EP3328504A1 - Antitranspirant - Google Patents

Antitranspirant

Info

Publication number
EP3328504A1
EP3328504A1 EP16736496.7A EP16736496A EP3328504A1 EP 3328504 A1 EP3328504 A1 EP 3328504A1 EP 16736496 A EP16736496 A EP 16736496A EP 3328504 A1 EP3328504 A1 EP 3328504A1
Authority
EP
European Patent Office
Prior art keywords
cas
phase
cosmetic
product according
cosmetic product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP16736496.7A
Other languages
German (de)
English (en)
Inventor
Elke Grotheer
Franz STÄB
Thomas Schmidt-Rose
Michael Seet
Robert Klauck
Frank Lehmbeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP3328504A1 publication Critical patent/EP3328504A1/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/041—Appliances specially adapted for applying liquid, e.g. using roller or ball using a roller, a disc or a ball
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216—Rigid containers disposed one within the other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/68—Dispensing two or more contents, e.g. sequential dispensing or simultaneous dispensing of two or more products without mixing them
    • B65D83/682—Dispensing two or more contents, e.g. sequential dispensing or simultaneous dispensing of two or more products without mixing them the products being first separated, but finally mixed, e.g. in a dispensing head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application

Definitions

  • the present invention relates to a cosmetic for reducing or preventing apoekkrinen sweat formation from a packaging with two pantries and two cosmetic part preparations, characterized in that a chamber
  • secreted aqueous secretion There are three types of sweat glands in the skin, namely, apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun;
  • the eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water.
  • the apocrine sweat glands occur only in the hairy body areas of the armpit and genital region and on the nipples. They produce small amounts of a milky secretion that contains proteins and lipids and is chemically neutral.
  • Sweating also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature.
  • the volume-rich aqueous secretion of the eccrine glands which can produce up to 2-4 liters per hour or 10-14 liters a day in adults, is used for this purpose.
  • the sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell. In humans, the apocrine sweat plays in particular in connection with the emotional or stress related
  • Cosmetic antiperspirants or deodorants / deodorants are used to eliminate body odor or to reduce their formation.
  • Body odor arises when the per se odorless fresh sweat by microorganisms such. Staphylococci and
  • Deodorant and "antiperspirant”. Rather, especially in the German-speaking Space - products for use in the underarm area generally referred to as deodorants or "deodorants.” This is irrelevant to the question of whether an antiperspirant effect is present.
  • Antiperspirants are antiperspirants that - in contrast to the
  • Deodorants which generally prevent microbial decomposition of already formed sweat - to prevent the secretion of sweat at all.
  • non-colloidal silver also shows odor neutralization (masking), influencing of bacterial metabolisms, the pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic reactions to fragrant substances.
  • Sweat odor consists to a large extent of branched-chain fatty acids, which are released by bacterial enzymes from odorless sweat.
  • Classic deodorizing agents counteract this by reducing the growth of bacteria.
  • the substances used for this purpose also act nonselectively against useful skin germs and can lead to skin irritations in sensitive individuals.
  • the classic antiperspirants used are, in particular, aluminum salts or aluminum / zirconium salts. These inhibit the flow of sweat by obstructing the excretory ducts of the sweat glands by precipitating them together with the skin's own proteins and thus leading to so-called plugs. Therefore, there may be a congestion of sweat within the gland.
  • Corneocytes in the sweat gland duct (Shelley WB and Hurley HJ, Acta, Derm. Venereol. (1975) 55: 241-60), or by the emergence of an ACH / AZG gel (Reiler HH and Luedders WL, in: Advances in Modern Hemisphere Publishing Company, Washington and London. Toxicology, Dermatoxicology and Pharmacology, FN Marzulli and HI Maibach, Eds (1977) Vol. 4: 1-5) formed by neutralization in the sweat gland duct is still open.
  • such aluminum salts as aluminum hydroxychlorides can cause skin damage if used frequently and on sensitive persons.
  • the use of the aluminum salts can cause discoloration of textiles which come into contact with the antiperspirant.
  • antiperspirants and deodorants (Deo) are offered in a variety of product forms, with scooters, pump sprayers and aerosols dominating in Europe, and deodorant sticks ("sticks") in the US, Central and South America. Both anhydrous (suspensions) and water-containing products (hydro-alcoholic formulations, emulsions) are known.
  • a satisfactory deodorant means the following conditions are met: 1)
  • liquid deodorants and antiperspirants Apart from the liquid deodorants and antiperspirants, solid preparations, for example powders, powder sprays, are also known and customary as intimate cleaners.
  • the nature of the composition of cosmetic preparations finds its natural limits, due to the compatibility of the individual components with each other and the stability of
  • Dual chamber packing means are well known in the art.
  • a very simple form is known to those skilled in the art from US 20070233012, in which the contents of two different chambers can be output simultaneously.
  • FR 2852928 discloses a two-chamber container in which the product is removed by means of two pumps in such a way that the preparations are mixed only in the output channel.
  • EP 958062 discloses a dual chamber packing means with concentrically arranged pumps.
  • EP 0461010 discloses a two-chamber aerosol canister in which the mixture of the
  • Formulations in which ACH is present as a solid, are extremely stable.
  • a disadvantage of the aluminum salts used hitherto for sweat inhibition is the currently not yet fully understood long-term toxicity.
  • Aluminum has been suspected for a long time to promote or trigger neurodegenerative diseases such as dementia, in particular Alzheimer's disease. Also, aluminum is associated with the development of breast cancer. So far, there is no verified evidence that works over the skin
  • Al salts are short-chain silicates in the form of silicic acids, which can reliably suppress sweat formation.
  • Silica acids are the oxygen acids of silicon. The easiest
  • Cyclotric acid and cyclotetravelic acid having the general empirical formula [Si (OH) 2 -O-] n .
  • Polymers are sometimes referred to as meta-silicic acid (H2S1O3, [-Si (OH) 2 -O-] n ). If these low-molecular-weight silicic acids continue to condense, amorphous colloids (silica sol) are formed.
  • General empirical formula of all silicas is H2n + 2Si n 03n + i - S1O2 ⁇ n H2O is often given as a molecular formula; However, the water is not with silicas
  • Silica the anhydride of silicic acid.
  • the salts of acids are called silicates.
  • esters of silicic acids are called silicic acid esters.
  • highly amorphous silicic acids are within the meaning of the invention, only the
  • Silica acids are understood to have an extension of 1 to 100 nm, measured by dynamic light scattering. These low molecular weight, highly amorphous silicas are also known as low molecular weight polysilicic acids and are referred to below as NPK.
  • the silicas prepared by this method are stable only at these very low pH levels. From a pH of 3.5 condensation occurs, which is noticeable by precipitation gelation. These precipitates of high molecular weight silicic acids no longer have an AT effect.
  • NPK non-semiconductor phosphatidylcholine
  • pH values below 3.5 are physiologically incompatible, formulations must be found in which the pH is at least 3.5 and in which there is no gelation or precipitation of amorphous colloids (silica sol).
  • a further object of the present invention was therefore to develop a product which is suitable as the basis for cosmetic deodorants or antiperspirants and which does not have the disadvantages of the prior art, in particular is distinguished by good skin tolerance.
  • the object of the invention is, in particular, to provide silicic acid-containing antiperspirant preparations comprising low molecular weight polysilicic acids (NPK) in combination with one or more stabilizers, with a physiologically tolerable pH having sufficient stability.
  • NPK low molecular weight polysilicic acids
  • Stabilizers for use as hypoallergenic antiperspirants ie for reducing or preventing apoekkrinen sweat formation, are suitable if the pH increase takes place shortly before the application and thereby the disadvantages of the prior art, the lack of stability of physiologically acceptable NPK preparations is eliminated , It was amazing that by separately providing a NPK-containing preparation and a base in a two-chamber package, the NPK-containing preparation being mixed with the base just prior to or during dispensing and / or application is not only excellent for cosmetic purposes Moreover, they are more effective and gentler than the use of stable compositions of the prior art.
  • the invention is therefore a cosmetic product comprising a two-chamber container suitable for the application of cosmetic preparations, characterized in that a chamber contains a partial preparation containing low molecular weight, highly amorphous silica (NPK) in combination with one or more stabilizers (phase 1) and the second chamber containing an emulsion preparation (phase 2), wherein in the application, the contents of the first and second chambers are simultaneously removed from the chambers and mix the phases 1 and 2 at the issue or shortly before the issue.
  • NPK highly amorphous silica
  • the invention encompasses the use of NPK, as an antiperspirant active, preferably in topically administrable, in particular cosmetic and / or dermatological, preparations, wherein the pH of the preparation only before application to a
  • physiologically acceptable level is set, in particular the pH of the applied preparation is not less than 3.5.
  • the stabilizers are selected from group A:
  • Hexenol ice 3 (CAS 928-96-1), terpineol (CAS 8000-41 -7), linalool (CAS 78-70-6),
  • Tetrahydrolinalool (CAS 78-69-3), triethyl citrate (CAS 77-93-0), 2-isobutyl-4-hydroxy-4-methyltetrahydropyran (CAS 63500-71-0), hexyl salicylate (CAS 6259-76-3 ), Phenylethyl alcohol (CAS 60-12-8), 3-methyl-5-phenyl-1-pentanol (CAS 55066-48-3), 2,6-dimethyl-7-octene-2-o (CAS 18479 -58-8), benzyl salicylate (CAS 1 18-58-1), geraniol (CAS 106-24-1), citronellol (CAS 106-22-9) and ethyllinalool (CAS 10339-55-6); group B: alcohols and diols and group C: substances with at least three hydroxyl groups.
  • Particularly advantageous group B stabilizers are: ethanol, 2-propanol, PEG 8, triethylene glycol, methylphenylbutanol, decanediol, polyglyceryl-2-caprate, oxalic acid.
  • Particularly advantageous stabilizers from group C are: sucrose (mannose, mannitol), glycerol, pentaerythritol, threitol, erythritol, hyaluronic acid.
  • compositions - ie the use of cosmetic or dermatological preparations on the skin - containing NPK in combination with one or more stabilizers chosen from the group A, B and / or C allows the reduction or prevention of stress sweating.
  • NPK act as a sweat inhibitor and reduce the formation of sweat and thus indirectly also the smell of sweat.
  • NPK-containing preparation By mixing the NPK-containing preparation with an emulsion before application and application, preparations are provided which have a high physiological compatibility.
  • NPK-containing preparation with the pH of the emulsion increasing the pH before the application of a two-chamber packaging makes the use of NPK-containing preparations as a compatible antiperspirant only possible.
  • Products according to the invention with NPK allow an antiperspirant effect on the order of known and proven antiperspirant active ingredients, wherein the required concentration of NPK is much lower than when using ACH.
  • products according to the invention preferably comprise, in addition to an NPK-containing preparation, no further antiperspirant substances or preparations, in particular no aluminum salts, in particular no ACH and / or AACH (activated aluminum chlorohydrate).
  • An essential advantage of the products according to the invention is, moreover, that no discoloration on the skin or clothing is evident as compared with the AT agents based on aluminum salts. The so-called whiteness as well as those after repeated wearing and washing in textiles resting directly on the underarm skin are not observed
  • the stabilized silicas can be easily incorporated into the products according to the invention
  • NPK solution Be incorporated into products of suitable compositions. They are preferably added as NPK solution to the other constituents of the formulations. The proportion of NPK solution can make up to 98% of the total amount of the formulation. in the
  • a thickener and a perfume are added to the NPK suspension, perfume meaning a mixture comprising one or more olfactorily detectable individual substances.
  • Silica acids stabilized for use according to the invention can be e.g. Produce according to the following methods on a laboratory scale:
  • the pH reduction can also be carried out any other acids, as long as they a) can reduce the pH accordingly and b) their salts, in particular sodium salt, are physiologically acceptable or cause no skin irritation.
  • Hydrochloric acid is preferably used to lower the pH.
  • the fast pH reduction is crucial for the successful formation of the NPK. If the pH reduction is too slow, form very high molecular weight silica, which have no antiperspirant activity, to gelation.
  • Increasing the pH in step 3 to a cosmetically acceptable level is optional and can be accomplished with caustic soda, caustic potash, or with weaker bases.
  • Suitable bases include: 2-aminobutanol, 2- (2-aminoethoxy) ethanol, aminoethyl propanediol, aminomethyl propanediol, aminomethyl propanol, aminopropanediol, bis-hydroxyethyl tromethamines, butyl diethanolamines, butylethanolamines, dibutyl ethanolamines, diethanolamines, diethyl ethanolamines, diisopropanolamines, dimethylamino Methylpropanol, dimethyl isopropanolamines, dimethyl MEA, ethanolamines, ethyl ethanolamines,
  • Isopropanolamines methyl diethanolamines, methylethanolamines, triethanolamines,
  • Triisopropanolamines Triisopropanolamines, tromethamines, polyethylenimines, tetrahydroxypropylethylenediamine, ammonia.
  • the increase in pH can also be carried out with buffer systems, which is also considered in the context of the invention as a base, which are added either in aqueous solution or anhydrous.
  • the buffer systems can consist of the abovementioned bases and cosmetically acceptable acids and have a pH of from 3 to 11, preferably from 7 to 9.
  • acids which are particularly suitable for the preparation of buffers are citric acid, lactic acid, tartaric acid, fatty acids, Phosphoric acid, phosphonic acids, polyacrylic acids, succinic acid, malic acid, oxalic acid, amino acids.
  • Alkali hydroxides whose cations are physiologically compatible and easy to keep in solution.
  • sodium and / or potassium hydroxide solution are suitable for raising the pH.
  • the pH increase can advantageously be carried out in stages, with a more concentrated base, for example 5N NaOH, being used for the first stage and only a less concentrated base, for example 0.5N NaOH, being used to adjust the final pH. It is advantageous to first bring the pH to pH 2 with 5N NaOH and then further increase to at least pH 3.5 with 0.5N NaOH.
  • Particularly suitable stabilizers for this preparation method are ethanol, glycerol, 2-propanol, PEG 8, triethylene glycol, urea, oxalic acid, hyaluronic acid, ethylhexylglycerol, pentaerythritol, threitol, erythritol, methylphenylbutanol, polyglyceryl 2-caprate, decanediol
  • glycerol and ethanol in a ratio of 1:10 to 6:10, in particular 5 to 30 wt .-% glycerol and 30 wt .-% EtOH based on the total amount of sodium silicate solution prepared in step 1.
  • step 3 The same conditions apply to the pH reduction (step 3) and the pH increase (step 4) as to step 2 and step 3 of method I.
  • Suitable stabilizers for this stabilized NPK preparation process are sucrose, mannose and / or mannitol.
  • step 3 increase the pH to a value less than 3.5 by adding one or more bases
  • step 3 increase the pH to a value less than 3.5 by adding one or more bases
  • Suitable stabilizers for this stabilized NPK preparation process is glycerol.
  • the pH increase with 0.1 to 0.5 M sodium hydroxide in glycerol is advantageous, as this possible, pH peaks' can be prevented.
  • step 2 (method I and III) and step 3 (method II) by combining the reactants
  • the stability increases with decreasing temperature, so that storage in the refrigerator (at 5 to 8 degrees Celsius) is advantageous.
  • the cosmetic products according to the invention containing in a chamber a stabilized NPK preparation, in the form of aerosols, so from
  • W / O or C7W emulsions such as creams or lotions, which can be applied from standard two-chamber bottles and containers.
  • a good method is also the spreading or rubbing by means of flat applicators, which are fed by a two-chamber container, in particular applicators with flocked and / or textile surface, since they have a low tendency to clog.
  • Preferred application form for the antiperspirants with stabilized NPK are water-containing aerosols.
  • the hydrous aerosols especially the W / O emulsions are mentioned.
  • This form of application is preferred, since it represents the most common form in the world of deodorant / AT.
  • the stabilized NPK is present dissolved in the preparation and does not have to be resuspended by shaking before using the spray. The clogging probability of the nozzles is thereby reduced.
  • pump sprays offer a contactless application of the AT preparation to the skin.
  • pressure-resistant containers can be dispensed with.
  • Two-chamber pump sprays can be made metal-free, in particular aluminum-free.
  • containers made of PE, PP or PET which are closed with one or two metal-free spray pump (s), wherein metal-free means that the pumped preparation does not come into contact with metallic components.
  • metal-free means that the pumped preparation does not come into contact with metallic components.
  • the feed is via one or two risers and the mixture of the NPK-containing preparation (phase 1) with the emulsion (phase 2) takes place before or after the pump (s) ,
  • the stabilized NPK (Phase 1) are in the inventive
  • Antiperspirant formulations preferably in an amount of 0, 1 to 10 wt .-%, content of NPK based on the total mass of the preparation, i. including the possibly existing propellants used. Particularly advantageous are concentrations of 0.5 to 3 wt .-%.
  • the proportion of one or more stabilizers in phase 1 can advantageously be selected up to 85% by weight, in particular up to 30% by weight, based on the total mass of the preparation.
  • the proportion of SiO 2 equivalents in phase 1 is advantageously in the range of 0.1. Up to 6 wt .-%, preferably 0.5 to 3 wt .-%, based on the total mass of the preparation selected.
  • the proportion of one or more stabilizers in phase 1 can advantageously be selected up to 85% by weight, in particular up to 30% by weight, based on the total mass of the preparation.
  • the proportion of NPK in phase 1 is advantageously in the range of 0, 1 to 6 wt .-%, preferably 0.5 to 3 wt .-%, based on the total mass of the preparation chosen.
  • the preparations containing stabilized NPK (phase 1) or the emulsion (phase 2) contain cosmetic auxiliaries as are customarily used in such preparations, e.g. Preservatives, preservatives, bactericides, perfumes, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, anti-foaming agents, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances or other common ingredients a cosmetic or dermatological formulation such as electrolytes, organic solvents, alcohols, polyols, emulsifiers, polymers, foam stabilizers or silicone derivatives.
  • cosmetic auxiliaries e.g. Preservatives, preservatives, bactericides, perfumes, UV filters, antioxidants, water-soluble vitamins, minerals, suspended solid particles, anti-foaming agents, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances or other common ingredients a cosmetic or dermatological formulation such as
  • the preparations are preferably produced and used in an optically appealing transparent manner.
  • Phase 2 is advantageously characterized in that it is in the form of an aqueous or aqueous-alcoholic solution, an emulsion (W / O, O / W, W / Si, Si / W or multiple emulsion, macro, micro or nanoemulsion). , a dispersion, a Pickering emulsion, a gel, a hydrodispersion gel or an anhydrous preparation.
  • phase 1 and phase 2 can also be added to deodorants.
  • the usual cosmetic deodorants are based on different active principles.
  • antimicrobial substances as cosmetic deodorants, the bacterial flora on the skin can be reduced.
  • only the odor causing microorganisms should be effectively reduced.
  • the sweat flow itself is thereby In the ideal case, only the microbial decomposition of the sweat is temporarily stopped.
  • the combination of astringents with antimicrobial substances in one and the same composition is also common.
  • odor maskers such as the common perfume ingredients
  • odor absorbers for example the phyllosilicates described in DE 40 09 347, of these in particular montmorillonite, kaolinite, mit, beidellite, nontronite, saponite, hectorite, bentonite, smectite , Further, for example, zinc salts of ricinoleic acid.
  • Germ-inhibiting agents are also suitable for incorporation into the preparations according to the invention.
  • Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan), 1, 6-di- (4-chlorphenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds , Clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,1-t-trimethyl-2, 6,10-dodecatriene-1-ol),
  • phase 1 and / or phase 2 also contain polymers.
  • the polymers preferably originate from the range of celluloses and / or polystyrenes. They are advantageously hydrophobic or hydrophilic modified. They serve to adjust the viscosity of the phases and facilitate the pumpability and miscibility, as well as the drain or
  • Usable polymers therefore include celluloses, polystyrenes and / or alkyl-acrylic
  • Crosspolymers and may optionally be added to the NPK preparations.
  • phase 1 and 2 of the product according to the invention in addition to water, ethanol and isopropanol, glycerol and propylene glycol skin-care fat or fat-like substances and oils such as oleic acid, cetyl alcohol,
  • phase 2 preparations which can be used according to the invention:
  • Glucoside Propylene Glycol Isostearate, Glycol Stearate), Glyceryl Isostearate), Sorbitan Sesquioleate, Glyceryl Stearate, Lecithin, Sorbitan Oleate, Sorbitan Monostearate NF, Sorbitan Stearate, Sorbitan Isostearate, Steareth-2, Oleth-2, Glyceryl Laurate, Ceteth-2, PEG-30
  • Glucosides PEG-8 Oleates, Polyglyceryl-3 Methyglucose Distearates, PG-10 Stearates, Oleth-10, Oleth-10 / Polyoxyl 10 Oleyl Ether NF, Ceteth-10, PEG-8 Laurate, Ceteareth-12, Cocamide MEA, Polysorbate 60 NF, Polysorbate 60, PEG-40 Hydrogenated Castor Oil, Polysorbate 80, Isosteareth-20, PEG-60 Almond Glycerides, Polysorbate 80 NF, PEG-150 Laurate, PEG-20 Methyl Glucose Sesquistearate, Ceteareth-20, Oleth-20, Steareth -20, steareth-21, ceteth-20, isoceteth-20, PEG-30 glyceryl laurate, polysorbate 20, polysorbate 20 NF, laureth-23, PEG-100 stearate, steareth-100, PEG-80 sorbitan laur
  • glyceryl isostearates Preference is given to using glyceryl isostearates, glyceryl stearates, steareth-2, ceteareth-20, steareth-21, PEG-40 hydrogenated castor oil, PG-10 stearates, isoceteth-20, isosteareth-20 and ceteareth-12.
  • solubilizers can be used as emulsifiers for the Phase 2 preparations which can be used according to the invention, it is further preferable to choose PEG-40
  • suitable cationic emulsifiers are from the group Cetrimonium Chloride, Palmitamidopropyltrimonium Chloride, Quaternium-87, Behentrimonium Chloride, Distearoylethyl Dimonium Chloride, Distearyldimonium Chloride, Stearamidopropyl
  • Dimethylamine and / or Behentrimonium methosulfate It is likewise advantageous to add conventional antioxidants to Phase 2 preparations in the context of the present invention. According to the invention, all antioxidants which are suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.
  • the amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular from 1 to 10% by weight, based on the total weight of the preparation ,
  • phase 2 is a solution or emulsion or dispersion, may be used as a solvent, bodying agent and / or
  • Oils such as triglycerides of capric or caprylic and alkyl benzoate, but preferably cyclic silicone oils or volatile hydrocarbons;
  • esters of fatty acids with lower C-number alcohols e.g. with isopropanol, propylene glycol or
  • Glycerol or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids; Vegetable oils such as e.g. Avocado oil, meadowfoam seed oil, olive oil, sunflower oil, rapeseed oil, almond oil, evening primrose oil, coconut oil. Palm oil, linseed oil, shea butter.
  • Vegetable oils such as e.g. Avocado oil, meadowfoam seed oil, olive oil, sunflower oil, rapeseed oil, almond oil, evening primrose oil, coconut oil. Palm oil, linseed oil, shea butter.
  • Alcohols, diols or polyols of low C number, and their ethers in particular propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products.
  • Skin care substances such as Panthenol, allantoin, urea, urea derivatives, guanidine, ascorbic acid, glyceryl glucose
  • mixtures of the aforementioned ingredients are used.
  • water can be another ingredient.
  • Suitable propellants for cosmetic and / or dermatological preparations which can be sprayed from aerosol containers in the context of the present invention are the customary known volatile volatile liquefied propellants, for example hydrocarbons (propane, butane, isobutane), which can be used alone or mixed with one another. Also,
  • Dimethyl ether, nitrous oxide, carbon dioxide, nitrogen and compressed air are advantageous to use.
  • propellants per se which would in principle be suitable for the realization of the present invention in the form of aerosol preparations, but which should nevertheless be dispensed with because of a harmful effect on the environment or other concomitant circumstances, in particular fluorocarbons and fluorochlorinated hydrocarbons. hydrocarbons (CFCs).
  • Phase 2 cosmetic preparations can also be in the form of gels which, in addition to an effective content of the active ingredient according to the invention and solvents customarily used for this purpose, preferably water, also contain organic thickeners (thickeners), e.g.
  • Tamarind flour preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • the thickener is included in the formulation e.g. in an amount between 0, 1 and 40 wt .-%, preferably between 0.5 and 25 wt .-%, included. Otherwise, the usual measures for putting together cosmetic
  • the numbers represent parts by weight, based on the total mass of the preparation.
  • Steareth-21 (Tego alkanol S 21, 6.7 6.7 6.7 6.7 6.7 6.7
  • Steareth-2 (Tego Alkanol S2, 11.7 11.7 11.7 11.7 11.7 11.7 11.7 Evonik Industries)
  • Trisodium EDTA 20% (Edeta 5,0 5,0 5,0 5,0 5,0).
  • Phase 2 In which the water-soluble constituents are heated together with the specified amount of water to 75 ° C. The oil components and emulsifiers are heated separately to 75 ° C. The phases are combined and homogenized. The emulsion is cooled to room temperature with stirring.
  • Phase 1 and Phase 2 may be in different proportions from the
  • ratios of 10:90 to 90:10 can be predetermined by different pump volumes.
  • the axillary sweat volume is determined gravimetrically by cotton pads are balanced in the sauna after a 15min sweat phase.
  • the relative sweat reduction for the silica compared to the untreated area is 54, 1%.
  • the efficacy is therefore at the level of 10% ACH (see table). sample baseline after application rel. Reduction significance

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Abstract

Produit cosmétique comprenant un contenant à deux logements destiné à l'application de préparations cosmétiques, caractérisé en ce que le premier logement contient une préparation contenant de l'acide silicique (phase1) et en ce que le second logement contient une préparation contenant une émulsion (phase 2).
EP16736496.7A 2015-07-27 2016-07-11 Antitranspirant Ceased EP3328504A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102015214145.4A DE102015214145A1 (de) 2015-07-27 2015-07-27 Schweiß verringernde kosmetische Zubereitung
PCT/EP2016/066394 WO2017016860A1 (fr) 2015-07-27 2016-07-11 Antitranspirant

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EP3328504A1 true EP3328504A1 (fr) 2018-06-06

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EP16736496.7A Ceased EP3328504A1 (fr) 2015-07-27 2016-07-11 Antitranspirant

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US (1) US20180214359A1 (fr)
EP (1) EP3328504A1 (fr)
JP (1) JP2018521100A (fr)
CN (1) CN107847770A (fr)
AU (1) AU2016299199A1 (fr)
BR (1) BR112018001773A2 (fr)
DE (1) DE102015214145A1 (fr)
WO (1) WO2017016860A1 (fr)

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1270739B (de) * 1961-06-26 1968-06-20 Dr Med Georg Wolf Ernst Mittel zur kosmetischen Behandlung der Haut
CH470183A (de) * 1968-09-27 1969-03-31 Charles Olivier Fa Schweissgeruch verhinderndes Mittel
FR2223049A1 (en) * 1973-03-30 1974-10-25 Conditionnement Cosmetologie N Halogenate antibacterial compns. - potentiated with alkali metal salts or capric, caproic and caprylic acids
CA1037868A (fr) * 1973-07-18 1978-09-05 Martin Callingham Compose organique desodorisant
DE3740186A1 (de) 1987-06-24 1989-01-05 Beiersdorf Ag Desodorierende und antimikrobielle zusammensetzung zur verwendung in kosmetischen oder topischen zubereitungen
CA1330538C (fr) * 1988-04-14 1994-07-05 Maria A. Curtin Antisudorifique et methode pour sa fabrication
DE3938140A1 (de) 1989-11-16 1991-08-08 Beiersdorf Ag Desodorierende kosmetische mittel
DE4009347A1 (de) 1990-03-23 1991-09-26 Beiersdorf Ag Desodorierende kosmetische mittel
FR2662672B1 (fr) 1990-05-31 1992-08-21 Aerosols & Bouchage Dispensateur de melange.
DE4204321A1 (de) 1992-02-13 1993-08-19 Beiersdorf Ag Verfahren zur isolierung und reinigung von fettsaeuren und hydroxyfettsaeuren und verwendungen von hydroxyfettsaeuren sowie zubereitungen, die sie enthalten
DE4229737C2 (de) 1992-09-05 1996-04-25 Beiersdorf Ag Desodorierende kosmetische Mittel mit einem Gehalt an Fettsäuren
DE4229707A1 (de) 1992-09-05 1994-03-10 Beiersdorf Ag Germicide Wirkstoffkombinationen
DE4237081C2 (de) 1992-11-03 1996-05-09 Beiersdorf Ag Verwendung von Di- oder Triglycerinestern als Deowirkstoffe
DE4309372C2 (de) 1993-03-23 1997-08-21 Beiersdorf Ag Kosmetische Desodorantien, enthaltend Gemische aus Wollwachssäuren oder Wollwachssäurekomponenten und Fettsäurepartialglyceriden unverzweigter Fettsäuren
DE4324219C2 (de) 1993-07-20 1995-08-10 Beiersdorf Ag Desodorierende Wirkstoffkombinationen auf der Basis von alpha, omega-Alkandicarbonsäuren und Wollwachssäuren
FR2750397B1 (fr) * 1996-06-28 1998-08-07 Oreal Dispositif pour le stockage separe d'au moins deux produits, leur melange et la distribution du melange ainsi obtenu et procede de fabrication
NL1005189C2 (nl) 1997-02-05 1998-08-06 Airspray Int Bv Afgeefsamenstel voor het afgeven van twee vloeibare componenten.
DE19902962C1 (de) * 1999-01-26 2000-07-06 Goldwell Gmbh Zweikomponentenbehältnis und Verfahren zu dessen Herstellung
FR2792298B1 (fr) * 1999-04-16 2001-06-01 Oreal Dispositif pour le melange extemporane d'au moins deux produits dont un est notamment une poudre
DE10012949A1 (de) * 2000-03-16 2001-09-27 Henkel Kgaa Kieselsäureester-Mischungen
DE10109063A1 (de) * 2001-02-24 2002-09-05 Beiersdorf Ag Mehrkammerbehälter mit Substanzausgabevorrichtung
AU2003273570B2 (en) * 2002-05-31 2009-01-08 Liquistone Ltd Aqueous solution of non-colloidal silicic acid and boric acid
JP4286154B2 (ja) 2002-06-26 2009-06-24 株式会社ダイゾー 複数内容物吐出用の包装容器、その包装容器を用いた包装製品およびその包装製品の製造方法
DE10237460A1 (de) * 2002-08-16 2004-02-26 Beiersdorf Ag Schminkprodukt
US20040149775A1 (en) 2003-01-30 2004-08-05 Szu-Chang Chen Cosmetic container having double chamber
FR2852928B1 (fr) 2003-03-24 2006-02-24 Airlessystems Distributeur de produit fluide.
GB0403409D0 (en) * 2003-11-06 2004-03-24 Unilever Plc Improved detergent composition with benefit agents
US7303767B2 (en) * 2005-02-03 2007-12-04 J.M. Huber Corporation Personal care compositions comprising coated/treated metal silicate absorbent particles
CN101228226A (zh) * 2005-07-22 2008-07-23 罗地亚研究及科技公司 具有改进的易使用性的多糖基产品、其制造方法及其应用
US20070148113A1 (en) * 2005-12-05 2007-06-28 Cyril Lemoine Antiperspirant compositions comprising at least one dispersion of cationic colloidal silica particles, antiperspirant product, and cosmetic process for treating perspiration
DE102005059935A1 (de) * 2005-12-13 2007-06-14 Henkel Kgaa Kosmetisches Mittel mit gesteigerter Duftintensität und -persistenz
US20070233012A1 (en) 2006-02-24 2007-10-04 Lerrick Andrew J Multi-chamber spray container and system
FR2900550B1 (fr) 2006-05-05 2008-10-03 Oreal Dispositif de conditionnement et d'application.
DE102008031927B4 (de) 2008-07-08 2017-09-14 Beiersdorf Ag Kosmetische Zubereitungen mit passiviertem Silber
FR2977151B1 (fr) * 2011-06-28 2013-09-27 Oreal Utilisation cosmetique comme actif anti-transpirant d'un silicate alcalin
EP2457846A3 (fr) * 2012-02-16 2012-06-27 Bayer MaterialScience AG Module de distribution pour compositions cosmétiques
WO2014099164A2 (fr) * 2012-12-19 2014-06-26 Colgate-Palmolive Company Complexe d'halogénure d'acide aminé de zinc avec de la cystéine
FR3006178B1 (fr) * 2013-05-30 2015-06-26 Oreal Utilisation cosmetique comme actif deodorant d'un materiau silicie obtenu par hydrolyse et condensation d'un tetraalcoxysilane et d'un c7-c20-alkyl trialcoxysilane
GB201402669D0 (en) * 2014-02-14 2014-04-02 Medical Res Council Stabilised silicate compositions and their uses

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JP2018521100A (ja) 2018-08-02
DE102015214145A1 (de) 2017-02-02
BR112018001773A2 (pt) 2018-09-11
US20180214359A1 (en) 2018-08-02
AU2016299199A1 (en) 2018-02-22
WO2017016860A1 (fr) 2017-02-02
CN107847770A (zh) 2018-03-27

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