EP3863405A1 - Desinfektionszusammensetzung zur topischen anwendung - Google Patents
Desinfektionszusammensetzung zur topischen anwendungInfo
- Publication number
- EP3863405A1 EP3863405A1 EP19823795.0A EP19823795A EP3863405A1 EP 3863405 A1 EP3863405 A1 EP 3863405A1 EP 19823795 A EP19823795 A EP 19823795A EP 3863405 A1 EP3863405 A1 EP 3863405A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- mass
- composition
- equal
- formula
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 316
- 230000000699 topical effect Effects 0.000 title claims abstract description 59
- 230000000249 desinfective effect Effects 0.000 title claims abstract description 12
- 239000000645 desinfectant Substances 0.000 claims abstract description 53
- 239000002562 thickening agent Substances 0.000 claims abstract description 22
- 239000003349 gelling agent Substances 0.000 claims abstract description 21
- 229940071124 cocoyl glutamate Drugs 0.000 claims abstract description 18
- -1 acyl radical Chemical class 0.000 claims description 118
- 150000001875 compounds Chemical class 0.000 claims description 39
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 36
- 229920001282 polysaccharide Polymers 0.000 claims description 29
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 28
- 150000004676 glycans Chemical class 0.000 claims description 28
- 239000005017 polysaccharide Substances 0.000 claims description 28
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 25
- 210000000416 exudates and transudate Anatomy 0.000 claims description 25
- 229920001285 xanthan gum Polymers 0.000 claims description 25
- 235000010493 xanthan gum Nutrition 0.000 claims description 23
- 239000000230 xanthan gum Substances 0.000 claims description 23
- 229940082509 xanthan gum Drugs 0.000 claims description 23
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000002253 acid Substances 0.000 claims description 21
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 21
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 21
- 239000008103 glucose Substances 0.000 claims description 20
- 229920000084 Gum arabic Polymers 0.000 claims description 18
- 235000010489 acacia gum Nutrition 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 239000000205 acacia gum Substances 0.000 claims description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 12
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims description 12
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 12
- 229920006395 saturated elastomer Polymers 0.000 claims description 11
- 229920002678 cellulose Polymers 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 10
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 239000004302 potassium sorbate Substances 0.000 claims description 8
- 235000010241 potassium sorbate Nutrition 0.000 claims description 8
- 229940069338 potassium sorbate Drugs 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims description 8
- 239000004299 sodium benzoate Substances 0.000 claims description 8
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 7
- 244000215068 Acacia senegal Species 0.000 claims description 6
- 239000005711 Benzoic acid Substances 0.000 claims description 6
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 235000010233 benzoic acid Nutrition 0.000 claims description 6
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 6
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 5
- 150000003254 radicals Chemical class 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- LEGVTAFKUDAZRE-UHFFFAOYSA-N 5-ethylnonane-1,2,3-triol Chemical compound CCCCC(CC)CC(O)C(O)CO LEGVTAFKUDAZRE-UHFFFAOYSA-N 0.000 claims description 4
- 235000006491 Acacia senegal Nutrition 0.000 claims description 4
- 239000004287 Dehydroacetic acid Substances 0.000 claims description 4
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- 235000019258 dehydroacetic acid Nutrition 0.000 claims description 4
- 229940061632 dehydroacetic acid Drugs 0.000 claims description 4
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 claims description 4
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims description 4
- 229920000867 polyelectrolyte Polymers 0.000 claims description 4
- 239000012028 Fenton's reagent Substances 0.000 claims description 3
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 3
- 239000004288 Sodium dehydroacetate Substances 0.000 claims description 3
- 229960004365 benzoic acid Drugs 0.000 claims description 3
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- MGZTXXNFBIUONY-UHFFFAOYSA-N hydrogen peroxide;iron(2+);sulfuric acid Chemical compound [Fe+2].OO.OS(O)(=O)=O MGZTXXNFBIUONY-UHFFFAOYSA-N 0.000 claims description 3
- 150000002978 peroxides Chemical class 0.000 claims description 3
- 235000010235 potassium benzoate Nutrition 0.000 claims description 3
- 239000004300 potassium benzoate Substances 0.000 claims description 3
- 229940103091 potassium benzoate Drugs 0.000 claims description 3
- 231100000075 skin burn Toxicity 0.000 claims description 3
- 229960003885 sodium benzoate Drugs 0.000 claims description 3
- 235000019259 sodium dehydroacetate Nutrition 0.000 claims description 3
- 229940079839 sodium dehydroacetate Drugs 0.000 claims description 3
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 239000004283 Sodium sorbate Substances 0.000 claims description 2
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims description 2
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229940099404 potassium cocoate Drugs 0.000 claims description 2
- 231100000241 scar Toxicity 0.000 claims description 2
- 206010040872 skin infection Diseases 0.000 claims description 2
- 229940080279 sodium cocoate Drugs 0.000 claims description 2
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 claims description 2
- 235000019250 sodium sorbate Nutrition 0.000 claims description 2
- 241000220479 Acacia Species 0.000 claims 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 abstract description 16
- 125000000217 alkyl group Chemical group 0.000 abstract description 9
- 230000008719 thickening Effects 0.000 abstract description 2
- 239000006260 foam Substances 0.000 description 25
- 229960001031 glucose Drugs 0.000 description 23
- 239000003921 oil Substances 0.000 description 22
- 235000019198 oils Nutrition 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 19
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 238000005187 foaming Methods 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 12
- 159000000000 sodium salts Chemical class 0.000 description 12
- 229920001296 polysiloxane Polymers 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 10
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 description 10
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 10
- 229920000926 Galactomannan Polymers 0.000 description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 10
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 description 10
- 239000000284 extract Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- VPYJNCGUESNPMV-UHFFFAOYSA-N triallylamine Chemical compound C=CCN(CC=C)CC=C VPYJNCGUESNPMV-UHFFFAOYSA-N 0.000 description 10
- 229940096522 trimethylolpropane triacrylate Drugs 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 230000009471 action Effects 0.000 description 9
- 150000001298 alcohols Chemical class 0.000 description 9
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 description 9
- 239000001993 wax Substances 0.000 description 9
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 8
- 229940114081 cinnamate Drugs 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 8
- 150000002148 esters Chemical class 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 7
- 125000003423 D-mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 7
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 238000004821 distillation Methods 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 229940083542 sodium Drugs 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
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- 239000000126 substance Substances 0.000 description 7
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- 229940117913 acrylamide Drugs 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- 150000001768 cations Chemical class 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 150000002191 fatty alcohols Chemical class 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000006116 polymerization reaction Methods 0.000 description 6
- 239000012429 reaction media Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
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- 239000010936 titanium Substances 0.000 description 6
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- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 5
- DSSYKIVIOFKYAU-OIBJUYFYSA-N (S)-camphor Chemical compound C1C[C@]2(C)C(=O)C[C@H]1C2(C)C DSSYKIVIOFKYAU-OIBJUYFYSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- 101150028385 ATG2 gene Proteins 0.000 description 4
- 101100536419 Arabidopsis thaliana TATC gene Proteins 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 102100028765 Heat shock 70 kDa protein 4 Human genes 0.000 description 4
- 101150054249 Hspa4 gene Proteins 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- MGQIWUQTCOJGJU-UHFFFAOYSA-N [AlH3].Cl Chemical class [AlH3].Cl MGQIWUQTCOJGJU-UHFFFAOYSA-N 0.000 description 4
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- 229940024606 amino acid Drugs 0.000 description 4
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- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 235000013980 iron oxide Nutrition 0.000 description 4
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 4
- 238000010907 mechanical stirring Methods 0.000 description 4
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- 238000006386 neutralization reaction Methods 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 229920000569 Gum karaya Polymers 0.000 description 3
- 240000007472 Leucaena leucocephala Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 241000934878 Sterculia Species 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 150000001720 carbohydrates Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
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- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- PJHKBYALYHRYSK-UHFFFAOYSA-N triheptanoin Chemical compound CCCCCCC(=O)OCC(OC(=O)CCCCCC)COC(=O)CCCCCC PJHKBYALYHRYSK-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical group OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical class [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
- DUNKXUFBGCUVQW-UHFFFAOYSA-J zirconium tetrachloride Chemical compound Cl[Zr](Cl)(Cl)Cl DUNKXUFBGCUVQW-UHFFFAOYSA-J 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/16—Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Definitions
- Disinfecting composition for topical use is a composition for topical use
- the present invention relates to compositions for topical use, preferably used for hygienic disinfection and for disinfecting washing of the hands, mucous membranes, damaged parts of the skin.
- the present invention finds application in the cosmetic and dermocosmetic, dermopharmaceutical and human and veterinary pharmaceutical fields.
- the objective of hand disinfection, hand decontamination and more generally skin antisepsis is to prevent the transmission of microorganisms and viruses or to suppress their unwanted introduction into threatened and / or injured areas of the body or more sensitive areas.
- the compositions for hygienic disinfection and for disinfecting washing of hands and sensitive skin parts must meet efficiency requirements, some of which are defined by standards. Different methods are possible for treating the hands after contamination.
- compositions for topical use for disinfecting washing and hygienic hand disinfection must be effective after having acted for short periods (for example 30 seconds or 1 minute). For toxicological reasons, it is also necessary, in addition to adequate efficacy, in particular compatibility with human skin.
- compositions include as biocidal agents, for example short chain alcohols and excipients, regreasing agents, moisturizers and perfumes to improve the compatibility and acceptance of the skin.
- the known compositions often also include additional agents such as biguanides (for example chlorhexidine), quaternary ammonium compounds (for example benzalkonium chloride), phenolic derivatives (for example orthophenylphenol) or carboxylic acids.
- additional agents such as biguanides (for example chlorhexidine), quaternary ammonium compounds (for example benzalkonium chloride), phenolic derivatives (for example orthophenylphenol) or carboxylic acids.
- biguanides for example chlorhexidine
- quaternary ammonium compounds for example benzalkonium chloride
- phenolic derivatives for example orthophenylphenol
- formulations for topical foaming and disinfecting use require rapid foaming when applied to the part of the body to be disinfected.
- the formation of foam constitutes one of the proofs of the effectiveness of the application and of the disinfection.
- the speed of foam formation (or expansion time), the volume of this foam, its stability, as well as the pleasant sensations it induces, are important parameters to take into account to hope for the commercial success of these formulations.
- Formulations for topical foaming and disinfecting use include foaming surfactants, whether of a cationic, anionic, amphoteric or nonionic nature. These surfactants are called amphiphilic because they consist of a hydrophilic part (or polar head), soluble in water, and by a lipophilic part (hydrophobic tail) which has an affinity with oils and fats. This amphiphilic structure makes it possible both to dissolve greasy dirt and to remove it by a washing operation.
- Anionic surfactants are historically the surfactants which have been used to prepare foaming formulations for topical use.
- Sulphated anionic surfactants are a class of surfactants frequently used because of their good foaming properties. These surfactants to produce an aerated foam whose feel is not considered unpleasant by the consumer.
- these surfactants have the drawback of being sensitive to the degree of hardness of the water and to the presence of greasy dirt, which consequently results in a reduction in the volume of foam initially generated by these formulations but above all in a reduction in the stability over time of this volume of foam.
- foam stabilizing additives are often not very biodegradable and sometimes toxic, which makes them non-compliant with the new environmental requirements and regulations, and for application to the skin.
- compositions based on a sodium salt of cocoyl glutamate and mixtures of alkylpolyglucosides Cl 2- 16, and / or alkylpolyglucosides in which the alkyl chain carries from 4 to 7 carbon atoms do not allow to produce stable foam after addition of disinfecting agent.
- a solution of the present invention is a disinfectant composition (C D ) for topical use comprising for 100% of its mass
- composition (i) From 50% to 99% by mass, preferably from 55% to 99% by mass, and even more preferably from 57% to 99% by mass of a composition (Ci) comprising for 100% of its mass:
- composition (g) From 14% to 80% by mass of a composition (C 3 ) or of a mixture of compositions (C 3 ), said composition (C 3 ) being represented by formula (III):
- R 3 represents a linear or branched, saturated or unsaturated aliphatic radical containing from 12 to 16 carbon atoms
- G 3 represents the remainder of a reducing sugar and p represents a decimal number greater than or equal to 1.05 and less or equal to 5;
- composition (d) From 20% to 80% of a composition (C 4 ) or of a mixture of compositions (C 4 ), said composition (C 4 ) being represented by formula (V):
- R 4 represents a linear aliphatic radical, chosen from the radicals n-butyl (nC 4 H9-), n-pentyl (n-CsHn-), n-hexyl (nC 6 Hi 3 -), n-heptyl (nC 7 Hi 5 -), G 4 represents the remainder of a reducing sugar and q represents a decimal number greater than or equal to 1.05 and less than or equal to 5.
- composition according to the invention will preferably be of foaming form.
- alkali metals for example the cation sodium (Na + ), potassium (K + ) or lithium (Li + ),
- alkyloxyalkyl ammonium, bis (alkyloxyalkyl) ammonium or tris (alkyloxyalkyl) ammonium cations in which the alkyloxyalkyl radical (s) contain from two to six carbon atoms, for example the 2-ethoxy ethanammonium cation,
- the disinfectant composition (C D ) according to the invention may have one or more of the following characteristics:
- the gelling and / or thickening agent is chosen from polysaccharides consisting of derivatives of oses, polysaccharides consisting solely of oses, cellulose and cellulose derivatives, starches and linear or branched or crosslinked polyelectrolytes ;
- composition (C 3 ) consists of a mixture of compounds represented by the formulas (IIIi), (III 2 ), (III 3 ), (III 4 ) and (III5):
- composition (C 4 ) consists of a mixture of compounds represented by the formulas (Vi), (V2), (V 3 ), (V 4 ) and (V 5 ):
- composition (C2) comprises from 0% to 3% by mass of at least one alcohol of formula (IV):
- R3 is as defined for formula (III), and / or from 0% to 3% by mass of at least one alcohol of formula (VI):
- R 4 is as defined for formula (V);
- G3 and G 4 identical or different, independently of one another, represent the remainder of a reducing sugar, glucose, dextrose, sucrose, fructose, idose, gulose, galactose, maltose, isomaltose, maltotriose, lactose, cellobiose, mannose, ribose, xylose, arabinose, lyxose, allose, l 'altrose, dextran and tallose;
- the mixture (Mi) comprises for 100% of its mass, from 55% to 99% by mass of said composition (Ci) and from 1% by mass to 45% by mass of said composition (C 2 ), and more particularly of 57% at 99% by mass of said composition (Ci) and from 1% by mass to 43% by mass of said composition (C 2 );
- composition (Ci) comprises for 100% of its mass, from 65% to 90% by mass of one or more compounds of formula (I) and from 10% to 35% by mass of one or more compounds of formula (II); and more particularly from 65% to 85% by mass of one or more compounds of formula (I) and from 15% to 35% by mass of one or more compounds of formula (II);
- composition (C 2 ) comprises for 100% of its mass:
- the composition (C 2 ) comprises for 100% of its mass, a mass proportion in said composition (C 3 ) greater than or equal to 14% and less than or equal to 65%, a mass proportion in said alcohol of formula (IV) greater than or equal to 0% and less than or equal to 3%, a mass proportion in said composition (C 4 ) greater than or equal to 35% at and less than or equal to 80% and a mass proportion in said alcohol of formula (VI) greater than or equal to 0% and less than or equal to 3%;
- G 3 represents the remainder of a reducing sugar chosen from the residues of glucose, xylose and arabinose;
- p represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5, preferably greater than or equal to 1.05 and less than or equal to 2.0, and even more preferably greater than or equal to 1.25 and less than or equal to 2.0;
- R 3 represents a linear alkyl radical chosen from the n-dodecyl (n-Ci 2 H 2 5-), n-tetradecyl (n-Ci 4 H 29 -) radicals and n-hexadecyl (n-Ci 6 H 32 -);
- G 4 represents the remainder of a reducing sugar chosen from the residues of glucose, xylose and arabinose;
- q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5, preferably greater than or equal to 1.05 and less than or equal to 2.0, and even more preferably greater than or equal to 1.25 and less than or equal to 2.0.
- R 4 represents a linear alkyl radical chosen from the n-hexyl (nC 6 Hi 3 ) and n-heptyl (nC 7 Hi 5 ) radicals; preferably in formulas (V) and (VI), R 4 represents the heptyl radical (nC 7 Hi 5 -) and according to another preferential mode, in formulas (V) and (VI), R 4 represents the radical n -hexyl (nC 6 Hi 3 -).
- composition (C 2 ) comprises a mixture of compositions (C 3 ) and of compositions (C 4 ), said mixture comprising for 100% of its mass:
- composition (g 2 ) - from 5% to 16.25% by mass of a composition (C 3 ) represented by formula (III) in which R 3 represents the n-tetradecyl radical (n-Ci 4 H 29 ), and
- composition (ei) From 35% to 80% by mass of a composition (C 4 ) represented by the formula (V) in which R 4 represents the n-heptyl radical (nC 7 Hi 5 ); the composition (C 2 ) comprises a mixture of compositions (C 3 ) and of compositions (C 4 ), said mixture comprising for 100% of its mass:
- composition (gi) From 13.6% to 44.4% by mass, more particularly from 17% to 44.4% by mass of a composition (C 3 ) represented by the formula (III) in which R 3 represents the radical n -dodecyl (nC ⁇ ffe),
- composition (g 2 ) From 5% to 16.25% by mass, more particularly from 6.25% to 16.25% by mass of a composition (C 3 ) represented by formula (III) in which R 3 represents the radical n-tetradecyl (n-Ci 4 H 29 ), and
- composition (ei) From 35% to 80% by mass, more particularly from 35% by mass to 75% by mass, of a composition (C 4 ) represented by the formula (V) in which R 4 represents the n-hexyl radical (nC 6 Hi 3 );
- G 3 represents the remainder of a reducing sugar chosen from the remains of glucose, xylose and arabinose
- p represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5, more particularly greater than or equal to 1.05 and less than or equal to 2.0, and even more particularly greater than or equal to 1.25 and less than or equal to 2.0
- R 3 represents a linear alkyl radical chosen from the radicals n-dodecyl (n-Ci 2 H 25 ), n-tetradecyl (n-Ci 4 H 29 ), and n-hexadecyl (n-Ci 6 H 32 );
- G 3 represents the remainder of the glucose
- p represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5
- R 3 represents a linear alkyl radical chosen from the radicals n -dodecyl (n-Ci 2 H 25 ), n-tetradecyl (n-Ci 4 H 29 ), and n-hexadecyl (n-Ci 6 H 32 );
- G 3 represents the remainder of xylose
- p represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5
- R 3 represents a linear alkyl radical chosen from the radicals n -dodecyl (n-Ci 2 H 25 ), the n-tetradecyl radical (n-Ci 4 H 29 ), and the n-hexadecyl radical (n-Ci 6 H 32 );
- G 4 represents the remainder of a reducing sugar chosen from the remains of glucose, xylose and arabinose, q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5, more particularly greater than or equal to 1.05 and less than or equal to 2.0, and even more particularly greater than or equal to 1.25 and less than or equal to 2.0, and R 4 represents an aliphatic alkyl radical chosen from the n-hexyl radicals (nC 6 Hi 3 ), the n-heptyl radical (nC 7 Hi 5 ); - in formula (V), G 4 represents the rest of the glucose, q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5, and R 4 represents an aliphatic alkyl radical chosen from the radicals n -hexyl (n-CY.Hi 3 ⁇ 4), n-heptyl (nC 7 Hi 5 );
- G 4 represents the remainder of the glucose
- q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5
- R 4 represents the n-heptyl radical (n- C7H15 );
- G 4 represents the rest of the xylose
- q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5
- R 4 represents an aliphatic alkyl radical chosen from the radicals n- hexyl (n-CYHi 3 ⁇ 4), n-heptyl (nC 7 Hi 5 );
- G 4 represents the remainder of xylose
- q represents a decimal number greater than or equal to 1.05 and less than or equal to 2.5
- R 4 represents the n-heptyl radical (n- C 7 HI 5 );
- Mass of the composition (C3) / Mass of the composition (C 4 ) is greater than or equal to 20/80 and less than or equal to 70/30, preferably greater than or equal to 20/80 and less than or equal to 65 / 35, and even more preferably greater than or equal to 25/75 and less than or equal to 65/35;
- At least one gelling and / or thickening agent is chosen from xanthan gum (Gx), exudate from acacia gum (G A ), the mixture of xanthan gum (Gx) and exudate of acacia gum (G A ) in a mass ratio between xanthan gum (Gx) and acacia exudate gum (G A ) greater than or equal to 1/3 and less than or equal to 3 / 1;
- At least one disinfecting agent is chosen from the elements of the group consisting of sorbic acid, sodium sorbate, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, benzoic acid, sodium benzoate, potassium benzoate; 1- (2-ethylhexyl) glycerol; hydrogen peroxide; activated peroxides such as mixtures of hydrogen peroxide and sodium bicarbonate, mixtures of hydrogen peroxide and urea, mixtures of hydrogen peroxide and peracetic acid and mixtures of hydrogen peroxide and iron (Fenton's reagent); hydroperoxycarbonates; peracetic acid; sodium hypochlorite; - the disinfectant composition (C D ) comprises for 100% of its mass: a) - From 35% to 99.3% of water;
- AG gelling and / or thickening agent
- the compound of formula (I) is chosen from monosodium N-cocoyl glutamate, monopotassium N-cocoyl glutamate, disodium N-cocoyl glutamate, dipotassium N-cocoyl glutamate,
- the compound of formula (II) is chosen from sodium cocoate and potassium cocoate,
- R 3 represents a linear or branched, saturated or unsaturated aliphatic radical, comprising from 12 to 16 carbon atoms, G 3 represents the remainder of glucose or xylose and p represents a decimal number greater than or equal 1.05 and less than or equal to 2.5;
- R 3 represents a linear or branched, saturated or unsaturated aliphatic radical, comprising from 12 to 16 carbon atoms,
- R 4 represents the n-heptyl radical (nC 7 Hi 5 )
- G 4 represents the remainder of glucose or xylose and q represents a decimal number greater than or equal to 1.05 and less than or equal at 2,
- R 4 represents the n-heptyl radical (nC 7 Hi 5 ).
- residues (G 3 ) and (G 4 ) denotes formulas (III) and (V) as defined above, the residues of saccharide derivatives without glycosidic bond established between a carbon anomeric and oxygen of an acetal group, as they are defined in the reference work: "Biochemistry, Daniel Voet / Judith G. Voet, p. 250, John Wyley & Sons, 1990.”
- the oligomeric structures (G 3 ) p and (G 4 ) q can be in any form of isomerism, whether it is optical isomerism, geometric isomerism or position isomerism; it can also represent a mixture of isomers.
- the group FU is linked to G 3 by the anomeric carbon of the saccharide residue, so as to form an acetal function.
- the group R 4 is linked to G 4 by the anomeric carbon of the saccharide residue, so as to form an acetal function.
- a linear alkyl radical chosen from the n-dodecyl (n-Ci 2 H25-), n-tetradecyl (n-Ci 4 H 29 -) and n-hexadecyl (n-Ci 6 H 3 2-) radicals,
- r represents an integer between 8 and 16, for example the isododecyl, isotridecyl, isotetradecyl, isopentadecyl or isohexadecyl radical;
- t is an integer between 2 and 12
- s is an integer between 2 and 14
- the sum s + t is greater than or equal to 10, and less than or equal to 14, for example the 2-ethyl radical decyl, 2-butyl octyl, 2-ethyl dodecyl, 2-butyl decyl, 2-hexyl octyl, 2-hexyl decyl or 2-butyl dodecyl.
- the compounds of formulas (I) as described above are generally obtained by N-acylation of the corresponding amino acids or their salts. It is described for example in the international application published under the number WO 98/09611. It is used either on an amino acid or on a mixture of amino acids.
- the acylating agent generally consists of an activated derivative of the carboxylic acid of formula:
- R 1 is as defined above, such as a symmetrical anhydride of this acid, the methyl ester of this acid, or an acid halide such as acid chloride or acid bromide. It can also consist of a mixture of activated derivatives of carboxylic acids derived from natural oils or fats of animal or vegetable origin such as coconut, coconut, palm kernel, palm, soybean, rapeseed, corn, beef tallow, spermaceti oil or herring oil.
- the subject of the invention is the disinfectant composition (C D ) according to the invention, characterized in that, in which said composition (Ci) included in the surfactant mixture (Mi), said composition (Ci) is obtained by a process comprising at least:
- a mixture of acid chlorides comprising for 100% molar, from 40% molar to 60% molar dodecanoyl chloride, 10 mol% to 20
- the mixture of acid chlorides used comprises 100% by mol, 11% by mol of octanoyl chloride, 9.5% by mol of decanoyl chloride, 51% by mol of dodecanoyl chloride, 15, 5 mol% of tetradecanoyl chloride, 6.5 mol% of hexadecanoyl chloride, 2 mol% of octadecanoyl chloride, 3 mol% of 9-octadecenoyl chloride and 1.5% octadeca- 9 chloride, l2-diènoyl.
- the subject of the invention is the composition (C D ) for topical use as defined above, characterized in that, in the composition (Ci) included in the surfactant mixture (Mi), the compound or compounds of formula (I) are chosen from monosodium N-cocoyl glutamate, monopotassium N-cocoyl glutamate, disodium N-cocoyl glutamate and dipotassium N-cocoyl glutamate.
- the invention relates to said composition (C D ) for topical use as defined above, characterized in that the composition (C 3 ), is obtained by the implementation of a process comprising at least one step A ') of glycosylation of:
- G 3 represents the remainder of a reducing sugar chosen from the residues of glucose, xylose and arabinose.
- the invention relates to said composition (C D ) for topical use as defined above, characterized in that the composition (C 4 ), is obtained by the implementation of a process comprising at minus a glycosylation stage A of:
- G 4 represents the remainder of a reducing sugar chosen from the residues of glucose, xylose and arabinose.
- the invention relates to said composition (C D ) for topical use as defined above, characterized in that the composition (C 3 ) is obtained by the implementation of a process comprising at least a glycosylation stage A ′ generally carried out with mechanical stirring, by bringing a molar equivalent of a reducing sugar (G 3 ) into contact with from one to five molar equivalents of the mixture of l-dodecanol and l-tetradecanol , and hexadecanol-1, as described above, in the presence of an acidic catalytic system, under predetermined temperature and partial vacuum conditions.
- a process comprising at least a glycosylation stage A ′ generally carried out with mechanical stirring, by bringing a molar equivalent of a reducing sugar (G 3 ) into contact with from one to five molar equivalents of the mixture of l-dodecanol and l-tetradecanol , and hexadecanol-1, as described above, in the
- step A of the process for preparing the composition (C 4 ), as defined above, is generally carried out with mechanical stirring, by bringing a molar equivalent of a reducing sugar (G 4 ) into contact. with from one to four molar equivalents of at least one alcohol of formula (V), in the presence of an acidic catalytic system, under predetermined temperature and partial vacuum conditions.
- temperature and partial vacuum conditions are for example temperature values between 70 ° C and 130 ° C, and a partial vacuum between 300 mbar (3.10 4 Pa) and 20 mbar (2.10 3 Pa).
- step A ′ and step Ai ′ of glycosylation makes it possible to respectively form the composition (C 3 ), ie a mixture of compounds represented by the formulas (IPi), (PI 2 ), (HL), (III 4 ) and (III5) as defined above, and optionally an excess of the alcohol of formula (IV) or of the mixture of alcohols of formula (IV), and the composition (C 4 ), ie a mixture of compounds represented by formulas (Vi), (V 2 ), (V3), (V 4 ) and (V 5 ) as defined above, and optionally an excess of the alcohol of formula (VI).
- step A 'or step Ai' of the process for the preparation of the respective compositions (C3) and (C 4 ) as defined above can be followed respectively by step B 'or d' a step Bi 'of elimination of the alcohols respectively of formula (IV), or of the mixture of alcohols of formula (IV), and of formula (VI), which have not reacted during step A') or of step Ai '.
- Such a preparation process can be supplemented, if necessary or if desired, by neutralization, filtration and discoloration operations.
- acid catalytic system denotes, in step A 'and in step Ai' of the process defined above, strong acids such as sulfuric acid, hydrochloric acid, phosphoric acid, acid nitric, methane sulfonic acid, (para-toluene) sulfonic acid, (trifluoromethane) sulfonic acid, hypophosphorous acid, hyponitrous acid, polyphosphoric acid, or ion exchange resins.
- step B ') or step B ⁇ ) of the process as described above the alcohols of formula (IV) respectively, or the mixture of alcohols of formula (IV), or the alcohol of formula (V) are eliminated according to methods known to a person skilled in the art such as, for example, by distillation, such as hard film thin film distillation, molecular distillation or extraction by solvents.
- thickening agent present in the composition (CD) for topical use which is the subject of the present invention, is meant a chemical compound or a chemical composition which increases the viscosity of the medium into which it is introduced.
- gelling agent present in the composition (CD) for topical use which is the subject of the present invention, is meant a chemical compound or a chemical composition which transforms a liquid medium into a structured state, which does not flow , by forming a three-dimensional network within the liquid; the gel being considered as an intermediate state between the liquid state and the solid state.
- polysaccharides in the context of the present invention, by polysaccharides, is meant saccharide polymers.
- the IUP AC definition of saccharides designates oses, compounds of oses proper and their derivatives obtained either by reduction of a carbonyl group, or by oxidation of one or more hydroxyl functions, or by replacement of one or more hydroxyl functions by a hydrogen atom, by an amine group, a phosphate function, a sulfate function.
- the polysaccharides most commonly used for the preparation of industrial, food, cosmetic or pharmaceutical compositions are mainly made up of oses, such as glucose, galactose, mannose or derivatives of oses for which the hydroxyl function of the terminal carbon has been oxidized to a carboxyl function.
- Two distinct groups can be distinguished among polysaccharides: polysaccharides consisting only of oses (or poly-oses) and polysaccharides consisting of derivatives of oses.
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from polysaccharides consisting solely of oses (or poly-oses).
- glucans which are homopolymers of glucose abundant in nature
- glucomannoglycans xyloglycans
- galactomannans which are polymers whose main chain consists of units of D-mannose, linked together at b-1,4, and on which units of D-galactose are grafted laterally by a-1,6 bonds.
- Galactomannans are present in several plant species, and more particularly in leguminous species in which they constitute the albumen of seeds.
- the degree of substitution (DS) of D-galactose units on the main D-mannose chain of galactomannans varies between 0 and 1:
- the galactomannans from cassia gum have a degree of substitution (DS) of about 1/5, signifying the lateral grafting of one unit of D-galactose every 5 units of D-mannose present on the main chain of polysaccharide.
- DS degree of substitution
- the galactomannans from locust bean gum have a degree of substitution (DS) of approximately 1/4, signifying the lateral grafting of one unit of D-galactose every 4 units of D-mannose present on the main chain of polysaccharide.
- the galactomannans from tara gum have a degree of substitution (DS) of about 1/3, meaning the lateral grafting of one unit of D-galactose every 3 units of D-mannose present on the main chain of polysaccharide.
- the galactomannans from guar gum have a degree of substitution (DS) of about 1/2, meaning the lateral grafting of one unit of D-galactose every 2 units of D-mannose present on the main chain of polysaccharide.
- the galactomannans from fenugreek gum have a degree of substitution (DS) of about 1/1, meaning the lateral grafting of a D-galactose unit for almost all the D-mannose units present on the main chain polysaccharide.
- the gelling and / or thickening agents present in the composition (CD) for topical use which is the subject of the present invention, are chosen from polysaccharides consisting solely of oses (or poly-oses) included in the group consisting galactomannan from Tara gum, galactomannan from guar gum and galactomannane from carob gum.
- the gelling agents and / or thickeners present in the composition (CD) for topical use which is the subject of the present invention are chosen from polysaccharides consisting of derivatives of oses.
- polysaccharides made up of derivatives of oses one can distinguish:
- galactose polymers which may have appendix sulphate ester groups, represented in particular by algal polysaccharides such as carrageenans and agar;
- Uronanes which are polymers of uronic acids such as algin and pectin;
- heteropolymers of oses and uronic acids often of complex composition, these polymers are found in particular in the exudates of sap (such as for example the exudate of gum arabic and the exudate of karaya gum) but they are also produced by microorganisms, such as, for example, xanthan gum and gellan gum;
- Glucosaminoglycans which are polysaccharides formed from glucose derived by replacement of its hydroxyl on C-2 by an amine (called 2-amino-2-deoxy-D-glucose or, more simply, glucosamine).
- the amine function can also be acetylated.
- hydrocolloids in this class is chitosan, formed only of units glucosamine, and hyaluronan, the repeat unit of which is a dimer of glucosamine and glucuronic acid.
- Xanthan gum has become the most widely used microbial polysaccharide in the industry in recent decades.
- Xanthan is a polysaccharide synthesized by bacteria of the genus Xanthomonas and, commercially, only the species X. campestris is used.
- the main chain of (Gx) is identical to that of cellulose, that is to say that it is formed of bD-glucose units linked by carbons 1 and 4.
- each branch consisting of a triholoside composed of two mannoses and a glucuronic acid, of the type: b-D-Manp-f 1 4) -P-D-GlcAp- (l 2) -a-D- Manp- (l 3) [I. Capron et al, “About the native and renaturated conformation of xanthan exopolysaccharide”. 1997).
- Xanthan gum (GX) is available as a sodium, potassium or calcium salt.
- Acacia gum is a branched complex polysaccharide whose main chain consists of bD-galactose units linked together by carbons 1 and 3.
- the chains connected to the main chain are made up of bD-galactose units linked between them by carbons 1 and 6, also carrying ⁇ -arabinose units, and in lesser proportions b-glucoronosyl units.
- Both the main chain and the pendant chains contain a-L-arabinosyl, a-L-rhamnopyranosyl, b-D-glucuronopyranosyl and 4-0-methyl ⁇ -D-glucuronopyranosyl units.
- the gelling and / or thickening agents present in the composition (C D ) for topical use which is the subject of the present invention are polysaccharides consisting of derivatives of oses chosen from the elements of the group consisting of carrageenans, l agar, algins, pectins, gum arabic exudate, karaya gum exudate, xanthan gum, gellan gum, chitosan and hyaluronan, and / or mixtures thereof.
- the gelling and / or thickening agents present in the composition (C D ) for topical use which is the subject of the present invention are polysaccharides consisting of derivatives of oses chosen from the elements of the group consisting of acacia gum exudate, karaya gum exudate, xanthan gum and / or mixtures thereof.
- the gelling and / or thickening agents present in the composition (CD) for topical use which is the subject of the present invention, are polysaccharides consisting of derivatives of oses chosen from the elements of the group consisting of exudate acacia gum (GA), xanthan gum (Gx), the mixture of xanthan gum (Gx) and acacia gum exudate (GA) used in a mass ratio between xanthan gum (Gx) and the acacia exudate gum (GA) is greater than or equal to 1/3 and less than or equal to 3/1, in particular marketed by SEPPIC under the brand name SOLAGUM TM AX.
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from cellulose and cellulose derivatives.
- cellulose denotes a polysaccharide which is constituted by a linear chain of D-Glucose molecules, the average molecular mass of which is at least lO.OOOgmol 1 , more particularly at least minus 15,000gmol _1 , more particularly at least l7,000gmol _1 , even more particularly at least 20,000gmol _1 , even more particularly at least 25,000gmol _1 .
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from cellulose derivatives.
- cellulose derivatives denotes the elements of the group consisting of hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, methyl hydroxy ethyl cellulose, methyl hydroxy propyl cellulose, G hydroxy propyl cellulose, the sodium salt of carboxy methyl cellulose, dihydroxy propyl cellulose ether (as described in the American patent published under the number US 4,096,326).
- starch denotes a mixture of amylose and amylopectin, and more particularly the elements of the group consisting of corn starch, wheat starch, potato starch and cassava starch.
- polymers of polyelectrolyte type linear or branched or crosslinked
- These synthetic anionic polyelectrolytes are in the form of reverse latexes, obtained by radical polymerization in reverse emulsion, or in the form of powders, obtained by precipitating polymerization or by atomization of reverse latexes.
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from linear or branched or crosslinked polyelectrolytes, resulting from the radical polymerization of at least one monomer selected from the group consisting of acrylic acid and / or its sodium salt, methacrylic acid and / or its sodium salt, 2-hydroxyethyl acrylate, methacrylate of 2 -hydroxyethyl, acrylamide, N, N-dimethyl acrylamide, N-isopropyl acrylamide, 2-acrylamido-2-methylpropanesulfonic acid and / or its sodium or potassium salt, N-vinyl pyrrolidone, in the presence of a crosslinking agent chosen from polyethylene monomers comprising at least two ethylenic functions, and more particularly chosen from elements of the group consisting of ethylene glycol dimethacrylate, tetraallyloxyet hane, ethylene glycol dimethacrylate
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from the elements of the group consisting of:
- the gelling agents and / or thickeners present in the composition (C D ) for topical use which is the subject of the present invention are chosen from the elements of the group consisting of xanthan gum (Gx), exudate acacia gum (G A ), the mixture of xanthan gum (Gx) and exudate of acacia gum (G A ) in a mass ratio between xanthan gum (Gx) and gum acacia exudate (G A ) is greater than or equal to 1/3 and less than or equal to 3/1, the sodium salt copolymer of 2- acrylamido 2-methyl propanesulfonic acid and 2 acrylate -hydroxy ethyl, crosslinked with triallyl amine and / or trimethylol propanetriacrylate and / or methylene-bis (acrylamide), the sodium salt copolymer of 2-acrylamido-2-methylpropanesulfonic acid and acrylamide , crosslinked with triallyl amine and / or
- disinfectant means a substance or a chemical composition which kills or inactivates micro-organisms present on the surface of the skin to which it has been applied.
- the disinfecting agents included in the composition (C D ) for topical use which is the subject of the present invention belong to biocidal products as defined by the regulations concerning the making available on the market and the use of biocidal products (EU Regulation No. 528 / 20l2 of May 22, 2012).
- Biocidal products represent all substances and mixtures, made up of one or more active molecules, intended to destroy, repel or render harmless living pests, to prevent their action or to combat them in any other way by chemical or biological action. These products are divided, according to their applications, into four groups which are (i) disinfectants, (ii) protective products aimed at preventing microbial development and the development of algae, (iii) pest control products and (iv) other biocidal products such as anti-fouling products or for embalming and taxidermy.
- each disinfecting agent presents several performance criteria, such as (i ') its speed of effectiveness, (ii') its decontamination efficiency which is measured by a factor of reduction of an initial contaminating population under the effect of disinfectant (initial population / final population after treatment) or by the reduction in log of this factor and (iii ') its compatibility with building materials. Disinfectants are therefore classified according to their disinfection efficiency and we speak of disinfectants with a high, medium or low level of disinfection.
- composition (C D ) for topical use which is the subject of the present invention comprises at least one disinfecting agent chosen from disinfectants with a high disinfection level, namely disinfectants having a higher factor (initial contaminating population / final population after treatment) to 10 6 .
- the invention relates to a composition (C D ) for topical use as defined above, characterized in that the at least disinfecting agent is chosen from the elements of the group consisting of sorbic acid, sorbate sodium, potassium sorbate, dehydroacetic acid, sodium dehydro acetate, benzoic acid, sodium benzoate, potassium benzoate; 1- (2-ethylhexyl) glycerol; hydrogen peroxide; activated peroxides such as mixtures of hydrogen peroxide and sodium bicarbonate, mixtures of hydrogen peroxide and urea, mixtures of hydrogen peroxide and peracetic acid and mixtures of hydrogen peroxide and iron (Fenton's reagent); hydroperoxycarbonates; peracetic acid; sodium hypochlorite.
- the at least disinfecting agent is chosen from the elements of the group consisting of sorbic acid, sorbate sodium, potassium sorbate, dehydroacetic acid, sodium dehydro acetate, benzoic acid, sodium benzoate, potassium be
- the subject of the invention is a composition (C D ) for topical use as defined above, characterized in that the at least disinfecting agent is hydrogen peroxide or sodium hypochlorite.
- the subject of the invention is a composition (C D ) for topical use as defined above, characterized in that the at least disinfecting agent is a mixture of potassium sorbate and sodium benzoate, and even more particularly a mixture comprising for 100% of its mass, (i) from 30% to 40% by mass of potassium sorbate and from 60% to 70% by mass of sodium benzoate.
- the subject of the invention is a composition (C D ) for topical use as defined above, characterized in that the at least disinfecting agent is l- (2-ethylhexyl) glycerol.
- the subject of the invention is a composition (C D ) for topical use as defined above, characterized in that the at least disinfecting agent is a mixture of benzyl alcohol, benzoic acid, dehydroacetic acid.
- composition (C D ) for topical use which is the subject of the present invention can be packaged in pressurized form in an aerosol device or in a device of the “pump bottle” type.
- the composition (C D ) for topical use according to the invention as defined above can also be applied in the form of fine droplets by means of mechanical or propellant pressurization devices.
- propellants which can be combined with the composition (C D ) for topical use according to the invention, there are the hydrofluorinated compounds, such as dichlorodifluoromethane, trichlorofluoromethane, difluoroethane, isobutane, butane, propane.
- composition (C D ) for topical use as defined above may also comprise excipients and / or active principles usually used in the field of formulations for topical use, in particular cosmetic, dermo cosmetic, pharmaceutical or dermo-pharmaceutical products. .
- composition (C D ) for topical use which is the subject of the present invention and as defined above, can also comprise one or more auxiliary compounds chosen from thickening and / or gelling surfactants, film-forming compounds, solvents and co-solvents, hydrotropic agents, plasticizing agents, opacifying agents, pearling agents, sequestering agents, chelating agents, antioxidant agents, perfumes, essential oils, preserving agents, conditioning agents, deodorant agents, whitening agents intended for discoloration of hair and skin, active ingredients intended to provide a treating and / or protective action with respect to the skin or the hair, sun filters, mineral fillers or pigments, particles providing a visual effect or intended for the encapsulation of active ingredients, exfoliating particles, texturing agents, optical brighteners, insect repellents.
- auxiliary compounds chosen from thickening and / or gelling surfactants, film-forming compounds, solvents and co-solvents, hydrotropic agents, plasticizing agents, opacifying agents, pearling agents, sequestering agents, chel
- water-soluble antioxidant agents which can be combined with the composition (C D ) for topical use according to the invention, there are ascorbic acid, glutathione, tartaric acid, oxalic acid, tetra sodium. glutamate diacetate.
- water-soluble sequestering agents which can be combined with the composition (C D ) for topical use according to the invention, there are the salts of ethylenediamine tetracetic acid (EDTA), such as the sodium salt of EDTA , the salts of diethylenetriamine pentacetic acid (DTP A) such as the sodium salts of DTP A, acetyl glutamic acid (Dissolvine range).
- EDTA ethylenediamine tetracetic acid
- DTP A diethylenetriamine pentacetic acid
- DTP A acetyl glutamic acid
- composition (C D ) for topical use according to the invention there is Tris citrate (tetramethyl hydroxy piperidinol), benzotriazolyl butylphenol sulfonate sodium, benzotriazolyl dodecyl p-cresol.
- texture agents possibly present in the composition (C D ) for topical use which is the subject of the present invention
- N-acylated derivatives of amino acids for example lauroyl lysine sold under the name AMINOHOPE TM FF, octenyl starch succinate sold under the name DRYFFO TM, myristyl polyglucoside sold under the name MONTANOV 14, cellulose fibers, cotton fibers, chitosan fibers, talc, sericitis, mica, perlite.
- composition (C D ) for topical use which is the subject of the present invention, there are:
- Vitamin A retinol
- vitamin C ascorbic acid
- sugar derivatives of ascorbic acid e.g. ascorbyl glucoside
- tocopherol vitamin E
- vitamins B3 or B 10 niacinamide and its derivatives
- SEPIWHITE TM MSH arbutin, kojic acid, hydroquinone, VEGEWHITE TM, GATULINE TM, SYNERLIGHT TM
- SEPIWHITE TM MSH arbutin
- kojic acid hydroquinone
- VEGEWHITE TM GATULINE TM
- SYNERLIGHT TM SYNERLIGHT
- BIOWHITE TM PHYTOLIGHT TM, DERMALIGHT TM, CLARISKIN TM,
- the compounds showing a hydrating action for example diglycerol, triglycerol, urea, hydroxyureas, glycerolglucoside, diglycerolglucoside, polyglycerylglucosides, erythritylglucoside, sorbitylglucoside, xylitylglucoside, the composition sold under the brand name AQUAX TM comprising xylitylglucoside, anhydroxylitol and xyllitol;
- Extracts rich in tannins in polyphenols and / or isoflavones for example grape extracts, pine extracts, wine extracts, olive extracts; soy extracts, for example Raffermine TM; wheat extracts, for example TENSINE TM or GLIADINE TM; plant extracts rich in terpenes; extracts of freshwater or marine algae; marine extracts in general such as corals;
- Anti-aging active ingredients such as SEPILIFT TM DPHP, LIPACIDE TM PVB, SEPIVINOL TM, SEPIVITAL TM, MANOLIVA TM, PHYTO-AGE TM, TIMECODE TM; SURVICODE TM;
- Active ingredients increasing the synthesis of components of the extracellular matrix, for example collagen, elastins, glycosaminoglycans; - Active ingredients favorably acting on chemical cellular communication such as cytokines or physical ones such as integrins;
- Active ingredients that create a feeling of “warming” on the skin such as activators of skin microcirculation (for example nicotinic acid derivatives) or products that create a feeling of “freshness” on the skin (for example menthol and drifts) ;
- Active ingredients improving skin microcirculation for example veinotonics; draining active ingredients; active ingredients for decongestant purposes, for example extracts of ginko biloba, ivy, horse chestnut, bamboo, ruscus, small holly, centalla asiatica, fucus, rosemary, willow;
- active ingredients which act as skin tightening agents for example hydrolysates of vegetable proteins, hydrolysates of marine origin such as hydrolysates of laminaria extracts, hydrolysates of fish cartilage, marine elastin, the product marketed by SEPPIC under the brand name SES AFL AS H TM, collagen solutions.
- -Tanning or browning agents for the skin for example dihydroxyacetone, isatin, alloxane, ninhydrin, glyceraldehyde, mesotartaric aldehyde, glutaraldehyde, erythrulose.
- deodorant agents optionally present in the composition (C D ) for topical use which is the subject of the present invention
- alkali silicates zinc salts such as zinc sulphate, zinc gluconate, zinc chloride , zinc lactate
- quaternary ammonium salts such as cetyltrimethylammonium salts, cetylpyridinium salts
- glycerol derivatives such as glycerol caprate, glycerol caprylate, polyglycerol caprate; 1,2-decanediol; 1,3-propanediol; salicylic acid; sodium bicarbonate; cyclodextrins; metallic zeolites; Triclosan TM; aluminum hydrobromide, aluminum hydrochlorides, aluminum chloride, aluminum sulfate, aluminum and zirconium hydrochlorides, aluminum and zirconium hydrochloride, aluminum and zirconium tetrachloride , aluminum and zirconium pent
- oils optionally present in the composition (C D ) for topical use which is the subject of the present invention
- mineral oils such as paraffin oil, petrolatum oil, isoparaffins or white mineral oils
- oils of animal origin such as squalene or squalane
- vegetable oils such as phytosqualane, sweet almond oil, coconut oil, castor oil, jojoba oil, olive oil, rapeseed oil, peanut oil, sunflower oil, wheat germ oil, corn germ oil, soybean oil, cottonseed oil, alfalfa oil, poppy oil, pumpkin oil, evening primrose oil, millet oil, barley oil, rye oil, safflower oil, sayoulier oil, passionflower oil, hazelnut oil, palm oil, shea butter, apricot kernel oil, coriander seed oil, beech oil, calophyllum oil, sysymbrium oil, avocado oil, calendula oil, oils from flowers or vegetables ethoxylated vegetable oils; synthetic oils such
- waxes possibly present in the composition (C D ) for topical use which is the subject of the present invention
- waxes is meant in the present application the compounds and / or mixtures of compounds insoluble in water, having a solid appearance at a temperature greater than or equal to 45 ° C.
- nonionic emulsifying surfactants which can be combined with the composition (C D ) for topical use which is the subject of the present invention
- esters of fatty acids and of sorbitol such as the products sold under the names MONTANE TM 40, MONTANE TM 60, MONTANE TM 70, MONTANE TM 80 and MONTANE TM 85
- compositions comprising glycerol stearate and ethoxylated stearic acid between five moles and one hundred and fifty moles of ethylene oxide such as the composition comprising ethoxylated stearic acid containing one hundred and thirty-five moles of ethylene oxide and glycerol stearate sold under the name SIMULSOL TM 165
- mannitan esters ethoxylated mannitan esters
- sucrose esters methyl glucoside esters
- alkyl polyglycosides comprising an aliphatic radical, linear or
- composition (C D ) for topical use which is the subject of the present invention
- pigments, organic solar filters and inorganic solar filters are designated.
- pigments used as a protective agent against ultraviolet radiation from the sun which may be present in the composition (C D ) for topical use which is the subject of the present invention there are for example titanium dioxide, brown iron oxides, oxides of yellow iron, black iron oxides, or red iron oxides or even white or colored pearlescent pigments such as Mica-Titanium.
- organic sunscreens used as a protection agent against ultraviolet radiation from the sun possibly present in the composition (C D ) for topical use which is the subject of the present invention there are for example:
- PABA para-aminobenzoic acids
- monoglycerol esters of PABA the ethyl esters of N, N-propoxy PABA
- the ethyl esters of N, N-diethoxy PABA the ethyl esters of N, N-dimethyl PABA
- the methyl esters of N, N-dimethyl PABA the butyl esters of N, N-dimethyl PABA;
- salicylic acid derivatives such as amyl salicylate, homomenthyl salicylate, ethylhexyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate;
- cinnamic acid derivatives such as ethylhexyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, p-methoxypropyl cinnamate, cinnamate of p-methoxyisopropyl, p-methoxyisoamyl cinnamate, p-methoxyoctyl cinnamate (p-methoxy 2-ethylhexyl cinnamate), p-methoxy 2-ethoxyethyl cinnamate, p-methoxycyclohexyl cinnamate, cinnamate ethyl-a-cyano-P-phenyl, 2-ethylhexyl-Da-cyano-P-phenyl cinnamate, glyceryl diparamethoxy
- inorganic solar filters used as a protection agent against ultraviolet radiation from the sun possibly present in the formulation (F 2 ) for topical use which is the subject of the present invention there are for example: titanium oxides, zinc oxides , cerium oxide, zirconium oxide, yellow, red or black iron oxides, chromium oxides.
- These mineral screens can be micronized or not, have undergone or not surface treatments and may be presented in the form of aqueous or oily pre-dispersions.
- the subject of the invention is also a disinfectant composition (C D ) according to the invention for disinfecting hand washing.
- disinfectant wash or “hygienic wash” or “antiseptic wash” of the hands, is meant within the meaning of the present invention a process which makes it possible to carry out a disinfection of the hands, by washing, effective and well tolerated.
- the disinfectant wash carried out with an antiseptic soap, whose effectiveness is validated by compliance with European and AFNOR standards.
- composition (C D ) for topical use as defined above is used to create a foam, generated:
- pressurized packaging in which is the composition (C D ) for topical use associated with a propellant, generating the foam which is then applied to the skin area to be treated,
- the invention also relates to a disinfectant composition (C D ) according to the invention for treating a skin infection, a skin burn, a scar, a wound, in humans or animals.
- C D disinfectant composition
- wounds skin burns may be subject to surgical procedures.
- the following examples illustrate the invention without, however, limiting it.
- cocoyl chloride is added gradually with stirring, which is a mixture of acid chlorides comprising for 100% by mass 8% by mass of octanoyl chloride, 8% by mass of decanoyl chloride, 50 % by mass of lauroyl chloride, 17% by mass of myristoyl chloride, 8% by mass of palmitoyl chloride, 3% by mass of stearoyl chloride, 4% by mass of oleoyl chloride and 2% by mass of linoleoyl chloride, then 140 additional kilograms of the 30% sodium hydroxide solution to maintain the pH between 11 and 12. The temperature is maintained between 20 ° C and 50 ° C for two hours.
- the mixture obtained is acidified by adding 54 kilograms of an aqueous solution of sulfuric acid at 70% by mass, then diluted with 193 kilograms of water to obtain an aqueous solution of disodium N-cocoylglutamate [composition (Ci)].
- the reaction medium is placed under partial vacuum of about 0.18 ⁇ 10 5 Pa (180mbar) and maintained at 100 ° C.-105 ° C. for four hours with distillation of the water formed.
- reaction medium After cooling to 85 ° C-90 ° C and neutralization by adding 40% sodium hydroxide, the reaction medium thus obtained is drained at 70 ° C and filtered to remove the grains of unreacted glucose.
- the filtrate is then poured into another reactor and the excess of the mixture of fatty alcohols (Ni) removed by distillation using a thin film film evaporator, then the residue diluted in water.
- the composition (C 3 ) is obtained, which comprises 50% by mass of water and 50% by mass of a mixture of alkyl polyglucosides (MAAP G I), for which the proportions in alkyl polyglucosides and the average degree of polymerization of their polyglucoside residue are determined by gas chromatography (GC); it therefore comprises for 100% by mass 69% by mass of n-dodecyl polyglucosides, 25% by mass of n-tetradecyl polyglucosides and 6% by mass of n-hexacyl polyglucosides with a degree of polymerization equal to 1.25.
- MAAP G I mixture of alkyl polyglucosides
- heptanol-1 2.7 molar equivalents of heptanol-1 are poured with stirring into a reactor maintained at 40 ° C., then 1 molar equivalent of anhydrous glucose, followed by 0.15% by mass of 98% sulfuric acid per 100% by mass of the mixture.
- the reaction medium is placed under partial vacuum of about 0.18 ⁇ 10 5 Pa (180mbar) and maintained at 100 ° C.-105 ° C. for four hours with distillation of the water formed. After cooling to 85 ° C-90 ° C and neutralization by adding 40% sodium hydroxide, the reaction medium thus obtained is drained at 70 ° C and filtered to remove the grains of unreacted glucose.
- the filtrate is then poured into another reactor and the excess of heptanol distilled under partial vacuum, then the residue diluted in water.
- composition (C 4 ) After stirring for 30 minutes at 50 ° C., the composition (C 4 ) is obtained comprising 26.4% by mass of water and 73.6% by mass of n-heptyl polyglucosides (MAAPG2), with a degree of polymerization, determined by CPG, equal to 1.25.
- MAAPG2 n-heptyl polyglucosides
- the reaction medium is placed under partial vacuum of about 0.18 ⁇ 10 5 Pa (180mbar) and maintained at 100 ° C.-105 ° C. for four hours with distillation of the water formed.
- reaction medium After cooling to 85 ° C-90 ° C and neutralization by adding 40% sodium hydroxide, the reaction medium thus obtained is drained at 70 ° C and filtered to remove the grains of unreacted glucose.
- the filtrate is then poured into another reactor, the excess of the mixture of fatty alcohols (N 3 ) removed by distillation using a thin film film evaporator, then the residue diluted in water.
- the composition (C ' s) is obtained, which comprises 40% by mass of water and 60% by mass of a mixture of alkyl polyglucosides (MAAPG 3 ) for which the proportions in alkyl polyglucosides and the average degree of polymerization of their polyglucoside residue are determined by CPG; so he understands for 100% by mass 52% by mass of n-octyl polyglucoside and 48% by mass of n-decyl polyglucoside, with an average degree of polymerization equal to 1.30.
- MAAPG 3 mixture of alkyl polyglucosides
- composition (Ti) comprising disodium N-cocoylglutamate [composition (Ci)], a mixture of n-dodecyl polyglucosides, n-tetradecyl
- composition (C 3 ) polyglucosides and n-hexadecyl polyglucosides [composition (C 3 )], and n-heptyl polyglucoside [composition (C 4 )]
- a composition (Ti) is prepared by pouring, with stirring, into a reactor maintained at 40 ° C., the composition (Ci) and the compositions (C3) and (C 4 ). The mixture is stirred for thirty minutes to obtain the compositions (Ti).
- the quantities used are listed in Table 2 below.
- composition (T 2 ) comprising disodium N-cocoylglutamate [composition (Ci)] and a mixture of n-dodecyl polyglucosides, n-tetradecyl
- a composition (T 2 ) is prepared by pouring, with stirring, into a reactor maintained at 40 ° C., the composition (Ci) and the composition (C3). The mixture is stirred for thirty minutes to obtain the compositions (T 2 ).
- the quantities used are listed in Table 2 below.
- compositions (Ti) and (T2) are recorded in Table 3 below.
- T ' [(MA APGI ) + (MA APG2 )] / [(MAi) + (MA APGI ) + (MA APG2 )]
- compositions according to the invention and of comparative compositions 3.1) Preparation of compositions according to the invention Ei to Es and of a comparative composition Eo
- compositions Eo to Es are prepared at a temperature of 25 ° C, in a suitable volume reactor fitted with mechanical stirring of the anchor type at a speed of 50 revolutions.min 1 .
- the ingredients are introduced one after the other gradually until a homogeneous and liquid composition is obtained.
- compositions are detailed in the following table 4:
- Euxyl TM K7l2 aqueous solution containing 45% of active material, said active material comprising for 100% of its mass, 33% by mass of potassium sorbate and 67% by mass of sodium benzoate.
- Euxyl TM K903 mixture of benzyl alcohol, benzoic acid, acid
- compositions Fo to F 4 comprising composition (T 2 )
- compositions Fo to F 4 are prepared according to the procedure described in paragraph 3.1 above.
- compositions Fo to F 4 are detailed in the following table 5:
- compositions F5 to F9 are prepared according to the procedure described in paragraph 3.1 above.
- compositions F 5 to F9 are detailed in the following table 6:
- compositions Fio to F I4 are prepared according to the procedure described in paragraph 3.1 above.
- compositions Fio to F I4 are detailed in table 7 below:
- compositions Fis to F19 are prepared according to the procedure described in paragraph 3.1 above.
- compositions Fis to F19 are detailed in the following table 8:
- compositions F 2 o to F 24 are prepared according to the procedure described in paragraph 3.1 above.
- compositions F 2 o to F 24 are detailed in the following table 9:
- the evaluation of the foaming properties of the compositions tested is carried out by forming a foam, from a WHO hard water solution comprising a predetermined mass content of the compositions tested, by mechanical stirring at a temperature of 20 ° C.
- aqueous solutions are prepared so as to obtain solutions at 0.5% by mass of surfactant active material in WHO hard water, from the compositions Eo to E 4 , and Fo to F 24 , as described below. -above.
- WHO hard water contains, for one liter of deionized water, 0.403 grams of anhydrous calcium chloride and 0.139 grams of magnesium chloride hexahydrate; which gives it a hardness title equal to 34 ° Th.
- Tfoi s . This is the duration of agitation at the end of which the suppression of the vortex in the beaker is observed. Beyond this time, the foam completely surrounds the stem of the pale and its level is horizontal;
- the half-life time (Ti / 2 ): this is the time at the end of which the foam obtained from a certain volume of foaming solution has spun an amount of solution corresponding to half of the initial volume. For this test, the half-life time is reached when the upper level of the spin water reaches the 125 cm 3 mark on the beaker;
- compositions Ei to E 6 according to the invention make it possible to prepare foams having all the qualities required to be used in a hard surface decontamination process, since they are generated quickly, in a sufficient volume (> l00mm), stable (with a half-life of more than four hours).
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- Animal Behavior & Ethology (AREA)
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- Birds (AREA)
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- Wood Science & Technology (AREA)
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- Engineering & Computer Science (AREA)
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- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1859467A FR3087089B1 (fr) | 2018-10-12 | 2018-10-12 | Composition desinfectante a usage topique |
PCT/FR2019/052392 WO2020074826A1 (fr) | 2018-10-12 | 2019-10-09 | Composition désinfectante a usage topique |
Publications (1)
Publication Number | Publication Date |
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EP3863405A1 true EP3863405A1 (de) | 2021-08-18 |
Family
ID=65244262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19823795.0A Withdrawn EP3863405A1 (de) | 2018-10-12 | 2019-10-09 | Desinfektionszusammensetzung zur topischen anwendung |
Country Status (6)
Country | Link |
---|---|
US (1) | US20210386640A1 (de) |
EP (1) | EP3863405A1 (de) |
JP (1) | JP2022502420A (de) |
CN (1) | CN112804877A (de) |
FR (1) | FR3087089B1 (de) |
WO (1) | WO2020074826A1 (de) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4096326A (en) | 1976-10-13 | 1978-06-20 | Hercules Incorporated | Dihydroxypropyl cellulose |
WO1998009611A1 (fr) | 1996-09-09 | 1998-03-12 | Societe D'exploitation De Produits Pour Les Industries Chimiques - Seppic | Utilisation cosmetique de composes a structure lipoaminoacide et compositions cosmetiques a activite apaisante incorporant certains de ces composes |
US6433061B1 (en) | 2000-10-24 | 2002-08-13 | Noveon Ip Holdings Corp. | Rheology modifying copolymer composition |
FR3061025B1 (fr) * | 2016-12-23 | 2019-01-25 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Nouveau melange tensioactif, nouvelle composition en comprenant et son utilisation dans les emulseurs pour combattre les incendies |
FR3068043A1 (fr) * | 2017-06-22 | 2018-12-28 | Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic | Nouveau melange tensioactif, nouvelle composition en comprenant et son utilisation en cosmetique |
-
2018
- 2018-10-12 FR FR1859467A patent/FR3087089B1/fr active Active
-
2019
- 2019-10-09 WO PCT/FR2019/052392 patent/WO2020074826A1/fr unknown
- 2019-10-09 CN CN201980064318.7A patent/CN112804877A/zh active Pending
- 2019-10-09 US US17/284,380 patent/US20210386640A1/en active Pending
- 2019-10-09 JP JP2021517024A patent/JP2022502420A/ja active Pending
- 2019-10-09 EP EP19823795.0A patent/EP3863405A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2020074826A8 (fr) | 2020-07-02 |
WO2020074826A1 (fr) | 2020-04-16 |
FR3087089A1 (fr) | 2020-04-17 |
JP2022502420A (ja) | 2022-01-11 |
US20210386640A1 (en) | 2021-12-16 |
CN112804877A (zh) | 2021-05-14 |
FR3087089B1 (fr) | 2021-01-15 |
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