EP3599013A1 - Appareil de mélange - Google Patents

Appareil de mélange Download PDF

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Publication number
EP3599013A1
EP3599013A1 EP18185420.9A EP18185420A EP3599013A1 EP 3599013 A1 EP3599013 A1 EP 3599013A1 EP 18185420 A EP18185420 A EP 18185420A EP 3599013 A1 EP3599013 A1 EP 3599013A1
Authority
EP
European Patent Office
Prior art keywords
receptacles
holder
containers
mixing apparatus
mixer according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18185420.9A
Other languages
German (de)
English (en)
Inventor
Larry STIVER
Vincent AHLHEIT
Peter SIESEL
Dominic Erb
Klaus LUN
Christoph KARTHAUS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Trading AG
Original Assignee
Tecan Trading AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecan Trading AG filed Critical Tecan Trading AG
Priority to EP21191494.0A priority Critical patent/EP3932532A1/fr
Priority to EP18185420.9A priority patent/EP3599013A1/fr
Priority to US17/261,325 priority patent/US11969700B2/en
Priority to CN201980048278.7A priority patent/CN112469496B/zh
Priority to CN202310636479.7A priority patent/CN116550196A/zh
Priority to EP23159223.9A priority patent/EP4218996A1/fr
Priority to PCT/EP2019/069871 priority patent/WO2020020923A1/fr
Priority to EP19742060.7A priority patent/EP3826757B1/fr
Publication of EP3599013A1 publication Critical patent/EP3599013A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2214—Speed during the operation
    • B01F35/22142—Speed of the mixing device during the operation
    • B01F35/221422—Speed of rotation of the mixing axis, stirrer or receptacle during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/325—Driving reciprocating or oscillating stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
    • B01F35/42—Clamping or holding arrangements for mounting receptacles on mixing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

Definitions

  • the present invention relates to a mixing apparatus, in particular for mixing substances in closed containers.
  • piercing ampoules can be arranged on a swivel table which can be swiveled by means of a drive.
  • the swivel table comprises individual specific holders for ampoules with different diameters or the swivel table comprises a pattern of fingers which protrude from the table top and between which different ampoules can be arranged, with smaller ampoules rolling back and forth between the fingers when swiveled.
  • a holder for ampoules is rotatably mounted on two sides, the holder being pivotable by means of a drive.
  • An ampoule can be inserted in each container holder of the holder.
  • An object of the present invention is to provide a mixing apparatus in which the risk of confusion is reduced and in which the insertion and removal of the containers which contain substances to be mixed is facilitated.
  • a mixing apparatus comprises a drive unit with a drive and with a shaft which is pivotable about a pivot axis and which is operatively connected to the drive, a pivot holder which is arranged on the shaft, the pivot axis being oriented essentially horizontally, the pivot holder comprising a base, on which receptacles are provided, which extend away from the base and into which holders for containers can be inserted.
  • the drive unit comprises a housing in which an electro-mechanical drive, with or without a gear, is arranged.
  • the base can be designed as a plate or as a frame.
  • the swivel mount can be swiveled around the swivel axis by any angle in both directions. That the swivel mount can be pivoted back and forth by any angle, for example by means of the drive unit, or the swivel mount can be rotated one or more times around the pivot axis in one of the two directions of rotation.
  • Powders or fluids such as suspensions or emulsions, can therefore be mixed.
  • whole blood i.e. Blood plasma or blood serum can be mixed with blood cells on their own or with additional substances.
  • the substances to be mixed can be filled into test tubes or ampoules.
  • Prick ampoules include glass or plastic containers, which are closed at the top with a lid that includes a septum.
  • the septum comprises a soft plastic, for example made of PTFE or silicone, which can be pierced with a pipette needle or tip.
  • a lid can be screwed onto the open-topped container with a thread.
  • the mixing apparatus comprises a control unit with which the swivel angle, the swivel speed and the swivel direction can be set are. By setting these values, an optimal mixture of substances can be achieved.
  • the receptacles comprise first receptacles which are arranged in an area of the base near the shaft and second receptacles which are arranged in an area of the base remote from the shaft.
  • the holders can be inserted into the first receptacle with a first end and into the second receptacle with a second end. The position and orientation of each holder is thus clearly and reliably determined. Between one of the first receptacles and a second receptacle aligned with it in the direction of the pivot axis, further receptacles aligned with it can be provided.
  • the additional receptacles give the holders additional hold or they allow the insertion of shorter holders which do not extend over the entire length of the swivel receptacle.
  • the receptacles comprise elevations which can protrude into complementary recesses in the ends of the holders.
  • the elevations are elements that extend directly from the base of the swivel mount.
  • the elevations can be pins, for example pins with a circular cross section. However, other cross sections are also conceivable.
  • the elevations can also be slot nuts, for example for T-slots or dovetail slots.
  • the receptacles can also include recesses into which complementary elevations of the ends of the holders can protrude, and which also form a pin-hole connection or a slot nut-slot connection.
  • several receptacles are arranged next to one another in a direction transverse to the pivot axis.
  • several identical or different holders can be inserted next to each other in the swivel holder, whereby the contents of several containers can be mixed at the same time.
  • the recordings are arranged symmetrically with respect to the pivot axis.
  • the mixing apparatus comprises first spacers which can be inserted into the receptacles and into which the holders for the containers can be inserted, and second spacers which are arranged between the receptacles and on which the holders for the containers can rest.
  • the spacers increase the distance between the inserted holders and the base of the swivel mount. This is advantageous if shorter vessels are to be inserted into the holders and the upper end of the inserted vessels should be at substantially the same distance from the base as the longer vessels.
  • By grading the thickness of the spacers it is possible to ensure that the upper ends of the conventional vessels are essentially aligned with one another when they are in the mixing apparatus. Different spacers can be arranged on the swivel mount at the same time, as a result of which different vessels can be arranged in the mixing apparatus at the same time and their upper ends are essentially flush with one another.
  • third receptacles are provided on the swivel receptacle on the side of the receptacles, with which a retaining element can be fixed or removed at least in the area between the receptacles spaced apart from the base.
  • the third receptacles are designed in such a way that the retaining element can be removed or slidably arranged therein. Accordingly, a releasable holding element can be provided or a sliding element can be provided with which the retaining element can be moved or pivoted in one plane.
  • the mixing apparatus comprises a bearing unit which lies opposite the drive unit with respect to the swivel mount and in which the swivel mount is pivotably mounted in alignment with the shaft. Due to the double-sided mounting of the swivel mount, the corresponding bearings and the swivel mount have to be dimensioned a few stable, which means that they take up less space and less mass has to be moved.
  • the mixing apparatus comprises at least one holder for containers which can be inserted into the receptacles.
  • each holder comprises a plurality of container receptacles which are arranged along a longitudinal axis and are formed between the two ends.
  • the container receptacles can for example be countersunk holes with a circular cross section. Other cross sections are however also possible.
  • Each container receptacle can comprise at least one lateral opening, which extends laterally outwards from the respective container receptacle transversely to the longitudinal axis.
  • the at least one opening can be a slot or a window.
  • Each container receptacle can comprise two lateral openings which are arranged opposite one another with respect to the longitudinal axis and which, together with the container receptacle, form a passage in the holder. Accordingly, a slot and a window, two slots or two windows can be assigned to each container receptacle.
  • a clamping tab can be provided for each window of the holder, which protrudes through the window into the respective container receptacle, as a result of which a container accommodated therein can be clamped in it.
  • a tab plate can be arranged on the holder, which comprises all clamping tabs.
  • the mixing apparatus comprises at least one retaining element, which is arranged in the third receptacles.
  • the retaining element comprises a perforated plate, the holes being arranged such that they are aligned with the container receptacles formed in the holder, the inner dimensions of the holes being smaller than the inner dimensions of the container receptacles.
  • the mentioned embodiments of the mixing apparatus can be used in any combination, provided they do not contradict each other.
  • a mixing system according to the invention comprises a machine stand on which a mixing apparatus according to the invention is arranged.
  • the mixing plant can comprise a working surface which is arranged on the machine stand and the mixing apparatus is arranged on the working surface.
  • the mixing system comprises a pipetting unit with which fluids located in the mixing apparatus can be supplied or removed.
  • the pipetting unit comprises a transport unit on which pipette tips are arranged and with which the pipette tips can be moved horizontally and / or vertically in a region above the machine stand or above the work surface.
  • the mixing system comprises a reading unit with which markings can be read from the containers to be picked up by the mixing apparatus.
  • the markings can be selected from the group comprising 1D barcode, 2D barcode, RFID tag and the like.
  • the insertion can be an insert, for example if the swivel mount comprises cylindrical pins and the holder is provided with correspondingly complementary bores.
  • the insertion can also be an insertion, for example if the swivel receptacle comprises sliding blocks and the holder is provided with a correspondingly complementary groove.
  • fastening elements can be removed, which fix the retaining element in the corresponding receptacles, and the retaining element can then be lifted off and placed at a different location independently of the mixing apparatus.
  • the retaining element can be pushed linearly away from the area above the swivel mount by means of a displacement mechanism.
  • this can be done Retaining element can be pivoted away from the area above the pivot mount in one plane by means of a twisting mechanism. If the retaining element is arranged in a fixed manner on the swivel receptacle, then the holder must be pushed into the swivel receptacle under the retaining element, for example along the swivel axis.
  • the contents of a mother tube which contains whole blood, for example, can be mixed on its own or with additional substances.
  • part of the whole blood can be pipetted from the mother tube to a daughter tube.
  • the daughter tube can be empty beforehand or can contain a substance such as a reagent.
  • the contents of the daughter tube can then be mixed again.
  • the holder with the containers arranged therein can be removed from the mixing apparatus and fed to an analysis device.
  • the Figure 1 shows a perspective view of a first embodiment of a mixing apparatus according to the invention.
  • the mixing apparatus comprises a drive unit 1 with a drive 10 which is operatively connected to a rotatable shaft 11 and which can pivot or rotate it about a pivot axis A.
  • the pivot axis A is oriented essentially horizontally.
  • a swivel mount 2 is operatively connected to the shaft 11 and can thus be swiveled about the swivel axis A by the drive 10.
  • the Swivel mount comprises a base plate 20 which comprises first receptacles 21 in a region near the shaft and which comprises second receptacles 22 in a region remote from the shaft.
  • a holder 3 can be removably arranged in each case in a first receptacle 21 and a second receptacle 22 aligned therewith in the direction of the pivot axis.
  • Containers 7 can be accommodated in the holder 3.
  • the holder comprises lateral slots 320 through which markings on the containers 7 can be seen.
  • the mixing apparatus comprises a bearing unit 5, which is arranged on the side of the swivel mount 2, which is opposite the drive unit 1.
  • the swivel mount 2 is mounted in the bearing unit 5 so that it can swivel about the swivel axis A.
  • the bearing unit 5 is connected to the drive unit 1 via a connecting plate 6 and aligned.
  • a retaining element 4 is removably arranged in third receptacles 25 above the holders 3 and the containers 7 accommodated therein.
  • the distance between the retaining element 4 and the holders 3 is dimensioned such that the surface of the retaining element 4 directed against the holders 3 lies essentially against the free ends of the containers 7 accommodated in the holder 3 or has a distance of a few millimeters, for example 1 to 5 Millimeter.
  • a pipetting unit 81 with a transport unit 810 and pipette tips 811 the transport unit 810 aligning the pipette tips 811 with the containers 7 and lowering the pipette tips 811 so that they protrude into the interior of the containers 7.
  • the Figure 2 shows the mixer of the Figure 1 , without inserted holder and without retaining element.
  • the first receptacles 21 and the second receptacles 22 comprise a low area and an elevated area, the low area being a smaller distance from the base plate 20 and the raised area being a greater distance from the base plate 20.
  • first spacers 23 can be provided, which are placed on the low areas and increase the distance to the base plate 20.
  • the first and second receptacles 21, 22, as well as the first spacers 23, comprise elevations 210, 220 in the form of cylindrical pins.
  • second spacers 24 are provided, which are arranged essentially uniformly distributed between the first receptacles 21 and the second receptacles 22 of the raised areas.
  • a third receptacle 25 in the form of a cylindrical pin is arranged.
  • the distance between the holders 3 and the base plate 20 is greater by the thickness of the third spacers 23 than in the rest of the area.
  • the Figure 3 shows the mixer of the Figure 2 with inserted holders 3, in which containers 7.70 are inserted.
  • the longer containers 7 are arranged with their holders 3 in the receptacles without a first spacer 23 and the shorter containers 70 are with the same holders 3 in the Spacers 23 arranged.
  • the first spacers 23 are coordinated with the shorter containers 7 and the longer containers 70 in such a way that the upper sides of all containers 7, 70 are aligned with one another.
  • the Figure 4 shows a perspective view of a holder 3 for containers 7 which can be used in the mixing apparatus according to the invention.
  • the holder 3 extends essentially along a longitudinal axis L and comprises a first end 30 and an opposite second end 31, with which each holder 3 into the first, respectively second receptacles 21, 22 of the pivot receptacle 2 can be used.
  • the two ends 30, 31 are designed as tabs which extend laterally outwards along the longitudinal axis L from the upper surface of the holder 3.
  • the two ends 30, 31 each comprise a recess 300, 310 in the form of a through hole with a circular cross section.
  • the cross section of the bores 300, 310 is coordinated with the cross section of the complementary pins 210, 220 in such a way that the holders 3 can be inserted into or removed from the swivel mount 2 with little effort.
  • container receptacles 32 are formed in the holder 3 in the form of cylindrical bores, which extend downward from the upper side of the holder over part of the height of the holder 3.
  • Each container receptacle 32 comprises a slot 320 and a window 321, both of which extend laterally outwards from the container receptacle 32, transversely to the longitudinal axis L, the window 321 being arranged on the side of the container receptacle 32 which is opposite the slot.
  • a tab plate 323 On the side of the holder 3, which one comprising the window 321, a tab plate 323 is arranged, which comprises clamping tabs 322, which each protrude through a window 321 into the interior of the container receptacle. With the clamping tabs 322, the containers 7 accommodated in the holder 3 can be laterally clamped in the container receptacles 32, so that they cannot fall out of the holder when it is turned upside down.
  • the Figure 5 shows a sketched perspective view of a second embodiment of a mixing apparatus according to the invention.
  • the connecting plate 6 comprises a recess 60 between the drive unit 1 and the bearing unit 5.
  • the swivel mount 2 is arranged and mounted between the drive unit 1 and the bearing unit 5 such that the surface of the base plate 20 is essentially flush with the surface of the connecting plate 6 is aligned.
  • the pivot mount 2 can be pivoted freely in the recess 60 in the connecting plate 6 with the drive unit 1.
  • the connecting plate is arranged directly on a machine stand 8.
  • the elevations 210, 220 of the first and second receptacles 21, 22 of the swivel receptacle 2 are designed as sliding blocks which extend away from the base plate 20.
  • the sliding blocks are aligned with each other with respect to the pivot axis A and are arranged next to one another in rows transverse to the pivot axis A.
  • Third receptacles 25 are arranged on the base plate 20, with which the retaining element 4 is fixedly connected to the base plate 20.
  • the retaining element 4 in turn comprises holes.
  • In this illustration is on the connecting plate 6, on the side A storage unit 5 is arranged in the storage unit 5 and the storage unit comprises a recess 50, which allows the reading unit 82 to recognize and read in markings on both sides of the storage unit 5. With such an arrangement, the containers 7 can be inserted into the holder 3 at any position.
  • a pipetting unit 81 with a transport unit 810 and with pipette tips 811 is also partially shown, the pipette tips 811 being movable in space at least above the mixer by means of the transport unit 810. This arrangement allows fluids to be added or removed from the containers 7 accommodated in the mixing apparatus. Accordingly, fluids can also be pipetted into the mixing apparatus before or after mixing.
  • the Figure 6 shows a sketched perspective view of a third embodiment of a mixing apparatus according to the invention.
  • this embodiment does not include a bearing unit 5. Accordingly, no connecting plate 6 is required.
  • the drive unit 1 and the reading unit 82 are arranged on a work surface 80 which is arranged on the machine stand 8.
  • Receiving elements 800 are provided on the working surface 80, which in this embodiment are identical to the elevations 210, 220 and with which the drive unit 1 and the reading unit 82 are arranged, aligned and releasably attachable to the work surface 80.
  • the swivel mount 2 is mounted only on the side of the shaft 11, ie on the side of the drive unit 1.
  • the side of the swivel mount 2, which lies opposite the drive unit 2, is free-floating.
  • the holders 3 with the containers 7 accommodated therein can be inserted into the swivel receptacle 2 at any position and unhindered.
  • the detection of the container 7 and its position in the holder 3 can in turn take place when it is pushed in, as a result of which the process reliability is significantly increased.
  • the Figure 7 shows a sketched perspective view of a holder 3 which can be inserted into the mixing apparatus of the second or third embodiment.
  • the holder 3 essentially corresponds to that of FIG Figure 4 , ie it extends along the longitudinal axis L, has container receptacles 32 which comprise a slot 320 and a window 321 and has clamping tabs 322 which are formed in one piece with the tab plate 323 and which protrude through the windows 321 into the interior of the container receptacles 32 ,
  • the holder 3 comprises a groove 33 which is arranged on the underside of the holder 3, ie on the side of the holder 3 which lies opposite the container receptacles 32. A T-slot is shown.
  • a dovetail groove or another retaining groove can also be provided.
  • the groove 33 extends along the longitudinal axis L, at least over the area of the holder 3, which includes the container receptacles 32.
  • the groove 33 is open at the first end 30 of the holder 3, so that the elevations 210, 220 can be easily moved into the groove 33.
  • a handle 34 is arranged on the second side 31 of the holder 3, with which the holder 3 can be easily gripped by hand.
  • a recess 340 is provided in the handle 34, which enables the reading unit 82 to recognize that the holder 3 is completely inserted into the swivel mount 2.
  • the Figure 8 shows a sketched perspective view of a handling unit 9 which can be pushed into the mixing apparatus of the second or third embodiment.
  • the handling unit 9 is designed such that it has a holder 3 according to FIG Figure 4 can record. Accordingly, first and second receptacles 92, 93 are provided, which are complementary to the first and second ends 30, 31 of the holder 3.
  • the receptacles 92, 93 of the handling unit 9 are connected by a plate 90 which extends along the longitudinal axis L.
  • a groove 91 is provided on the underside of the plate 90, ie on the side of the plate which lies opposite the receptacles 92, 93.
  • the groove 91 is designed as a T-groove or the like and extends at least over the area of the plate 90 which lies between the two receptacles 92, 93. On the side of the first receptacle 92, the groove 91 is open towards the outside. A handle 94 with a recess 940 is provided on the side of the second receptacle 93. Spacers can be used in the handling unit 9, similar to those in connection with the Figure 2 described spacers. alternative Handling units 9 with differently designed plates 90 or receptacles 92, 93 can be provided.
  • the Figure 9 shows a perspective view of a mixing plant with a mixing apparatus of the Figure 1 , which is aligned pivoted and a non-pivoted mixer. Both devices are arranged with receiving elements 800 on the work surface 80, which are arranged on the machine stand 8.
  • the mixing system further comprises the pipetting unit 81 with the transport unit 810 and the pipette tips 811.
  • the transport unit 810 can move the pipette tips 811 over the work surface 80 in a first horizontal direction X, in a second horizontal direction Y and in a vertical direction Move towards Z.
  • a reading unit 82 is arranged next to the mixing apparatus on the work surface 80.
  • the reading unit 82 is also aligned and fixed with the receiving elements 800 on the work surface 80.
  • handling units 9 with the handles 94 can be pushed over the receiving elements 800 in order to recognize the markings on the container 7 arranged in holders 3.
  • Handle 11 shaft 340 recess 2 swivel mount 4
  • Retaining element 20 baseplate 5 storage unit 21 first shot 50 recess 210 survey 6 connecting plate 22 second shot 60 recess 220 survey 7 container 23 first spacer 70 container 24 second spacer 8th machine stand 25 third shot 80 working surface 3 holder 800 receiving elements 30 first end 81 Pipetting unit 300 recess 810 Transport unit 31 second end 811 pipette tip 310 recess 82 reader 32 container receptacle 9 Handling unit 320 slot 90 plate 321 window 91 groove 322 clamping plate 92 first shot 323 link plate 93 second shot 94 Handle A swivel axis 940 recess L longitudinal axis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Accessories For Mixers (AREA)
EP18185420.9A 2018-07-25 2018-07-25 Appareil de mélange Withdrawn EP3599013A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP21191494.0A EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés
EP18185420.9A EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
US17/261,325 US11969700B2 (en) 2018-07-25 2019-07-24 Mixing apparatus, mixing system and method for mixing substances in closed containers
CN201980048278.7A CN112469496B (zh) 2018-07-25 2019-07-24 用于在闭合容器中混合物质的混合设备、混合系统和方法
CN202310636479.7A CN116550196A (zh) 2018-07-25 2019-07-24 用于在闭合容器中混合物质的混合设备、混合系统和方法
EP23159223.9A EP4218996A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés
PCT/EP2019/069871 WO2020020923A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, installation de mélange et procédé pour le mélange de substances dans des contenants fermés
EP19742060.7A EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18185420.9A EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP21191494.0A Division EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés

Publications (1)

Publication Number Publication Date
EP3599013A1 true EP3599013A1 (fr) 2020-01-29

Family

ID=63047178

Family Applications (4)

Application Number Title Priority Date Filing Date
EP21191494.0A Pending EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés
EP18185420.9A Withdrawn EP3599013A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange
EP23159223.9A Pending EP4218996A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés
EP19742060.7A Active EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP21191494.0A Pending EP3932532A1 (fr) 2018-07-25 2018-07-25 Appareil de mélange, installation de mélange et procédé de mélange de substances dans des récipients fermés

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP23159223.9A Pending EP4218996A1 (fr) 2018-07-25 2019-07-24 Appareil mélangeur, système mélangeur et procédé pour mélanger des substances dans conteneurs fermés
EP19742060.7A Active EP3826757B1 (fr) 2018-07-25 2019-07-24 Appareil de mélange

Country Status (4)

Country Link
US (1) US11969700B2 (fr)
EP (4) EP3932532A1 (fr)
CN (2) CN112469496B (fr)
WO (1) WO2020020923A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10967341B2 (en) * 2018-07-25 2021-04-06 Tecan Trading Ag Mixing device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226094A (en) * 1963-08-01 1965-12-28 Royal Alexandra Hosp Children Warming and shaking apparatus
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EP3826757A1 (fr) 2021-06-02
EP3932532A1 (fr) 2022-01-05
EP3826757B1 (fr) 2023-04-26
EP4218996A1 (fr) 2023-08-02
US11969700B2 (en) 2024-04-30
CN116550196A (zh) 2023-08-08
CN112469496B (zh) 2023-06-16
WO2020020923A1 (fr) 2020-01-30
CN112469496A (zh) 2021-03-09
US20210260541A1 (en) 2021-08-26

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