EP3756460A1 - Cadre et support d'organes - Google Patents

Cadre et support d'organes Download PDF

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Publication number
EP3756460A1
EP3756460A1 EP20182153.5A EP20182153A EP3756460A1 EP 3756460 A1 EP3756460 A1 EP 3756460A1 EP 20182153 A EP20182153 A EP 20182153A EP 3756460 A1 EP3756460 A1 EP 3756460A1
Authority
EP
European Patent Office
Prior art keywords
organ
body part
tube
frame
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20182153.5A
Other languages
German (de)
English (en)
Other versions
EP3756460B1 (fr
Inventor
Shinji Torai
Syuhei Yoshimoto
Katsuhide KONISHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Screen Holdings Co Ltd
Original Assignee
Screen Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Screen Holdings Co Ltd filed Critical Screen Holdings Co Ltd
Publication of EP3756460A1 publication Critical patent/EP3756460A1/fr
Application granted granted Critical
Publication of EP3756460B1 publication Critical patent/EP3756460B1/fr
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L3/00—Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets
    • F16L3/02—Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets partly surrounding the pipes, cables or protective tubing
    • F16L3/04—Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets partly surrounding the pipes, cables or protective tubing and pressing it against a wall or other support

Definitions

  • the present invention relates to a frame used in an organ holder for holding an organ, and to an organ holder that includes this frame.
  • an organ is temporarily preserved during the period from when the organ is removed from a donor to when the organ is transplanted into a recipient.
  • Various preservation and perfusion methods have been developed in order to preserve isolated organs in transplantable conditions.
  • a simple cooling method is known in which blood in an organ is replaced with a low-temperature organ preservation solution in order to suppress cell metabolism, and then the organ is immersed in a low-temperature preservation solution.
  • a perfusion preservation method in which the vascular network of a preserved organ is perfused with a preservation solution for the purpose of eliminating waste materials in the organ.
  • Japanese Patent Application Laid-Open No. 3-151303 describes a conventional device for preserving an organ outside the body.
  • a hammock made of hydrophobic cloth is used to hold an organ.
  • the position of the organ relative to the hammock may be shifted in case the organ is simply placed in the hammock as in Japanese Patent Application Laid-Open No. 3-151303 . It is thus difficult to transport the organ without damage from the donor to the recipient.
  • solution-sending tubes and drainage tubes such as catheters
  • solution-sending tubes and drainage tubes are connected to blood vessels of an organ in order to supply perfusate into the organ or to drain perfusate from the organ.
  • these tubes are shifted in position when the organ is held in the hammock, there is the problem that the organ is more likely to become damaged due to a strain on the organ.
  • the present invention provides a frame for holding a tube connected to an organ during perfusion preservation of the organ.
  • the frame includes a ring-shaped body part locatable to surround a periphery of the organ, and at least one tube clamp part mounted on the body part.
  • the tube clamp part includes a tube holder that holds the tube, and the tube clamp part is mounted so as to be movable in a circumferential direction of the body part.
  • the present invention it is possible to fix the tube connected to the organ at an appropriate position to the tube clamp part. This stabilizes the relative positions of the organ and the tube. Accordingly, it is possible to reduce the probability of the organ becoming damaged due to a strain on the organ.
  • donors and recipients may be humans, or may be non-human animals. That is, in the present application, organs including livers may be human organs, or may be organs of non-human animals.
  • the non-human animals may be rodents such as mice and rats, ungulates such as pigs, goats, and sheep, non-human primates such as chimpanzees, or other non-human mammals, or may be nonmammalian animals.
  • FIG. 1 is a schematic view illustrating a configuration of the perfusion device 100. The details of the frame 1 and the organ holder 10 will be described later.
  • the perfusion device 100 is a device for temporarily preserving an organ such as a liver removed from a donor outside the body until when the organ is transplanted into a recipient.
  • the perfusion device 100 performs perfusion while supplying perfusate to the organ.
  • the following description is given of the case where a liver 9 is taken as an example of the organ subjected to perfusion processing.
  • the reactor 90 is an organ container capable of housing therein a liquid and an organ such as the liver 9 held by the organ holder 10.
  • the reactor 90 is, for example, a cup-shaped (closed-end tubular) container.
  • the perfusion device 100 includes a reservoir 20, two (two-line) perfusate inflow parts 30, a perfusate outflow part 40, and a controller 50.
  • the number of perfusate inflow parts 30 and the number of perfusate outflow parts 40 may be one (one line) or may be two (two lines) depending on perfusion conditions or the type of the organ to be perfused.
  • the reservoir 20 is a container for accumulating perfusate.
  • a temperature regulating mechanism 21 and a gas exchange mechanism 22 are provided around the reservoir 20, a temperature regulating mechanism 21 and a gas exchange mechanism 22 are provided.
  • the perfusate is an ETK solution.
  • the perfusate may be any other type of perfusate such as an UW solution.
  • the temperature regulating mechanism 21 regulates the temperature of the perfusate accumulated in the reservoir 20.
  • the gas exchange mechanism 22 supplies a gas such as oxygen to the perfusate accumulated in the reservoir 20 so as to cause this gas to dissolve in the perfusate.
  • the gas exchange mechanism 22 may be interposed in inflow tubes 31, which will be described later, of the perfusate inflow parts 30.
  • the perfusate inflow parts 30 supply the perfusate from the reservoir 20 to the liver 9.
  • Each perfusate inflow part 30 includes an inflow tube 31, a pump 32, a temperature regulating unit 33, a deaerating unit 34, and a pressure gauge 35.
  • the pump 32, the temperature regulating unit 33, the deaerating unit 34, and the pressure gauge 35 are interposed in the inflow tube 31.
  • the inflow tubes 31 are connected at one ends to the reservoir 20.
  • the inflow tubes 31 are also connected at the other ends to the organ to be perfused during the perfusion treatment.
  • the other ends of the inflow tubes 31 are connected to blood vessels of the liver 9. This allows the perfusate to be supplied from the reservoir 20 to the blood vessels of the liver 9.
  • one of the inflow tubes 31 is connected to the portal vein of the liver 9, and the other inflow tube 31 is connected to the hepatic artery of the liver 9.
  • the hepatic artery is an arterial blood vessel, so that the pressure of the blood in the hepatic artery is high.
  • the portal vein is a venous blood vessel, so that the pressure of the blood in the portal vein is extremely lower than the pressure in the hepatic artery.
  • the perfusion device 100 including the two-line perfusate inflow parts 30 can individually set the pressure of the perfusate to be supplied to the hepatic artery and the pressure of the perfusate to be supplied to the portal vein.
  • the pumps 32 produce flows of the perfusate from the reservoir 20 to the liver 9 in the inflow tubes 31.
  • a pump equipped with a brushless motor is used as each pump 32.
  • the temperature regulating units 33 regulate the temperature of the perfusate in the inflow tubes 31.
  • each temperature regulating unit 33 regulates the temperature of the perfusate in the inflow tube 31 to a set temperature by immersing part of the inflow tube 31 in a liquid whose temperature has been set to 4°C, 20°C, or 37°C, for example.
  • the deaerating units 34 remove gas components of the perfusate in the inflow tubes 31.
  • the pressure gauges 35 measure the pressure of the perfusate in the inflow tubes 31.
  • the perfusate outflow part 40 drains the perfusate from the liver 9.
  • the perfusate outflow part 40 includes an outflow tube 41.
  • the outflow tube 41 is connected at one end to an organ to be perfused during the perfusion treatment.
  • the outflow tube 41 is connected to the suprahepatic inferior vena cava (SH-IVC) or infrahepatic inferior vena cava (IH-IVC) of the liver 9.
  • the outflow tube 41 is also connected at the other end to the reservoir 20.
  • the perfusion device 100 is configured to cause the perfusate drained from the liver 9 to flow back into the reservoir 20, but the present invention is not limited to this configuration.
  • the perfusate drained from the liver 9 may be disposed of or accumulated in another container, instead of being sent back into the reservoir 20.
  • each of the reservoir 20, the perfusate inflow parts 30, and the perfusate outflow part 40 may include a measuring unit for detecting a pH or a specific component under appropriate conditions.
  • other devices such as a flowmeter or a solenoid valve that controls communication may be interposed in the inflow tubes 31 and the outflow tube 41.
  • the controller 50 is a unit for controlling operations of each component of the perfusion device 100. As schematically illustrated in Fig. 1 , the controller 50 is configured as, for example, a computer that includes an arithmetic processor 51 such as a CPU, a memory 52 such as a RAM, and a storage 53 such as a hard disk drive.
  • an arithmetic processor 51 such as a CPU
  • a memory 52 such as a RAM
  • a storage 53 such as a hard disk drive.
  • the liver 9 is connected to the two inflow tubes 31 and the one outflow tube 41.
  • another drainage tube for draining bile may be connected to the bile duct of the gallbladder removed together with the liver 9.
  • a frame described below taking the frame 1 as one embodiment can be used to suppress a shift in the relative positions of the organ and the tubes.
  • organ holder 10 including the frame 1 according to the first embodiment of the present invention will be described with reference to Figs. 2 to 4 .
  • Fig. 2 is a perspective view of the organ holder 10.
  • Fig. 3 is a side view of the organ holder 10.
  • Figs. 4 and 5 are partial sectional views of the organ holder 10. In Figs. 4 and 5 , one tube clamp part 70 is illustrated in a side view, not in a section.
  • the organ holder 10 includes the frame 1 and a placement sheet 11 attached to the frame 1.
  • the frame 1 is an appliance for holding tubes connected to an organ in perfusion preservation of the organ.
  • the frame 1 includes a body part 60, at least one tube clamp part 70 detachable from the body part 60, and a sheet fixing frame 80.
  • Figs. 2 and 3 six tube clamp parts 70 are illustrated.
  • the body part 60 is a ring-shaped member locatable to surround the periphery of an organ.
  • the "ring-shape" as used herein refers to a shape that includes not only a complete ring shape but also a partly open ring shape (e.g., a C-shaped ring).
  • the body part 60 has roughly a circular figure, but the present invention is not limited thereto.
  • the body part 60 may have roughly an oval figure, a polygonal figure such as quadrangular or hexagonal, or may have any other figure.
  • the body part 60 has an internal space 600 that continues in the circumferential direction.
  • the internal space 600 is a space that extends in the direction of extension of the body part 60.
  • the body part 60 includes one internal space 600 arranged along the entire length in the circumferential direction.
  • the body part 60 may include a plurality of internal spaces each extending along part of the length in the circumferential direction.
  • the body part may include three internal spaces each having a length equivalent to an interior angle of 110°.
  • the body part 60 has a first opening 61 and a second opening 62 at the top, the first and second openings connecting the outside of the body part 60 and the internal space 600.
  • the second opening 62 communicates with the first opening 61 in the circumferential direction.
  • the first opening 61 has a radial width smaller than that of the internal space 600.
  • the second opening 62 has a radial width greater than that of the first opening 61.
  • the radial width of the second opening 62 is the same as the radial width of the internal space 600.
  • the first opening 61 is provided along the entire circumference of the body part 60, except a portion where the second opening 62 is provided. That is, the first opening 61 and the second opening 62 are arranged along the entire circumference at the top of the internal space 600.
  • the internal space 600 may have a circumferential portion in which neither the first opening 61 nor the second opening 62 is provided.
  • Each tube clamp part 70 is a member that holds a tube connected to an organ when mounted on the body part 60.
  • the tube clamp part 70 is mounted so as to be movable in the circumferential direction of the body part 60.
  • the tube clamp part 70 includes a tube holder 71, a pull-out stopper 72, and a connector 73.
  • the tube holder 71 has a recess 711 for holding a tube.
  • the tube is fitted into the recess 711 of the tube holder 71.
  • the pull-out stopper 72 has a width greater than that of the first opening 61 in any direction. However, the width of the pull-out stopper 72 is smaller than the width of the second opening 62. Thus, by disposing the pull-out stopper 72 through the second opening 62 into the internal space 600, it is possible to mount the tube clamp part 70 on the body part 60. Similarly, by taking out the pull-out stopper 72 through the second opening 62 from the inside of the internal space 600, it is possible to detach the tube clamp part 70 from the body part 60. As illustrated in Fig. 4 , the pull-out stopper 72 in the present embodiment is spherical in shape.
  • the pull-out stopper 72 is unable to be moved in and out through the first openings 61 between an exterior space and the internal space 600. Accordingly, the tube clamp part 70 is unable to be mounted on and detached from the body part 60 at any circumferential positon other than the position of the second opening 62.
  • the connector 73 is a columnar portion that directly connects the tube holder 71 and the pull-out stopper 72.
  • the connector 73 is directly fixed at one end to the pull-out stopper 72.
  • the connector 73 is also directly fixed at the other end to the tube holder 71.
  • the connector 73 is thinner than the width of the first opening 61. As illustrated in Fig. 4 , when the tube clamp part 70 is mounted on the body part 60, i.e., when the pull-out stopper 72 is located inside the internal space 600, the other end of the connector 73 and the tube holder 71 are located outside the body part 60.
  • the body part 60 includes a plurality of parts fixation portions 63 at the inner edge of the first opening 61.
  • Each parts fixation portion 63 is a notch that is recessed inward from the edge of the first opening 61.
  • Each parts fixation portion 63 is formed to a size that just fits the connector 73 of the tube clamp part 70. Accordingly, by inclining a tube clamp part 70 and fitting the connector 73 into a parts fixation portion 63 as illustrated in Fig. 5 , it is possible to stop the circumferential movement of the tube clamp part 70.
  • the inclination of the tube clamp part 70 can be adjusted in fine increments by adjusting the fitting depth of the connector 73 to the parts fixation portion 63.
  • the pull-out stopper 72 in the present embodiment is spherical in shape, the angle of the pull-out stopper 72 can be changed freely.
  • each tube clamp part 70 is mounted so as to be movable in the circumferential direction of the body part 60.
  • a tube connected to the organ can be fixed at an appropriate position to a tube clamp part 70 of the frame 1 arranged around the organ. This stabilizes the relative positions of the organ and the tube. Accordingly, it is possible to reduce the probability of the organ becoming damaged due to a strain on the organ.
  • one second opening 62 and thirty-five parts fixation portions 63 are arranged at equal interior angle intervals of 10°.
  • the parts fixation portions 63 are arranged at circumferential intervals in this way, it is possible to increase the degree of flexibility in the arrangement of tubes. This stabilizes the relative positions of the organ and tubes without putting a stain on the organ. As a result, the strain on the organ is further reduced.
  • tubes can be fixed loosely by simply arranging the tube clamp parts 70 at positions other than the positions of the parts fixation portions 63 in the first opening 61.
  • appropriate usage methods may be devised, such as arranging the tube clamp parts 70 at the parts fixation portions 63.
  • the pull-out stoppers 72 are spherical in shape, so that the tube clamp parts 70 mounted on the body part 60 are rotatable in the horizontal direction. This enables adjusting the orientations of tubes held by the tube clamp parts 70.
  • the sheet fixing frame 80 is a ring-shaped member arranged opposing the lower face of the body part 60.
  • the sheet fixing frame 80 is fixed along the lower face of the body part 60 with fastening devices 81.
  • the fastening devices 81 fix the body part 60 and the sheet fixing frame 80 with each other, with the placement sheet 11 sandwiched between the body part 60 and the sheet fixing frame 80.
  • the fastening devices 81 are, for example, screws. In that case, the fastening devices 81 are fitted into screw holes in the sheet fixing frame 80, the through holes in the placement sheet 11, and screw holes in the lower face of the body part 60 as illustrated in Fig. 4 .
  • the placement sheet 11 is a member for placing and holding an organ on its upper face.
  • the placement sheet 11 is formed of, for example, a resin having an elastic force or a non-woven fabric.
  • the type or number of the placement sheet 11 attached to the frame 1 are appropriately selected depending on the type of an organ to be preserved or the purpose of preserving an organ. For example, two types of placement sheet 11 may be used in an overlapping manner.
  • the relative positions of the organ and tubes fixed to the tube clamp parts 70 can be further stabilized by holding the organ on the placement sheet 11 fixed to the frame 1. This further reduces the strain on the organ.
  • the placement sheet 11 is bowed inward and downward of the lower edge of the frame 1 at the center.
  • the placement sheet 11 may have such a bowl-like shape in advance.
  • the placement sheet 11 may have a flat shape along the lower edge of the frame 1 and may become bowl-shaped as illustrated by the weight of the organ placed thereon.
  • the placement sheet 11 may not become much deformed and may become bowed inward very little, like a placement sheet 11A according to a second embodiment, which will be described later.
  • the placement sheet 11 has a plurality of through holes 111. These through holes 11 allows a liquid to pass through above and below the placement sheet 11. Accordingly, if the organ holder 10 with the placement sheet 11 attached to the frame 1 is set in the reactor 90, the organ placed on the placement sheet 11 can be immersed in a liquid that fills the inside of the reactor 90.
  • the placement sheet 11 is a sheet formed of a non-woven fabric or a resin and having the through holes 111, but the present application is not limited thereto.
  • the placement sheet 11 may be formed of a reticulate mesh fabric or a net.
  • the frame 1 may be used singly, instead of being used in combination with the placement sheet 11.
  • the frame 1 is located so as to surround the organ, and tubes connected to the organ or tubes to be connected to the organ are fixed to the tube clamp parts 70. This reduces the probability that the tubes connected to the organ may move and put a stain on the organ during organ treatment.
  • the body part 60, the tube clamp parts 70, and the sheet fixing frame 80 of the frame 1 are all formed of heat-resistant resins.
  • the heat-resistant resins include polycarbonate, polypropylene, and polytetrafluoroethylene (PTFE). Using such heat-resistant materials for the frame 1 enables autoclave sterilization of the frame 1.
  • each component of the frame 1 may be formed of other resins such as nylon.
  • the frame 1 may also be disposable. In that case, the sterilization of the frame 1 is unnecessary.
  • an organ holder 10A including a frame 1A according to the second embodiment of the present invention will be described with reference to Figs. 6 to 9 .
  • the following description omits a description of some components that are common to those of the frame 1 according to the first embodiment.
  • Constituent elements that are equivalent to or correspond to those of the first embodiment are given the reference numerals with "A" attached to the corresponding reference numerals in the first embodiment.
  • Fig. 6 is a perspective view of the organ holder 10A.
  • part of a tube T held by one tube clamp part 70A is illustrated.
  • Fig. 7 is a side view of the organ holder 10A.
  • Figs. 8A to 8D are perspective views illustrating variations in the posture of each tube clamp part 70A.
  • Fig. 9 is a partial sectional view of the organ holder 10A.
  • the organ holder 10A includes the frame 1A and a placement sheet 11A attached to the frame 1A.
  • the frame 1A includes a body part 60A, at least one tube clamp part 70A detachable from the body part 60A, and a sheet fixing frame 80A.
  • a body part 60A includes a body part 60A, at least one tube clamp part 70A detachable from the body part 60A, and a sheet fixing frame 80A.
  • Figs. 6 and 7 four tube clamp parts 70A are illustrated.
  • the body part 60A has an internal space 600A that continues in the circumferential direction.
  • the body part 60A has one internal space 600A arranged along the entire length in the circumferential direction.
  • the body part 60A has a first opening 61A and a second opening 62A at the top, the first and second openings connecting the outside of the body part 60A and the internal space 600A.
  • the first opening 61A is provided along the entire circumference of the body part 60A, except a portion where the second opening 62A is provided.
  • the first opening 61A has a radial width smaller than that of the internal space 600A.
  • the second opening 62A has a radial width greater than that of the first opening 61A. In the present embodiment, the radial width of the second opening 62A is the same as the radial width of the internal space 600A.
  • each tube clamp part 70A includes a tube holder 71A, a pull-out stopper 72A, a connector 73A, a first socket 74A, a double-ball member 75A, and a second socket 76A.
  • the tube holder 71A has a recess 711A for holding a tube.
  • the tube is fitted into the recess 711A of the tube holder 71A.
  • the pull-out stopper 72A includes a generally rectangular pull-out stopper plate 721A and two plungers (biasing members) 722A.
  • the plungers 722A are, for example, ball plungers.
  • the pull-out stopper plate 721A is located inside the internal space 600A.
  • the tube clamp part 70A is mounted such that the short sides of the pull-out stopper plate 721A are oriented in the radial direction of the body part 60A and the long sides of the pull-out stopper plate 721A are oriented in the circumferential direction of the body part 60A.
  • the connector 73A is fixed at one end to the center on the upper side of the pull-out stopper plate 721A.
  • the balls of the plungers 722A are fixed so as to be exposed to the underside of the pull-out stopper plate 721A.
  • the pull-out stopper plate 721A is biased upward.
  • the radial width of the second opening 62A is greater than the length of the short sides of the pull-out stopper plate 721A. Also, the circumferential width of the second opening 62A is greater than the length of the long sides of the pull-out stopper plate 721A.
  • the widths of the short sides and the long sides of the pull-out stopper plate 721A are greater than the width of the first opening 61A.
  • the pull-out stopper 72A is unable to be moved in and out through the first opening 61A between the exterior space and the internal space 600A.
  • the tube clamp part 70A is unable to be mounted on and detached from the body part 60A at any circumferential position other than the position of the second opening 62A.
  • the connector 73A is a portion that indirectly connects the tube holder 71A and the pull-out stopper 72A.
  • the connector 73A has a rectangular parallelepiped shape on one side and is directly fixed to the pull-out stopper 72A.
  • the connector 73A also has a columnar shape on the other side and has the end on the other side fixed directly to the first socket 74A.
  • the double-ball member 75A includes a spherical first ball 751A, a spherical second ball 752A, and a rod-like ball connector 753A that connects the two balls 751A and 752A.
  • the first socket 74A has a recessed face that is in contact with the spherical surface of the first ball 751A. Fitting the first ball 751A into the first socket 74A forms a first ball joint that provides spherical articulated coupling.
  • the tube holder 71A is directly fixed to the second socket 76A.
  • the second socket 76A has a recessed face that is in contact with the spherical surface of the second ball 752A. Fitting the second ball 752A into the second socket 76A forms a second ball joint that provides spherical articulated coupling.
  • the connector 73A connects the tube holder 71A and the pull-out stopper 72A via the two ball joints configured of the first socket 74A, the double-ball member 75A, and the second socket 76A. Accordingly, the tube holder 71A has a high degree of flexibility in changing the relative positions and angles of the pull-out stopper 72A and the connector 73A.
  • the internal space 600A is delimited by the inner wall that includes an upper inner wall and a lower inner wall, the upper inner wall of the internal space 600A being referred to as a first inner wall 601A, and the lower inner wall of the internal space 600A being referred to as a second inner wall 602A.
  • the first inner wall 601A and the second inner wall 602A oppose each other.
  • springs in the plungers 722A are compressed to a small extent.
  • the plungers 722A stretch between the first inner wall 601A and the second inner wall 602A and give resistance to the first inner wall 601A and the second inner wall 602A.
  • friction is developed between the upper face of the pull-out stopper plate 721A and the first inner wall 601A, and this restricts the circumferential movement of the tube clamp part 70A.
  • the tube clamp part 70A can be moved by being pressed down.
  • the springs in the plungers 722A are further compressed, and this reduces the resistance and friction between the upper face of the pull-out stopper plate 721A and the first inner wall 601A. Therefore, the tube clamp part 70A can be moved with ease.
  • tube clamp parts 70A By using these tube clamp parts 70A, it is possible to fix and use the tube clamp parts 70A in any place within the range of existence of the first opening 61A. Accordingly, the position of the tubes held by the tube clamp parts 70A can be adjusted in fine increments.
  • the body part 60A, the tube clamp parts 70A, and the sheet fixing frame 80A of the frame 1A, except the plungers 722A, are all formed of heat-resistant resins.
  • the plungers 722A are formed of a metal. In this way, the use of heat-resistant materials and a metal to form the frame 1A enables autoclave sterilization of the frame 1A.
  • handles 64A for lifting the frame 1A may be attached to the top of the body part 60A, as illsutrated in Figs. 6 and 7 . This allows the organ holder 10A to be carried stably.
  • the outer side face of the body part 60A has a holding groove 65A arranged along the entire circumference as illsutrated in Fig. 7 .
  • a holding groove 65A arranged along the entire circumference as illsutrated in Fig. 7 .
  • the holding groove 65A may be provided only in part of the outer side face of the body part 60A.
  • the holding groove 65A preferably has a width greater than or equal to 1.5 cm in the up-down direction. This enables an operator to readily insert his/her fingers into the holding groove 65A.
  • the tube clamp parts 70 and 70A are movable along almost the entire circumference of the body parts 60 and 60A, but the present invention is not limited thereto.
  • the tube clamp parts may be configured to be mountable at predetermined several positions in the circumferential direction of the body part.
  • part of the tube clamp parts 70 and 70A can be located inside the body parts 60 and 60A, but the present invention is not limited thereto.
  • the tube clamp parts may be mounted on a mounting mechanism provided on the outer surface of a body part.
EP20182153.5A 2019-06-26 2020-06-25 Cadre et support d'organes Active EP3756460B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2019118336A JP7190398B2 (ja) 2019-06-26 2019-06-26 フレームおよび臓器保持具

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EP3756460A1 true EP3756460A1 (fr) 2020-12-30
EP3756460B1 EP3756460B1 (fr) 2021-12-29

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JP (1) JP7190398B2 (fr)

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JP2023181777A (ja) * 2022-06-13 2023-12-25 株式会社Ｓｃｒｅｅｎホールディングス 臓器保持具および撮影方法

Citations (7)

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US11357227B2 (en) 2022-06-14
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US20200404903A1 (en) 2020-12-31
EP3756460B1 (fr) 2021-12-29

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