EP4153093A1 - Ensemble pour dispositif de fermeture implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, et prothèse de valvule tricuspide pouvant être implantée de manière minimalement invasive - Google Patents

Ensemble pour dispositif de fermeture implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, et prothèse de valvule tricuspide pouvant être implantée de manière minimalement invasive

Info

Publication number
EP4153093A1
EP4153093A1 EP21731899.7A EP21731899A EP4153093A1 EP 4153093 A1 EP4153093 A1 EP 4153093A1 EP 21731899 A EP21731899 A EP 21731899A EP 4153093 A1 EP4153093 A1 EP 4153093A1
Authority
EP
European Patent Office
Prior art keywords
elements
arrangement according
closure elements
closure
support structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21731899.7A
Other languages
German (de)
English (en)
Inventor
Christian Butter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immanuel Albertinen Diakonie GmbH
Original Assignee
Immanuel Albertinen Diakonie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immanuel Albertinen Diakonie GmbH filed Critical Immanuel Albertinen Diakonie GmbH
Publication of EP4153093A1 publication Critical patent/EP4153093A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2403—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with pivoting rigid closure members
    • A61F2/2406—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with pivoting rigid closure members without fixed axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2403—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with pivoting rigid closure members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475—Venous valves

Definitions

  • Arrangement for a closure device which can be implanted minimally invasively in the upper or lower vena cava of a human body and a minimally invasively implantable tricuspid valve prosthesis
  • the invention relates to an arrangement for a closure device that can be implanted minimally invasively in the upper or lower vena cava of a human body, and a tricuspid valve prosthesis that can be implanted minimally invasively.
  • a minimally invasively implantable mitral or tricuspid valve prosthesis is known from document EP 3 231 393 A1.
  • the valve prosthesis is firmly connected to a self-expanding, wide-meshed stent for positioning and fixing, the shape of which is adapted to a three-dimensionally measured geometry of a patient's left or right atrium and, after implantation, rests against the inner wall of the forecourt.
  • the object of the invention is to provide an arrangement for a closure device that can be implanted minimally invasively in the upper or lower vena cava of a human body, as well as a minimally invasively implantable tricuspid valve prosthesis that can be reliably localized at the site of implantation and that opens and closes reliably enable.
  • the independent claim 15 relates to a minimally invasive implantable tricuspid plate prosthesis. Further refinements are the subject of the dependent subclaims.
  • an arrangement is created for a closure device that can be implanted minimally invasively in the upper or the inferior vena cava of a human body, which has the following: a valve device, having closure elements which extend flat over a respective element surface and each between a closed position in which the closure elements jointly close a valve opening, and an opening position can be displaced in which a flow through the valve opening is exposed. ben is, and a support structure which is arranged in the region of the valve opening and is formed with support elements and at least one opening. In the closed position, the closure elements rest at least partially on the support elements and, in the open position, are at least partially spaced from the support elements and thus open the opening for the flow.
  • the arrangement also has an anchoring device which is formed with an anchorage and is designed to anchor the valve device in the region of the upper or lower vena cava adjacent to the vein opening to the right atrium of the heart.
  • a minimally invasively implantable tricuspid valve prosthesis with such an arrangement is created.
  • the proposed closure device can be securely fixed at the implantation site with the aid of the anchoring device.
  • the valve device with the closure elements ensures reliable opening and closing in order to prevent or allow the flow.
  • valve opening is designed as a round or circular Ventilöff voltage.
  • the support structure can be designed to extend over part of the surface of the valve opening or over the entire surface thereof.
  • the closure elements can be designed as non-rigid closure elements which (optionally additionally) bend in order to pivot open into the open position so that the flow is released.
  • one or more of the closure elements are essentially rigid in area.
  • the rigid closure element pivots between the closed and the geöff Neten position, essentially maintaining the surface shape of the closure element in the closed position.
  • a hinge device can be provided, for example.
  • the opening can be designed with an opening in the area of the center of the valve opening.
  • one or more further openings can be provided in the support structure.
  • a Sieve insert can be provided, which is detachably or non-detachably arranged in the area of the associated opening on the support structure.
  • Adjacent closure elements can overlap at least in the closed position in edge-side sections, and the support elements can extend at least along the overlapping edge-side sections.
  • the support elements can optionally run additionally outside the overlap areas in order to also support the closure elements outside the overlap areas.
  • the valve device can be designed as a one-way valve. This means that the valve device lets through in one flow direction and blocks in the opposite direction, which is achieved with the help of the closure elements resting on the support structure in the closed position, which can at least partially lift off the support structure in the flow direction in order to release the flow.
  • the closure elements can each be formed to encompass a circular cutout area, with adjacent closure elements overlapping along the radii laterally delimiting the circular cutout area.
  • the closure elements are designed to be comparable in plan view to the shape of a piece of cake.
  • the circular segment surface can be rounded. It can also be provided that a radially inner end section of the circular segment surface is cut off in the region of the tip.
  • the radially inner tip sections of the circular cutout surfaces of the closure elements can overlap in the area of the opening.
  • An overlap area formed in this way can have a size (expansion) of approximately 1 mm to approximately 4 mm in at least one direction, alternatively of approximately 1 mm to approximately 2 mm.
  • the closure elements can each cover a section of a circle of at least approximately 90 degrees.
  • four closure elements can be provided in order to jointly close the valve opening in the closed position.
  • the respective segments of a circle can cover an angle of at most approximately 120 degrees to approximately 130 degrees.
  • the closure elements can be fastened at least in sections along an outer circumferential edge, in such a way that a section of the closure element lying radially inward with respect to the circumferential edge can pivot open into the open position and thus release the flow.
  • the fastening of the closure elements along the outer circumferential edge can be detachable or non-detachable.
  • a joint connection can be provided, for example by means of gluing or welding.
  • the closure elements can be molded in one piece onto the anchoring device and / or the support structure, for example by means of 2-component injection molding.
  • the anchoring device and / or on the support structure can be made of a hard plastic component
  • the closure elements can be made of a soft plastic component.
  • the fastening of the closure elements along the outer circumferential edge can encompass an arc of about 60 degrees to about 110 degrees, alternatively an arc of about 90 degrees to 110 degrees, for example about 105 degrees. If the closure elements are formed as circular sections, corner areas in which the outer circular arc meets the laterally delimiting radii can be designed so that they are not subject to attachment.
  • the opening in the support structure can have a throughflow nozzle.
  • the opening can be arranged essentially centered in the valve opening.
  • a nozzle surface extending transversely to the direction of flow or throughflow of the valve device can be arranged essentially parallel to the valve opening surface extending transversely to the direction of flow or throughflow.
  • the nozzle surface can lie essentially in the same plane as the valve opening surface.
  • the nozzle surface is arranged offset (at a distance) from the valve opening surface in the flow direction.
  • the offset can be, for example, approximately 5 mm to approximately 12 mm, alternatively approximately 7 mm to approximately 10 mm, for example approximately 8 mm to approximately 9 mm.
  • the opening can be formed with a diameter of approximately 2 mm to approximately 6 mm, alternatively with a diameter of approximately 4 mm to approximately 5 mm.
  • the throughflow nozzle can be designed in a comparable manner.
  • the support structure can have support elements which extend in a star shape, for example along circular radii of the valve opening.
  • the star-shaped supporting elements which are designed, for example, as supporting webs, can extend from the opening or the flow-through nozzle to an edge of the supporting structure.
  • the support elements arranged in a star shape can be essentially the same radially circumferentially be spaced apart, for example at a distance of about 90 degrees to about 120 degrees.
  • the support elements for example designed as webs, can have a shape tapering towards a support surface in cross-section, the closure elements coming to rest in the closed position in the region of the support surface.
  • the support elements can have a width of approximately 1 mm to approximately 5 mm, alternatively from approximately 1 mm to approximately 3 mm, for example from approximately 1.5 mm to approximately 2.5 mm. If the support elements are designed as webs, this gives a web width in plan view of the valve opening.
  • the support structure can support the closure elements in the closed position in a substantially two-dimensional flat plane.
  • the opening area of the aperture can be located transversely to the direction of flow or flow essentially in the plane of the valve opening area.
  • a flat support surface is provided for the closure elements by means of the support structure.
  • the support structure can support the closure elements in the closed position in a curved three-dimensional plane.
  • a three-dimensionally shaped support surface is provided for the closure elements by means of the support structure.
  • the support structure can be formed with a bell shape, so that a bell-shaped support surface is provided. It can be provided that the opening surface of the opening or the throughflow nozzle is arranged offset in the throughflow or flow direction relative to the valve opening surface.
  • a flexible sealing collar can be provided.
  • the flexible sealing collar can be formed circumferentially around the valve device.
  • the anchoring device can have at least one of the following anchoring sections: a first anchoring section which is covered with pericardium or a synthetic membranous plastic material, and a second anchoring section which is free of pericardium and the synthetic membranous plastic material.
  • the anchorage can be formed with a self-expanding anchorage.
  • the self-expanding anchorage can have at least one anchorage from the following group: self-expanding spiral element and self-expanding stent.
  • closure elements can consist of a biological material. Some of the closure elements can consist of a non-biological material. Alternatively, all closure elements can be made from a non-biological material.
  • FIG. 1 shows a schematic perspective illustration of a closure device implanted in the region of a vein
  • FIG. 2 shows a schematic representation of a valve device in a closed position from above, in which the closure elements rest on a support structure
  • FIG. 3 shows a schematic perspective illustration of a support structure for locking elements with a three-dimensional support
  • FIG. 4 shows a schematic perspective illustration of a support structure with a two-dimensional support
  • FIG. 5 shows a schematic representation of the valve device from FIG. 2 in an open position, in which the closure elements are arranged at least partially lifted from the support structure;
  • FIG. 6 shows a schematic illustration of a closure element which is fixed along part of the outer circular arc
  • FIG. 7 shows a schematic representation of a section of the support structure with a flow nozzle and support elements extending therefrom in a star shape.
  • FIG. 1 shows a schematic perspective illustration of a minimally invasively implanted closure device 1 in the region of a vein 2.
  • the flow in the vein can be opened and closed, with a flow only in the area shown in FIG shown flow or flow direction is enabled.
  • the closure device 1 closes in the opposite direction and thus prevents backflow.
  • a section of a vena cava 3, a section of a hepatic vein 4 and a section of the right atrium of the heart 5 are shown.
  • the closure device 1 has a valve device 6, an anchoring device 7 and a flexible sealing ring 8 which is formed circumferentially.
  • the anchoring device 7 is formed as a self-expanding anchoring with a spiral 9.
  • Fig. 2 shows a schematic representation of the valve device 6 in a closed position, in which no flow takes place, from above.
  • closure elements 10 rest on support elements 11 of a support structure 12, for which FIGS. 3 and 4 show different designs.
  • the closure elements 10 come to rest in overlap regions 13 on the support elements 11, in which edge-side sections 13a of the closure elements 10 overlap.
  • the closure elements 10 are formed as circular sections which are each delimited by a circular arc 10a and two radii 10b, 10c. In the area of the radii 10b, 10c, the overlap areas 13 are formed between adjacent closure elements 10.
  • the circular sections of the locking elements 10 each cover an area of slightly more than 120 degrees in order to form the overlap areas 13.
  • the support elements 11 of the support structure 12 extend in a star shape starting from a central region 14 and are arranged equally spaced around the circumference.
  • the support structure has a circumferential edge 15 (cf. in particular FIGS. 3 and 4).
  • FIGS. 3 and 4 show schematic perspective representations of different embodiments for the support structure 12. The same reference numerals are used in FIGS. 3 and 4 for the same features.
  • a three-dimensional support 20 is formed for the closure elements 10.
  • An opening surface 21 of an opening 22 in the central region 14 is arranged offset in the direction of flow or throughflow relative to the valve opening surface, which is surrounded by the circumferential edge 15.
  • FIG. 4 shows an alternative embodiment of the support structure 12, in which a two-dimensional, flat support 30 is provided for the closure elements 10.
  • FIG. 5 shows a schematic perspective illustration of the valve device 6 in an open position, in which the closure elements 10 are lifted (pivoted open) from the support elements 11 of the support structure 12 at least in the central region 14, so that the opening 22 and further opening areas 17 of the support structure 12 are released and a flow is enabled.
  • a sieve insert 18 is provided in the region of the valve opening, which can be detachably or non-detachably connected to the support structure 12.
  • the closure elements 10 are designed as non-rigid closure elements which bend upwards in order to release the flow.
  • the closure elements 10 can be made of a plastic material, for example.
  • the closure elements 10 can be arranged on the support structure 12 by means of a joint connection, for example by means of gluing or welding.
  • Fig. 6 shows schematically a closure element 10 which is designed as a section of a circle.
  • the closure element 10 is fastened to the support structure 12 along a connection area 40 which extends along the circular arc 10 a. Outside the connection area 40, the closure element 10 is free from a connection with the support structure 12, in particular also in corner areas 41, 42 in which the radii 10b, 10c and the circular arc 10a of the circular segment meet.
  • FIG. 7 shows a section of the support structure 12 in the central region 14 with the opening 22 which, in the embodiment shown, is formed with a flow nozzle 50.
  • support elements 11 extend in a star shape.

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention se rapporte à un ensemble destiné à un dispositif de fermeture (1) qui est implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, ayant un dispositif de valve (6) et un dispositif d'ancrage (7). Le dispositif de valve (6) comprend des éléments de fermeture et une structure de support. Les éléments de fermeture s'étendent de manière bidimensionnelle sur une surface d'élément respective et sont chacun transférable entre une position fermée, dans laquelle les éléments de fermeture ferment ensemble une ouverture de valve, et une position ouverte, dans laquelle un écoulement à travers l'ouverture de valve est permis. La structure de support est disposée dans la zone de l'ouverture de valve et est pourvue d'éléments de support et d'au moins un passage, les éléments de fermeture, en position fermée, s'appuyant au moins partiellement sur les éléments de support et, dans la position ouverte, étant au moins partiellement espacés des éléments de support et permettant ainsi l'écoulement à travers le passage. Le dispositif d'ancrage (7) présente une ancre et est conçu pour ancrer le dispositif de valve (6) dans la zone de la veine cave supérieure ou inférieure, adjacente à l'ouverture de la veine dans l'oreillette droite du cœur. L'invention se rapporte en outre à une prothèse de valvule tricuspide qui peut être implantée de manière minimalement invasive.
EP21731899.7A 2020-05-19 2021-05-18 Ensemble pour dispositif de fermeture implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, et prothèse de valvule tricuspide pouvant être implantée de manière minimalement invasive Pending EP4153093A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020113585.8A DE102020113585A1 (de) 2020-05-19 2020-05-19 Anordnung für eine in die obere oder die untere Hohlvene eines menschlichen Körpers minimal-invasiv implantierbare Verschlusseinrichtung und minimal-invasiv implantierbare Trikuspidalklappen-Prothese
PCT/DE2021/100441 WO2021233502A1 (fr) 2020-05-19 2021-05-18 Ensemble pour dispositif de fermeture implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, et prothèse de valvule tricuspide pouvant être implantée de manière minimalement invasive

Publications (1)

Publication Number Publication Date
EP4153093A1 true EP4153093A1 (fr) 2023-03-29

Family

ID=76421880

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21731899.7A Pending EP4153093A1 (fr) 2020-05-19 2021-05-18 Ensemble pour dispositif de fermeture implantable dans la veine cave supérieure ou inférieure d'un corps humain de manière minimalement invasive, et prothèse de valvule tricuspide pouvant être implantée de manière minimalement invasive

Country Status (7)

Country Link
US (1) US20230181315A1 (fr)
EP (1) EP4153093A1 (fr)
JP (1) JP2023526079A (fr)
CN (1) CN115666448A (fr)
CA (1) CA3178779A1 (fr)
DE (1) DE102020113585A1 (fr)
WO (1) WO2021233502A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007018A2 (fr) * 2003-07-16 2005-01-27 The Regents Of The University Of California Dispositifs biomedicaux implantables en alliage metallique sous forme de film mince
DE102008012438B4 (de) * 2008-02-29 2014-12-24 Nvt Ag Mechanische Aortenklappe für die endovaskuläre Implantation
EP3231393B1 (fr) 2016-04-13 2023-06-21 Christian Vallbracht Valve tricuspide et mitrale implantable a invasion minimale

Also Published As

Publication number Publication date
CN115666448A (zh) 2023-01-31
DE102020113585A1 (de) 2021-11-25
CA3178779A1 (fr) 2021-11-25
WO2021233502A1 (fr) 2021-11-25
JP2023526079A (ja) 2023-06-20
US20230181315A1 (en) 2023-06-15

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