EP4146173A1 - Formulations de modulateurs de récepteurs de glucocorticoïdes de type pyrimidine cyclohexyle - Google Patents

Formulations de modulateurs de récepteurs de glucocorticoïdes de type pyrimidine cyclohexyle

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Publication number
EP4146173A1
EP4146173A1 EP21800134.5A EP21800134A EP4146173A1 EP 4146173 A1 EP4146173 A1 EP 4146173A1 EP 21800134 A EP21800134 A EP 21800134A EP 4146173 A1 EP4146173 A1 EP 4146173A1
Authority
EP
European Patent Office
Prior art keywords
amount
mixture
composition
compound
blending
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21800134.5A
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German (de)
English (en)
Other versions
EP4146173A4 (fr
Inventor
Yip-Fong CHIA
Stephen ARBOLEDA
Yan ALSMEYER
Gordon Davis
Tyler CLIKEMAN
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Corcept Therapeutics Inc
Original Assignee
Corcept Therapeutics Inc
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Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of EP4146173A1 publication Critical patent/EP4146173A1/fr
Publication of EP4146173A4 publication Critical patent/EP4146173A4/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Definitions

  • cortisol hydrocortisone
  • Glucocorticoids are secreted in response to ACTH (corticotropin), which shows both circadian rhythm variation and elevations in response to stress and food.
  • Cortisol levels are responsive within minutes to many physical and psychological stresses, including trauma, surgery, exercise, anxiety and depression.
  • Cortisol is a steroid and acts by binding to an intracellular, glucocorticoid receptor (GR).
  • GR glucocorticoid receptor
  • a mineralocorticoid receptor (MR) also known as a type I glucocorticoid receptor (GR I)
  • MR mineralocorticoid receptor
  • GR I type I glucocorticoid receptor
  • compositions including modulators of one or both of GR and MR may be used to treat a variety of diseases and disorders.
  • GR may be present in two forms: a ligand-binding GR-alpha of 777 amino acids; and, a GR-beta isoform which lacks the 50 carboxy terminal residues. Since these residues include the ligand binding domain, GR-beta is unable to bind the natural ligand, and is constitutively localized in the nucleus.
  • the biologic effects of cortisol can be modulated at the GR level using receptor modulators, such as agonists, partial agonists and antagonists.
  • receptor modulators such as agonists, partial agonists and antagonists.
  • Several different classes of agents are able to inhibit the physiologic effects of GR-agonist binding. These antagonists include compositions which, by binding to GR, inhibit the ability of an agonist to effectively bind to and/or activate the GR.
  • One such known GR antagonist, mifepristone has been found to be an effective anti-glucocorticoid agent in humans (Bertagna (1984) J. Clin. Endocrinol. Metab. 59:25). Mifepristone binds to the GR with high affinity, with a dissociation constant (Kd) of 10 M (Cadepond (1997) Amur Rev. Med. 48:129).
  • Hepatic steatosis also referred to as fatty liver disease, is a cellular pathology that manifests in the intracellular accumulation of triglycerides and lipids by hepatocytes.
  • Hepatic steatosis is a prevalent liver condition that may arise from a number of etiologies. Such liver disorders include fatty liver disease, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), alcohol-induced fatty liver disease (AFLD), drug- or alcohol-related liver diseases, viral diseases, immune-mediated liver diseases, metabolic liver diseases, and complications associated with hepatic insufficiency and/or liver transplantation.
  • Nonalcoholic fatty liver disease is a common hepatic disorder with histological features similar to those of alcohol-induced fatty liver disease, in individuals who consume little or no alcohol. Effective treatments for hepatic steatosis remain insufficient. To date, no therapeutic drug treatment is established for such patients. Thus, there is a need for novel therapeutic options for managing hepatic steatosis.
  • antipsychotic medication is an important treatment for many psychiatric disorders, and provides significant relief to the nearly 20 million patients suffering from such disorders.
  • antipsychotic medications such as olanzapine, risperidine, clozapine, quetiapine, sertindole, and other such medications, often lead to significant weight gain as well as alleviating psychotic symptoms.
  • Numerous reports indicate that about 40-80% of patients who receive antipsychotic medications for long periods of time experience substantial weight gain, ultimately exceeding their ideal body weight by 20% or more (see, e.g., Umbricht et al., J Clin. Psychiatry 55 (Suppl. B): 157-160, 1994; Baptista, Acta Psychiatr.
  • the present invention provides a composition comprising:
  • a sustaining polymer in an amount from 10.0 to 32.0% (w/w); microcrystalline cellulose in an amount from 10.0 to 25.0% (w/w); and croscarmellose sodium (Ac-Di-Sol) in an amount from 5.0 to 11.0% (w/w).
  • the present invention provides a method of preparing a composition of the present invention, including: a) forming a mixture comprising a solvent, poly[(methyl methacrylate)-co- (methacrylic acid)], and Compound I, (E)-6-(4-Phenylcyclohexyl)-5-(3- trifluoromethylbenzyl)-lH-pyrimidine-2,4-dione: b) spray-drying the mixture to form an intermediate mixture; c) blending a first intragranular mixture comprising the intermediate mixture, a sustaining polymer, microcrystalline cellulose, and croscarmellose sodium; d) roller compacting the first intragranular mixture to form a roller compacted mixture; and e) blending a first extragranular mixture comprising the roller compacted mixture and croscarmellose sodium, thereby preparing the composition.
  • the present invention provides a method of treating a disorder or condition through modulating a glucocorticoid receptor, comprising administering to a subject in need of such treatment, a therapeutically effective amount of a composition of the present invention, thereby treating the disorder or condition.
  • the present invention provides a method of treating a disorder or condition through antagonizing a glucocorticoid receptor, comprising administering to a subject in need of such treatment, a therapeutically effective amount of a composition of the present invention, thereby treating the disorder or condition.
  • the present invention provides a method of treating fatty liver disease, comprising administering to a subject in need thereof, a therapeutically effective amount of a composition of the present invention, thereby treating fatty liver disease.
  • the present invention provides a method of treating antipsychotic induced weight gain, comprising administering to a subject in need thereof, a therapeutically effective amount of a composition of the present invention, thereby treating antipsychotic induced weight gain.
  • FIG. 1 shows the XRPD pattern for Compound I Form B.
  • FIG. 2 shows the XRPD peaks for Compound I Form B.
  • FIG. 3 shows the DSC and TGA thermogram for Compound I Form B.
  • FIG. 4 shows the dissolution graph of formulations Dl, D2, D3 and El using Compound I (CORT118335).
  • FIG. 5 shows in vivo bioavailability results of Compound I (miricorilant) in monkeys administered tablets prepared according to the Cl, D3 and El compositions. Tablets prepared with the new formulations performed beter than tablets prepared with earlier formulations; the improvement in bioavailability in vivo was several-fold compared with the earlier formulations.
  • FIG. 6 shows a table of PK data for compositions D3 and El against Cl.
  • FIG. 7 shows a table of PK data for compositions Cl, D1 and D2.
  • composition as used herein is intended to encompass a product comprising the specified ingredients in the specified amounts, as well as any product, which results, directly or indirectly, from combination of the specified ingredients in the specified amounts.
  • pharmaceutically acceptable it is meant the carrier(s), diluent(s) or excipient(s) must be compatible with the other ingredients of the formulation and not deleterious to the recipient thereof.
  • “Sustaining polymer” refers to a polymer capable of enhancing the dissolved concentration of an active agent in an in vivo or in vitro environment relative to a comparative composition that does not include the sustaining polymer, and maintains the greater dissolved concentration for an extended period of time.
  • “Pharmaceutically acceptable excipient” refers to a substance that aids the administration of an active agent to and absorption by a subject.
  • Pharmaceutical excipients useful in the present invention include, but are not limited to, binders, fillers, disintegrants, lubricants, surfactants, coatings, sweeteners, flavors and colors.
  • binders include, but are not limited to, binders, fillers, disintegrants, lubricants, surfactants, coatings, sweeteners, flavors and colors.
  • Treatment refers to any indicia of success in the treatment or amelioration of an injury, pathology or condition, including any objective or subjective parameter such as abatement; remission; diminishing of symptoms or making the injury, pathology or condition more tolerable to the patient; slowing in the rate of degeneration or decline; making the final point of degeneration less debilitating; improving a patient's physical or mental well-being.
  • the treatment or amelioration of symptoms can be based on objective or subjective parameters; including the results of a physical examination, neuropsychiatric exams, and/or a psychiatric evaluation.
  • administering refers to oral administration to the subject.
  • “Patient” or “subject” refers to a living organism suffering from or prone to a disease or condition that can be treated by administration of a pharmaceutical composition as provided herein.
  • Non-limiting examples include humans, other mammals, bovines, rats, mice, dogs, monkeys, goat, sheep, cows, deer, horse, and other non-mammalian animals.
  • the patient is human.
  • “Therapeutically effective amount” refers to an amount of a compound or of a pharmaceutical composition useful for treating or ameliorating an identified disease or condition, or for exhibiting a detectable therapeutic or inhibitory effect. The exact amounts will depend on the purpose of the treatment, and will be ascertainable by one skilled in the art using known techniques (see, e.g. , Lieberman, Pharmaceutical Dosage Forms (vols. 1-3, 1992); Lloyd, The Art, Science and Technology of Pharmaceutical Compounding (1999); Pickar, Dosage Calculations (1999); and Remington: The Science and Practice of Pharmacy, 20th Edition, 2003, Gennaro, Ed., Lippincott, Williams & Wilkins).
  • Glucocorticoid receptor refers to one of the family of intracellular receptors which specifically bind to cortisol and/or cortisol analogs such as dexamethasone (See, e.g., Turner & Muller, J. Mol. Endocrinol. October 1, 2005 35 283-292).
  • the glucocorticoid receptor is also referred to as the cortisol receptor.
  • the term includes isoforms of GR, recombinant GR and mutated GR.
  • a cortisol receptor is a glucocorticoid receptor (GR), specifically the type II GR, which specifically binds cortisol and/or cortisol analogs such as dexamethasone (See, e.g., Turner & Muller, J. Mol. Endocrinol. October 1, 2005 35 283-292).
  • GR glucocorticoid receptor
  • MR Mineralocorticoid receptor
  • GR I glucocorticoid receptor
  • Glucocorticoid receptor modulator refers to any compound which modulates any biological response associated with the binding of a glucocorticoid receptor to an agonist.
  • the glucocorticoid receptor may be GR, or both.
  • a GRM that acts as an agonist such as dexamethasone, increases the activity of tyrosine aminotransferase (TAT) in HepG2 cells (a human liver hepatocellular carcinoma cell line; ECACC, UK).
  • TAT tyrosine aminotransferase
  • TAT activity can be measured as outlined in the literature by A. Ali el al. , J. Med. Chem., 2004, 47, 2441-2452.
  • Glucocorticoid receptor antagonist refers to any compound which inhibits any biological response associated with the binding of a glucocorticoid receptor to an agonist.
  • the glucocorticoid receptor may be GR, or both.
  • GR antagonists can be identified by measuring the ability of a compound to inhibit the effect of dexamethasone. TAT activity can be measured as outlined in the literature by A. Ali et al, J. Med. Chem., 2004, 47, 2441-2452.
  • An inhibitor is a compound with an IC50 (half maximal inhibition concentration) of less than 10 micromolar. See Example 1 of U.S. Patent 8,685,973, the entire contents of which is hereby incorporated by reference in its entirety.
  • Modulate and “modulating” are used in accordance with its plain ordinary meaning and refer to the act of changing or varying one or more properties. “Modulation” refers to the process of changing or varying one or more properties. For example, as applied to the effects of a modulator on a target protein, to modulate means to change by increasing or decreasing a property or function of the target molecule or the amount of the target molecule. [0037] “Modulator” refers to a composition that increases or decreases the level of a target molecule or the function of a target molecule or the physical state of the target of the molecule.
  • Antagonizing refers to inhibiting the binding of an agonist at a receptor molecule or to inhibiting the signal produced by a receptor-agonist.
  • a receptor antagonist inhibits or dampens agonist-mediated responses, such as gene expression.
  • Antagonist refers to a substance capable of detectably lowering expression or activity of a given gene or protein.
  • the antagonist can inhibit expression or activity 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100% or less in comparison to a control in the absence of the antagonist. In some embodiments, the inhibition is 1.5-fold, 2-fold, 3-fold, 4- fold, 5-fold, 10-fold, or more than the expression or activity in the absence of the antagonist.
  • Inhibition refers to a compound that prohibits or a method of prohibiting, a specific action or function.
  • disorders or conditions refers to a state of being or health status of a patient or subject capable of being treated with the glucocorticoid receptor modulators of the present invention.
  • disorders or conditions include, but are not limited to, obesity, hypertension, depression, anxiety, and Cushing's Syndrome.
  • Fatty liver disease refers to a disease or a pathological condition caused by, at least in part, abnormal hepatic lipid deposits.
  • Fatty liver disease includes, e.g., alcoholic fatty liver disease, nonalcoholic fatty liver disease, and acute fatty liver of pregnancy.
  • Fatty liver disease may be, e.g., macrovesicular steatosis or microvesicular steatosis.
  • Non-alcoholic fatty liver disease refers to one of the types of fatty liver which occurs when fat is deposited (steatosis) in the liver due to causes other than excessive alcohol use. NAFLD is considered to cover a spectrum of disease activity. This spectrum begins as fatty accumulation in the liver (hepatic steatosis). Most people with NAFLD have few or no symptoms. Patients may complain of fatigue, malaise, and dull right-upper-quadrant abdominal discomfort. Mild jaundice may be noticed, although this is rare. More commonly NAFLD is diagnosed following abnormal liver function tests during routine blood tests. By definition, alcohol consumption of over 20 g/day (about 25 ml/day of net ethanol) excludes the condition.
  • Non-alcoholic steatohepatitis (“NASH”) refers to the most extreme form of NAFLD. NAFLD can progress to become non-alcoholic steatohepatitis (NASH), a state in which steatosis is combined with inflammation and fibrosis (steatohepatitis). NASH is a progressive disease. Over a 10-year period, up to 20% of patients with NASH will develop cirrhosis of the liver, and 10% will suffer death related to liver disease.
  • NASH non-alcoholic steatohepatitis
  • Substance use disorder refers to the compulsive use of a substance despite unpleasant or harmful consequences of that use.
  • a substance use disorder may involve impaired control (e.g., use of excessive amounts of the substance, or over longer periods of time, than was originally intended), social impairment (e.g., failure to fulfill major roles obligations at work, school, or home), risky use (e.g., recurrent use of the substance in situations in which it is physically hazardous), and pharmacological criteria (e.g., tolerance or withdrawal).
  • impaired control e.g., use of excessive amounts of the substance, or over longer periods of time, than was originally intended
  • social impairment e.g., failure to fulfill major roles obligations at work, school, or home
  • risky use e.g., recurrent use of the substance in situations in which it is physically hazardous
  • pharmacological criteria e.g., tolerance or withdrawal
  • a substance use disorder may have formerly been termed an “addiction” although, since the publication of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition DSM-5 (hereafter “DSM-V”), terms such as “addiction” and “addict” have been replaced for the terms “substance use disorder” (replacing “addiction”) and person suffering from a substance use disorder (replacing “addict”).
  • DSM-V Diagnostic and Statistical Manual of Mental Disorders Fifth Edition DSM-5
  • a person suffering from a substance use disorder may be termed as suffering from a substance use disorder related to a particular substance; prior to the publication of DSM-V, such a person may have been described as being “addicted to” that substance. For example, where a person has a substance use disorder related to a stimulant, that person may have been described as being “addicted to” that stimulant prior to the publication of DSM-V.
  • “Substance” as recited in phrases such as “substance use disorder related to said substance” and “substance use disorder related to the substance” refers to the substance for which a patient has a craving, or which the patient uses compulsively despite unpleasant or harmful consequences of that use.
  • a “substance” is the substance used by, or ingested, or otherwise administered to (including self-administration) a person who suffers from a substance use disorder related to that substance.
  • the terms “substance of addiction”, and “substance of abuse” may have formerly been used to refer such a substance, which substance may formerly have been termed an “addictive substance” (e.g., prior to the publication of DSM-V).
  • “Person suffering from a substance use disorder” refers to a person suffering from a substance use disorder related to a particular substance, or, in some cases, more than one particular substance.
  • a “substance” may be a drug, or alcohol, or a cigarette, or other substance a person may take (ingest).
  • a “substance” may be alcohol, a stimulant, an opioid, or other substance.
  • substituted group herein, mean at least one.
  • a compound is substituted with “an” alkyl or aryl, the compound is optionally substituted with at least one alkyl and/or at least one aryl, wherein each alkyl and/or aryl is optionally different.
  • a compound is substituted with “a” substituent group, the compound is substituted with at least one substituent group, wherein each substituent group is optionally different.
  • the present invention provides pharmaceutically acceptable compositions of (E)-6- (4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-lH-pyrimidine-2,4-dione (Compound I; see U.S. Patent No. 8,685,973) which provide surprisingly improved bioavailability of Compound I.
  • Compound I is difficult to solubilize in a forms suitable for use in pharmaceutical compositions; routine methods have proven unsuccessful in providing pharmaceutically acceptable compositions of this compound.
  • the compositions disclosed herein overcome the previously problems of solubility and bioavailability, and provide pharmaceutically acceptable compositions with enhanced bioavailability, suitable for use in treating conditions and disorders amenable to treatment by administration of Compound I.
  • compositions of (E)-6-(4-Phenylcyclohexyl)-5-(3- trifluoromethylbenzyl)-lH-pyrimidine-2,4-dione Compound I; CORT118335; miricorilant; see U.S. Patent No. 8,685,973.
  • the present invention provides a composition including Compound I having the structure:
  • the compound can also be named 6-(/ra/ v-4-phenylcyclohexyl)-5-(3- (trifluoromethyl (phenyl )methyl)pyri midi ne-2.4( 1 //.3//)-dione or 6-((lr,4r)-4- phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidine-2,4(lH,3H)-dione.
  • the present invention provides a composition comprising:
  • a sustaining polymer in an amount from 10.0 to 32.0% (w/w); microcrystalbne cellulose in an amount from 10.0 to 25.0% (w/w); and croscarmellose sodium (Ac-Di-Sol) in an amount from 5.0 to 11.0% (w/w).
  • Compound I can be present in the composition in any suitable amount.
  • Representative amounts of Compound I include, but are not limited to, about 10 mg, or 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160,
  • composition includes Compound I in an amount of about 150 mg.
  • Compound I can be present in the composition in any suitable weight percentage.
  • Representative amounts of Compound I in the composition include, but are not limited to, 1 to 50% (w/w), or 5 to 45%, or 5 to 40%, or 10 to 35%, or 15 to 32%, or 16 to 31%, or 17 to 30%, or 18 to 29%, or 20 to 28%, or 21 to 27%, or 22 to 26%, or 23 to 25% (w/w).
  • Other amount of Compound I in the composition include, but are not limited to, about 15% (w/w), or about 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, or about 35%
  • Compound I is present in an amount of from 20.0 to 28.0%
  • Compound I is present in an amount of from 22.0 to 28.0%
  • Compound I is present in an amount of about 22.8% (w/w). In some embodiments, Compound I is present in an amount of about 22.9% (w/w). In some embodiments, Compound I is present in an amount of about 25.0% (w/w). In some embodiments, Compound I is present in an amount of about 26.1% (w/w). In some embodiments, Compound I is present in an amount of about 27.3% (w/w). In some embodiments, Compound I is present in an amount of about 30.0% (w/w).
  • the composition includes
  • Compound I is present in an amount from 20.0 to 28.0% (w/w); a polymer in an amount from 20.0 to 28.0% (w/w); and a sustaining polymer in an amount from 10.0 to 28.0% (w/w).
  • the composition can also include one or more polymers.
  • Representative polymers include, but are not limited to, polyacrylates, polymethyacrylates, poly(methyl methacrylate), poly(methacrylic acid), cellulose, etc.
  • the polymer can include homopolymers and copolymers.
  • the copolymers can include block copolymers, random copolymers, etc.
  • the monomers of the copolymer can be present in any suitable molar ratio, such as from 10: 1 to 1:10.
  • the polymer can include poly [(methyl methacrylate)-co-(methacrylic acid)].
  • the composition includes
  • Compound I is present in an amount from 20.0 to 28.0% (w/w); a poly[(methyl methacrylate)-co-(methacrylic acid)] in an amount from 20.0 to 28.0% (w/w); and a sustaining polymer in an amount from 10.0 to 28.0% (w/w).
  • the poly[(methyl methacrylate)-co-(methacrylic acid)] is Eudragit LI 00.
  • the poly[(methyl methacrylate)-co-(methacrylic acid)] can be present in any suitable ratio to Compound I.
  • the weight ratio of Compound I to the poly[(methyl methacrylate)-co-(methacrylic acid)] can be from 5:1 to 1:5, or 4:1 to 1:2, 3:1 to 1:2, 2:1 to 1: 1.5, or 1.5:1 to 1:1.5.
  • the weight ratio of Compound I to the poly [(methyl methacrylate)-co-(methacrylic acid)] is about 1:1.
  • the poly[(methyl methacrylate)-co-(methacrylic acid)] can be present in the composition in any suitable weight percentage.
  • Representative amounts of the poly [(methyl methacrylate)-co-(methacrylic acid)] in the composition include, but are not limited to, 1 to 50% (w/w), or 5 to 45%, or 5 to 40%, or 10 to 35%, or 15 to 32%, or 16 to 31%, or 17 to 30%, or 18 to 29%, or 20 to 28%, or 21 to 27%, or 22 to 26%, or 23 to 25% (w/w).
  • Other amount of the poly[(methyl methacrylate)-co-(methacrylic acid)] in the composition include, but are not limited to, about 15% (w/w), or about 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26,
  • the poly [(methyl methacrylate)-co-(methacrybc acid)] is present in an amount of from 20.0 to 28.0% (w/w).
  • the poly[(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of from 22.0 to 28.0% (w/w). In some embodiments, the poly[(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of about 22.8% (w/w). In some embodiments, the poly[(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of about 22.9% (w/w). In some embodiments, the poly[(methyl methacrylate)-co- (methacrybc acid)] is present in an amount of about 25.0% (w/w).
  • the poly [(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of about 26.1% (w/w). In some embodiments, the poly[(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of about 27.3% (w/w). In some embodiments, the poly[(methyl methacrylate)-co-(methacrylic acid)] is present in an amount of about 30.0% (w/w).
  • compositions of the present invention can also include a sustaining polymer.
  • the sustaining polymer can include, but is not limited to, an ionizable cellulosic polymer, a non-ionizable cellulosic polymer, an ionizable non-cellulosic polymer, a non- ionizable non-cellulosic polymer, or a combination thereof.
  • Ionizable cellulosic polymers include hydroxypropyl methyl cellulose succinate, cellulose acetate succinate, methyl cellulose acetate succinate, ethyl cellulose acetate succinate, hydroxypropyl cellulose acetate succinate, hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl cellulose acetate phthalate succinate, cellulose propionate succinate, hydroxypropyl cellulose butyrate succinate, hydroxypropyl methyl cellulose phthalate, cellulose acetate phthalate, methyl cellulose acetate phthalate, ethyl cellulose acetate phthalate, hydroxypropyl cellulose acetate phthalate, hydroxypropyl methyl cellulose acetate phthalate, cellulose propionate phthalate, hydroxypropyl cellulose butyrate phthalate, cellulose acetate trimellitate, methyl cellulose acetate trimellitate, ethyl cellulose acetate trimellitate,
  • Non-ionizable cellulosic polymers include hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, and hydroxyethyl ethyl cellulose, and combinations thereof.
  • lonizable non-cellulosic polymers include carboxylic acid functionalized polymethacrylates, carboxylic acid functionalized polyacrylates, amine-functionalized polyacrylates, amine-functionalized polymethacrylates, proteins, and carboxylic acid functionalized starches, and combinations thereof.
  • Non-ionizable non-cellulosic polymers include vinyl polymers and copolymers having at least one substituent selected from the group consisting of hydroxyl, alkylacyloxy, and cyclicamido; vinyl copolymers of at least one hydrophilic, hydroxyl-containing repeat unit and at least one hydrophobic, alkyl- or aryl-containing repeat unit; polyvinyl alcohols that have at least a portion of their repeat units in the unhydrolyzed form, polyvinyl alcohol polyvinyl acetate copolymers, polyethylene glycol polypropylene glycol copolymers, polyvinyl pyrrolidone, and polyethylene polyvinyl alcohol copolymers, and combinations thereof.
  • the sustaining polymer comprises hydroxypropyl methylcellulose acetate succinate (HPMCAS), hydroxypropyl methylcellulose (HPMC), poly(vinylpyrrolidone-co-vinyl acetate) (PVPVA), carboxymethyl ethylcellulose (CMEC), or a combination thereof.
  • the sustaining polymer comprises HPMCAS or PVPVA.
  • the HPMCAS may be, for example, HPMCAS-HF (also HPMCAS-H) or Affmisol® 126 HPMCAS polymer (The Dow Chemical Company).
  • HPMCAS-HF has an average particle size of ⁇ 10 pm, such as an average particle size of 5 pm, as measured by laser diffraction.
  • HPMCAS-HF and Affmisol® 126 HPMCAS each have an acetyl content of 10-14 wt%, a succinoyl content of 4-8 wt%, a methoxyl content of 22-26 wt%, and a hydroxypropoxy content of 6-10 wt%.
  • HPCMAS-HF and Affmisol® 126 HPMCAS have an acid content of 0.7 mmol acid/gram and are soluble at pH > 6.5.
  • the PVPVA may be, for example, PVPVA64 - a linear random copolymer with a 6:4 ratio of /V-vinylpyrrolidone and vinyl acetate.
  • One commercially available example is Kollidon® VA 64 polymer (BASF Corporation).
  • the sustaining polymer comprises PVPVA.
  • the sustaining polymer is hydroxypropyl methylcellulose acetate succinate (HPMCAS).
  • HPMCAS Hydroxypropyl methylcellulose acetate succinate
  • HPMCAS-HF high fine grade
  • HPMCAS-M medium grade
  • HPPMCAS- L low grade
  • the sustaining polymer is hydroxypropyl methylcellulose acetate succinate high fine grade (HPMCAS-H).
  • the sustaining polymer can be present in any suitable ratio to Compound I.
  • the weight ratio of Compound I to the sustaining polymer can be from 5:1 to 1:5, or 4:1 to 1:2, 3:1 to 1:2, 2:1 to 1:1.5, or 1.5:1 to 1:1.5.
  • the weight ratio of Compound I to the sustaining polymer is about 2:1.
  • the weight ratio of Compound I to the sustaining polymer is about 1.3:1.
  • the weight ratio of Compound I to the sustaining polymer is about 1:1.
  • the weight ratio of Compound I to the HPMCAS-H is about 1:1.
  • the sustaining polymer can be present in the composition in any suitable weight percentage.
  • Representative amounts of the sustaining polymer in the composition include, but are not limited to, 1 to 50% (w/w), or 5 to 45%, or 5 to 40%, or 10 to 35%, or 10 to 30%, or 13 to 28%(w/w).
  • Other amounts of the sustaining polymer in the composition include, but are not limited to, about 10% (w/w), or about 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or about 30% (w/w).
  • the sustaining polymer is present in an amount of from 13.0 to 28.0% (w/w).
  • the sustaining polymer is present in an amount of about 14.0% (w/w).
  • the sustaining polymer is present in an amount of about 20.5% (w/w). In some embodiments, the sustaining polymer is present in an amount of about 22.9% (w/w). In some embodiments, the sustaining polymer is present in an amount of about 23.0% (w/w). In some embodiments, the sustaining polymer is present in an amount of about 25.0% (w/w). In some embodiments, the sustaining polymer is present in an amount of about 26.1% (w/w).
  • compositions of the present invention can also include at least one filler in any suitable amount.
  • Representative fillers include, but are not limited to, starch, lactitol, lactose, an inorganic calcium salt, microcrystalline cellulose, sucrose, and combinations thereof.
  • the filler includes microcrystalline cellulose.
  • the filler includes microcrystalline cellulose (Avicel PH102).
  • the filler includes microcrystalline cellulose (Avicel PH101).
  • compositions of the present invention can also include at least one disintegrant in any suitable amount.
  • Representative disintegrants include, but are not limited to, agar-agar, alginic acid, calcium carbonate, microcrystalline cellulose, croscarmellose sodium, crospovidone, polacrilin potassium, sodium starch glycolate, potato or tapioca starch, other starches, pre-gelatinized starch, clays, other algins, other celluloses, gums (like gellan), low- substituted hydroxypropyl cellulose, or mixtures thereof.
  • the disintegrant includes croscarmellose sodium.
  • the disintegrant includes croscarmellose sodium (Ac-Di-Sol).
  • the composition includes:
  • Compound I in an amount from 22.0 to 28.0% (w/w);
  • Eudragit LI 00 in an amount from 22.0 to 28.0% (w/w); hydroxypropyl methylcellulose acetate succinate high fine grade in an amount from 13.0 to 28.0% (w/w); microcrystalline cellulose (Avicel PH102) in an amount from 13.0 to 20.0% (w/w); and croscarmellose sodium (Ac-Di-Sol) in an amount from 5.0 to 11.0% (w/w).
  • compositions of the present invention can also include sodium lauryl sulfate in any suitable amount.
  • Representative amounts of the sodium lauryl sulfate in the composition include, but are not limited to, from 0.1 to 10% (w/w), or 0.2 to 9%, or 0.3 to 8%, or 0.4 to 7%, or 0.4 to 6%, or 0.5 to 5%, or 1 to 5%, or 1 to 4%, or 1 to 3% or 1 to 2%, or 1.0 to 1.9%, or 1.2 to 1.8%, or 1.25 to 1.75%, or from 1.3 to 1.5% (w/w).
  • the composition includes sodium lauryl sulfate in an amount from 0.5 to 5.0% (w/w). In some embodiments, the composition includes sodium lauryl sulfate in an amount from 1.25 to 1.75% (w/w). In some embodiments, the composition includes sodium lauryl sulfate in an amount from 1.3 to 1.5% (w/w). In some embodiments, the composition includes sodium lauryl sulfate in an amount from 1.4% (w/w).
  • compositions of the present invention can also include a lubricant.
  • lubricants include, but are not limited to, calcium stearate, magnesium stearate, mineral oil, light mineral oil, glycerin, sorbitol, mannitol, polyethylene glycol, other glycols, stearic acid, sodium lauryl sulfate, sodium stearyl fumarate, vegetable based fatty acids lubricant, hydrogenated vegetable oil (e.g., peanut oil, cottonseed oil, sunflower oil, sesame oil, olive oil, com oil and soybean oil), zinc stearate, ethyl oleate, ethyl laurate, agar, or mixtures thereof.
  • the lubricant includes magensium stearate.
  • the composition includes:
  • Compound I in an amount of about 22.8% (w/w);
  • Eudragit LI 00 in an amount of about 22.8% (w/w); sodium lauryl sulfate in an amount of about 1.4% (w/w); hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 23.0% (w/w); microcrystalline cellulose (Avicel PH102) in an amount of about 19.4% (w/w); croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w); and magnesium stearate in an amount of about 0.5% (w/w).
  • the composition can be a tablet.
  • the tablet compositions can be of any suitable size such as, but not limited to, 25, 50, 75, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850,
  • the composition is a 650 mg tablet.
  • the composition includes:
  • Compound I in an amount of about 150 mg
  • Eudragit LI 00 in an amount of about 150 mg; sodium lauryl sulfate in an amount of about 9.3 mg; hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 152 mg; microcrystalline cellulose (Avicel PH102) in an amount of about 128.1 mg; croscarmellose sodium (Ac-Di-Sol) in an amount of about 66 mg; and magnesium stearate in an amount of about 3.3 mg.
  • compositions of the present invention can also include at least one glidant in any suitable amount.
  • the composition includes talc and colloidal silicon dioxide.
  • the composition includes colloidal silicon dioxide (Cab-O-Sil MP5).
  • the composition includes colloidal silicon dioxide (Cab-O-Sil MP5) in an amount from 0.1 to 2.0% (w/w).
  • the composition includes colloidal silicon dioxide (Cab-O-Sil MP5) in an amount from 0.1 to 1.5% (w/w).
  • the composition includes colloidal silicon dioxide (Cab- O-Sil MP5) in an amount from 0.5 to 2.0% (w/w).
  • the composition includes colloidal silicon dioxide (Cab-O-Sil MP5) in an amount from 0.50 to 1.5% (w/w).
  • the composition includes:
  • Compound I in an amount of about 22.8% (w/w);
  • Eudragit LI 00 in an amount of about 22.8% (w/w); sodium lauryl sulfate in an amount of about 1.4% (w/w); hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 23.0% (w/w); microcrystalline cellulose (Avicel PH102) in an amount of about 18.4% (w/w); croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w); colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 1.0% (w/w); and magnesium stearate in an amount of about 0.5% (w/w).
  • the composition includes:
  • Compound I in an amount of about 150 mg
  • Eudragit LI 00 in an amount of about 150 mg; sodium lauryl sulfate in an amount of about 9.3 mg; hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 150.9 mg; microcrystalline cellulose (Avicel PH102) in an amount of about 120.7 mg; croscarmellose sodium (Ac-Di-Sol) in an amount of about 65.6 mg; colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 6.6 mg; and magnesium stearate in an amount of about 3.3 mg.
  • compositions of the present invention can also include at least one filler in any suitable amount.
  • Representative fillers include, but are not limited to, talc, calcium carbonate (e.g., granules or powder), dibasic calcium phosphate, tribasic calcium phosphate, calcium sulfate (e.g., granules or powder), microcrystalline cellulose, powdered cellulose, dextrates, kaolin, mannitol, silicic acid, sorbitol, starch, pre-gelatinizcd starch, dextrose, fructose, honey, lactose anhydrate, lactose monohydrate, lactose and aspartame, lactose and cellulose, lactose and microcrystalline cellulose, maltodextrin, maltose, mannitol, microcrystalline cellulose & amp; guar gum, molasses, sucrose, or mixtures thereof.
  • the composition include microcrystalline cellulose.
  • the composition includes microcrystalline cellulose (Avicel PH102) in an amount from 10.0 to 30.0% (w/w).
  • the composition includes microcrystalline cellulose (Avicel PH 102) in an amount from 13.0 to 20.0% (w/w).
  • the composition includes:
  • Compound I in an amount of about 25.0% (w/w);
  • Eudragit L100 in an amount of about 25.0% (w/w); hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 25.0% (w/w); microcrystalline cellulose (Avicel PH102) in an amount of about 13.75% (w/w); croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w); colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 0.75% (w/w); and magnesium stearate in an amount of about 0.5% (w/w).
  • the composition includes:
  • Compound I in an amount of about 22.9% (w/w);
  • Eudragit L100 in an amount of about 22.9% (w/w); hydroxypropyl methylcellulose acetate succinate high fine grade in an amount of about 22.9% (w/w); microcrystalline cellulose (Avicel PH102) in an amount of about 19.8% (w/w); croscarmellose sodium (Ac-Di-Sol) in an amount of about 10.0% (w/w); colloidal silicon dioxide (Cab-O-Sil MP5) in an amount of about 1.0% (w/w); and magnesium stearate in an amount of about 0.5% (w/w).
  • compositions of the present invention can be prepared and administered in a wide variety of oral dosage forms.
  • Oral preparations include tablets, pills, powder, dragees, capsules, slurries, suspensions, etc., suitable for ingestion by the patient.
  • the present invention also provides pharmaceutical compositions including one or more pharmaceutically acceptable carriers and/or excipients and either a compound, or a pharmaceutically acceptable salt of a compound.
  • compositions from Compound I can be either solid or liquid.
  • Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules.
  • a solid carrier can be one or more substances, which may also act as diluents, flavoring agents, surfactants, binders, preservatives, tablet disintegrating agents, or an encapsulating material. Details on techniques for formulation and administration are well described in the scientific and patent literature, see, e.g., the latest edition of Remington's Pharmaceutical Sciences, Maack Publishing Co, Easton PA (“Remington's”).
  • the carrier is a finely divided solid, which is in a mixture with the finely divided active component.
  • the active component is mixed with the carrier having the necessary binding properties and additional excipients as required in suitable proportions and compacted in the shape and size desired.
  • Suitable carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like.
  • preparation is intended to include the formulation of the active compound with encapsulating material as a carrier providing a capsule in which the active component with or without other excipients, is surrounded by a carrier, which is thus in association with it.
  • cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges can be used as solid dosage forms suitable for oral administration.
  • Suitable solid excipients are carbohydrate or protein fillers including, but not limited to sugars, including lactose, sucrose, mannitol, or sorbitol; starch from com, wheat, rice, potato, or other plants; cellulose such as methyl cellulose, hydroxypropylmethyl- cellulose, or sodium carboxymethylcellulose; and gums including arabic and tragacanth; as well as proteins such as gelatin and collagen.
  • disintegrating or solubilizing agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, alginic acid, or a salt thereof, such as sodium alginate.
  • Dragee cores are provided with suitable coatings such as concentrated sugar solutions, which may also contain gum arabic, talc, polyvinylpyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures.
  • Dyestuffs or pigments may be added to the tablets or dragee coatings for product identification or to characterize the quantity of active compound (i.e., dosage).
  • Pharmaceutical preparations of the invention can also be used orally using, for example, push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a coating such as glycerol or sorbitol.
  • Push-fit capsules can contain The compositions mixed with a filler or binders such as lactose or starches, lubricants such as talc or magnesium stearate, and, optionally, stabilizers.
  • a filler or binders such as lactose or starches
  • lubricants such as talc or magnesium stearate
  • stabilizers In soft capsules, The compositions may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycol with or without stabilizers.
  • the carriers or excipients used in the pharmaceutical compositions of this invention are commercially-available.
  • conventional formulation techniques are described in Remington: The Science and Practice of Pharmacy, 20th Edition, Lippincott Williams & White, Baltimore, Md. (2000); and H. C. Ansel et al., Pharmaceutical Dosage Forms and Drug Delivery Systems, 7th Edition, Lippincott Williams & White, Baltimore, Md. (1999).
  • the pharmaceutical preparation can be prepared in unit dosage form. In such form the preparation is subdivided into unit doses containing appropriate quantities of the active component.
  • the unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the appropriate number of any of these in packaged form.
  • the quantity of active component in a unit dose preparation may be varied or adjusted from 0.1 mg to 10000 mg, 1.0 mg to 1000 mg, or 10 mg to 500 mg, according to the particular application and the potency of the active component.
  • the composition can, if desired, also contain other compatible therapeutic agents.
  • the dosage regimen also takes into consideration pharmacokinetics parameters well known in the art, i.e., the rate of absorption, bioavailability, metabolism, clearance, and the like (see, e.g., Hidalgo-Aragones (1996) J. Steroid Biochem. Mol. Biol. 58:611-617; Groning (1996) Pharmazie 51:337-341; Fotherby (1996) Contraception 54:59-69; Johnson (1995) J. Pharm. Sci. 84:1144-1146; Rohatagi (1995) Pharmazie 50:610-613; Brophy (1983) Eur. J. Clin. Pharmacol. 24:103-108; the latest Remington's, supra).
  • the state of the art allows the clinician to determine the dosage regimen for each individual patient, GR and /or MR modulator and disease or condition treated.
  • the compositions can be administered depending on the dosage and frequency as required and tolerated by the patient.
  • the compounds should provide a sufficient quantity of active agent to effectively treat the disease state.
  • the pharmaceutical formulations for oral administration of the compound is in a daily amount of between about 0.5 to about 30 mg per kilogram of body weight per day.
  • dosages can be from about 1 mg to about 20 mg per kg of body weight per patient per day are used.
  • Lower dosages can be used, particularly when the drug is administered to an anatomically secluded site, such as the cerebral spinal fluid (CSF) space, in contrast to administration orally, into the blood stream, into a body cavity or into a lumen of an organ.
  • CSF cerebral spinal fluid
  • Compound I described herein can be used in combination with other active agents known to be useful in modulating a glucocorticoid receptor, or with adjunctive agents that may not be effective alone, but may contribute to the efficacy of the active agent.
  • co-administration includes administering one active agent within 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, or 24 hours of a second active agent.
  • Co administration includes administering two active agents simultaneously, approximately simultaneously (e.g., within about 1, 5, 10, 15, 20, or 30 minutes of each other), or sequentially in any order.
  • co-administration can be accomplished by co-formulation, i.e., preparing a single pharmaceutical composition including both active agents.
  • the active agents can be formulated separately.
  • the active and/or adjunctive agents may be linked or conjugated to one another.
  • a pharmaceutical composition including a compound of the invention After formulated in one or more acceptable carriers, it can be placed in an appropriate container and labeled for treatment of an indicated condition.
  • labeling would include, e.g., instructions concerning the amount, frequency and method of administration.
  • compositions of the present invention can be prepared by a variety of methods.
  • the present invention provides a method of preparing a composition of the present invention, including: a) forming a mixture comprising a solvent, poly[(methyl methacrylate)-co- (methacrylic acid)], and Compound I, (E)-6-(4-Phenylcyclohexyl)-5-(3- trifluoromethylbenzyl)-lH-pyrimidine-2,4-dione: b) spray-drying the mixture to form an intermediate mixture; c) blending a first intragranular mixture comprising the intermediate mixture, a sustaining polymer, microcrystalline cellulose, and croscarmellose sodium; d) roller compacting the first intragranular mixture to form a roller compacted mixture; and e) blending a first extragranular mixture comprising the roller compacted mixture and croscarmellose sodium, thereby preparing the composition.
  • the mixture can include any suitable solvent or combination of solvents.
  • suitable solvents include, but are not limited to, petroleum ether, C1-C3 alcohols (methanol, ethanol, propanol, isopropanol), ethylene glycol and polyethylene glycol such as PEG400, alkanoates such as ethyl acetate, propyl acetate, isopropyl acetate, and butyl acetate, acetonitrile, alkanones such as acetone, butanone, methyl ethyl ketone (MEK), methyl propyl ketone (MPK) and methyl iso-butyl ketone (MIBK), ethers such as diethyl ether, methyl-t-butyl ether, tetrahydrofuran, methyl-tetrahydrofuran, 1 ,2-dimethoxy ethane and 1,4-dioxane, halogenated solvents such as methylene chloride,
  • Suitable solvents also include, but are not limited to halogenated C1-C3 alcohols (trifluoromethanol, trifluoroethanol (TFE), hexafluoroisopropanol (HFIPA)).
  • the solvent can be a polar aprotic solvent such as dichloromethane, N-methylpyrrolidone, tetrahydrofuran, ethyl acetate, acetone, methyl ethyl ketone, dimethylformamide (DMF), acetonitrile (AcCN), dimethyl sulfoxide (DMSO), among others.
  • the solvent can also be a polar protic solvent such as t-butanol, n- propanol, isopropanol, ethanol, methanol, acetic acid, among others.
  • the solvent can also be a non-polar solvent, such as, diethyl ether, methyl-t-butyl ether, tetrahydrofuran, methyl- tetrahydrofuran, 1,2-dimethoxy ethane and 1,4-dioxane, chloroform, and carbon tetrachloride.
  • Two or more solvents can be used in a solvent mixture in any suitable ratio.
  • the ratio of a first solvent and a second solvent can be from 10:1 to about 1:10 (volume/volume or weight/weight), or about 10:1 to 1:5, or 10:1 to 1:1, or 10:1 to 5:1, or 5:1 to 1:5, or 5:1 to 1:1, or 4:1 to 1:1, or 3:1 to 1:1, or 2:1 to 1:1.
  • Other solvent ratios include about 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 or about 1:10 (volume/ volume or weight/ weight).
  • the solvent includes methanol and dichloromethane. In some embodiments, the solvent includes acetone.
  • the poly[(methyl methacrylate)-co-(methacrylic acid)] is Eudragit LI 00.
  • the methods can include Compound I in any suitable form.
  • Compound I can be amorphous or crystalline.
  • Compound I is a crystalline anhydrate.
  • Compound I is crystalline Form B.
  • the methods of the present invention include a crystalline anhydrate form of the Compound I.
  • the Compound I Form B is characterized by an XRPD pattern comprising peaks at 16.7, 17.0, 17.3, 17.7, 19.0, 19.6, and 23.6° 2Q ⁇ 0.2° 2Q.
  • the Compound I Form B is characterized by an XRPD pattern comprising peaks at 9.8, 10.4, 11.2, 11.8, 13.4, 13.7, 14.8, 15.8, 16.2, 16.6,
  • the Compound I Form B is characterized by an XRPD pattern substantially as shown in FIG. 1
  • the Compound I Form B is characterized by a differential scanning calorimetry (DSC) thermogram having at least one endotherm with an onset of about 255 °C. In some embodiments, the Compound I Form B is characterized by a DSC thermogram substantially as shown in FIG. 3.
  • DSC differential scanning calorimetry
  • the Compound I Form B is characterized by: (a) an XRPD pattern comprising peaks at 16.7, 17.0, 17.3, 17.7, 19.0, 19.6, and 23.6° 2Q ⁇ 0.2° 2Q; and (b) a differential scanning calorimetry (DSC) thermogram having an endotherm with an onset of about 255 °C.
  • the Compound I Form B is characterized by: (a) an XRPD pattern substantially as shown in FIG. 1; and (b) a DSC thermogram substantially as shown in FIG. 3.
  • the sustaining polymer can be any suitable sustaining polymer as described above.
  • the sustaining polymer is hydroxypropyl methylcellulose acetate succinate (HPMCAS).
  • the sustaining polymer is hydroxypropyl methylcellulose acetate succinate high fine grade (HPMCAS-H).
  • the method includes: a) forming the mixture comprising the solvent, Eudragit LI 00, sodium lauryl sulfate (SLS), and Compound I; b) spray-drying the mixture to form the intermediate mixture; cl) blending the first intragranular mixture comprising the intermediate mixture, HPMCAS-H, microcrystalline cellulose, and croscarmellose sodium; c2) blending a second intragranular mixture comprising the first intragranular mixture and magnesium stearate; d) roller compacting the second intragranular mixture to form a roller compacted mixture; el) blending the first extragranular mixture comprising the roller compacted mixture and croscarmellose sodium; and e2) blending a second extragranular mixture comprising the first extragranular mixture and magnesium stearate, thereby preparing the composition.
  • the method can also include any suitable glidant as described above.
  • the first intragranular mixture further comprises a first glidant; and the first extragranular mixture further comprises a second glidant.
  • the first glidant and second glidant each comprise colloidal silicon dioxide.
  • the method includes: a) forming the mixture comprising the solvent, Eudragit LI 00, sodium lauryl sulfate (SLS), and Compound I; b) spray-drying the mixture to form the intermediate mixture; cl) blending the first intragranular mixture comprising the intermediate mixture, HPMCAS-H, microcrystalline cellulose, croscarmellose sodium and colloidal silicon dioxide; c2) blending a second intragranular mixture comprising the first intragranular mixture and magnesium stearate; d) roller compacting the second intragranular mixture to form a roller compacted mixture; el) blending the first extragranular mixture comprising the roller compacted mixture, croscarmellose sodium and colloidal silicon dioxide; and e2) blending a second extragranular mixture comprising the first extragranular mixture and magnesium stearate, thereby preparing the composition.
  • the method includes: a) forming the mixture comprising the solvent, poly [(methyl methacrylate)-co- (methacrylic acid)], and Compound I; b) spray-drying the mixture to form the intermediate mixture; cl) blending the first intragranular mixture comprising the intermediate mixture, HPMCAS-H, microcrystalline cellulose, croscarmellose sodium and colloidal silicon dioxide; c2) blending a second intragranular mixture comprising the first intragranular mixture and magnesium stearate; d) roller compacting the second intragranular mixture to form a roller compacted mixture; el) blending the first extragranular mixture comprising the roller compacted mixture, croscarmellose sodium and colloidal silicon dioxide; and e2) blending a second extragranular mixture comprising the first extragranular mixture and magnesium stearate, thereby preparing the composition.
  • the method can be used to prepare the compositions at any suitable scale, for example, from gram to kilogram.
  • the method can include Compound I in an amount of at least 5 g, 10 g, 15 g, 20 g, 25 g, 30 g, 35 g, 40 g, 45 g, 50 g, 60 g, 70 g, 80 g, 90 g, 100 g, 200 g, 300 g, 400 g, 500 g, 600 g, 700 g, 800 g, 900 g, 1 kg, 2 kg, 3 kg, 4 kg, 5 kg, 10 kg, 20 kg, 30 kg, 40 kg, 50 kg, 60 kg, 70 kg, 80 kg, 90 kg, 100 kg, 200 kg, 250 kg, 300 kg, 400 kg, 500 kg, or at least 1000 kg or more.
  • the temperature of the mixtures and reaction steps can be any suitable temperature, such as from 0 °C to 100 °C, or from 20 °C to 50 °C.
  • the method of the present invention can be performed at any suitable pressure.
  • the method can be at atmospheric pressure.
  • the various steps of the methods can also be exposed to any suitable environment, such as atmospheric gases, or inert gases such as nitrogen or argon.
  • the present invention provides a method of treating a disorder or condition through modulating a glucocorticoid receptor, comprising administering to a subject in need of such treatment, a therapeutically effective amount of a composition of the present invention, thereby treating the disorder or condition.
  • the present invention provides a method of treating a disorder or condition through antagonizing a glucocorticoid receptor, comprising administering to a subject in need of such treatment, a therapeutically effective amount of a composition of the present invention, thereby treating the disorder or condition.
  • the present invention provides methods of modulating glucocorticoid receptor activity using the techniques described herein.
  • the method includes contacting a GR with an effective amount of a composition of the present invention, and detecting a change in GR activity.
  • the present invention provides methods of modulating glucocorticoid receptor activity using the techniques described herein.
  • the method includes contacting a GR or both with an effective amount of a composition of the present invention, and detecting a change in GR activity, MR activity, or both.
  • the glucocorticoid receptor modulator is an antagonist of GR activity or MR activity, or both GR and MR activity (also referred to herein as “a glucocorticoid receptor antagonist”).
  • a glucocorticoid receptor antagonist refers to any composition or compound which partially or completely inhibits (antagonizes) the binding of a glucocorticoid receptor agonist (e.g. cortisol, aldosterone, and synthetic or natural cortisol or aldosterone analogs) to a GR, thereby inhibiting any biological response associated with the binding of a GR, to the agonist.
  • the glucocorticoid receptor modulator is a specific glucocorticoid receptor antagonist.
  • a specific glucocorticoid receptor antagonist refers to a composition or compound which inhibits any biological response associated with the binding of a GR to an agonist by preferentially binding to the GR rather than another nuclear receptor (NR).
  • the specific glucocorticoid receptor antagonist binds preferentially to GR rather than the androgen receptor (AR), estrogen receptor (ER) or progesterone receptor (PR).
  • the specific glucocorticoid receptor antagonist binds preferentially to GR rather than the progesterone receptor (PR).
  • the specific glucocorticoid antagonist binds preferentially to GR rather than to the androgen receptor (AR). In some embodiments, the specific glucocorticoid antagonist binds preferentially to GR rather than to the estrogen receptor (ER).
  • the specific glucocorticoid receptor antagonist binds to the GR with an association constant (Kd) that is at least 10-fold less than the Kd for AR or PR.
  • the specific glucocorticoid receptor antagonist binds to the GR with an association constant (Kd) that is at least 100-fold less than the Kd for AR or PR. In some embodiments, the specific glucocorticoid receptor antagonist binds to the GR with an association constant (Kd) that is at least 1000-fold less than the Kd for AR, PR or ER.
  • the disorder or condition is a substance use disorder, which may be an addiction disorder.
  • Addictive disorders such as substance abuse and dependence, are common disorders that involve the overuse of alcohol or drugs.
  • Substance abuse as a disorder, refers to the abuse of illegal substances or the abusive use of legal substances (e.g., alcohol).
  • Substance dependence is an addictive disorder that describes continued use of drugs or alcohol, even when significant problems related to their use have developed. Signs include an increased tolerance — that is, the need for increased amounts of the substance to attain the desired effect; withdrawal symptoms with decreased use; unsuccessful efforts to decrease use; increased time spent in activities to obtain the substance; withdrawal from social and recreational activities; and continued use of the substance even with awareness of the physical or psychological problems encountered by the extent of substance use.
  • Chemical dependence is also an addictive disorder that describes the compulsive use of chemicals (usually drugs or alcohol) and the inability to stop using them despite all the problems caused by their use.
  • the substances frequently abused, particularly by adolescents with addictive disorders include, but are not limited to, alcohol, marijuana, hallucinogens, cocaine, amphetamines, opiates, anabolic steroids, inhalants, methamphetamine, or tobacco.
  • the present invention provides a method of treating a substance use disorder, comprising administering to a subject in need thereof, a therapeutically effective amount of a pharmaceutical composition disclosed herein, thereby treating the substance use disorder.
  • the present invention provides a method of treating fatty liver disease, comprising administering to a subject in need thereof, a therapeutically effective amount of a composition of the present invention, thereby treating fatty liver disease.
  • the disorder or condition is the fatty liver disease is alcohol related liver disease (ARLD) or nonalcoholic fatty liver disease (NAFLD).
  • ARLD alcohol related liver disease
  • NAFLD nonalcoholic fatty liver disease
  • the alcohol related liver disease is alcohol fatty liver disease (AFL), alcoholic steatohepatitis (ASH) or alcoholic cirrhosis.
  • the disorder or condition is nonalcoholic fatty liver disease.
  • the nonalcoholic fatty liver disease is nonalcoholic steatohepatitis (NASH) or nonalcoholic cirrhosis.
  • the disorder or condition is nonalcoholic steatohepatitis.
  • NAFLD non-alcoholic steatohepatitis
  • steatohepatitis a state in which steatosis is combined with inflammation and fibrosis
  • NASH is a progressive disease. Over a 10-year period, up to 20% of patients with NASH will develop cirrhosis of the liver, and 10% will suffer death related to liver disease.
  • the method includes administering one or more second agents (e.g. therapeutic agents). In some embodiments, the method includes administering one or more second agents (e.g. therapeutic agents) in a therapeutically effective amount. In some embodiments, the second agent is an agent known to be useful in modulating a glucocorticoid receptor.
  • the present invention provides a method of treating antipsychotic induced weight gain, comprising administering to a subject in need thereof, a therapeutically effective amount of a composition of the present invention, thereby treating antipsychotic induced weight gain.
  • Compound I can be prepared as described in U.S. Patent No. 8,685,973, Example 6, Compound 3b.
  • Crystalline Compound I can be prepared as described in U.S. Provisional Application No. 63/020,919, filed May 6, 2020, titled “Polymorphs of Pyrimidine Cyclohexyl Glucocorticoid Receptor Modulators”.
  • the crystalline Form B of Compound I can be prepared by the method described below.
  • the resulting solution is heated to reflux at atmospheric pressure (approximately 38 to 40 °C) and distilled to remove 20 volumes of solvent. Concurrent with the distillation, a solvent exchange is performed by the addition of methanol (approximately 1 volume) for each volume of distillate collected to maintain a total solvent volume of approximately 13 - 14 volumes during the distillation. The distillation temperature is increased as needed to maintain a reasonable distillation rate;
  • the filter cake is then dried at ⁇ 50 °C for up to 72 h, sampling after at least 12 h of drying time for IPC analysis to determine residual solvent content;
  • Tablet formulations were prepared using the amounts described in the tables below.
  • formulation D3 having a unit dose of 150 mg Compound I and a tablet weight of 656 mg, was prepared as follows.
  • the resulting solution was spray dried using process conditions specific to the equipment utilized.
  • the solution When using a GEA Niro Mobile Minor, the solution was sprayed at a rate of 120 g/min, utilizing a drying gas flow rate of 1300 g/min and inlet and outlet temperatures of 86°C and 40°C, respectively.
  • the solution when using a small lab scale spray dryer, the solution was sprayed at a rate of 200 g/min, utilizing a drying gas flow rate of 3300 g/min and inlet and outlet temperatures of 65°C and 30°C, respectively.
  • a secondary drying process was performed to remove excess residual solvents from the intermediate mixture. Secondary drying was performed in a convection tray dryer operating at temperatures between 40°C and 60°C, with a total drying duration dictated by removal of residual solvents to predefined levels.
  • Each animal received an oral tablet dose of the appropriate test article formulation as outlined in the following study design table.
  • the gavage tube was rinsed with approximately 10 mL of tap water following dosing (prior to removal of the gavage tube).
  • Example 5 Monkey PK Study [0142] Four cynomolgus monkeys were assigned to study. The same animals were used for each phase with a minimum 7 day washout period between dosing for each phase. All animals were fasted for at least 8 hours prior to dosing and through the first 4 hours of blood sample collection (food was returned within 30 minutes following collection of the last blood sample at the 4 hour collection interval, where applicable). [0143] Each animal in received an oral tablet dose of the appropriate test article formulation as outlined in the following study design table. The gavage tube was rinsed with approximately 10 mL of tap water following dosing (prior to removal of the gavage tube).
  • Example 6 Human PK Study - 100 mg tablets [0145] An open label study was conducted in 6 heathy volunteers to assess the safety, tolerability and pharmacokinetics of miricorilant lOOmg tablets. A single oral dose of miricorilant 200mg as 2 x lOOmg tablets was administered 30 minutes after the consumption of breakfast. Intensive pharmacokinetic (PK) samples were collected at 1, 2, 4, 8, 12, 16, 24, 36, 48, 72 and 96 hours post-dose. The plasma concentrations of miricorilant were determined using a validated LC/MS bioanalytical assay . The geometric mean C max was 184ng/mL (at 4 hours post-dose), and the geometric mean AUC 0-24 was 2270ng.h/mL.
  • PK pharmacokinetic
  • Example 7 Human PK Study - 150 and 300 mg tablets
  • the geometric mean C max was 408ng/mL (at 4 hours post-dose), and the geometric mean AUCo-i ast was 6680ng.h/mL.
  • the geometric mean C max was 265ng/mL (at 4 hours post-dose), and the geometric mean AUCo-i ast was 3540ng.h/mL.
  • the difference in dose was 3 fold (900mg Cl tablets compared with 300mg D3 tablets) the difference AUC was less than 2 fold, indicating superior performance of the D3 tablets as compared to the Cl tablets.

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Abstract

La présente invention concerne des formulations de (E)-6-(4-phénylcyclohexyl)-5-(3-trifluorométhylbenzyl)-1H-pyrimidine-2,4-dione et leurs procédés de préparation et leurs méthodes d'utilisation.
EP21800134.5A 2020-05-06 2021-05-05 Formulations de modulateurs de récepteurs de glucocorticoïdes de type pyrimidine cyclohexyle Pending EP4146173A4 (fr)

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CA3202353A1 (fr) 2020-12-21 2022-06-30 Jeffrey Mark Dener Procede de preparation de modulateurs des recepteurs de glucocorticoides de type pyrimidine cyclohexyle

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