EP3738599A4 - Composition comprenant des probiotiques et un polypeptide présentant une affinité de liaison pour les ige et son utilisation - Google Patents

Composition comprenant des probiotiques et un polypeptide présentant une affinité de liaison pour les ige et son utilisation Download PDF

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Publication number
EP3738599A4
EP3738599A4 EP19738433.2A EP19738433A EP3738599A4 EP 3738599 A4 EP3738599 A4 EP 3738599A4 EP 19738433 A EP19738433 A EP 19738433A EP 3738599 A4 EP3738599 A4 EP 3738599A4
Authority
EP
European Patent Office
Prior art keywords
probiotics
ige
polypeptide
composition
binding affinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19738433.2A
Other languages
German (de)
English (en)
Other versions
EP3738599C0 (fr
EP3738599B1 (fr
EP3738599A1 (fr
Inventor
Myoung Ho Jang
Young Chul Sung
Zungyoon YANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GI Innovation Inc
Original Assignee
GI Innovation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GI Innovation Inc filed Critical GI Innovation Inc
Publication of EP3738599A1 publication Critical patent/EP3738599A1/fr
Publication of EP3738599A4 publication Critical patent/EP3738599A4/fr
Application granted granted Critical
Publication of EP3738599C0 publication Critical patent/EP3738599C0/fr
Publication of EP3738599B1 publication Critical patent/EP3738599B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
EP19738433.2A 2018-01-12 2019-01-14 Composition comprenant des probiotiques et un polypeptide présentant une affinité de liaison pour les ige et son utilisation Active EP3738599B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20180004421 2018-01-12
PCT/KR2019/000524 WO2019139434A1 (fr) 2018-01-12 2019-01-14 Composition comprenant des probiotiques et un polypeptide présentant une affinité de liaison pour les ige et son utilisation

Publications (4)

Publication Number Publication Date
EP3738599A1 EP3738599A1 (fr) 2020-11-18
EP3738599A4 true EP3738599A4 (fr) 2021-10-27
EP3738599C0 EP3738599C0 (fr) 2023-12-27
EP3738599B1 EP3738599B1 (fr) 2023-12-27

Family

ID=67218660

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19738433.2A Active EP3738599B1 (fr) 2018-01-12 2019-01-14 Composition comprenant des probiotiques et un polypeptide présentant une affinité de liaison pour les ige et son utilisation

Country Status (17)

Country Link
US (1) US20220347236A1 (fr)
EP (1) EP3738599B1 (fr)
JP (1) JP7041272B2 (fr)
KR (1) KR102038679B1 (fr)
CN (1) CN111587118B (fr)
AU (1) AU2019206205A1 (fr)
BR (1) BR112020013818A2 (fr)
CA (1) CA3086224A1 (fr)
CL (1) CL2020001800A1 (fr)
ES (1) ES2969110T3 (fr)
IL (1) IL275593B (fr)
MX (1) MX2020007032A (fr)
PE (1) PE20210108A1 (fr)
PH (1) PH12020551069A1 (fr)
SG (1) SG11202005863TA (fr)
TW (1) TWI737955B (fr)
WO (1) WO2019139434A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022000285A (es) * 2019-07-08 2022-02-03 Gi Innovation Inc Dimero de polipeptido con alto contenido de acido sialico, que comprende el dominio extracelular de la subunidad alfa del receptor fc de ige y composicion farmaceutica que comprende el mismo.
US20230279124A1 (en) * 2020-07-17 2023-09-07 Gi Innovation, Inc. Fusion protein comprising ige fc receptor alpha subunit extracellular domain and anti-il-4r antibody, and use thereof
KR20220011931A (ko) * 2020-07-22 2022-02-03 (주)지아이이노베이션 IgE Fc 수용체를 포함하는 융합단백질 및 이를 포함하는 개 알레르기성 질환 치료 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008028068A2 (fr) * 2006-08-30 2008-03-06 Genentech, Inc. POLYPEPTIDES FCεR1α DE PRIMATES NON HUMAINS
WO2019135668A1 (fr) * 2018-01-08 2019-07-11 주식회사 프로젠 Domaine extracellulaire de sous-unité alpha du récepteur fc ige, composition pharmaceutique le comprenant et son procédé de production

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JPH092959A (ja) * 1995-06-16 1997-01-07 Yakult Honsha Co Ltd ＩｇＥ抗体産生抑制剤および抗アレルギー剤
JPH10309178A (ja) * 1997-05-09 1998-11-24 Wakamoto Pharmaceut Co Ltd ビフィズス菌を有効成分とする抗アレルギー剤および醗酵食品
JP2000095697A (ja) * 1998-09-18 2000-04-04 Advance Co Ltd 抗アレルギー剤
AUPQ415899A0 (en) * 1999-11-19 1999-12-16 Vasse Research Institute Pty Ltd Compositions for and methods of treatment of allergic diseases
EP1239032A1 (fr) * 2001-03-02 2002-09-11 Société des Produits Nestlé S.A. Bactéries lactiques en tant qu'agents pour le traitement et la prévention des allergies
JP2009067679A (ja) * 2005-12-27 2009-04-02 Univ Of Tokushima 抗ヒスタミン作用を有する医薬
US20100303777A1 (en) * 2006-12-14 2010-12-02 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
AR065368A1 (es) * 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
ES2623925T3 (es) 2007-05-30 2017-07-12 Postech Academy-Industry- Foundation Proteínas de fusión de inmunoglobulina
EP2065048A1 (fr) * 2007-11-30 2009-06-03 Institut Pasteur Utilisation d'une souche de L. casei pour la préparation d'une composition pour l'inhibition de l'activation de mastocytes
CA2713525A1 (fr) * 2008-02-06 2009-08-13 The Procter & Gamble Company Compositions, methodes et kits de stimulation de la reponse immunitaire a une maladie respiratoire
WO2010013143A2 (fr) * 2008-08-01 2010-02-04 Institut Pasteur Procédés d'inhibition de l'activation des mastocytes et de traitement de maladies et de troubles inflammatoires dépendant des mastocytes, faisant appel à lactobacillus
ES2742419T3 (es) 2008-09-17 2020-02-14 Xencor Inc Nuevas composiciones y métodos para tratar trastornos mediados por IgE
BR112012009846B8 (pt) * 2009-10-26 2021-05-25 Genentech Inc método in vitro e kit para detecção de um anticorpo antifármaco de isotipo ige, e uso de um anticorpo antifármaco de isotipo ige no tratamento de distúrbio mediado por ige
KR20120135865A (ko) * 2011-06-07 2012-12-17 (주)네오팜 ＦｃεＲＩ의 수용성 단편을 포함하는 복합체 및 이를 포함하는 ＩｇＥ 매개 알레르기성 질환 치료용 조성물
WO2012169735A2 (fr) * 2011-06-07 2012-12-13 (주)네오팜 Complexe comprenant des fragments hydrosolubles de fcεri et composition le contenant pour traiter les maladies allergiques médiées par l'ige
CN103169733B (zh) * 2011-12-26 2014-11-12 浙江贝因美科工贸股份有限公司 复合益生菌、其在治疗过敏性疾病中的应用及孕产妇防过敏益生菌冲剂
TWI691512B (zh) * 2015-02-20 2020-04-21 日商橘生藥品工業股份有限公司 Ｆｃ融合高親和性ＩｇＥ受體α鏈
JP2018515426A (ja) * 2015-03-12 2018-06-14 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア 細菌組成物およびその使用方法
KR101778734B1 (ko) 2016-03-11 2017-09-18 대한민국(농촌진흥청장) 비피도박테리움 롱검 kacc 91563으로부터 분리된 esbp 및 이를 이용한 항알레르기 조성물

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008028068A2 (fr) * 2006-08-30 2008-03-06 Genentech, Inc. POLYPEPTIDES FCεR1α DE PRIMATES NON HUMAINS
WO2019135668A1 (fr) * 2018-01-08 2019-07-11 주식회사 프로젠 Domaine extracellulaire de sous-unité alpha du récepteur fc ige, composition pharmaceutique le comprenant et son procédé de production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019139434A1 *

Also Published As

Publication number Publication date
ES2969110T3 (es) 2024-05-16
TW201932129A (zh) 2019-08-16
JP2021510689A (ja) 2021-04-30
AU2019206205A1 (en) 2020-06-25
CN111587118B (zh) 2023-11-21
EP3738599C0 (fr) 2023-12-27
WO2019139434A1 (fr) 2019-07-18
IL275593B (en) 2022-01-01
SG11202005863TA (en) 2020-07-29
EP3738599B1 (fr) 2023-12-27
TWI737955B (zh) 2021-09-01
IL275593A (en) 2020-08-31
CN111587118A (zh) 2020-08-25
CA3086224A1 (fr) 2019-07-18
EP3738599A1 (fr) 2020-11-18
BR112020013818A2 (pt) 2020-12-01
CL2020001800A1 (es) 2020-10-30
PE20210108A1 (es) 2021-01-19
RU2020122021A (ru) 2022-02-14
KR20190086396A (ko) 2019-07-22
JP7041272B2 (ja) 2022-03-23
MX2020007032A (es) 2020-12-03
KR102038679B1 (ko) 2019-10-30
PH12020551069A1 (en) 2021-09-06
US20220347236A1 (en) 2022-11-03

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