WO2021005988A1 - Dispositif de perfusion - Google Patents

Dispositif de perfusion Download PDF

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Publication number
WO2021005988A1
WO2021005988A1 PCT/JP2020/023828 JP2020023828W WO2021005988A1 WO 2021005988 A1 WO2021005988 A1 WO 2021005988A1 JP 2020023828 W JP2020023828 W JP 2020023828W WO 2021005988 A1 WO2021005988 A1 WO 2021005988A1
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WIPO (PCT)
Prior art keywords
perfusion
perfusion device
liquid supply
pipe
supply pipe
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PCT/JP2020/023828
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English (en)
Japanese (ja)
Inventor
寛央 笠松
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株式会社Ｓｃｒｅｅｎホールディングス
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Publication of WO2021005988A1 publication Critical patent/WO2021005988A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts

Definitions

  • the present invention relates to a perfusion device that perfuse an organ with a preservative solution outside the body.
  • organ transplant surgery such as liver transplantation
  • the organ is temporarily preserved outside the body after the organ is removed from the donor until the organ is transplanted to the recipient.
  • a preservative solution is perfused into the organ.
  • Conventional devices for storing organs outside the body are described in, for example, Patent Documents 1 and 2.
  • various sensors are provided on the piping path of the perfusion device. If air bubbles are generated and stay in the pipe, an error may occur in the measurement results of some of these sensors, such as a flow rate sensor. Therefore, there is a demand for a technique capable of preventing air bubbles generated in the pipe from accumulating in a specific place.
  • the present invention has been made in view of such circumstances.
  • a perfusion device for perfusing a preservative solution to an organ outside the body it is possible to suppress the accumulation of air bubbles generated in the pipe at a specific location and to suppress the accumulation of air bubbles in the pipe. It is an object of the present invention to provide a structure capable of suppressing blockage of a flow path due to abrupt bending.
  • the first invention of the present application is a perfusion device for perfusing a preservative solution to an organ outside the body, and includes an arrangement table on which an organ and a pipe for perfusion are arranged, and the upper surface of the arrangement table is , The lower surface, the upper surface at a position higher than the lower surface, the inclined surface connecting the lower surface and the upper surface, and gradually increasing from the lower surface toward the upper surface.
  • the second invention of the present application is the perfusion device of the first invention, further including a reservoir support portion for supporting a reservoir serving as a supply source of a preservation solution, and the reservoir support portion is provided on the upper surface.
  • the third invention of the present application is the perfusion device of the first invention or the second invention, further including a reactor support portion in which a reactor for holding an organ is arranged, and the reactor support portion is provided on the lower surface. There is.
  • the fourth invention of the present application is the perfusion device of the third invention, in which the reactor support portion has a recess recessed downward from the lower surface, and the reactor is arranged in the recess.
  • the fifth invention of the present application is the perfusion device of any one of the first to fourth inventions, further including a flow rate sensor for measuring the flow rate of the storage liquid flowing in the pipe, and the flow rate sensor is a flow sensor. It is arranged on the inclined surface.
  • the sixth invention of the present application is the perfusion device of any one of the first to fifth inventions, further including a bubble sensor for detecting bubbles in the storage liquid flowing in the pipe, and the bubble sensor is , Arranged on the inclined surface.
  • the seventh invention of the present application is the perfusion device of any one of the first to sixth inventions, and the inclination angle of the inclined surface with respect to the horizontal plane is 30 ° or more and 60 ° or less.
  • the eighth invention of the present application is a perfusion device according to any one of the first to seventh inventions, further comprising an artificial lung that supplies oxygen to a preservation solution flowing in the pipe. It is arranged on the upper surface.
  • the ninth invention of the present application is a perfusion device according to any one of the first to eighth inventions, further comprising a temperature control water generating unit that generates temperature control water and supplies it to a portion to be kept warm.
  • the temperature control water generation unit is arranged inside the arrangement table.
  • the tenth invention of the present application is a perfusion device according to any one of the first to ninth inventions, further including a computer as a control unit, and the computer and wiring connected to the computer are arranged. It is located inside the table.
  • the eleventh invention of the present application is a perfusion device according to any one of the first to tenth inventions, in which the lower surface, the inclined surface, and the upper surface are linearly arranged in a top view. ing.
  • the twelfth invention of the present application is a perfusion device of any one of the first to eleventh inventions, further including an edge protrusion protruding upward from at least a part of the upper edge of the arrangement table.
  • piping can be arranged along the inclined surface between the lower surface and the upper surface.
  • piping can be arranged along the inclined surface between the lower surface and the upper surface.
  • the third invention it is possible to prevent air bubbles generated in the pipe from being mixed into the blood vessels in the organ.
  • the organ can be placed at a lower position. Therefore, it is possible to further suppress the air bubbles generated in the pipe from being mixed into the blood vessels in the organ.
  • the fifth invention it is possible to suppress the accumulation of air bubbles in the flow rate sensor. As a result, the measurement error of the flow rate sensor can be suppressed.
  • the number of parts arranged on the upper surface of the arrangement table can be reduced by arranging the temperature control water generating unit inside the arrangement table. Therefore, the perfusion device can be made smaller.
  • the tenth invention it is possible to prevent droplets such as a preservative from being applied to the control unit and the electrical wiring. Therefore, it is possible to suppress failures of the control unit and the electrical wiring.
  • the preservative liquid when the preservative liquid flows out to the upper surface of the arrangement table, the preservative liquid can be blocked by the edge protrusions.
  • the "donor” and “recipient” may be humans or non-human animals. That is, in the present application, the "organ” may be a human organ or a non-human animal organ.
  • non-human animals may be rodents including mice and rats, ungulates including pigs, goats, and sheep, non-human primates including chimpanzees, and other non-human mammals, and mammals. It may be an animal other than an animal.
  • FIG. 1 is a diagram showing a piping configuration of the perfusion device 1 according to the embodiment.
  • This perfusion device 1 is a device for temporarily storing the organ 9 removed from the donor outside the body until the organ 9 is transplanted to the recipient when the organ 9 is transplanted.
  • the perfusion device 1 preserves the organ 9 while perfusing the preservation solution into the blood vessels in the organ 9.
  • the organ 9 stored in the perfusion device 1 may be another organ such as a kidney, a heart, or a pancreas, or may be a part of the organ.
  • the perfusion device 1 of the present embodiment includes a reactor 10, a reservoir 20, a portal vein liquid supply unit 30, a hepatic artery liquid supply unit 40, a drainage unit 50, and a temperature control water generation unit 60. It has.
  • Reactor 10 is a cage for holding organ 9.
  • the reactor 10 has an outer reactor 11 and an inner reactor 12.
  • the outer reactor 11 is a bottomed cylindrical container.
  • a storage liquid is stored inside the outer reactor 11.
  • the inner reactor 12 has an annular reactor frame 121 and a mounting sheet 122 stretched inside the reactor frame 121.
  • As the material of the mounting sheet 122 a resin having biocompatibility, sterilization retention, and flexibility is used. Further, the mounting sheet 122 is provided with a plurality of openings.
  • the inner reactor 12 is arranged inside the outer reactor 11. Then, the organ 9 is placed on the upper surface of the mounting sheet 122 of the inner reactor 12 arranged inside the outer reactor 11. The organ 9 is retained in a state of being partially immersed in the preservation solution stored inside the outer reactor 11. As a result, the drying of the organ 9 is suppressed.
  • the reservoir 20 is a source of a preservation solution for perfusing the organ 9.
  • a pouch bag (so-called drip bag) in which a storage solution is stored is used.
  • the reservoir 20 is replaced with a new one after each use.
  • the reservoir 20 may be a container (for example, a bottle) other than the pouch bag.
  • an ETK solution or a UW solution is typically used.
  • a storage solution other than the ETK solution and the UW solution may be used.
  • the preservation solution may be the same type of preservation solution as the preservation solution stored in the outer reactor 11, or may be a different type of preservation solution.
  • the portal vein supply unit 30 is a piping system for supplying a preservation solution from the reservoir 20 to the portal vein of the liver, which is an organ 9.
  • the portal vein liquid supply unit 30 includes a first liquid supply pipe 31, a pump 32, a second liquid supply pipe 33, an artificial lung 34, a third liquid supply pipe 35, a bubble trap 36, and a fourth. It has a liquid supply pipe 37, a flow rate / bubble sensor 38, and a fifth liquid supply pipe 39.
  • the upstream end of the first liquid supply pipe 31 is connected to the output port of the reservoir 20.
  • the downstream end of the first liquid supply pipe 31 is connected to the input port of the pump 32.
  • the pump 32 operates according to the drive current from the control unit 80, which will be described later, to form a flow of the storage liquid toward the downstream side.
  • the upstream end of the second liquid supply pipe 33 is connected to the output port of the pump 32.
  • the downstream end of the second liquid supply pipe 33 is connected to the input port of the artificial lung 34.
  • the artificial lung 34 supplies oxygen to the preservation solution flowing in the pipe to dissolve it.
  • the artificial lung 34 also has a function of maintaining the preservation solution at a constant temperature by the temperature control water supplied from the temperature control water generation unit 60.
  • the upstream end of the third liquid supply pipe 35 is connected to the output port of the artificial lung 34.
  • the downstream end of the third liquid supply pipe 35 is connected to the input port of the bubble trap 36.
  • the bubble trap 36 removes bubbles from the storage liquid flowing in the pipe.
  • the upstream end of the fourth liquid supply pipe 37 is connected to the output port of the bubble trap 36.
  • the downstream end of the fourth liquid supply pipe 37 is connected to the input port of the flow rate / bubble sensor 38.
  • the flow rate / bubble sensor 38 has a function as a flow rate sensor for measuring the flow rate of the storage liquid flowing in the pipe and a function as a bubble sensor for detecting bubbles in the storage liquid flowing in the pipe.
  • the upstream end of the fifth liquid supply pipe 39 is connected to the output port of the flow rate / bubble sensor 38.
  • the downstream end of the fifth liquid supply pipe 39 is connected to the portal vein of the liver, which is an organ 9, via a catheter.
  • the storage liquid in the reservoir 20 becomes the first liquid supply pipe 31, the pump 32, the second liquid supply pipe 33, the artificial lung 34, the third liquid supply pipe 35, the bubble trap 36, and the third. It is supplied to the portal vein through the 4 liquid supply pipe 37, the flow rate / bubble sensor 38, and the 5th liquid supply pipe 39.
  • the first liquid supply pipe 31, the second liquid supply pipe 33, the third liquid supply pipe 35, the fourth liquid supply pipe 37, and the fifth liquid supply pipe 39 are disposable which are replaced with new ones every time they are used. It may be a product.
  • the hepatic artery liquid supply unit 40 is a piping system for supplying a preservation solution from the reservoir 20 to the hepatic artery of the liver, which is an organ 9.
  • the hepatic artery liquid supply unit 40 includes a sixth liquid supply pipe 41, a pump 42, a seventh liquid supply pipe 43, an artificial lung 44, an eighth liquid supply pipe 45, a bubble trap 46, and a ninth liquid supply pipe. It has a liquid supply pipe 47, a flow rate / bubble sensor 48, and a tenth liquid supply pipe 49.
  • the upstream end of the sixth liquid supply pipe 41 is connected to the output port of the reservoir 20.
  • the downstream end of the sixth liquid supply pipe 41 is connected to the input port of the pump 42.
  • the pump 42 operates according to the drive current from the control unit 80, which will be described later, to form a flow of the storage liquid toward the downstream side.
  • the upstream end of the seventh liquid supply pipe 43 is connected to the output port of the pump 42.
  • the downstream end of the seventh liquid supply pipe 43 is connected to the input port of the artificial lung 44.
  • the artificial lung 44 supplies oxygen to the preservation solution flowing in the pipe to dissolve it. Further, the artificial lung 44 also has a function of maintaining the preservation solution at a constant temperature by the temperature control water supplied from the temperature control water generation unit 60.
  • the upstream end of the eighth liquid supply pipe 45 is connected to the output port of the artificial lung 44.
  • the downstream end of the eighth liquid supply pipe 45 is connected to the input port of the bubble trap 46.
  • the bubble trap 46 removes bubbles from the storage liquid flowing in the pipe.
  • the upstream end of the ninth liquid supply pipe 47 is connected to the output port of the bubble trap 46.
  • the downstream end of the ninth liquid supply pipe 47 is connected to the input port of the flow rate / bubble sensor 48.
  • the flow rate / bubble sensor 48 has a function as a flow rate sensor for measuring the flow rate of the storage liquid flowing in the pipe and a function as a bubble sensor for detecting bubbles in the storage liquid flowing in the pipe.
  • the upstream end of the tenth liquid supply pipe 49 is connected to the output port of the flow rate / bubble sensor 48.
  • the downstream end of the tenth liquid supply pipe 49 is connected to the hepatic artery of the liver, which is an organ 9, via a catheter.
  • the storage liquid in the reservoir 20 becomes the sixth liquid supply pipe 41, the pump 42, the seventh liquid supply pipe 43, the artificial lung 44, the eighth liquid supply pipe 45, the bubble trap 46, and the third. It is supplied to the hepatic artery through the 9 liquid supply pipe 47, the flow rate / bubble sensor 48, and the 10th liquid supply pipe 49.
  • the sixth liquid supply pipe 41, the seventh liquid supply pipe 43, the eighth liquid supply pipe 45, the ninth liquid supply pipe 47, and the tenth liquid supply pipe 49 are disposable and are replaced with new ones every time they are used. It may be a product.
  • the drainage unit 50 is a piping system for draining the storage liquid from the organ 9. As shown in FIG. 1, the drainage unit 50 includes a first drainage pipe 51, a flow rate / bubble sensor 52, a second drainage pipe 53, a pH / dissolved oxygen sensor unit 54, a third drainage pipe 55, and a pump 56. , And a fourth drainage pipe 57.
  • the upstream end of the first drainage pipe 51 is connected to the hepatic vein of the liver, which is an organ 9, via a catheter.
  • the downstream end of the first drainage pipe 51 is connected to the input port of the flow rate / bubble sensor 52.
  • the flow rate / bubble sensor 52 has a function as a flow rate sensor for measuring the flow rate of the storage liquid flowing in the pipe and a function as a bubble sensor for detecting bubbles in the storage liquid flowing in the pipe.
  • the upstream end of the second drainage pipe 53 is connected to the output port of the flow rate / bubble sensor 52.
  • the downstream end of the second drainage pipe 53 is connected to the input port of the pH / dissolved oxygen sensor unit 54.
  • the pH / dissolved oxygen sensor unit 54 includes a pH sensor that measures the pH value in the storage liquid flowing in the pipe and a dissolved oxygen sensor that measures the dissolved oxygen concentration in the storage liquid flowing in the pipe.
  • the upstream end of the third drainage pipe 55 is connected to the output port of the pH / dissolved oxygen sensor unit 54.
  • the downstream end of the third drainage pipe 55 is connected to the input port of the pump 56.
  • the pump 56 operates according to the drive current from the control unit 80, which will be described later, to form a flow of the storage liquid toward the downstream side.
  • the upstream end of the fourth drainage pipe 57 is connected to the output port of the pump 56.
  • the downstream end of the fourth drainage pipe 57 is connected to the input port of the reservoir 20.
  • the storage liquid discharged from the hepatic vein is discharged from the above-mentioned first drainage pipe 51, flow rate / bubble sensor 52, second drainage pipe 53, pH / dissolved oxygen sensor unit 54, and third drainage. It is supplied to the reservoir 20 again through the liquid pipe 55, the pump 56, and the fourth drain pipe 57. However, the preservation solution discharged from the organ 9 may be discarded without returning to the reservoir 20. Further, the first drainage pipe 51, the second drainage pipe 53, and the third drainage pipe 55 may be disposable products that are replaced with new ones each time they are used.
  • the temperature control water generation unit 60 is a unit that generates temperature control water and supplies it to a portion to be kept warm.
  • the temperature control water generation unit 60 generates temperature control water at a constant temperature by heating or cooling the water stored in the tank.
  • the temperature of the temperature-controlled water is, for example, 4 ° C, 20 ° C, 37 ° C, or the like.
  • the temperature control water generated in the temperature control water generation unit 60 is supplied from the tank to the artificial lungs 34 and 44. As a result, the temperature of the preservation solution in the artificial lungs 34 and 44 is adjusted.
  • FIG. 2 is a perspective view of the perfusion device 1.
  • FIG. 3 is a side view of the perfusion device 1.
  • FIG. 4 is a top view of the perfusion device 1.
  • the perfusion device 1 includes the above-mentioned reactor 10, reservoir 20, portal vein liquid supply unit 30, hepatic artery liquid supply unit 40, drainage unit 50, and temperature control water generation unit.
  • the arrangement table 70 and the control unit 80 are provided.
  • the placement table 70 is a housing in which the above-mentioned reactor 10, portal vein liquid supply unit 30, hepatic artery liquid supply unit 40, and drainage unit 50 are arranged on the upper surface.
  • the placement table 70 is placed and used in the vicinity of the operating table 90 in the operating room when performing organ transplantation.
  • a plurality of wheels 71 are provided at the lower part of the arrangement table 70. These wheels 71 allow the placement table 70 to move relative to the floor of the operating room.
  • the arrangement table 70 has a rectangular shape having a long side and a short side in a top view.
  • the perfusion device 1 is arranged so that one short side of the arrangement table 70 is close to the operating table 90.
  • each part will be described with the side closer to the operating table 90 as the "front side” and the side far from the operating table 90 as the "rear side” in the posture when the arrangement table 70 is used.
  • the upper surface of the arrangement table 70 includes a lower surface 72, an upper surface 73, and an inclined surface 74.
  • the lower surface 72, the inclined surface 74, and the upper surface 73 are arranged in a straight line from the front side to the rear side in a top view.
  • the lower surface 72 is the portion of the upper surface of the arrangement table 70 that is located on the frontmost side.
  • the lower surface 72 extends substantially horizontally at a height equivalent to the height of a general operating table 90 used for organ transplantation.
  • the height h1 from the lower end of the wheel 71 to the lower surface 72 is, for example, 900 to 1000 mm.
  • a reactor support portion 721 is provided on the lower surface 72.
  • the reactor support portion 721 has a recess 722 that is recessed downward at the center of the lower surface 72.
  • the reactor 10 is arranged in the recess 722.
  • the upper surface 73 is the portion of the upper surface of the arrangement table 70 that is located on the rearmost side.
  • the upper surface 73 spreads substantially horizontally at a position higher than the lower surface 72.
  • the height h2 from the lower end of the wheel 71 to the upper surface 73 is, for example, 1200 to 1300 mm.
  • a reservoir support portion 731 is provided on the upper surface 73.
  • the reservoir support portion 731 has a rear frame 732 extending upward from the rear end edge portion of the upper surface 73 on the rear side.
  • a hook 733 is provided on the rear surface of the rear frame 732. In the examples of FIGS. 2 to 4, the pouch bag as the reservoir 20 is supported by being hung on the hook 733.
  • the display unit 84 is fixed to the upper part of the rear frame 732.
  • a liquid crystal display is used for the display unit 84.
  • the inclined surface 74 is a portion of the upper surface of the arrangement table 70 located between the lower surface 72 and the upper surface 73.
  • the inclined surface 74 connects the rear edge portion of the lower surface 72 and the front edge portion of the upper surface 73.
  • the inclined surface 74 is inclined so as to gradually increase toward the rear side.
  • the inclination angle ⁇ of the inclined surface 74 with respect to the horizontal plane is, for example, 30 ° or more and 60 ° or less, more preferably 40 ° or more and 50 ° or less.
  • a part of the upstream side of the first liquid supply pipe 31, the pump 32, and the second liquid supply pipe 33 is arranged on the rear side side surface of the arrangement table 70. .. Further, of the above-mentioned hepatic artery liquid supply section 40, a part of the upstream side of the sixth liquid supply pipe 41, the pump 42, and the seventh liquid supply pipe 43 is arranged on the rear side side surface of the arrangement table 70. ing.
  • the perfusion device 1 many parts of the portal vein supply part 30, the hepatic artery supply part 40, and the drainage part 50 are arranged on the upper surface 73.
  • the height of the upper surface 73 is such that a worker such as a surgeon or a nurse can easily perform the work in an upright posture. Therefore, the connection work of each part of the portal vein liquid supply part 30, the hepatic artery liquid supply part 40, and the drainage part 50 can be easily and quickly performed.
  • a part of the downstream side of the fourth liquid supply pipe 37, the flow rate / bubble sensor 38, and a part of the upstream side of the fifth liquid supply pipe 39 are on the inclined surface 74. Have been placed. Further, of the hepatic artery liquid supply section 40, a part of the downstream side of the 9th liquid supply pipe 47, the flow rate / bubble sensor 48, and a part of the upstream side of the 10th liquid supply pipe 49 are also on the inclined surface 74. Have been placed. Further, a part of the drainage unit 50 on the downstream side of the first drainage pipe 51, a flow rate / bubble sensor 52, and a part on the upstream side of the second drainage pipe 53 are also arranged on the inclined surface 74. There is.
  • the fourth liquid supply pipes 37 to the fifth liquid supply pipe 39 of the liquid supply unit 30 for the portal vein and the ninth liquid supply pipes 47 to 10 of the liquid supply unit 40 for the hepatic artery are supplied.
  • the liquid pipe 49 and the first liquid drain pipe 51 to the second drain pipe 53 of the liquid drain portion 50 are arranged along the inclined surface 74. In this way, when air bubbles are generated in these pipes, the air bubbles float toward the upper surface 73 side. Therefore, it is possible to suppress the accumulation of air bubbles on the lower surface 72 side. Therefore, it is possible to prevent air bubbles from being mixed into the blood vessels in the organ 9 held in the reactor 10.
  • the reactor 10 is arranged in the recess 722 provided on the lower surface 72.
  • the organ 9 can be placed at a lower position than when there is no recess 722.
  • the organ 9 can be placed at the lowest position in the circulation pathway of the preservation solution. Therefore, it is possible to further suppress the mixing of air bubbles generated in the pipe into the blood vessels in the organ 9.
  • the flow rate / bubble sensors 38, 48, 52 are arranged on the inclined surface 74. Therefore, it is possible to prevent bubbles from staying in the flow rate / bubble sensors 38, 48, 52. Therefore, it is possible to prevent an error from occurring in the flow rate measurement results of the flow rate / bubble sensors 38, 48, and 52.
  • the angle formed by the inclined surface 74 and the upper surface 73 in the side view is an obtuse angle. Therefore, the fourth liquid supply pipe 37, the ninth liquid supply pipe 47, and the second drainage pipe 53 do not suddenly bend between the inclined surface 74 and the upper surface 73. Further, in the side view, the angle formed by the inclined surface 74 and the lower surface 72 is also an obtuse angle. Therefore, even between the inclined surface 74 and the lower surface 72, the fifth liquid supply pipe 39, the tenth liquid supply pipe 49, and the first drainage pipe 51 do not suddenly bend. Therefore, it is possible to prevent the flow paths in these pipes 37, 39, 47, 49, 51, 53 from being blocked by so-called kink.
  • the temperature control water generation unit 60 is arranged inside the arrangement table 70, not on the upper surface of the arrangement table 70. As a result, the number of parts arranged on the upper surface of the arrangement table 70 is reduced. Therefore, the perfusion device 1 can be miniaturized.
  • the arrangement table 70 of the present embodiment has an edge protrusion 75.
  • the edge projection 75 projects upward from at least a part of the edge of the upper surface of the arrangement table 70. In the unlikely event that the storage liquid flows out from the pipe on the upper surface of the arrangement table 70, the storage liquid is blocked by the edge protrusion 75.
  • the edge projection 75 is provided on the peripheral edge of the upper surface of the arrangement table 70 other than the edge on the front side. Therefore, the preservative liquid that has flowed out of the pipe flows toward the front side on the upper surface of the arrangement table 70, and flows downward only from the edge portion on the front side. Therefore, the outflowing storage solution can be easily recovered.
  • the control unit 80 is a means for controlling the operation of each unit of the perfusion device 1.
  • the control unit 80 is composed of a computer.
  • the control unit 80 and the electrical wiring connected to the control unit 80 are arranged inside the arrangement table 70. By doing so, it is possible to prevent droplets of the preservative solution or the like from being applied to the control unit 80 and the electrical wiring. Therefore, the failure of the control unit 80 and the electrical wiring can be suppressed.
  • FIG. 5 is a block diagram showing the electrical connection between the control unit 80 and each unit of the perfusion device 1.
  • the control unit 80 includes a processor 81 such as a CPU, a memory 82 such as a RAM, and a storage unit 83 such as a hard disk drive.
  • a computer program CP for controlling the operation of the perfusion device 1 is stored in the storage unit 83.
  • the control unit 80 includes the pumps 32, 42, 56, the flow rate / bubble sensor 38, 48, 52, the pH / dissolved oxygen sensor unit 54, the temperature control water generation unit 60, and the display. Each is electrically connected to the unit 84.
  • the control unit 80 controls the operation of each of these units according to the computer program CP stored in the storage unit 83. As a result, the perfusion treatment for the organ 9 proceeds.
  • the control unit 80 performs control such as stopping the pumps 32 and 42.
  • the inclined surface 74 was flat. However, the inclined surface 74 may have a curved surface shape. Further, the lower surface 72 and the inclined surface 74 may be connected by a smooth curved surface having no corners. Further, the upper surface 73 and the inclined surface 74 may be connected by a smooth curved surface having no corners. Further, the inclined surface 74 may have fine irregularities.
  • the perfusion device 1 of the above embodiment includes flow rate / bubble sensors 38, 48, 52 having both a flow rate sensor function and a bubble sensor function.
  • the perfusion device 1 may include a flow rate sensor and a bubble sensor separately.
  • the perfusion device 1 of the above embodiment includes a pH / dissolved oxygen sensor unit 54 including a pH sensor and a dissolved oxygen sensor.
  • the perfusion device 1 may include a pH sensor and a dissolved oxygen sensor as separate units.
  • the perfusion device 1 of the above embodiment includes two liquid supply units 30 and 40 and one drainage unit 50.
  • the number of the liquid supply part and the drainage part may be appropriately selected according to the type of the organ 9.

Abstract

L'invention concerne un dispositif de perfusion (1) qui comprend une table d'agencement (70) sur laquelle un organe interne (9) et des tuyaux de perfusion sont disposés. La surface supérieure de la table d'agencement (70) comprend une surface inférieure (72), une surface supérieure (73) plus haute que la surface inférieure (72), et une surface inclinée (74). La surface inclinée (74) relie la surface inférieure (72) et la surface supérieure (73), et augmente progressivement en hauteur de la surface inférieure (72) vers la surface supérieure (73). Le dispositif de perfusion (1) peut avoir des tuyaux disposés le long de la surface inclinée (74) entre la surface inférieure (72) et la surface supérieure (73). Par conséquent, si une bulle d'air se forme à l'intérieur des tuyaux, il est possible d'empêcher la bulle d'air de s'accumuler sur le côté surface inférieure (72). En outre, en disposant les tuyaux le long de la surface inclinée (74), il est possible d'empêcher le trajet d'écoulement de se bloquer en raison d'une courbure nette dans les tuyaux.
PCT/JP2020/023828 2019-07-08 2020-06-17 Dispositif de perfusion WO2021005988A1 (fr)

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JP2019126714A JP2021011451A (ja) 2019-07-08 2019-07-08 灌流装置

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WO2021181985A1 (fr) * 2020-03-10 2021-09-16 株式会社Ｓｃｒｅｅｎホールディングス Dispositif de perfusion
WO2023047976A1 (fr) * 2021-09-22 2023-03-30 株式会社Ｓｃｒｅｅｎホールディングス Plateforme de placement d'organe, contenant de stockage d'organe et procédé de placement d'organe

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