EP3799861A1 - Pädiatrische suspensionsformulierung - Google Patents

Pädiatrische suspensionsformulierung Download PDF

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Publication number
EP3799861A1
EP3799861A1 EP20199781.4A EP20199781A EP3799861A1 EP 3799861 A1 EP3799861 A1 EP 3799861A1 EP 20199781 A EP20199781 A EP 20199781A EP 3799861 A1 EP3799861 A1 EP 3799861A1
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EP
European Patent Office
Prior art keywords
omeprazole
mixture
sodium
pharmaceutically acceptable
storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20199781.4A
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English (en)
French (fr)
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EP3799861B1 (de
Inventor
Maurice Joseph Anthony Clancy
Dennis Mark McDaid
Damien Patrick Flynn
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Xeolas Pharmaceuticals Ltd
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Xeolas Pharmaceuticals Ltd
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Priority to EP23210683.1A priority Critical patent/EP4331572A3/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Definitions

  • the sodium and potassium are present at a ratio of about 1:3.2 by weight.
  • the first mixture further comprises (b) a first desiccant.
  • the first mixture further comprises (c) a first buffering agent.
  • the first mixture further comprises both (b) the first desiccant and (c) the first buffering agent.
  • the second mixture further comprises a second desiccant.
  • FIG. 1 depicts a delivery device suitable for use for storage-stable systems of the present disclosure.
  • GERD gastro-esophageal reflux disease. This is a disease where acid from the stomach escapes into the gullet (the tube which connects the throat to the stomach) causing pain, inflammation, and heartburn. In children, the symptoms of the condition can include the return of stomach contents into the mouth (regurgitation), being sick (vomiting), and poor weight gain.
  • the term "preadolescent” refers to a person of 10-13 years old.
  • the buffering capacity of the oral pharmaceutical suspensions described herein is from about 0.5 mEq/ml to about 4 mEq/ml of the oral suspension. In some embodiments, the buffering capacity of the oral pharmaceutical suspensions described herein is from about 1.6 mEq/ml to about 2.3 mEq/ml of the oral suspension.
  • the storage-stable PPI system (such as a storage-stable omeprazole system) has a moisture content of about 0.5% to about 1.5%. In some embodiments, the storage-stable PPI system (such as a storage-stable omeprazole system) has a percentage of moisture of no more than about 1%.
  • the one or more buffering agents present in the storage-stable PPI systems described herein (such as storage-stable omeprazole systems) in an amount sufficient to increase gastric fluid pH to a pH that prevents degradation of at least some of the PPI (such as omeprazole or a pharmaceutically acceptable salt thereof) in the gastric fluid.
  • the first and second buffering agents are present in an amount sufficient to increase gastric fluid pH to a pH that prevents degradation of at least some of the PPI or a pharmaceutically acceptable salt of omeprazole in the gastric fluid.
  • the first mixture and the second mixture together comprise sodium bicarbonate and potassium bicarbonate at a ratio of about 1:100 to about 100:1 by weight. In some embodiments, the first mixture and the second mixture together comprise sodium bicarbonate and potassium bicarbonate at a ratio of about 1:2.5 to about 1:3.4 by weight. In some embodiments, sodium bicarbonate and potassium bicarbonate are present at a ratio of about 1:2.7 by weight.
  • the oral pharmaceutical suspension contains no sodium from a sodium-containing buffering agent such as sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, sodium hydrogen phosphate, trisodium phosphate, sodium dihydrogen citrate, disodium hydrogen citrate, trisodium citrate, sodium tetraborate, sodium acetate, disodium hydrogen phthalate, sodium hydrogen phthalate, sodium bitartrate, disodium tartrate, and sodium succinate.
  • a sodium-containing buffering agent such as sodium carbonate, sodium bicarbonate, sodium dihydrogen phosphate, sodium hydrogen phosphate, trisodium phosphate, sodium dihydrogen citrate, disodium hydrogen citrate, trisodium citrate, sodium tetraborate, sodium acetate, disodium hydrogen phthalate, sodium hydrogen phthalate, sodium bitartrate, disodium tartrate, and sodium succinate.
  • about 1 ml of the oral pharmaceutical suspension contains about 1 mg, about 2 mg, about 4 mg, or about 8 mg of a PPI or a pharmaceutically acceptable salt thereof. In certain embodiments, about 1 ml of the oral pharmaceutical suspension contains about 1 mg, about 2 mg, about 4 mg, or about 8 mg of omeprazole, or a pharmaceutically acceptable salt thereof.
  • oral pharmaceutical suspensions described herein contain sodium and potassium at a ratio of from about 1:100 to about 100:1 by weight. In certain embodiments, oral pharmaceutical suspensions described herein contain sodium and potassium at a ratio of from about 1:50 to about 50:1 by weight. In certain embodiments, oral pharmaceutical suspensions described herein contain sodium and potassium at a ratio of from about 1:10 to about 10:1 by weight. In certain embodiments, oral pharmaceutical suspensions described herein contain sodium and potassium at a ratio of from about 1:2 to about 1:5 by weight.
  • the oral pharmaceutical suspension provides a biphasic pharmacokinetic profile having a first and second C max and a first and second T max following oral administration in a subject in need thereof.
  • the 5 ml dose of the oral pharmaceutical suspension further comprises about 11.45 mg methyl paraben sodium salt and about 25 mg sodium benzoate.
  • Suitable preservatives include those that are suitable for use in pharmaceutical preparations, including antimicrobial preservatives.
  • Suitable antimicrobial preservatives include, for example, sodium benzoate, potassium benzoate, calcium benzoate, methyl paraben sodium, ethyl paraben sodium, and mixtures thereof.
  • the preservative is sodium benzoate, methyl paraben sodium, or a mixture thereof.
  • the preservative is a mixture of sodium benzoate and methyl paraben sodium.
  • Suitable opacifiers include pharmaceutically acceptable substances added to a material in order to make the ensuing system opaque, such as titanium dioxide (TiO 2 ).
  • Insert the Bottle Adaptor and replace the red cap with the grey plastic screw-cap Leave for fifteen minutes. Shake for 20 seconds prior to each use.
  • Example L Shake the bottle for 10 seconds to loosen the powder. Tap the base of the bottle three times on a hard horizontal surface. Remove the red cap from the bottle. Add 64mL of water by using a suitable measuring device. Securely fasten the red cap onto the bottle and shake vigorously for 30 seconds. Remove the red cap and red ring and throw away. Insert the Bottle Adaptor and replace the red cap with the grey plastic screw-cap. Leave for fifteen minutes. Shake for 20 seconds prior to each use.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP20199781.4A 2019-10-04 2020-10-02 Pädiatrische suspensionsformulierung Active EP3799861B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP23210683.1A EP4331572A3 (de) 2019-10-04 2020-10-02 Pädiatrische suspensionsformulierung

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962911035P 2019-10-04 2019-10-04
US201962911689P 2019-10-07 2019-10-07
US202063062785P 2020-08-07 2020-08-07

Related Child Applications (1)

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EP23210683.1A Division EP4331572A3 (de) 2019-10-04 2020-10-02 Pädiatrische suspensionsformulierung

Publications (2)

Publication Number Publication Date
EP3799861A1 true EP3799861A1 (de) 2021-04-07
EP3799861B1 EP3799861B1 (de) 2023-11-22

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EP23210683.1A Pending EP4331572A3 (de) 2019-10-04 2020-10-02 Pädiatrische suspensionsformulierung
EP20199781.4A Active EP3799861B1 (de) 2019-10-04 2020-10-02 Pädiatrische suspensionsformulierung

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US (2) US11826359B2 (de)
EP (2) EP4331572A3 (de)
JP (1) JP2022550690A (de)
KR (1) KR20220103711A (de)
CN (1) CN114929222A (de)
AU (1) AU2020358472A1 (de)
CA (1) CA3153555A1 (de)
ES (1) ES2974364T3 (de)
IE (1) IE20200221A1 (de)
IL (1) IL291778B2 (de)
MX (1) MX2022003917A (de)
TW (1) TW202126301A (de)
WO (1) WO2021064682A1 (de)

Citations (11)

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Publication number Priority date Publication date Assignee Title
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
WO2001051050A1 (en) * 2000-01-11 2001-07-19 The Curators Of The University Of Missouri Novel substituted benzimidazole dosage forms and method of using same
ES2283172A1 (es) * 2005-01-21 2007-10-16 Universidad De Granada Suspension extemporanea de omeprazol para via oral.
EP2201952A1 (de) 2001-07-09 2010-06-30 Curators Of The University Of Missouri Omeprazole-Darreichungsformen und ihre Verwendungen
US8093271B2 (en) 2006-06-05 2012-01-10 Laboratorios Bago S.A. Anti-acid pharmaceutical composition in powder form and process for making it
WO2013139377A1 (en) * 2012-03-20 2013-09-26 Laboratorios Bagó S.A. Method for producing enteric alginate microcapsules via ionic gelation containing diclofenac or one of the salts thereof and multiparticled pharmaceutical composition containing them
US20140311929A1 (en) 2013-04-18 2014-10-23 Nupharm Laboratories Limited Liquid dosage form and delivery system
US9051100B2 (en) 2008-09-01 2015-06-09 Fresh Co., Ltd. Cap and container with cap
US20180042901A1 (en) * 2016-08-11 2018-02-15 Adamis Pharmaceuticals Corporation Drug compositions comprising an anti-parasitic and proton pump inhibitor
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
EP3471725A1 (de) 2016-06-16 2019-04-24 Cutispharma, Inc. Zusammensetzung und verfahren zur suspension von protonenpumpenhemmern

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EP2068854A2 (de) 2006-07-29 2009-06-17 Graceway Pharmaceuticals, LLC Verfahren zur behandlung und/oder prävention eines magensäureleidens mit einem protonenpumpeninhibitor (ppi) und cholinerger agonist zur einleitung von rascher ppi-wirkung mit oder ohne nahrung
EP2068841B1 (de) 2006-10-05 2018-09-26 Santarus, Inc. Neuartige formulierungen von protonenpumpenhemmern und verfahren zu ihrer verwendung
EP2252274A4 (de) 2008-02-20 2011-05-11 Univ Missouri Zusammensetzung mit einer kombination aus omeprazol und lansoprazol und puffermittel sowie anwendungsverfahren
JP2017524471A (ja) 2014-07-30 2017-08-31 サン ファーマシューティカル インダストリーズ リミテッドＳｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｉｎｄｕｓｔｒｉｅｓ Ｌｔｄ． 二重室の包装体
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EP1905426B1 (de) 2006-06-05 2012-09-05 Laboratorios Bagó S.A. Pharmazeutische Säureschutzzusammensetzung in Pulverform, pharmazeutische Zubereitung damit und Herstellungsverfahren dafür
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US20140311929A1 (en) 2013-04-18 2014-10-23 Nupharm Laboratories Limited Liquid dosage form and delivery system
US10238803B2 (en) 2016-05-02 2019-03-26 Sun Pharmaceutical Industries Limited Drug delivery device for pharmaceutical compositions
EP3471725A1 (de) 2016-06-16 2019-04-24 Cutispharma, Inc. Zusammensetzung und verfahren zur suspension von protonenpumpenhemmern
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MANABE N., HARUMA K., ITO M., TAKAHASHI N., TAKASUGI H., WADA Y., NAKATA H., KATOH T., MIYAMOTO M., TANAKA S.: "Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trial : Efficacy of adding sodium alginate", DISEASES OF THE ESOPHAGUS, vol. 25, no. 5, 1 July 2012 (2012-07-01), AU , pages 373 - 380, XP093035350, ISSN: 1120-8694, DOI: 10.1111/j.1442-2050.2011.01276.x
SAEID NAIMA, ELMZIBRI MOHAMMED, HAMRANI ABDESLAM, LATIFA QANDOUSSI, BELGHITI HAKIM, EL BERRI HICHAM, BENJEDDOU KAOUTAR, BOUZIANI A: "Assessment of Sodium and Potassium Intakes in Children Aged 6 to 18 Years by 24 h Urinary Excretion in City of Rabat, Morocco", JOURNAL OF NUTRITION AND METABOLISM, HINDAWI PUBLISHING CORPORATION, US, vol. 2018, 1 August 2018 (2018-08-01), US , pages 1 - 8, XP093039132, ISSN: 2090-0724, DOI: 10.1155/2018/8687192
THAKUR ATULKUMAR, RANVIRSINGH BASAPPA VEERBHADRAIAH, BASAVARAJ, BHARATH SRINIVASAN, DEVESWARAN RAJAMANICKAM, MADHAVAN VARADHARAJAN: "Formulation and Evaluation of Floating Alginate Beads of an Anti-Ulcer Drug", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, GLOBAL RESEARCH ONLINE PUBLISHING HOUSE, IN, vol. 21, 1 August 2013 (2013-08-01), IN , pages 120 - 124, XP093039141, ISSN: 0976-044X
TIAN NIU, ZHANG ZEFENG, LOUSTALOT FLEETWOOD, YANG QUANHE, COGSWELL MARY E: "Sodium and potassium intakes among US infants and preschool children, 2003–2010,,,", AMERICAN JOURNAL OF CLINICAL NUTRITION, vol. 98, no. 4, 1 October 2013 (2013-10-01), pages 1113 - 1122, XP093039136, ISSN: 0002-9165, DOI: 10.3945/ajcn.113.060012

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IL291778B2 (en) 2024-09-01
CN114929222A (zh) 2022-08-19
EP3799861B1 (de) 2023-11-22
MX2022003917A (es) 2022-06-14
EP4331572A2 (de) 2024-03-06
WO2021064682A1 (en) 2021-04-08
US20230390266A1 (en) 2023-12-07
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