EP4166147A4 - Sensibilisator zur krebsbehandlung - Google Patents

Sensibilisator zur krebsbehandlung Download PDF

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Publication number
EP4166147A4
EP4166147A4 EP21825603.0A EP21825603A EP4166147A4 EP 4166147 A4 EP4166147 A4 EP 4166147A4 EP 21825603 A EP21825603 A EP 21825603A EP 4166147 A4 EP4166147 A4 EP 4166147A4
Authority
EP
European Patent Office
Prior art keywords
sensitizer
cancer treatment
cancer
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP21825603.0A
Other languages
English (en)
French (fr)
Other versions
EP4166147A1 (de
Inventor
Somaiah NAVITA
Yasuhiro Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kortuc Inc
Original Assignee
Kortuc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kortuc Inc filed Critical Kortuc Inc
Publication of EP4166147A1 publication Critical patent/EP4166147A1/de
Publication of EP4166147A4 publication Critical patent/EP4166147A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP21825603.0A 2020-06-15 2021-06-14 Sensibilisator zur krebsbehandlung Withdrawn EP4166147A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020103121 2020-06-15
PCT/JP2021/022520 WO2021256427A1 (ja) 2020-06-15 2021-06-14 抗がん療法の増感剤

Publications (2)

Publication Number Publication Date
EP4166147A1 EP4166147A1 (de) 2023-04-19
EP4166147A4 true EP4166147A4 (de) 2024-08-07

Family

ID=79268070

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21825603.0A Withdrawn EP4166147A4 (de) 2020-06-15 2021-06-14 Sensibilisator zur krebsbehandlung

Country Status (11)

Country Link
US (1) US20230330230A1 (de)
EP (1) EP4166147A4 (de)
JP (2) JPWO2021256427A1 (de)
CN (1) CN115803035A (de)
AU (1) AU2021292668A1 (de)
BR (1) BR112022025512A2 (de)
CA (1) CA3182871A1 (de)
IL (1) IL298758A (de)
MX (1) MX2022015897A (de)
WO (1) WO2021256427A1 (de)
ZA (1) ZA202213321B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4475905A4 (de) * 2022-02-11 2026-03-25 Insitu Biologics Inc Krebstherapeutikaformulierungen mit verzögerter freisetzung
JP7684719B2 (ja) * 2023-02-17 2025-05-28 合同会社Kortuc Japan 腫瘍に対する免疫を賦活させるための医薬組成物及びその方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078528A1 (de) * 2006-09-22 2009-07-15 Kochi University Strahlensensibilisator oder chemotherapie-sensibilisator gegen krebs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63123392A (ja) 1986-11-14 1988-05-27 Denki Kagaku Kogyo Kk ヒアルロン酸の製造方法
JP2587268B2 (ja) 1988-04-18 1997-03-05 チッソ株式会社 低粘度ヒアルロン酸又はその塩の製造方法
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
JPH02234689A (ja) 1989-03-09 1990-09-17 Denki Kagaku Kogyo Kk ヒアルロン酸の製造方法
US5051257A (en) * 1989-05-09 1991-09-24 Pietronigro Dennis D Antineoplastic solution and method for treating neoplasms
EP1005874B1 (de) 1997-08-22 2005-05-18 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronsäure-gel, verfahren zur dessen herstellung und hyaluronsäure-gel enthaltendes medizinisches material
WO2001024684A2 (en) * 1999-10-07 2001-04-12 Aguilar Cordova Carlos Estuard Methods for treatment of solid tumors and metastasis by gene therapy
KR100620291B1 (ko) 2000-02-03 2006-09-13 덴끼 가가꾸 고교 가부시키가이샤 히알루론산 겔, 이의 제조방법 및 이를 함유하는 의용재료
JP4958368B2 (ja) 2002-02-28 2012-06-20 電気化学工業株式会社 架橋ヒアルロン酸
RU2326691C2 (ru) * 2002-07-18 2008-06-20 Хеликс Биофарма Корп. Использование уреазы для ингибирования роста раковых клеток
JP2006345701A (ja) * 2003-07-01 2006-12-28 Taisho Pharmaceut Co Ltd タキサン類応答性の判別方法
RU2415670C2 (ru) * 2005-04-01 2011-04-10 Тайхо Фармасьютикал Ко., Лтд. Усиливающий агент для радиационной терапии, включающий производное пиридина в качестве активного ингредиента
EP2957287B1 (de) * 2013-02-15 2019-04-03 KORTUC Inc. Strahlungs-/chemotherapiesensibilisator zur lokalen intratumoralen injektion und zur kontrollierten freisetzung von wasserstoffperoxid mit hydrogel als träger

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078528A1 (de) * 2006-09-22 2009-07-15 Kochi University Strahlensensibilisator oder chemotherapie-sensibilisator gegen krebs

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
NAOYA HAYASHI ET AL: "Computed Tomography Demonstration of the Production and Distribution of Oxygen Gas Following Intratumoral Injection of a New Radiosensitizer (KORTUC) for Patients with Breast Cancer-Is Intratumoral Injection Not an Ideal Approach to Solve the Major Problem of Tumor Hypoxia in Radiotherapy?", CANCERS, vol. 8, no. 4, 1 April 2016 (2016-04-01), CH, pages 43, XP093168139, ISSN: 2072-6694, DOI: 10.3390/cancers8040043 *
NIMALASENA SAMANTHA ET AL: "Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, USA, vol. 108, no. 4, 22 June 2020 (2020-06-22), pages 1019 - 1029, XP086298855, ISSN: 0360-3016, [retrieved on 20200622], DOI: 10.1016/J.IJROBP.2020.06.022 *
R AKIMA: "New enzyme-targeting radiosensitizer (kortuc) containing hydrogen peroxide & sodium hyaluronate for intratumoral injection using mice transplanted with sccvii tumor", INTERNATIONAL JOURNAL OF CANCER AND CLINICAL RESEARCH, vol. 3, no. 2, 21 March 2016 (2016-03-21), pages 048, XP093167445, ISSN: 2378-3419 *
S NIMALASENA: "Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial - Supplementary Material", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS., vol. 108, no. 4, 22 June 2020 (2020-06-22), USA, XP093168112, ISSN: 0360-3016, DOI: 10.1016/j.ijrobp.2020.06.022 *
See also references of WO2021256427A1 *

Also Published As

Publication number Publication date
US20230330230A1 (en) 2023-10-19
ZA202213321B (de) 2024-04-24
WO2021256427A1 (ja) 2021-12-23
IL298758A (en) 2023-02-01
CA3182871A1 (en) 2021-12-23
BR112022025512A2 (pt) 2023-01-17
MX2022015897A (es) 2023-01-24
JPWO2021256427A1 (de) 2021-12-23
CN115803035A (zh) 2023-03-14
EP4166147A1 (de) 2023-04-19
AU2021292668A1 (en) 2023-02-09
JP2022168328A (ja) 2022-11-07

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