EP3826757B1 - Appareil de mélange - Google Patents

Appareil de mélange Download PDF

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Publication number
EP3826757B1
EP3826757B1 EP19742060.7A EP19742060A EP3826757B1 EP 3826757 B1 EP3826757 B1 EP 3826757B1 EP 19742060 A EP19742060 A EP 19742060A EP 3826757 B1 EP3826757 B1 EP 3826757B1
Authority
EP
European Patent Office
Prior art keywords
mixing apparatus
retainer
base plate
plate
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19742060.7A
Other languages
German (de)
English (en)
Other versions
EP3826757A1 (fr
Inventor
Dominic Erb
Philipp RIEDEL
Christian Strebel
Gero FEHR
Klaus LUN
Christoph KARTHAUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Trading AG
Original Assignee
Tecan Trading AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecan Trading AG filed Critical Tecan Trading AG
Priority to EP23159223.9A priority Critical patent/EP4218996B1/fr
Publication of EP3826757A1 publication Critical patent/EP3826757A1/fr
Application granted granted Critical
Publication of EP3826757B1 publication Critical patent/EP3826757B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2214—Speed during the operation
    • B01F35/22142—Speed of the mixing device during the operation
    • B01F35/221422—Speed of rotation of the mixing axis, stirrer or receptacle during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/325—Driving reciprocating or oscillating stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/42—Clamping or holding arrangements for mounting receptacles on mixing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

Definitions

  • the present invention relates to a mixing apparatus, in particular for mixing substances in closed containers.
  • the pivoting table comprises individual specific holders for ampoules with different diameters or the pivoting table comprises a pattern of fingers which protrude from the tabletop of the pivoting table and between which different ampoules can be arranged, with smaller ampoules rolling back and forth between the fingers when pivoted.
  • a holder for ampoules is rotatably mounted on two sides, with the holder being pivotable by means of a drive.
  • An ampoule can be inserted into each container receptacle of the holder.
  • U.S. 5,578,268 A discloses a mixing apparatus according to the preamble of claim 1.
  • An object of the present invention is to provide a mixing apparatus in which the risk of mix-ups is reduced and in which the insertion and removal of the containers containing substances to be mixed is facilitated. Mixing up the containers should be avoided, especially with patient samples.
  • a mixing apparatus comprises a drive unit with a drive and with a shaft which can be pivoted about a pivot axis and which is operatively connected to the drive, a pivot mount which is arranged on the shaft, the pivot axis being aligned essentially horizontally, the pivot mount having a base plate and at least a retainer spaced therefrom, wherein the swivel mount is designed in such a way that holders for containers can be inserted between the base plate and the at least one retainer in the direction of the swivel axis.
  • the drive unit includes a housing in which an electromechanical drive, with or without a gear, is arranged.
  • the drive unit can include a belt drive.
  • the swivel mount can be swiveled about the swivel axis by any desired angle in both directions.
  • the swivel mount can be swiveled back and forth by any desired angle, for example by means of the drive unit, or the swivel mount can be rotated once or several times around the swivel axis in one of the two directions of rotation.
  • powders or fluids such as suspensions or emulsions, can be mixed.
  • whole blood, ie blood plasma or blood serum can be mixed with blood cells alone or with additional substances.
  • the substances to be mixed can be filled into test tubes or vials.
  • Lactating ampoules comprise glass or plastic containers which are closed at the top with a lid which includes a septum.
  • the septum comprises a soft plastic, for example made of PTFE or silicone, which can be pierced with a pipette needle or tip.
  • a pipette needle or tip For example, such a The lid can be screwed onto the open-topped container with a thread.
  • the mixing apparatus includes a control unit with which the pivoting angle, the pivoting speed and the pivoting direction can be adjusted. By setting these values, an optimal mixture of the substances can be achieved.
  • receptacles are provided on the side of the base plate directed towards the at least one retainer, which are aligned in the direction of the pivot axis and into which the holders for containers can be inserted.
  • the receptacles include elevations which can protrude into complementary recesses in the holder.
  • the bumps are elements that extend directly from the base plate of the swivel mount.
  • the elevations can be pins, for example pins with a circular cross-section. However, other cross sections are also conceivable.
  • the elevations can also be slot nuts, for example for T-slots or dovetail slots.
  • the receptacles can include recesses into which complementary elevations of the holder can protrude, and which also form a pin-groove connection or a sliding block-groove connection.
  • the recordings are arranged one after the other along the pivot axis.
  • the recordings include first recordings, which are arranged in an area of the base plate close to the shaft and second receptacles, which are arranged in a region of the base plate remote from the shaft.
  • the holders are insertable with a first end in the first receptacle and with a second end in the second receptacle.
  • the additional mounts give the holders additional support or they allow the insertion of shorter holders which do not extend over the entire length of the swivel mount.
  • a plurality of receptacles are arranged next to one another in a direction transverse to the pivot axis.
  • several identical or different holders can be inserted next to each other into the swivel mount, whereby the contents of several containers can be mixed at the same time.
  • the recordings are arranged symmetrically with respect to the pivot axis.
  • the mixing apparatus comprises first spacers which can be inserted into the receptacles and into which the holders for the containers can be inserted, and second spacers which are arranged between the receptacles and on which the holders for the containers can rest.
  • first spacers which can be inserted into the receptacles and into which the holders for the containers can be inserted
  • second spacers which are arranged between the receptacles and on which the holders for the containers can rest.
  • a drive plate is provided in a first end area of the base plate, which is aligned essentially perpendicular to the base plate and essentially perpendicular to the pivot axis and which connects the shaft to the base plate.
  • the base plate is connected to the at least one retainer through the drive plate.
  • a support element is provided in a second end area of the base plate, opposite the first end area, which includes a cylindrical lateral surface, the axis of which is congruent with the pivot axis.
  • the base plate is connected to the at least one retainer by the support element.
  • the support element comprises a plate which is aligned essentially perpendicular to the base plate and to the pivot axis.
  • the support element comprises a central opening and the base plate protrudes at least partially through the central opening.
  • At least one connector is provided which connects the drive plate to the support element.
  • the drive plate includes at least one groove for receiving the at least one retainer.
  • elevations can be provided on the drive plate, in which the at least one retainer is held or with which the at least one retainer is guided or clamped.
  • elevations can be ribs or pins.
  • the support element comprises at least one fixation for fastening the at least one retainer.
  • a fixation can comprise an at least partially detachable element.
  • the fixation can be pivotable and can comprise a fixing element.
  • a fixation can also be provided for the drive plate, with which the at least one retainer can be detachably fastened.
  • the mixing apparatus comprises a bearing unit with at least one roller on which the support element is rotatably mounted with the lateral surface.
  • the storage unit is with respect to the swivel mount drive unit opposite.
  • the support element is mounted pivotably in alignment with the shaft in the bearing unit. Due to the bearing of the swivel mount on both sides, the corresponding bearings and the swivel mount must be dimensioned to be less stable, which means that they require less space and as a result less mass has to be moved.
  • the bearing unit comprises two or more rollers on which the support element is rotatably mounted with the lateral surface. At least one of the rollers can be resiliently mounted. At least one of the rollers can be driven synchronously with the drive unit.
  • the drive unit and the bearing unit are arranged on a common connecting plate.
  • the connecting plate can be designed to be continuously closed or it can include at least one recess in the area of the swivel mount.
  • the at least one retainer comprises at least one plate having at least one through-opening, the through-openings being arranged in such a way that, when the holders are inserted, they are aligned with the container receptacles formed in the holders.
  • the inner dimensions of the through-openings are smaller than the inner dimensions of the container receptacles of the insertable holders.
  • the inner dimensions of the passage opening can also be smaller than the outer dimensions of the lid of the container.
  • the at least one retainer includes a first panel and a second panel, wherein the distance between the base plate and the first plate is greater than that between the base plate and the second plate.
  • the two panels can be independent of each other or can be connected to each other.
  • first panel and the second panel are integrally formed together.
  • At least one tab is integrally formed together and substantially flush with the at least one panel.
  • At least one rib is formed integrally with the at least one panel and extends along the pivot axis over at least a portion of the at least one panel.
  • the at least one rib may be formed in one or both lateral edge portions of each panel.
  • ribs can be arranged between the two edge regions of each plate.
  • At least one tab is integrally formed together with the at least one rib and is spaced parallel to the at least one panel.
  • the at least one tab may be located in one or both of the two free ends of the retainer.
  • the mixing apparatus includes at least one encoder with which the position of the swivel mount can be determined.
  • the mixing device comprises at least one lock, with which the position of the swivel mount can be fixed.
  • the mixing apparatus comprises at least one container holder inserted between the base plate and the at least one retainer.
  • the at least one holder can also be inserted into the receptacles.
  • each holder comprises a plurality of container receptacles arranged along a longitudinal axis and formed between the two ends.
  • the container receptacles can, for example, be countersunk holes with a circular cross-section. However, other cross sections are also possible.
  • Each container receptacle can comprise at least one lateral opening which extends laterally outwards from the respective container receptacle transversely to the longitudinal axis. The at least one opening can be a slit or a window.
  • Each container receptacle can comprise two lateral openings which are arranged opposite one another with respect to the longitudinal axis and which, together with the container receptacle, form a passage in the holder.
  • a slot and a window, two slots or two windows can be assigned to each container receptacle.
  • a clamping lug can be provided for each container receptacle or for each window of the holder, which projects through the window into the respective container receptacle, as a result of which a container received therein can be clamped and held therein.
  • a tab plate can be attached to the holder be arranged, which includes all the clamping lugs.
  • the clamping tabs may be integrally formed together with the remainder of the holder.
  • the embodiments of the mixing apparatus mentioned can be used in any combination, provided they do not contradict one another.
  • a mixing plant according to the invention comprises a machine stand on which a mixing apparatus according to the invention is arranged.
  • the mixing plant can comprise a work surface which is arranged on the machine stand and the mixing apparatus is arranged on the work surface.
  • the mixing system comprises a pipetting unit with which fluids can be supplied to or removed from containers located in the mixing apparatus.
  • the pipetting unit comprises a transport unit on which pipette tips are arranged and with which the pipette tips can be moved horizontally and/or vertically in an area above the machine stand or above the work surface.
  • the mixing plant comprises a reading unit with which markings on the containers to be picked up by the mixing apparatus can be read.
  • the markers are selectable from the group consisting of 1D barcode, 2D barcode, RFID tag and the like.
  • the reading unit can also recognize markings that are attached to the holders for holding the containers. With The reading unit also shows which position of the container holder a container is in and which position is empty. It can also be seen whether all holders for containers pushed into the mixing apparatus are completely pushed in between the base plate and the retainer.
  • the mentioned embodiments of the mixing plant can be used in any combination, as long as they do not contradict each other.
  • the introduction can be an insertion, for example if the swivel mount includes cylindrical pins and the holder is provided with correspondingly complementary bores.
  • the introduction can also be a pushing in, for example if the swivel mount includes sliding blocks and the holder is provided with a correspondingly complementary groove.
  • fastening elements can be removed which fix the retaining element in the corresponding receptacles and the retaining element can then be lifted off and placed at a different location independently of the mixing apparatus.
  • the retaining element can be linearly pushed away from the area above the swivel mount by means of a displacement mechanism.
  • the retaining element can be swiveled away from the area above the swivel mount in one plane by means of a twisting mechanism. If the retaining element is arranged in a fixed manner on the pivoting mount, then the holder must be pushed into the pivoting mount under the retaining element, for example along the pivot axis.
  • the contents of a mother tube which contains, for example, whole blood
  • a mother tube which contains, for example, whole blood
  • additional substances for example, a portion of the whole blood can be transferred from the mother tube to a daughter tube.
  • the daughter tube may be previously empty or may contain a substance such as a reagent.
  • the contents of the daughter tube can then be mixed again.
  • the holder with the containers arranged therein can be removed from the mixing apparatus and fed to an analysis device.
  • the figure 1 shows a perspective view of a mixing apparatus 100 according to the invention.
  • the mixing apparatus 100 also includes a swivel mount 2 which is arranged on the shaft 11 .
  • the swivel mount 2 comprises a base plate 20 and a retainer 4 spaced therefrom, the swivel mount 2 being designed such that holders 3 for containers can be inserted in the direction of the pivot axis A between the base plate 20 and the retainer 4 .
  • a circular disk-shaped drive plate 21 connects the shaft 11 to the base plate 20.
  • the drive plate 21 is essentially perpendicular to the swivel bracket A and essentially perpendicular to the base plate 20.
  • a circular disk-shaped support plate 22 is provided on the end of the swivel mount 2 opposite the drive plate 21.
  • the retainer 4 in this embodiment a retaining plate with holes, is detachably arranged between the drive plate 21 and the support plate 22.
  • the retainer 4 can be fixed with a pivotable fixation 211 and at the Support plate 22 with a pivotable fixation 222.
  • elevations 200 are provided in the form of sliding blocks.
  • a reading unit 82 with a limiter 83 is provided on the opposite side of the platen 22 from the drive side. With the reading unit 82 markings on the holder 3 and/or on the containers arranged in the holder 3 can be read.
  • the support plate 22 is supported and rotatably mounted on two rollers 50 of a bearing unit 5 .
  • the drive unit 1, the bearing unit 5, the reading unit 82 and the limiter 83 are arranged on a common connecting plate 6.
  • the figure 2 shows the mixing apparatus 100 of FIG figure 1 without the housing and the drive 10 of the drive unit 1, without the retainer 4, without the reading unit 82 and without the limiter 83.
  • the connectors 23 are designed and arranged in such a way that the retainer 4 can rest evenly on both connectors 23 when installed.
  • a pattern of T-slot nuts 200 is arranged on the base plate 20 of the swivel mount 2 .
  • containers 7 are arranged; shown are sample tubes with a pierceable cap, ie, with a cap having a pierceable septum.
  • the Figure 3A shows the retainer 4 of FIG figure 1 .
  • the retainer 4 comprises a bent plate with holes 40, with two first plates 41, or with two edge plates 41 and with a second plate 42, or with a central plate 42.
  • the two edge plates 41 are flush with each other and the central plate 42 is parallel to the two edge plates 41.
  • Ribs 44 extend essentially along the entire length of the retainer on the lateral outer boundary of the respective edge plate 41. Due to the one-piece design of the retainer 4, the offset of the first plate 41 to the second plate 42 creates a rib 44 in the respective transition area.
  • the Figure 3B shows an alternative embodiment of the retainer 4 of FIG figure 1 with only a first plate 41 and a second plate 42.
  • tabs 43 are provided which are separate from each other and are located only at one of the two free ends of the retainer.
  • only one rib 44 is formed in the transition area between the two plates 41,42.
  • the Figure 3C 10 shows a sectional view of the mixing apparatus 100 of FIG figure 1 transverse to the axis A, by a high container 7 and by a low container 70.
  • the high container 7 is sandwiched between the base plate 20 and the first plate 41 of the retainer 4 and the low Container 70 between the base plate 20 and the second plate 42 of the retainer 4.
  • the figure 4 shows a perspective view of a second embodiment of a swivel mount 2 with an alternative retainer 400.
  • Grooves 210 are provided in the drive plate 21, into which the retainers 400 can be inserted.
  • a fixation 222 is provided on the support plate 22, with which the retainers 400 can be detachably fastened.
  • the connectors 23 are designed as round rods arranged laterally.
  • a central opening 221 is provided in the support plate 22, through which the base plate 20 protrudes and through which the holders for containers can be inserted. Holders with tall containers can be inserted into the retainers 400 in the illustrated variant of the swivel mount 2 . If deeper containers are to be inserted, the retainers 400 must be rotated 180 degrees such that the outward surface of the plate 401 faces the base plate 20 and the open end of the retainer 400 faces the drive plate 21 .
  • the figure 5 12 shows a bottom perspective view of the retainer 400 of FIG figure 4 .
  • the retainer 400 includes a panel 401 having a slot 402 which extends substantially the entire length of the panel.
  • the width of the slit 402 is smaller than the outer dimensions of the container closures and is larger than the piercing area of the container closures.
  • ribs 403 extend over essentially the entire length of the Retainer 400.
  • a first free end of the retainer 400 is open and a second free end opposite the first free end is closed at the side.
  • a first tab 404 is provided, which is parallel and slightly offset to the plate 401 in the area of the plate 401 and protrudes at the first free end of the retainer 400 beyond this.
  • a second tab 405 is provided at the closed end of the retainer 400, which is parallel and slightly offset to the ribs 403 in the area of the ribs and protrudes beyond the second free end of the retainer.
  • the figure 6 shows a holder with containers inserted therein as in FIG figure 2 .
  • the holder 3 extends along the longitudinal axis L, has container receptacles 32 which comprise two lateral slots 320 and has clamping lugs 322 which are formed in one piece with the rest of the holder 3 and which protrude into the interior of the container receptacles 32 .
  • the holder 3 comprises a groove 33 which is arranged on the underside of the holder 3, ie on the side of the holder 3 which faces the container receptacles 32.
  • a T-slot is shown.
  • a dovetail groove or another retaining groove can also be provided.
  • the groove 33 extends along the longitudinal axis L, at least over the area of the holder 3 which includes the container receptacles 32 .
  • the groove 33 is open at the first end 30 of the holder 3 so that the elevations 200 of the swivel mount 2 can be moved easily into the groove 33 .
  • a handle 34 is arranged with which the holder 3 can be easily gripped by hand.
  • a recess 340 is provided in the handle 34, which enables the reading unit 82 to recognize that the holder 3 has been pushed completely into the swivel mount 2.
  • the figure 7 shows a perspective view of a mixing plant with a mixing apparatus 100 according to the invention, which is aligned pivoted, and a non-pivoted mixing apparatus 100. Both apparatuses are arranged with receiving elements 800 on the work surface 80, which are arranged on the machine stand 8.
  • the mixing system also includes the pipetting unit 81 with the transport unit 810 and the pipette tips 811.
  • the transport unit 810 can move the pipette tips 811 over the work surface 80 in a first horizontal direction X, in a second horizontal direction Y and in a vertical Move towards Z.
  • the reading unit 82 and the limiter 83 are arranged next to the mixers 100 on the work surface 80.
  • the reader unit 82 is also aligned and fixed to the receiving elements 800 on the work surface 80 .
  • Holders can be slid over the receiving elements 800 in front of the reading unit 82 in order to recognize the markings on the holders 3 and/or on the containers arranged in the holders 3 .

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Accessories For Mixers (AREA)

Claims (18)

  1. Mélangeur (100) comprenant :
    - une unité d'entraînement (1) pourvue d'un entraînement (10) et d'une tige (11) pouvant pivoter autour d'un axe de pivotement (A) orienté de façon sensiblement horizontale, laquelle tige étant en liaison active avec l'entraînement (10),
    - un logement pivotant (2) disposé sur la tige (11),
    le logement pivotant (2) comprenant une plaque de base (20) et au moins un dispositif de retenue (4, 400) espacé de celle-ci, le logement pivotant (2) étant conçu de telle sorte qu'il est possible d'introduire des supports (3) pour des récipients (7, 70) dans le sens de l'axe de pivotement (A) entre la plaque de base (20) et le au moins un dispositif de retenue (4, 400), une plaque d'entraînement (21) étant prévue dans une première zone d'extrémité de la plaque de base (20), laquelle plaque d'entraînement étant orientée sensiblement perpendiculairement à la plaque de base (20) et à l'axe de pivotement (A) et reliant la tige (11) à la plaque de base (20), caractérisé en ce qu'il est prévu dans une deuxième zone d'extrémité de la plaque de base (20) opposée à la première zone d'extrémité un élément d'appui (22) qui comprend une surface d'enveloppe cylindrique (220) dont l'axe est congruent avec l'axe de pivotement (A), et en ce qu'il est prévu une unité de support (5) comprenant au moins un galet (50) sur lequel est monté de façon à pouvoir pivoter l'élément d'appui (22) avec la surface d'enveloppe (220).
  2. Mélangeur (100) selon la revendication 1, comprenant une unité de commande (12) permettant de régler l'angle de pivotement, la vitesse de pivotement et le sens de pivotement, le logement pivotant (2) pouvant être pivoté autour de l'axe de pivotement (A) dans les deux sens et selon n'importe quel angle.
  3. Mélangeur (100) selon l'une des revendications précédentes, dans lequel il est prévu sur le côté de la plaque de base (2) orienté à l'opposé du au moins un dispositif de retenue (4, 400) des logements (200) qui sont orientés dans le sens de l'axe de pivotement (A) et dans lesquels il est possible d'introduire les supports (3) pour des récipients (7).
  4. Mélangeur (100) selon l'une des revendications précédentes, dans lequel la plaque de base (20) est reliée au moins un dispositif de retenue (4, 400) par le biais de la plaque d'entraînement (21).
  5. Mélangeur (100) selon la revendication 1, dans lequel la plaque de base (20) est reliée au moins un dispositif de retenue (4, 400) par l'élément d'appui (22), l'élément d'appui (22) comprenant une plaque qui est orientée de façon sensiblement perpendiculaire à la plaque de base (20) et à l'axe de pivotement (A), l'élément d'appui (22) comprenant une ouverture centrale (221) et la plaque de base (20) faisant saillie au moins partiellement à travers l'ouverture centrale (221).
  6. Mélangeur (100) selon la revendication 1 ou 5, dans lequel il est prévu au moins un connecteur (23) qui raccorde la plaque d'entraînement (21) à l'élément d'appui (22).
  7. Mélangeur (100) selon l'une des revendications 1 ou 4 à 6, dans lequel la plaque d'entraînement (21) comprend au moins une encoche (210) pour recevoir le au moins un dispositif de retenue (4, 400).
  8. Mélangeur (100) selon l'une des revendications 1 ou 5 à 7, dans lequel l'élément d'appui (22) comprend au moins une fixation (222) pour fixer le au moins un dispositif de retenue (4, 400).
  9. Mélangeur (100) selon la revendication 1, dans lequel l'unité de support (5) comprend deux galets (50) ou plus, sur lesquels est installé de façon à pouvoir pivoter l'élément d'appui (22) avec la surface d'enveloppe (220).
  10. Mélangeur (100) selon la revendication 1 ou 9, dans lequel l'unité d'entraînement (1) et l'unité de support (5) sont agencées sur une plaque de liaison commune (6).
  11. Mélangeur (100) selon l'une des revendications précédentes, dans lequel le au moins un dispositif de retenue (4, 400) comprend au moins une plaque (41 ; 401, 42) avec au moins une ouverture de passage (40 ; 402), les ouvertures de passage (40 ; 402) étant disposées de telle sorte qu'elles sont, lorsque les supports (3) sont insérés, alignées avec les logements de récipients (32) formés dans les supports (3).
  12. Mélangeur (100) selon la revendication 11, dans lequel le au moins un dispositif de retenue (4) comprend une première plaque (41) et une deuxième plaque (42), la distance entre la plaque de base (20) et la première plaque (41) étant supérieure à la distance entre la plaque de base (20) et la deuxième plaque (42).
  13. Mélangeur (100) selon l'une des revendications précédentes, comprenant au moins un support (3) pour les récipients (7, 70), lequel support est introduit entre la plaque de base (20) et le au moins un dispositif de retenue (4, 400).
  14. Installation de mélange comprenant :
    - un support de machine (8) sur lequel est agencé un mélangeur (100) selon l'une des revendications 1 à 13, comprenant une unité de pipetage (81) permettant d'introduire ou de prélever du fluide dans les récipients (7, 70) se trouvant dans le mélangeur (100), l'unité de pipetage (81) comprenant une unité de transport (810) sur laquelle sont disposés des embouts de pipette (811) et qui permet de déplacer les embouts de pipette (811) à l'horizontal et/ou à la verticale dans une zone au-dessus du support de machine (8) ou au-dessus de la surface de travail (80).
  15. Installation de mélange selon la revendication 14, comprenant une unité de lecture (82) disposée sur le support de machine (8) ou sur la plaque de liaison (6) du mélangeur (100) et qui permet de lire les marquages des récipients (7, 70) devant être pris par le mélangeur (100) et/ou des supports (3) devant être pris par le mélangeur (100).
  16. Procédé pour faire fonctionner un mélangeur (100) ou une installation de mélange, comprenant les étapes consistant à :
    - fournir un mélangeur (100) selon l'une des revendications 1 à 13 ;
    - introduire un support (3) avec à l'intérieur des récipients (7,70) disposés entre la plaque de base (20) et le au moins un dispositif de retenue (4, 400) dans le sens de l'axe de pivotement (A) ; et
    - faire pivoter le logement pivotant (2) autour de l'axe de pivotement (A) grâce à l'unité d'entraînement (1).
  17. Procédé selon la revendication 16, comprenant l'étape consistant à :
    - lire les marquages d'un support (3) et/ou des récipients (7, 70) disposés dans un support (3) à l'aide de l'unité de lecture (82) avant ou pendant l'introduction du support (3).
  18. Procédé selon la revendication 16 ou 17, comprenant au moins une des étapes suivantes consistant à :
    - prélever, à l'aide de l'unité de pipetage (81), des fluides des récipients (7, 70) se trouvant dans le mélangeur (100) après avoir fait pivoter le logement pivotant (2) ;
    - introduire des fluides, à l'aide de l'unité de pipetage (81), dans les récipients (7, 70) se trouvant dans le mélangeur (100) avant de faire pivoter le logement pivotant (2).
EP19742060.7A 2018-07-25 2019-07-24 Appareil de mélange Active EP3826757B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23159223.9A EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18185420.9A EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
PCT/EP2019/069871 WO2020020923A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, installation de mélange et procédé pour le mélange de substances dans des contenants fermés

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP23159223.9A Division EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés
EP23159223.9A Division-Into EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés

Publications (2)

Publication Number Publication Date
EP3826757A1 EP3826757A1 (fr) 2021-06-02
EP3826757B1 true EP3826757B1 (fr) 2023-04-26

Family

ID=63047178

Family Applications (4)

Application Number Title Priority Date Filing Date
EP18185420.9A Withdrawn EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
EP21191494.0A Pending EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés
EP19742060.7A Active EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange
EP23159223.9A Active EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP18185420.9A Withdrawn EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
EP21191494.0A Pending EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés

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Application Number Title Priority Date Filing Date
EP23159223.9A Active EP4218996B1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés

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Country Link
US (2) US11969700B2 (fr)
EP (4) EP3599013A1 (fr)
CN (2) CN116550196A (fr)
WO (1) WO2020020923A1 (fr)

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Also Published As

Publication number Publication date
US20210260541A1 (en) 2021-08-26
US11969700B2 (en) 2024-04-30
EP4218996A1 (fr) 2023-08-02
WO2020020923A1 (fr) 2020-01-30
EP3826757A1 (fr) 2021-06-02
CN112469496B (zh) 2023-06-16
CN116550196A (zh) 2023-08-08
EP3599013A1 (fr) 2020-01-29
EP4218996B1 (fr) 2024-07-31
US20240252997A1 (en) 2024-08-01
CN112469496A (zh) 2021-03-09
EP3932532A1 (fr) 2022-01-05

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