EP3735466A4 - Vecteurs d'orthopoxvirus modifiés - Google Patents
Vecteurs d'orthopoxvirus modifiés Download PDFInfo
- Publication number
- EP3735466A4 EP3735466A4 EP19736067.0A EP19736067A EP3735466A4 EP 3735466 A4 EP3735466 A4 EP 3735466A4 EP 19736067 A EP19736067 A EP 19736067A EP 3735466 A4 EP3735466 A4 EP 3735466A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- modified orthopoxvirus
- vectors
- orthopoxvirus vectors
- modified
- orthopoxvirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
- C12Y306/01023—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1) dUTP diphosphatase (3.6.1.23)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862614349P | 2018-01-05 | 2018-01-05 | |
US201862784371P | 2018-12-21 | 2018-12-21 | |
PCT/CA2019/050014 WO2019134048A1 (fr) | 2018-01-05 | 2019-01-04 | Vecteurs d'orthopoxvirus modifiés |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3735466A1 EP3735466A1 (fr) | 2020-11-11 |
EP3735466A4 true EP3735466A4 (fr) | 2022-01-12 |
Family
ID=67144045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19736067.0A Pending EP3735466A4 (fr) | 2018-01-05 | 2019-01-04 | Vecteurs d'orthopoxvirus modifiés |
Country Status (12)
Country | Link |
---|---|
US (2) | US11802292B2 (fr) |
EP (1) | EP3735466A4 (fr) |
JP (2) | JP7312412B2 (fr) |
KR (1) | KR20200121297A (fr) |
CN (1) | CN113039277A (fr) |
AU (1) | AU2019205036A1 (fr) |
BR (1) | BR112020013769A2 (fr) |
CA (1) | CA3122431A1 (fr) |
IL (1) | IL275813A (fr) |
MX (1) | MX2020007010A (fr) |
SG (1) | SG11202006457YA (fr) |
WO (1) | WO2019134048A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019410148A1 (en) * | 2018-12-21 | 2021-08-12 | Ottawa Hospital Research Institute | Modified orthopoxvirus vectors |
TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
KR20210135532A (ko) * | 2019-03-05 | 2021-11-15 | 암젠 인크 | 암 치료를 위한 종양 용해 바이러스의 용도 |
WO2020230785A1 (fr) * | 2019-05-14 | 2020-11-19 | 国立大学法人鳥取大学 | Virus de la vaccine induisant la fusion cellulaire et son utilisation |
WO2023135313A1 (fr) * | 2022-01-17 | 2023-07-20 | Nouscom Ag | Vecteur viral orthopox recombinant codant pour des protéines immunostimulatrices pour traiter le cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015027163A1 (fr) * | 2013-08-22 | 2015-02-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thérapies immuno-oncolytiques |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756102A (en) | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
JP3602530B2 (ja) * | 1991-03-07 | 2004-12-15 | ヴァイロジェネティクス コーポレイション | 遺伝子操作したワクチン菌株 |
ES2444699T3 (es) | 2002-08-12 | 2014-02-26 | Jennerex, Inc. | Virus vaccinia para uso en el tratamiento del cáncer |
US20040247578A1 (en) | 2002-10-15 | 2004-12-09 | University Of Pittsburgh Of Commonwealth System Of Higher Education | Methods and reagents for inducing immunity |
EP2029756B1 (fr) | 2006-06-20 | 2016-11-09 | Transgene S.A. | Procédé de production de poxvirus et compositions de poxvirus |
KR20080084528A (ko) | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
ME02340B (me) | 2008-06-10 | 2017-02-20 | Abbvie Inc | Triciklična jedinjenja |
HUE045108T2 (hu) | 2014-07-16 | 2019-12-30 | Transgene Sa | Onkolitikus vírus immunellenõrzõpont-modulátorok expresszálására |
CN105255840A (zh) | 2015-10-16 | 2016-01-20 | 西安医学院 | 通过去除显性表位b8r重组痘苗病毒的方法及其病毒 |
US20190022203A1 (en) | 2016-01-11 | 2019-01-24 | Turnstone Limited Partnership | Oncolytic virus and checkpoint inhibitor combination therapy |
WO2017209053A1 (fr) | 2016-05-30 | 2017-12-07 | アステラス製薬株式会社 | Nouveau virus de la vaccine génétiquement modifié |
RU2621868C1 (ru) | 2016-06-24 | 2017-06-07 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор"" (ФБУН ГНЦ ВБ "Вектор") | Рекомбинантный штамм VACΔ6 вируса осповакцины с нарушенными генами вирулентности C3L, N1L, J2R, A35R, A56R, B8R для получения живой культуральной аттенуированной вакцины против натуральной оспы и других ортопоксвирусных инфекций человека |
KR20190124750A (ko) | 2017-02-28 | 2019-11-05 | 사노피 | 치료적 rna |
AU2018301701A1 (en) | 2017-07-14 | 2020-02-27 | Elevatebio Technologies, Inc. | Encapsulated polynucleotides and methods of use |
AU2018359420A1 (en) | 2017-10-31 | 2020-06-04 | Kalivir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
JP2021509815A (ja) | 2018-01-05 | 2021-04-08 | オタワ ホスピタル リサーチ インスティチュート | 改変ワクシニアベクター |
AU2019410148A1 (en) | 2018-12-21 | 2021-08-12 | Ottawa Hospital Research Institute | Modified orthopoxvirus vectors |
-
2019
- 2019-01-04 US US16/959,632 patent/US11802292B2/en active Active
- 2019-01-04 CN CN201980017640.4A patent/CN113039277A/zh active Pending
- 2019-01-04 SG SG11202006457YA patent/SG11202006457YA/en unknown
- 2019-01-04 EP EP19736067.0A patent/EP3735466A4/fr active Pending
- 2019-01-04 KR KR1020207022477A patent/KR20200121297A/ko not_active Application Discontinuation
- 2019-01-04 AU AU2019205036A patent/AU2019205036A1/en active Pending
- 2019-01-04 WO PCT/CA2019/050014 patent/WO2019134048A1/fr active Search and Examination
- 2019-01-04 CA CA3122431A patent/CA3122431A1/fr active Pending
- 2019-01-04 JP JP2020557368A patent/JP7312412B2/ja active Active
- 2019-01-04 MX MX2020007010A patent/MX2020007010A/es unknown
- 2019-01-04 BR BR112020013769-3A patent/BR112020013769A2/pt unknown
-
2020
- 2020-07-02 IL IL275813A patent/IL275813A/en unknown
-
2023
- 2023-06-30 JP JP2023108025A patent/JP2023126868A/ja active Pending
- 2023-09-04 US US18/461,241 patent/US20240132913A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015027163A1 (fr) * | 2013-08-22 | 2015-02-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thérapies immuno-oncolytiques |
Non-Patent Citations (1)
Title |
---|
J. DIMIER ET AL: "Deletion of Major Nonessential Genomic Regions in the Vaccinia Virus Lister Strain Enhances Attenuation without Altering Vaccine Efficacy in Mice", JOURNAL OF VIROLOGY, vol. 85, no. 10, 15 May 2011 (2011-05-15), pages 5016 - 5026, XP055194226, ISSN: 0022-538X, DOI: 10.1128/JVI.02359-10 * |
Also Published As
Publication number | Publication date |
---|---|
AU2019205036A1 (en) | 2020-08-20 |
BR112020013769A2 (pt) | 2020-12-01 |
US20200392535A1 (en) | 2020-12-17 |
KR20200121297A (ko) | 2020-10-23 |
CN113039277A (zh) | 2021-06-25 |
EP3735466A1 (fr) | 2020-11-11 |
IL275813A (en) | 2020-08-31 |
MX2020007010A (es) | 2020-12-10 |
JP2021510082A (ja) | 2021-04-15 |
SG11202006457YA (en) | 2020-08-28 |
JP2023126868A (ja) | 2023-09-12 |
US20240132913A1 (en) | 2024-04-25 |
WO2019134048A1 (fr) | 2019-07-11 |
CA3122431A1 (fr) | 2019-07-11 |
US11802292B2 (en) | 2023-10-31 |
JP7312412B2 (ja) | 2023-07-21 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20200728 |
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Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
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AX | Request for extension of the european patent |
Extension state: BA ME |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: HUH, MICHAEL S. Inventor name: LE BOEUF, FABRICE Inventor name: TANG, MATTHEW Y. Inventor name: PELIN, ADRIAN Inventor name: BREITBACH, CAROLINE J. Inventor name: BURGESS, MICHAEL F. Inventor name: KELLER, BRIAN ANDREW Inventor name: BELL, JOHN C. Inventor name: BERNSTEIN, STEVEN H. |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20211215 |
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RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 7/01 20060101ALI20211209BHEP Ipc: C12N 5/10 20060101ALI20211209BHEP Ipc: C12N 15/39 20060101ALI20211209BHEP Ipc: C07K 14/07 20060101ALI20211209BHEP Ipc: A61P 35/00 20060101ALI20211209BHEP Ipc: A61K 35/768 20150101ALI20211209BHEP Ipc: A61K 35/76 20150101ALI20211209BHEP Ipc: C12N 15/863 20060101AFI20211209BHEP |
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P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230506 |