979-03-07 1986-01-27 Anic Spa Procedimento per la preparazione di alchil ammine aromatiche
CS231214B1 (en) * 1982-03-12 1984-10-15 Antonin Cerny Processing method of 1-substituted n+l8alpha-ergoline+p-n,diethyl urea

Also Published As

Publication number Publication date
FR2584720B1 (fr) 1987-10-02
DE3664471D1 (en) 1989-08-24
ATE44742T1 (de) 1989-08-15
PT82934A (fr) 1986-08-01
KR870001208A (ko) 1987-03-12
EP0208622A1 (fr) 1987-01-14
GR861782B (en) 1986-11-10
KR930010497B1 (ko) 1993-10-25
US4754037A (en) 1988-06-28
PT82934B (pt) 1989-01-30
EP0208622B1 (fr) 1989-07-19
FR2584720A1 (fr) 1987-01-16
JPS6216482A (ja) 1987-01-24
JPH0667936B2 (ja) 1994-08-31
CA1261319A (fr) 1989-09-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040712