EP3793693A1 - Préparation active antitranspirante sans eau - Google Patents

Préparation active antitranspirante sans eau

Info

Publication number
EP3793693A1
EP3793693A1 EP19714373.8A EP19714373A EP3793693A1 EP 3793693 A1 EP3793693 A1 EP 3793693A1 EP 19714373 A EP19714373 A EP 19714373A EP 3793693 A1 EP3793693 A1 EP 3793693A1
Authority
EP
European Patent Office
Prior art keywords
preparation
preparation according
organic compound
alkali metal
lactone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19714373.8A
Other languages
German (de)
English (en)
Inventor
Benjamin WINTER
Robert Klauck
Frank Lehmbeck
Thomas Raschke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP3793693A1 publication Critical patent/EP3793693A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present invention relates to an anhydrous cosmetic preparation containing at least one silicate of alkali metals, preferably of sodium and / or potassium and particularly preferably of sodium, and at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12 ,
  • Sweat is an aqueous secretion secreted by the skin of the human through the so-called sweat glands.
  • sweat glands There are three types of sweat glands in the skin, namely apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun; 29 (3): 169-79).
  • the eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water.
  • the apocrine sweat glands come only in the hairy body areas of the armpit and genital region and the
  • Sweating also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature.
  • the sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell.
  • the apocrine sweat plays in particular in the context of the emotional or
  • Cosmetic antiperspirants or deodorants / deodorants serve to
  • Body odor arises when the per se odorless fresh sweat by microorganisms such.
  • German-speaking countries - products for use in the underarm area generally referred to as deodorants or "deodorants”. This is irrelevant to the question of whether an antiperspirant effect is present.
  • Antiperspirants are antiperspirants that - in contrast to the
  • Deodorants which generally prevent microbial decomposition of already formed sweat - to prevent the secretion of sweat at all.
  • Non-colloidal silver also shows odor neutralization (masking), influence on bacterial metabolisms, pure perfuming as well as the use of precursors of certain perfume components, which are converted into fragrant substances by enzymatic reactions.
  • Sweat odor consists to a large extent of branched-chain fatty acids, which are released by bacterial enzymes from odorless sweat.
  • Classic deodorizing agents counteract this by reducing the growth of bacteria.
  • the substances used here are also unselective and useful
  • the classic antiperspirants used are, in particular, aluminum salts or aluminum / zirconium salts. These inhibit the flow of sweat by obstructing the excretory ducts of the sweat glands by precipitating them together with the skin's own proteins and thus leading to so-called plugs. Therefore, there may be a congestion of sweat within the gland.
  • Sweat gland duct is still open.
  • such aluminum salts as aluminum hydroxychlorides can cause skin damage if used frequently and on sensitive persons.
  • the use of the aluminum salts can cause discoloration of textiles which come into contact with the antiperspirant.
  • antiperspirants and deodorants (Deo) are offered in a variety of product forms, with scooters, pump sprayers and aerosols dominating in Europe, and deodorant sticks ("sticks") in the US, Central and South America. Both anhydrous (suspensions) and water-containing products (hydro-alcoholic formulations, emulsions) are known.
  • a disadvantage of the aluminum salts used hitherto for sweat inhibition is the currently not yet fully understood long-term toxicity.
  • Aluminum has long been suspected of promoting or inducing neurodegenerative diseases such as dementia, particularly Alzheimer's disease. Also, aluminum is associated with the onset of breast cancer
  • Examples 1 to 3 are roll-on formulations containing sodium silicate, an acid and water.
  • the pH of the formulations is in the range of 8 to 10.
  • Other examples disclose stick formulations containing sodium silicate and optionally an acid. All disclosed stick formulations are anhydrous. Among others, with C12-C15 alkyl benzoates and PEG-8 distearate esters in the
  • FR 2977151 A1 discloses aerosol sprays containing sodium silicate and at least one acid.
  • the preparations are anhydrous.
  • Mintel product no. 93863 “Cool Cotton Deodorant”, which is an aqueous formulation with fatty acids and various
  • Metal silicates is.
  • sodium silicate as an antiperspirant active ingredient is attributable to the fact that an aqueous solution containing sodium silicate polymerizes or forms a gel at a pH of less than 1, thus blocking the
  • anhydrous preparations known from FR 2977151 A1 contain at least one water-soluble, free acid. This leads to the fact that the pH of the preparation is immediately lowered when water is added. In the storage and use of these anhydrous preparations, it may also due to the presence of the water-soluble, free acid to a deactivation of the sodium silicate by
  • One way to prevent rapid polymerization or gel formation is to apply an aqueous sodium silicate solution directly to the skin at a high pH, for example pH 12, at which no polymerization takes place. On the skin then follows the natural regulation of the pH of the skin, which leads to a lowering of the pH. There is thus a delayed polymerization, but it comes in this
  • a further disadvantage of known antiperspirant cosmetic preparations is that they do not develop their antiperspirant activity as a function of the perspiration production. Rather, it is desirable to provide preparations whose antiperspirant activity begins only with onset of sweat production. The object of the present invention was thus to provide a cosmetic preparation which does not have the disadvantages of the prior art.
  • the invention relates to an anhydrous cosmetic preparation containing
  • At least one alkali metal silicate preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred
  • the present invention also provides the use of the combination of at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred, and an organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12, to provide an antiperspirant, anhydrous cosmetic preparation which is applied to the skin and blocks sweat pores only at the onset of sweating.
  • alkali metal silicate preferably sodium silicate and / or potassium silicate
  • sodium silicate being particularly preferred
  • the invention also provides a process for activating the antiperspirant activity of a cosmetic preparation on the skin, characterized in that, in a first step, a preparation containing the combination of at least one alkali metal silicate, preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred and at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12, is applied to the skin and in a second step, water is added to the applied preparation, wherein the addition of water is preferably carried out by sweating.
  • a preparation containing the combination of at least one alkali metal silicate preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred and at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12
  • water is added to the applied preparation, wherein the addition of water is preferably carried out by sweating.
  • the alkali metal silicates according to the invention in addition to the organic compounds according to the invention containing an ester group on the skin.
  • the silicates are dissolved by the water.
  • acids Due to the hydrolysis of the esters, acids are formed which retard the pH and delay the desired gel formation.
  • the formation of acids prevents the pH on the skin from being strongly alkaline over a long period of time.
  • it was surprising has been found that when the combination according to the invention is used, there is no or only little loss of action in relation to the antiperspirant activity of the preparation.
  • the indication includes not only the beginning and end values for the indicated ranges, but also the individual values within ranges in increments of 0.01% by weight.
  • Normal conditions performed.
  • the term "normal conditions” means 20 ° C, 1013 hPa and a relative humidity of 50%.
  • the formulations "according to the invention”, “advantageous according to the invention”, and “advantageous for the purposes of the present invention” always refer both to the preparation according to the invention and to the use according to the invention and to the processes according to the invention.
  • sodium silicate and / or potassium silicate are present in the cosmetic preparation as alkali metal silicate, sodium silicate being preferably present.
  • the preparation of the present invention is referred to as anhydrous.
  • sodium silicate is present in anhydrous form in the preparation according to the invention.
  • a most preferred form of sodium silicate to be used is sodium metasilicate (CAS: 6834-92-0).
  • Preparation contained alkali metal silicates are particularly fine-grained. Accordingly, the alkali metal silicate contained in the preparation according to the invention is advantageously characterized in that it has a bulk density of at least 800 g / L, preferably at least 950 g / L and particularly preferably at least 1050 g / L.
  • Anhydrous sodium silicate having a bulk density of 1100 g / l can be obtained inter alia from the company SILMACO N.V., Belgium. Bulk density can be determined according to DIN EN ISO 60: 2000-01.
  • Equivalent diameter (particle size) of less than 250 pm, preferably less than 150 pm, and more preferably less than 50 pm is used.
  • the alkali metal silicate sodium silicate having a mean
  • Equivalent diameter of less than 250 pm, preferably less than 150 pm, and more preferably less than 50 pm is used.
  • the particle size can be determined by light scattering, the mean equivalent diameter resulting from a measurement of at least 100 particles.
  • sodium silicate is contained as alkali metal silicate and the proportion of sodium silicate in the preparation of 0.25 wt .-% to 20 wt .-%, preferably 0.5 wt .-% to 8 wt .-% and particularly preferably 1 wt .-% to 3 wt .-%, each based on the total weight of the preparation.
  • the anhydrous cosmetic preparation contains at least one organic compound containing an ester group which hydrolyzes at a pH of 7.5 to 12.
  • the statement for the hydrolysis of the ester group refers to
  • Hydrolysis is considered to occur when a substance in a total amount of 0.1% by weight is added to an aqueous solution whose pH has been adjusted to 7.5 to 12 with caustic soda and within 20 minutes Under normal conditions, a pH change of at least 0.5, preferably at least 1, particularly preferably at least 4, takes place in the direction of the acidic pH range.
  • the aqueous solution used contains only water and sodium hydroxide solution.
  • An organic compound is considered to be in accordance with the invention if the required pH change occurs at at least one pH in the range from 7.5 to 12.
  • a preferred subject of the invention is therefore an anhydrous cosmetic
  • At least one alkali metal silicate preferably sodium silicate and / or potassium silicate, with sodium silicate being particularly preferred
  • organic compound b) according to the invention is water-soluble.
  • organic compounds b) according to the invention include, inter alia
  • Carboxylic acid esters, anhydrides or lactones Decisive is their functionality, which is based on the fact that a contained ester group hydrolyzed at a pH of 7.5 to 12 or hydrolyzed in particular at a pH of 11.
  • an acid group is formed from organic compounds which are advantageous according to the invention.
  • the organic compounds b) according to the invention may contain one or more ester groups which hydrolyze at a pH of 7.5 to 12.
  • a first advantageous group (A) of organic compounds b) according to the invention are non-cyclic esters of carboxylic acids and alcohols, the alcohol preferably being ethanol.
  • Preferred examples of this group are oxalic acid diesters and ethyl lactate, with lactic acid ethyl ester being particularly preferred.
  • the polymeric ester compounds of group (C) do not belong to the organic compounds of group (A).
  • a second advantageous group (B) according to the invention of organic compounds b) are cyclic esters advantageously selected from the group of lactones and cyclic diesters of hydroxycarboxylic acids.
  • the lactones of the invention include gluconic acid 1, 5-lactone, glucuric acid-6,3-lactone, 3,5-dihydroxy-3-methylpentanoic acid 5-lactone, riboklare-1, 4-lactone, galactonic acid-1, 4-lactone, Glucono-1, 4-lactone, Mannoic Acid-1, 4-lactone.
  • the cyclic diesters of ⁇ -hydroxycarboxylic acids include, among others, the lactide (lactides). Gluconic acid 1, 5-lactone and / or lactide are preferably selected. As the lactide, it is possible to use both the (S, S) -lactide, the (R, R) -lactide, the meso-lactide or mixtures of these isomers.
  • a third group (C) of organic compounds b) which is advantageous according to the invention represents polymeric ester compounds.
  • Polymeric ester compounds are non-cyclic esters which are composed of at least 3 identical monomeric esters.
  • a preferred example of such an ester compound is the polylactic acid, which further preferably has an average molecular weight of less than 5000 Da, more preferably less than 2000 Da, and further preferably less than 500 Da and
  • Polylactic acid can be used to control the hydrolysis rate.
  • Another group (D) of organic compounds b) which is advantageous according to the invention are acid anhydrides.
  • Known examples include acetic anhydrides or
  • organic compounds b) of the abovementioned groups can also be used in combination, preference being given to a combination of groups (A), (B) and (C). Particularly preferred is a combination of groups (A) and (B).
  • cosmetic preparations of the invention is advantageously from 0.5% by weight to 25% by weight, preferably from 1% by weight to 20% by weight and particularly preferably from 4% by weight to 12% by weight, based on the total weight of the cosmetic preparation.
  • advantageous embodiments of the invention are characterized in that the weight ratio of the alkali metal silicates to that of organic compounds b) is 1: 1 to 1:50, preferably 1: 2 to 1: 5.
  • the state of aggregation of the organic compounds b) used is either solid or liquid under normal conditions. If solid organic compounds b) are used, ie the organic compounds b) are solids, it has proved to be advantageous if these organic compounds b) are water-soluble, but the solubility of the organic compounds b) is lower than the water solubility the silicate used of the alkali metals. This leads to the fact that when the onset of sweating, the silicates are first dissolved and can penetrate into the sweat glands, before the hydrolysis of the organic compound b) begins and the pH is lowered, which triggers the desired gel formation. That way, one becomes
  • advantageous embodiments of the invention are also characterized in that the organic compound b) used is solid under normal conditions and the solubility of the organic compounds b) in water is lower than the water solubility of the silicate used of the alkali metals. If the organic compounds b) are solid under normal conditions, it is furthermore advantageous if they are as fine-grained as possible. Solid organic compounds b) having a mean equivalent diameter of less than 150 square meters, preferably less than 50 square meters, and in particular less than 10 square meters, are advantageously used. Through the use of particularly fine-grained solid organic compounds b), a lumping or a rough feeling on the skin is reduced and / or prevented.
  • the particle size can be determined by light scattering, the mean equivalent diameter resulting from a measurement of at least 100 particles.
  • anhydrous cosmetic preparations according to the invention contain no acids. That is, the proportion of acids in the preparation according to the invention is 0 wt .-%, based on the total weight of the preparation.
  • the proportion of the water-soluble acids in the preparation according to the invention is 0 wt .-%, based on the total weight of the preparation.
  • the cosmetic preparations of the invention contain no aluminum salts, in particular no aluminum chlorohydrate.
  • the cosmetic preparations according to the invention contain silicone oils.
  • the proportion of silicone oils may vary. In general, however, the proportion of silicone oils is advantageously at least 30% by weight, based on the total weight of the cosmetic preparation.
  • cosmetic preparations for use under the armpit include creams, pump sprays, aerosol sprays, gels, solid sticks or roll-on
  • a first advantageous embodiment of the invention is an aerosol spray containing the combination according to the invention.
  • An aerosol spray is a pressure vessel provided with a dispensing valve and containing the cosmetic preparation according to the invention and at least one propellant gas.
  • the propellant gases are advantageously selected from the group consisting of propane, n-butane, isobutane, pentane and / or nitrogen. Less suitable to use
  • Chlorofluorocarbons which affect the environment and therefore for the
  • the propellant gases are selected from the group consisting of propane, n-butane and isobutane.
  • Preferred filling ratios based on the weight of the cosmetic preparation to propellant gas are 40:60 to 2:98, preferably 25:75 to 3:97, most preferably 6:94.
  • the cosmetic preparation contains one or more silicone oils.
  • Silicone oils according to the invention can be selected from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).
  • the cosmetic preparation of the first advantageous embodiment contains silicone oils, it is preferred according to the invention if the proportion of silicone oils in the cosmetic preparation is 50% by weight to 70% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation according to the first advantageous embodiment contains dimethiconol, it is furthermore advantageous if the proportion of dimethiconol is from 6% by weight to 12% by weight, based on the total weight of the cosmetic preparation.
  • Embodiment of the invention contains one or more natural oils.
  • a particularly advantageous to be used oil is Persea Gratissima Oil.
  • the cosmetic preparation of the first advantageous embodiment of the invention contains isopropyl palmitate. Contains the cosmetic
  • isopropyl palmitates it is preferred if the proportion of isopropyl palmitates is from 5% by weight to 15% by weight, based on the total weight of the cosmetic preparation.
  • Embodiment of the invention contains Disteardiamoniumhectorit.
  • the cosmetic preparation according to the first advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, PPG-14 butyl ether, C12-15 alkyl benzoate, capric / Caprylic Triglyceride, Isopropyl Myristate, Isopropyl Stearate, Cetearyl Ethylhexanoate, Hydrogenated Polydecenes,
  • Paraffinum Liquidum Paraffinum Liquidum, PPG-15 Stearyl Ether, Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol;
  • Guerbet alcohol esters and mixtures of Guerbet alcohols and Guerbet alcohol esters (such as hexyldecanol and hexyldecyl laurate).
  • the cosmetic preparation according to the invention is in the form of a stick.
  • the cosmetic preparation contains silicone oils in a proportion of 30% by weight to 50% by weight, based on the total weight of the cosmetic preparation.
  • the silicone oils according to the invention can be chosen from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).
  • the cosmetic preparation contains one or more fatty alcohols, in particular stearyl alcohol. If the preparation contains fatty alcohols, it is furthermore preferred if the proportion of the fatty alcohols is from 15% by weight to 30% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation contains PPG-14 butyl ether. Does the preparation contain PPG-14 butyl Ether, it is further preferred if the proportion of PPG-14 butyl ether from 10 wt .-% to 20 wt .-%, based on the total weight of the cosmetic preparation is.
  • the cosmetic preparation contains talc. If the preparation contains talc, it is further preferred if the proportion of talc of 4 wt .-% to 8 wt .-%, based on the
  • Total weight of the cosmetic preparation is.
  • the cosmetic preparation contains hydrogenated castor oil. If the preparation contains hydrogenated castor oil, it is furthermore preferred if the proportion of hydrogenated castor oil is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation contains glyceryl stearate SE. If the preparation contains glyceryl stearate SE, it is furthermore preferred if the proportion of glyceryl stearate SE is from 0.2% by weight to 0.9% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation according to the second advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristates .
  • Isopropyl Palmitate Isopropyl Stearate, Cetearyl Ethyl Hexanoate, Hydrogenated Polydecenes, Paraffinum Liquidum, PPG-15 Stearyl Ether, Avocado Oil (Persea Gratissima Oil), Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol; Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbet alcohol esters (such as hexyldecanol and hexyldecyl laurate).
  • Preparations of the third advantageous embodiment are often described as soft solid. These preparations are advantageously characterized in that they are not flowable under normal conditions under its own weight but deformable.
  • the preparations of the third advantageous embodiments are composed according to the following description.
  • the cosmetic preparation of the third advantageous embodiment based on the total weight of the cosmetic preparation, silicone oils in a proportion of 60 wt .-% to 75 wt .-%.
  • the silicone oils according to the invention can be chosen from linear silicone oils (dimethicones) and cyclic silicone oils (cyclosilicone).
  • cosmetic preparation contains PPG-14 butyl ether. If the preparation contains PPG-14 butyl ether, it is furthermore preferred if the proportion of PPG-14 butyl ether is from 5% by weight to 15% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation containing hydrogenated castor oil. If the preparation contains hydrogenated castor oil, it is furthermore preferred if the proportion of hydrogenated castor oil is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic preparation.
  • the cosmetic preparation containing Silica Dimethyl Silylate. If the preparation contains silica dimethyl silylates, it is furthermore preferred if the proportion of silica dimethyl silylates is from 0.5% by weight to 4% by weight, based on the total weight of the cosmetic
  • the cosmetic preparation according to the third advantageous embodiment contains further components, such as further oils and / or perfumes, which are advantageously selected from the group sunflower oil, rapeseed oil, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristate .
  • Isopropyl Palmitate Isopropyl Stearate, Cetearyl Ethyl Hexanoate, Hydrogenated Polydecenes, Paraffinum Liquidum, PPG-15 Stearyl Ether, Avocado Oil (Persea Gratissima Oil), Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol; Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbetalkoholestem (such as hexyldecanol and hexyldecyl laurate).
  • Roll-on formulations are formulations that are about one
  • the anhydrous roll-on formulations comprising the combination according to the invention advantageously have a viscosity of a viscosity in the range of 1000 to 5000 mPas, measured 1 day after preparation with a Brookfield viscometer, spindle RV 4, 20 s-1, without Helipath, at 20 ° C ambient temperature and 20 ° C sample temperature m, on.
  • the roll-on formulations according to the invention are advantageously characterized in that they contain silicone oils in a proportion of at least 40% by weight, based on the total weight of the preparation, or of the roll-on formulation.
  • Formulations advantageously other components, such as other oils and / or perfumes containing, which are advantageously selected from the group sunflower oil, rapeseed oil, PPG-14 butyl ether, C12-15 alkyl benzoate, Capric / Caprylic triglyceride, isopropyl myristates,
  • Isopropyl Palmitate Isopropyl Stearate, Cetearyl Ethyl Hexanoate, Hydrogenated Polydecenes, Paraffinum Liquidum, PPG-15 Stearyl Ether, Avocado Oil (Persea Gratissima Oil), Glycine Soybean (Soybean) Oil, Olive Oil, Guerbet Alcohols; especially hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol; Guerbet alcohol esters, and mixtures of Guerbet alcohols and Guerbet alcohol esters (such as hexyldecanol and hexyldecyl laurate).
  • All cosmetic preparation according to the invention may further cosmetic
  • Antiperspirant preparations are used, such as. B. preservatives,
  • a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, ganic solvents or other silicone derivatives if the additive does not impair the required properties or is excluded according to the invention.
  • the hydrolysis behavior of various esters is examined below by way of example. For this purpose, in each case water and sodium hydroxide were mixed so that an aqueous
  • Sodium hydroxide solution was obtained with a pH of 1 1. Subsequently, 0.1% by weight each of an ester was added to the sodium hydroxide solution, and the pH of the solution was measured again after 20 minutes.
  • hydrolysis according to the invention takes place only in the case of the lactides and the gluconic acid-1, 5-lactone, while isopropyl palmitates and glyceryl stearate SE are not hydrolyzed.
  • the lactides and gluconic acid-1, 5-lactone organic compounds containing an ester group, while isopropyl palmitate and glyceryl stearate SE are not according to the invention.
  • the organic compound b) is characterized in that it has a pH value of 11 within 5 when added in a proportion of 0.1% by weight to an aqueous sodium hydroxide solution Minutes after addition, the pH is lowered to not less than 9.5 and 20 minutes after addition, a pH of less than 6, wherein the wt .-% fraction based on the total composition of the sodium hydroxide solution and the organic compound relates.
  • the pen formulations listed below were prepared. For this purpose, all components 1 to 5 were heated to 90 ° C and mixed.
  • Component 9 The mixture of all ingredients was poured into stick molds at 65 ° C as a homogeneous mass. Unless indicated otherwise, all amounts, proportions and percentages are based on the weight and the total amount or on the total weight of the preparations.
  • the stick of Ex.1 contains the gluconic acid-1, 5-lactone as an organic compound having an ester group.
  • Ex.2 contains no such compound and is thus not an example according to the invention.
  • the pins of Ex.1 and Ex.2 were used for further pH studies. In a first study, in each case 2 g of the respective stick of Examples Bsp.1 and Bsp.2 were added to 200 g of water and the pH of the solution was measured as a function of time. The measured values are shown in Figure 1 (Fig.1).
  • a continuous increase in the pH while the addition of the preparation of Example 1
  • a first increase in pH takes place before the pH decreases again 3 minutes after addition and so in one skin-compatible area remains.
  • the pH of the axilla with Ex.1 before application was determined to be 6.1.
  • the pH of the armpit with Ex.2 before application was determined to be 5.2.
  • 30 minutes after the orders a pH of 9.7 was determined for the armpit with the example formulation Ex.1, while the armpit with the example formulation Ex.2 has a pH value of 12.
  • a pH of 7.3 for the underarm was determined with the example formulation Ex.1 and a pH of 9.4 for the armpit with the example formulation Ex.2.
  • Study participants did not use any leave-on products (such as hand creams) or washing substances on the underarm area for at least three days before the study, as well as during the course of the study.
  • leave-on products such as hand creams
  • washing substances on the underarm area for at least three days before the study, as well as during the course of the study.
  • the forearms Before application of the test substances, the forearms are washed with a surfactant-containing solution. Subsequently, the test areas are recorded with the aid of a template on the forearm (inner side) for the recovery in the multiple application and the preparations of the example formulations Bsp.1 and Bsp.2 are each applied to the areas. In addition, areas remained untreated and thus served as a reference. 24 hours after application, a liquid-absorbing matrix (for example a cotton pad) was fixed on the test areas. The volunteers then spent 20 minutes on an ergometer to stimulate the sweat flow. After completion, a gravimetric evaluation of the liquid-absorbent matrix was carried out. Nine subjects participated in the study, each sample being examined twice in each subject.
  • a liquid-absorbing matrix for example a cotton pad
  • the example formulation Ex.1 showed a sweat reduction with the median of 15%, while the median of the example formulation Ex.2 was 17%. Both values are to be regarded as comparable within the study designs.
  • the present comparative experiments thus show that the formulations according to the invention have a comparable sweat reduction with a significantly improved skin compatibility. The skin is less exposed to high pH levels.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une préparation cosmétique sans eau contenant au moins un silicate de métal alcalin et au moins un composé organique contenant un groupe ester, qui s'hydrolyse à un pH de 7,5 à 12.
EP19714373.8A 2018-05-17 2019-03-26 Préparation active antitranspirante sans eau Withdrawn EP3793693A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018207690.1A DE102018207690A1 (de) 2018-05-17 2018-05-17 Wasserfreie antitranspirant wirksame Zubereitung
PCT/EP2019/057530 WO2019219280A1 (fr) 2018-05-17 2019-03-26 Préparation active antitranspirante sans eau

Publications (1)

Publication Number Publication Date
EP3793693A1 true EP3793693A1 (fr) 2021-03-24

Family

ID=65991793

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19714373.8A Withdrawn EP3793693A1 (fr) 2018-05-17 2019-03-26 Préparation active antitranspirante sans eau

Country Status (3)

Country Link
EP (1) EP3793693A1 (fr)
DE (1) DE102018207690A1 (fr)
WO (1) WO2019219280A1 (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009347A1 (de) * 1990-03-23 1991-09-26 Beiersdorf Ag Desodorierende kosmetische mittel
DE102009029671A1 (de) * 2009-09-22 2011-03-24 Henkel Ag & Co. Kgaa Wasserfreie Antitranspirant-Nonaerosole mit verbesserter Wirkstofffreisetzung
DE102009043004A1 (de) * 2009-09-28 2011-03-31 Beiersdorf Ag Aerosolzubereitungen mit stabilisierten partikulären Stoffen
FR2977151B1 (fr) 2011-06-28 2013-09-27 Oreal Utilisation cosmetique comme actif anti-transpirant d'un silicate alcalin
DE102012214015A1 (de) * 2012-08-07 2014-05-22 Henkel Ag & Co. Kgaa Ölkombination für Antitranspirant-Zusammensetzungen mit verbesserter Rückstandsmaskierung
DE102013208337A1 (de) * 2013-05-07 2014-11-13 Henkel Ag & Co. Kgaa Aerosolzusammensetzung mit verbesserten Sprüheigenschaften
DE102013209898A1 (de) * 2013-05-28 2014-12-04 Henkel Ag & Co. Kgaa Mund- und Zahnpflege- und -reinigungsmittel für sensitive Zähne
CA2917672A1 (fr) * 2013-07-29 2015-02-05 Colgate-Palmolive Company Compositions anti-transpirantes/deodorantes
WO2016005703A1 (fr) * 2014-07-09 2016-01-14 L'oreal Composition anhydre a base de poudre coiffante et/ou absorbante de sebum et de particules encapsulant un agent bénéfique
DE102015226630A1 (de) * 2015-12-23 2017-06-29 Beiersdorf Ag Verfahren zur Schweißreduktion

Also Published As

Publication number Publication date
DE102018207690A1 (de) 2019-11-21
WO2019219280A1 (fr) 2019-11-21

Similar Documents

Publication Publication Date Title
EP3300771B1 (fr) Utilisation d'isosorbidecaprylates/caprates dans des déodorants et des anti-transpirants
EP1725210B1 (fr) Utilisation d'un extrait eau/ethanol d'hibiscus pour traiter les odeurs corporelles
CH653888A5 (de) Desodorierende zusammensetzung.
EP1755531A1 (fr) Formulation anti-transpiration aqueuse
WO2019206466A1 (fr) Préparation à action anti-transpirante comprenant des sels de métal alcalino-terreux et des acides carboxyliques
EP3393427B1 (fr) Procédé de réduction de la transpiration
WO2017016858A1 (fr) Antitranspirant
EP3793693A1 (fr) Préparation active antitranspirante sans eau
WO2014095366A2 (fr) Protection améliorée contre l'odeur corporelle
WO2017016856A1 (fr) Préparation cosmétique réduisant la transpiration
EP2934437B1 (fr) Utilisation de sels d'aluminium pour lutter contre la transpiration due au stress
WO2017016857A1 (fr) Préparation cosmétique permettant de réduire la formation de sueur
DE102018206621A1 (de) Antitranspirantwirksame Zubereitung umfassend Erdalkalimetallsalze
DE2524364A1 (de) Antitranspirant in aerosolform
EP3328505B1 (fr) Antisudoral
WO2019219300A1 (fr) Procédé de réduction de sueur à l'acide malonique
DE202006015778U1 (de) Hautpflegendes Deodorant/Antitranspirant
WO2017016859A1 (fr) Antitranspirant
EP3328504A1 (fr) Antitranspirant
EP2183029A2 (fr) Stabilisation de formulation cosmétique ou dermatologique avec de l'acide mandélique

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: UNKNOWN

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20201217

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BEIERSDORF AG

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20221001